Search

Background and Objective: The mutation of F2 and PAI-1 genes can cause thrombophilia in women. The present study aimed to assess the relationship of recurrent pregnancy loss (RPL) with rs3136520 in F2 and rs6090 in PAI-1. Materials and Methods: This case-control study was conducted on 120 women with idiopathic RPL as case group and 120 healthy women without any history of infertility or abortion with at least one healthy child as the control group. These subjects were referred to a private genetic lab by a gynecologist. Both polymorphisms were studied using the amplification-refractory mutation system-polymerase chain reaction approach, and the obtained data were analyzed in SPSS software (version 26) using the chi-squared test (P˂0.05). Results: In the multiplicative model, there was a significant association between rs6090 and RPL (OR=0.222; 95%CI=0.082-0.599); nonetheless, no relationship was detected between rs3136520 and RPL (OR=1, 95%CI=0.488-2.049). Moreover, according to additive model, there was no association between rs3136520 and RPL; however, there was a significant relationship between AG genotype in rs6090 and RPL (OR=0.245; 95% CI=0.066-0.901). Conclusion: As evidenced by the obtained results, there was a protective association between rs6090 and RPL; nonetheless, there was no relationship between rs3136520 and RPL.

Objectives: The aim of this study was to evaluate the protective effect of the hydroalcoholic extract of orange peel on proliferating cell nuclear antigen (PCNA) and follicle-stimulating hormone receptor (FSH-R) gene expression in histological injuries and acid stress caused by ovarian torsion in adult rats. Materials and Methods: In this experimental study, 32 adult female rats were randomly divided into 4 groups. In group 1 (Sham), the abdominal wall was cut without applying torsion and in group 2, ovarian torsion was performed for 2 hours, followed by detorsion for 2 weeks. The hydro-alcoholic extract of orange peel was added to their diet for two weeks in group 3, followed by ovarian torsion for 2 hours and detorsion for 2 hours. Group 4 received the orange peel extract for two weeks and after then ovarian resection for the evaluation of histological damage and blood sampling to examine the serum level of antioxidant enzymes, as well as the expression of PCNA and FSH-R genes in the ovarian tissue. Results: Histological changes in the ovary tissue of rats showed that torsion and detorsion have destructive effects on the ovarian tissue, and torsion/detorsion led to a reduction in the expression of PCNA and FSH-R (P < 0.05). Based on biochemical and hormonal results, the ovarian torsion resulted in an imbalance in the oxidative stress markers and hormone profile of rats. Finally, the administration of the hydroalcoholic extract of orange peel due to its high antioxidant properties improves these effects. Conclusions: In general, administering an appropriate dose of the hydroalcoholic extract of orange peel for two consecutive weeks in the diet had a protective effect on the ovarian tissue at the risk of torsion/detorsion.

Objectives: This study was performed to investigate the relationship between the renal artery color Doppler with the umbilical artery and amniotic fluid index (AFI) in fetuses affected by intrauterine growth retardation (IUGR). Materials and Methods: This was a descriptive cross-sectional diagnostic study and the target population included pregnant mothers who were diagnosed to have fetuses with IUGR referring to the Al-Zahra treatment center in Tabriz. At least 40 samples were referred between October 2019 and May 2020. The patients were evaluated using the transabdominal ultrasound of the umbilical artery and fetal renal artery, and then using the color Doppler values of the umbilical artery and fetal renal artery. Results: The present research was performed on 40 pregnant females with an IUGR fetus with umbilical artery percentile upper that 95% whose minimum to maximum age range was 22-38 years. There is no relationship between umbilical artery and renal artery color Doppler. In addition, umbilical artery color Doppler is not related to amniotic fluid, also renal artery color Doppler demonstrated no significant correlation with amniotic fluid index. Conclusions: Based on our results, the PI of the umbilical artery had no significant correlation with that of the renal artery. In addition, there was no significant correlation with the PI of the renal artery and AFI.

Objectives: The present study aimed at determining the relationship between sleep quality and overweight and obesity in women of reproductive age referred to health centers and bases in Yazd in 2014-2015. Materials and Methods: A total of 450 women of reproductive age with a body mass index (BMI) of >18.5 were participated in this study and divided into 3 equal groups (n = 150) of normal weight, overweight, and obese. Instruments used in this study were the Pittsburgh Sleep Quality Index (PSQI) and a socio-demographic questionnaire. Data from the questionnaires were completed by the participants and analyzed using statistical methods. Results: In this study, 66% of normal weight women of reproductive age had an acceptable sleep quality, while 77% of overweight and 93% of obese women of reproductive age had poor sleep quality, respectively. The results of this study showed that a significant correlation existed between BMI of normal weight women of reproductive age and the components of sleep quality (P = 0.001). An inverse significant relationship was also found between BMI of overweight women of reproductive age and the components of sleep quality (P < 0.05) and finally, an inverse significant relationship was also found between BMI of obese women of reproductive age and the components of sleep quality (P < 0.05). A significant relationship also existed between socio-demographic and components of sleep quality (P < 0.05). It seems that among the components of sleep quality, the effect of sleep disorder, impaired daily functioning, and consumption of hypnotic drugs was higher than sleep duration and good sleep in overweight and obesity. Conclusion: The results of this study revealed that women of reproductive age with overweight and obesity have poor sleep quality. Among components of sleep quality, sleep disorder, impaired daily functioning, and consumption of hypnotic drugs have the most important role in reducing sleep quality. It seems that change in lifestyle can improve sleep quality and thus can reduce BMI

Vitamin D and calcium deficiency have been reported as one of the causes of preeclampsia. In this study, levels of vitamin D, calcium and phosphorus were evaluated in 51 normotensive pregnant women and 52 women with preeclampsia at the gestational age between 28 and 36 weeks in Tabriz. Logistic regression and general linear models were used for comparing levels and means of vitamin D, calcium and phosphorus between the two groups adjusting for education and Body Mass Index (BMI). The results showed that mean serum vitamin D (