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26 results on '"Shamblin, Joshua D."'

1. Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods

Author

Bell, Todd M., primary, Facemire, Paul, additional, Bearss, Jeremy J., additional, Raymond, Jo Lynne, additional, Chapman, Jennifer, additional, Zeng, Xiankun, additional, Shamblin, Joshua D., additional, Williams, Janice A., additional, Grosenbach, Douglas W., additional, Hruby, Dennis E., additional, Damon, Inger K., additional, Goff, Arthur J., additional, and Mucker, Eric M., additional

Published
2024
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2. Development of Clinical-Stage Human Monoclonal Antibodies That Treat Advanced Ebola Virus Disease in Nonhuman Primates

Author

Pascal, Kristen E., Dudgeon, Drew, Trefry, John C., Anantpadma, Manu, Sakurai, Yasuteru, Murin, Charles D., Turner, Hannah L., Fairhurst, Jeanette, Torres, Marcela, Rafique, Ashique, Yan, Ying, Badithe, Ashok, Yu, Kevin, Potocky, Terra, Bixler, Sandra L., Chance, Taylor B., Pratt, William D., Rossi, Franco D., Shamblin, Joshua D., Wollen, Suzanne E., Zelko, Justine M., Carrion, Ricardo, Worwa, Gabriella, Staples, Hilary M., Burakov, Darya, Babb, Robert, Chen, Gang, Martin, Joel, Huang, Tammy T., Erlandson, Karl, Willis, Melissa S., Armstrong, Kimberly, Dreier, Thomas M., Ward, Andrew B., Davey, Robert A., Pitt, Margaret L. M., Lipsich, Leah, Mason, Peter, Olson, William, Stahl, Neil, and Kyratsous, Christos A.

Published
2018

3. Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

Author

Bornholdt, Zachary A., Turner, Hannah L., Murin, Charles D., Li, Wen, Sok, Devin, Souders, Colby A., Piper, Ashley E., Goff, Arthur, Shamblin, Joshua D., Wollen, Suzanne E., Sprague, Thomas R., Fusco, Marnie L., Pommert, Kathleen B. J., Cavacini, Lisa A., Smith, Heidi L., Klempner, Mark, Reimann, Keith A., Krauland, Eric, Gerngross, Tillman U., Wittrup, Karl D., Saphire, Erica Ollmann, Burton, Dennis R., Glass, Pamela J., Ward, Andrew B., and Walker, Laura M.

Published
2016

4. High infection rates for adult macaques after intravaginal or intrarectal inoculation with Zika virus

Author

Haddow, Andrew D., Nalca, Aysegul, Rossi, Franco D., Miller, Lynn J., Wiley, Michael R., Perez-Sautu, Unai, Washington, Samuel C., Norris, Sarah L., Wollen-Roberts, Suzanne E., Shamblin, Joshua D., Kimmel, Adrienne E., Bloomfield, Holly A., Valdez, Stephanie M., Sprague, Thomas R., Principe, Lucia M., Bellanca, Stephanie A., Cinkovich, Stephanie S., Lugo-Roman, Luis, Cazares, Lisa H., Pratt, William D., Palacios, Gustavo F., Bavari, Sina, Pitt, M. Louise, and Nasar, Farooq

Subjects
Mosquitoes -- Analysis -- Health aspects, Disease transmission -- Risk factors -- Analysis -- Health aspects, Zika virus -- Analysis -- Health aspects, Infection -- Risk factors -- Analysis -- Health aspects, RNA -- Analysis -- Health aspects, Health
Abstract

Zika virus is a member of the Spondweni serogroup, family Flaviviridae, genus Flavivirus (1,2). Since the initial isolation of the virus in 1947 (3), intermittent reports of Zika virus infection [...]

Published
2017
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5. Detailed analysis of the pathologic hallmarks of Nipah virus (Malaysia) disease in the African green monkey infected by the intratracheal route

Author

Cline, Curtis, primary, Bell, Todd M., additional, Facemire, Paul, additional, Zeng, Xiankun, additional, Briese, Thomas, additional, Lipkin, W. Ian, additional, Shamblin, Joshua D., additional, Esham, Heather L., additional, Donnelly, Ginger C., additional, Johnson, Joshua C., additional, Hensley, Lisa E., additional, Honko, Anna N., additional, and Johnston, Sara C., additional

Published
2022
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8. EBOLA VIRUS: Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

Author

Bornholdt, Zachary A., Turner, Hannah L., Murin, Charles D., Li, Wen, Sok, Devin, Souders, Colby A., Piper, Ashley E., Goff, Arthur, Shamblin, Joshua D., Wollen, Suzanne E., Sprague, Thomas R., Fusco, Marnie L., Pommert, Kathleen B. J., Cavacini, Lisa A., Smith, Heidi L., Klempner, Mark, Reimann, Keith A., Krauland, Eric, Gerngross, Tillman U., Wittrup, Karl D., Saphire, Erica Ollmann, Burton, Dennis R., Glass, Pamela J., Ward, Andrew B., and Walker, Laura M.

Published
2016
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9. The utilization of advance telemetry to investigate critical physiological parameters including electroencephalography in cynomolgus macaques following aerosol challenge with eastern equine encephalitis virus

Author

Trefry, John C., primary, Rossi, Franco D., additional, Accardi, Michael V., additional, Dorsey, Brandi L., additional, Sprague, Thomas R., additional, Wollen-Roberts, Suzanne E., additional, Shamblin, Joshua D., additional, Kimmel, Adrienne E., additional, Glass, Pamela J., additional, Miller, Lynn J., additional, Burke, Crystal W., additional, Cardile, Anthony P., additional, Smith, Darci R., additional, Bavari, Sina, additional, Authier, Simon, additional, Pratt, William D., additional, Pitt, Margaret L., additional, and Nasar, Farooq, additional

Published
2021
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10. Transcriptomic Analysis Reveals Host miRNAs Correlated with Immune Gene Dysregulation during Fatal Disease Progression in the Ebola Virus Cynomolgus Macaque Disease Model

Author

Stefan, Christopher P., primary, Arnold, Catherine E., additional, Shoemaker, Charles J., additional, Zumbrun, Elizabeth E., additional, Altamura, Louis A., additional, Douglas, Christina E., additional, Taylor-Howell, Cheryl L., additional, Graham, Amanda S., additional, Delp, Korey L., additional, Blancett, Candace D., additional, Ricks, Keersten M., additional, Olschner, Scott P., additional, Shamblin, Joshua D., additional, Wollen, Suzanne E., additional, Zelko, Justine M., additional, Bloomfield, Holly A., additional, Sprague, Thomas R., additional, Esham, Heather L., additional, and Minogue, Timothy D., additional

Published
2021
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12. The Utilization of Advance Telemetry to Investigate Important Physiological Parameters Including Electroencephalography in Cynomolgus Macaques Following Aerosol Challenge with Eastern Equine Encephalitis Virus

Author

Trefry, John C, primary, Rossi, Franco D, additional, Accardi, Michael V, additional, Dorsey, Brandi L, additional, Sprague, Thomas R, additional, Wollen-Roberts, Suzanne E, additional, Shamblin, Joshua D, additional, Kimmel, Adrienne E, additional, Glass, Pamela J, additional, Miller, Lynn J, additional, Cardile, Anthony P, additional, Smith, Darci R, additional, Bavari, Sina, additional, Authier, Simon, additional, Pratt, William D, additional, Pitt, Margaret L, additional, and Nasar, Farooq, additional

Published
2020
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14. Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

Author

Golden, Joseph W., primary, Cline, Curtis R., additional, Zeng, Xiankun, additional, Garrison, Aura R., additional, Carey, Brian D., additional, Mucker, Eric M., additional, White, Lauren E., additional, Shamblin, Joshua D., additional, Brocato, Rebecca L., additional, Liu, Jun, additional, Babka, April M., additional, Rauch, Hypaitia B., additional, Smith, Jeffrey M., additional, Hollidge, Bradley S., additional, Fitzpatrick, Collin, additional, Badger, Catherine V., additional, and Hooper, Jay W., additional

Published
2020
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15. Modeling mosquito-borne and sexual transmission of Zika virus in an enzootic host, the African green monkey

Author

Haddow, Andrew D., primary, Perez-Sautu, Unai, additional, Wiley, Michael R., additional, Miller, Lynn J., additional, Kimmel, Adrienne E., additional, Principe, Lucia M., additional, Wollen-Roberts, Suzanne E., additional, Shamblin, Joshua D., additional, Valdez, Stephanie M., additional, Cazares, Lisa H., additional, Pratt, William D., additional, Rossi, Franco D., additional, Lugo-Roman, Luis, additional, Bavari, Sina, additional, Palacios, Gustavo F., additional, Nalca, Aysegul, additional, Nasar, Farooq, additional, and Pitt, M. Louise M., additional

Published
2020
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16. Virus-encoded miRNAs in Ebola virus disease

Author

Duy, Janice, primary, Honko, Anna N., additional, Altamura, Louis A., additional, Bixler, Sandra L., additional, Wollen-Roberts, Suzanne, additional, Wauquier, Nadia, additional, O’Hearn, Aileen, additional, Mucker, Eric M., additional, Johnson, Joshua C., additional, Shamblin, Joshua D., additional, Zelko, Justine, additional, Botto, Miriam A., additional, Bangura, James, additional, Coomber, Moinya, additional, Pitt, M. Louise, additional, Gonzalez, Jean-Paul, additional, Schoepp, Randal J., additional, Goff, Arthur J., additional, and Minogue, Timothy D., additional

Published
2018
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17. A conserved transcriptional response to intranasal Ebola virus exposure in nonhuman primates prior to onset of fever

Author

Speranza, Emily, primary, Bixler, Sandra L., additional, Altamura, Louis A., additional, Arnold, Catherine E., additional, Pratt, William D., additional, Taylor-Howell, Cheryl, additional, Burrows, Christina, additional, Aguilar, William, additional, Rossi, Franco, additional, Shamblin, Joshua D., additional, Wollen, Suzanne E., additional, Zelko, Justine M., additional, Minogue, Timothy, additional, Nagle, Elyse, additional, Palacios, Gustavo, additional, Goff, Arthur J., additional, and Connor, John H., additional

Published
2018
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18. Zika Virus Infection in Syrian Golden Hamsters and Strain 13 Guinea Pigs

Author

Miller, Lynn J., primary, Nasar, Farooq, additional, Schellhase, Christopher W., additional, Norris, Sarah L., additional, Kimmel, Adrienne E., additional, Valdez, Stephanie M., additional, Wollen-Roberts, Suzanne E., additional, Shamblin, Joshua D., additional, Sprague, Thomas R., additional, Lugo-Roman, Luis A., additional, Jarman, Richard G., additional, Yoon, In-Kyu, additional, Alera, Maria T., additional, Bavari, Sina, additional, Pitt, M. Louise M., additional, and Haddow, Andrew D., additional

Published
2018
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20. A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever

Author

Cashman, Kathleen A., primary, Wilkinson, Eric R., additional, Shaia, Carl I., additional, Facemire, Paul R., additional, Bell, Todd M., additional, Bearss, Jeremy J., additional, Shamblin, Joshua D., additional, Wollen, Suzanne E., additional, Broderick, Kate E., additional, Sardesai, Niranjan Y., additional, and Schmaljohn, Connie S., additional

Published
2017
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21. Low potential for mechanical transmission of Ebola virus via house flies (Musca domestica)

Author

Haddow, Andrew D., primary, Nasar, Farooq, additional, Schellhase, Christopher W., additional, Moon, Roger D., additional, Padilla, Susana L., additional, Zeng, Xiankun, additional, Wollen-Roberts, Suzanne E., additional, Shamblin, Joshua D., additional, Grimes, Elizabeth C., additional, Zelko, Justine M., additional, Linthicum, Kenneth J., additional, Bavari, Sina, additional, Pitt, M. Louise, additional, and Trefry, John C., additional

Published
2017
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22. Temporal Characterization of Marburg Virus Angola Infection following Aerosol Challenge in Rhesus Macaques

Author

Lin, Kenny L., primary, Twenhafel, Nancy A., additional, Connor, John H., additional, Cashman, Kathleen A., additional, Shamblin, Joshua D., additional, Donnelly, Ginger C., additional, Esham, Heather L., additional, Wlazlowski, Carly B., additional, Johnson, Joshua C., additional, Honko, Anna N., additional, Botto, Miriam A., additional, Yen, Judy, additional, Hensley, Lisa E., additional, and Goff, Arthur J., additional

Published
2015
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24. Detailed Analysis of the African Green Monkey Model of Nipah Virus Disease

Author

Johnston, Sara C., primary, Briese, Thomas, additional, Bell, Todd M., additional, Pratt, William D., additional, Shamblin, Joshua D., additional, Esham, Heather L., additional, Donnelly, Ginger C., additional, Johnson, Joshua C., additional, Hensley, Lisa E., additional, Lipkin, W. Ian, additional, and Honko, Anna N., additional

Published
2015
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25. Efficacy of Tecovirimat (ST-246) in Nonhuman Primates Infected with Variola Virus (Smallpox)

Author

Mucker, Eric M., primary, Goff, Arthur J., additional, Shamblin, Joshua D., additional, Grosenbach, Douglas W., additional, Damon, Inger K., additional, Mehal, Jason M., additional, Holman, Robert C., additional, Carroll, Darin, additional, Gallardo, Nadia, additional, Olson, Victoria A., additional, Clemmons, Cody J., additional, Hudson, Paul, additional, and Hruby, Dennis E., additional

Published
2013
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26. Ebola Virus Infections in Nonhuman Primates Are Temporally Influenced by Glycoprotein Poly-U Editing Site Populations in the Exposure Material.

Author

Trefry, John C., Wollen, Suzanne E., Nasar, Farooq, Shamblin, Joshua D., Kern, Steven J., Bearss, Jeremy J., Jefferson, Michelle A., Chance, Taylor B., Kugelman, Jeffery R., Ladner, Jason T., Honko, Anna N., Kobs, Dean J., Wending, Morgan Q. S., Sabourin, Carol L., Pratt, William D., Palacios, Gustavo F., and Pitt, M. Louise M.

Subjects
EBOLA virus, EBOLA virus disease, GLYCOPROTEINS, FILOVIRIDAE, RNA editing
Abstract

Recent experimentation with the variants of the Ebola virus that differ in the glycoprotein's poly-uridine site, which dictates the form of glycoprotein produced through a transcriptional stutter, has resulted in questions regarding the pathogenicity and lethality of the stocks used to develop products currently undergoing human clinical trials to combat the disease. In order to address these concerns and prevent the delay of these critical research programs, we designed an experiment that permitted us to intramuscularly challenge statistically significant numbers of naïve and vaccinated cynomolgus macaques with either a 7U or 8U variant of the Ebola virus, Kikwit isolate. In naïve animals, no difference in survivorship was observed; however, there was a significant delay in the disease course between the two groups. Significant differences were also observed in time-of-fever, serum chemistry, and hematology. In vaccinated animals, there was no statistical difference in survivorship between either challenge groups, with two succumbing in the 7U group compared to 1 in the 8U challenge group. In summary, survivorship was not affected, but the Ebola virus disease course in nonhuman primates is temporally influenced by glycoprotein poly-U editing site populations. [ABSTRACT FROM AUTHOR]

Published
2015
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