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Abstract Introduction Neonatal myiasis is a rare condition, with few reports available on the subject. Surgical management is recommended in some cases. In this study, we present the case of a 7-day-old male neonate with larvae in his scrotum who underwent surgery. Case presentation A full-term 7-day-old male infant (Aryan race) was referred to a children’s hospital. On the sixth day after birth, three 3–4 mm long larvae crawled out from his scrotum, with the number increasing over time. He was given intravenous antibiotics and topical mupirocin to combat secondary infections. The surgical treatment involved two steps: first, the larvae were extracted, and then the infection site was washed with betadine and hydrogen peroxide to help remove any possible remaining larvae. Conclusion Scrotal myiasis is a rare disease that occurs in infants and requires immediate treatment. Surgical treatment is effective in removing dead or decaying larvae from a deep-seated location and washing the infection site to prevent secondary infection.

Introduction: Batteries are widely used in all kinds of electrical and electronic equipment. These batteries contain several metals that lead to the leakage of metals into the soil and underground water in the burial places, which pose serious risks to human health and the environment. Materials and Methods: In this study, the concentration of 15 metals (Ag, Al, As, Ba, Cd, Co, Cs, Cu, Fe, Li, Mn, Pb, Sr, Zn, Ni) in different components of 7 used battery models was investigated using Waste Extraction Test (WET) and Toxicity Characteristic Leaching Procedure (TCLP) toxicity. The concentration of metals was measured by Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). Metal concentrations were compared with the United States Environmental Protection Agency (USEPA) and California Department of Toxic Substances Control (CDTSC) standards. Results: The results showed that the average concentration of metals in both WET and TCLP methods was high, but the concentration of most metals in WET method was relatively higher than in TCLP method. Conclusion: The results showed that the recovery of metals from batteries is necessary, moreover safe burial of batteries is essential to reduce environmental risks.

Background: Multiple sclerosis (MS) is a prevalent disease of the central nervous system that often leads to diminished resilience and quality of life in affected individuals. This study aims to compare the effects of nursing and peer education on improving the quality of life and resilience in patients with multiple sclerosis. Materials and methods: This three-group clinical trial study was conducted before and after interventions at the MS Society in Hamedan, Iran. In this study, 120 patients with MS were randomly selected and assigned to three groups: nurse education, peer education, and control. Quality of life and resilience questionnaires were self-reported before and two months after the completion of the intervention. The educational sessions were conducted over five meetings, each lasting between 45 and 60 min, held every two days. Group one received education led by nurses, while group two participated in peer-led education sessions. Results: The results indicated that before the intervention, there were no significant statistical differences in demographic variables, resilience, and quality of life among the three groups (p > 0.05). However, after the intervention, both the peer and nurse groups showed a significant increase in quality of life and resilience compared to the control group (p 0.05). Conclusions: Both nursing and peer education methods had an equal impact on enhancing the resilience and quality of life of patients with MS. It is recommended that peer support be utilized to empower MS patients, especially in contexts where there is a shortage of nurses.

Introduction: Given that hospital air is one of the important environmental sources for transmission of microorganisms, the importance of airborne transmission in the epidemiology of hospital-acquired infections (HAIs) has gained attention in the past two decades. Therefore, the present study aims to determine the concentration of bacteria in association with airborne particulate matter (PM) in the outdoor and indoor air of two hospital wards. Materials and methods: The GRIMM 1.109 dust monitor and the Andersen one-stage viable impactor were used for particle counting and bioaerosol sampling, respectively. Results: The average levels of airborne bacteria sampled from outdoor air were 33 colony-forming units (CFU/m3), and in the air samples of medical and infectious disease wards, they were 76 and 85 CFU/m3, respectively. Staphylococcus spp. and Acinetobacter spp. were the most prevalent bacteria in the samples. Statistical analysis showed a significant association between PM2.5, and PM10 particle mass concentrations and airborne bacteria concentrations in indoor air samples (P-value < 0.05). Conclusion: Some bacterial agents of HAIs existed in hospital air and may be problematic for immunocompromised patients. Higher levels of bacteria in indoor air compared to outdoor air may indicate that the bacteria were of indoor origin, such as the presence and activities of people. Moreover, the results showed that particle counting may be a useful tool for airborne bacteria monitoring.

Antibiotic resistance (AR) is a major global health concern, but current surveillance efforts primarily focus on healthcare settings, leaving a lack of understanding about AR across all sectors of the One Health approach. To bridge this gap, wastewater surveillance provides a cost-effective and efficient method for monitoring AR within a population. In this study, we implemented a surveillance program by monitoring the wastewater effluent from two large-scale municipal treatment plants situated in Isfahan, a central region of Iran. These treatment plants covered distinct catchment regions and served a combined population about two million of residents. Furthermore, the effect of physicochemical and microbial characteristics of wastewater effluent including biological oxygen demand (BOD), chemical oxygen demand (COD), total suspended solids (TSS), temperature, total coliforms and Escherichia coli concentration on the abundance of ARGs (blaCTX-M, tetW, sul1, cmlA, and ermB) and class 1 integron-integrase gene (intI1) were investigated. Sul1 and blaCTX-M were the most and least abundant ARGs in the two WWTPs, respectively. Principal Component Analysis showed that in both of the WWTPs all ARGs and intI1 gene abundance were positively correlated with effluent temperature, but all other effluent characteristics (BOD, COD, TSS, total coliforms and E. coli) showed no significant correlation with ARGs abundance. Temperature could affect the performance of conventional activated sludge process, which in turn could affect the abundance of ARGs. The results of this study suggest that other factors than BOD, COD and TSS may affect the ARGs abundance. The predicted AR could lead to development of effective interventions and policies to combat AR in the clinical settings. However, further research is needed to determine the relationship between the AR in wastewater and clinical settings as well as the effect of other influential factors on ARGs abundance.

Abstract Background Inflammasomes are a group of molecules that are strongly involved in causing inflammation. This study aimed to evaluate the expression of NLR family pyrin domain containing 1 (NLRP1), NLRP3, and Apoptosis-associated speck-like protein containing a CARD (ASC) as well as their association with serum level of interleukin (IL)-1β in patients with coronavirus disease 2019 (COVID-19). Methods Thirty COVID-19 patients and 30 healthy subjects (HS) were recruited. Peripheral blood specimens were collected from subjects to assess NLRP1, NLRP3, and ASC gene expression by Real time-PCR technique. Serum levels of IL-1β were also measured via the enzyme-linked immunosorbent assay (ELISA). Results The findings showed no significant differences in serum IL-1β level between COVID-19 patients and the HS group. mRNA expression of ASC (P = 0.008) and NLRP1 (P = 0.03) gene had a significant increase in COVID-19 patients compared to HS, while there was no significant increase in the expression of NLRP3 between the studied group. There were significant correlations between patient’s data and expression levels of NLRP1, NLRP3, IL-1β, and ACS. Conclusions NLRP1 and ASC may have a more critical role in the generation of the active form of IL-1β in COVID-19 patients compared to NLRP3. However, serum levels of IL-1β in patients did not show a significant increase, which may be due to the patient’s condition and the application of virus escape mechanisms through impaired NLRP3 expression and its malfunction.

Interval-valued neutrosophic sets have been shown to provide a limited platform for computational complexity, but neutrosophic sets are suitable for it. The neutrosophic sets are a suitable mechanism for interpreting the philosophical problems of real-life, but not for scientific problems because it is difficult to consolidate. This study aims to develop the notion of neutrosophic single-valued general machine over a finite group, which is knows as ”group neutrosophic general machine”, for simplicity, GNGM. After that, we present the notions of max-min GNGM, single-valued neutrosophic subgroup (SVNSG) and single-valued neutrosophic normal sub group (SVNNSG).

To determine the effect of physical activity by using the teach-back educational method on hemodialysis patients’ quality of life (QOL) and physical ability.

Introduction: Fine particulate matter (PM2.5) pollution is a global public health concern, particularly in arid and semi-arid regions that experience dust events. Exposure to PM2.5 has been associated with various short- and long-term health effects, which can be attributed to the composition of the fine particles. This study aimed to assess the concentration of bacteria and fungi in PM2.5 in the air of Isfahan, Iran which experiences air pollution.Methods: A total of thirty-nine PM2.5 samples were collected over 1 year. Bacterial and fungal concentrations associated with PM2.5 were measured using both culture-based method and real-time polymerase chain reaction (PCR).Results: The average concentration of PM2.5 was found to be 56 μg m−3, with many samples exceeding the recommended limit of 15 μg m−3 set by the World Health Organization for PM2.5 in ambient air. The mean culturable bacterial and fungal concentrations were 39 and 4 CFU m−3, respectively which showed a significant difference compared to the results obtained through real-time PCR. No significant correlation was found between the levels of bacterial and fungal cells and PM2.5 concentrations. The dominant phyla found in PM2.5 were Firmicutes and Actinobacteria, while Proteobacteria as Gram-negative bacteria were rarely detected.Discussion: The findings suggest that the climate conditions in Isfahan, characterized by its semi-arid nature with low humidity content, influences the activity and viability of microbial populations, resulting in low concentrations of bioaerosols in PM2.5. Furthermore, it seems that desert dust events do not contribute to increasing the potential health risks associated with bacterial and fungal bioaerosols in PM2.5.

Oral health status can be affected by some factors including drug abuse, systemic conditions and environmental pollutants. The present study was designed to investigate the most important and prevalent dental and oral conditions in adult population of Rafsanjan with the age of 35–70 years. Dental and oral health cohort center as part of the Rafsanjan Cohort Study (RCS) included in the prospective epidemiological research studies in IrAN was established in 2015. Of 9991 subjects enrolled in the RCS, 8682 people participated in the Oral Health Branch of Rafsanjan Cohort Study (OHBRCS).The OHBRCS included 4021 men and 4661 women with the mean age of 49.94 ± 9.51. The most prevalent of oral lesion in total population was candidiasis and the least was aphthous lesion. The prevalence of candidiasis, white and red lesions, periodontal pocket, dental calculus, CAL and the mean of DMFT were higher in the male group than that of female group (p

In this paper, we define the concepts of single-valued neutrosophic general automaton, complete and deterministic single-valued neutrosophic general automaton. We present a minimal single-valued neutrosophic general automaton that preserves the language for a given single-valued neutrosophic general automaton. Moreover, we present the closure properties such as union and intersection for single-valued neutrosophic general automata.

Abstract Background Obesity has become a major health issue in both high and middle-income countries, increasing the risk of cardiovascular diseases and all-cause mortality. Risk of obesity is related to both unchangeable factors such as genetics and gender, and modifiable lifestyle factors. Most importantly, finding the major modifiable lifestyle factors which contribute to obesity may provide valuable benefits to every society. This study aimed to determine the association of demographic and lifestyle parameters with overweight/obesity and abdominal obesity in a population of Iranian adults. Methods In this cross-sectional study, adult participants of Rafsanjan Cohort Study (RCS) (as one of the district areas of the PERSIAN cohort (Prospective Epidemiological Research Studies in IrAN) included the study population. RCS is a population-based prospective cohort of men and women aged 35–70 years, launched in August 2015. Individuals were recruited from four urban and suburban areas of Rafsanjan, south-eastern of Iran. Trained experts interviewed each participant and completed the related questionnaires about his/her socioeconomic status, demography, anthropometric features, personal habits, physical activity and medical history. Multinomial logistic regression models were used to examine the relationships between overweight/obesity/abdominal obesity and associated factors. Results From 9980 participants, 1974 (42.42%) males and 2115 (39.70%) females were overweight, 784 (16.85%) males, 2223 (41.73%) females were obese and 1895 (40.73%) males and 989 (18.57%) females were normal weight. Also, 832 (17.9%) males and 4548 (85.4%) females had abdominal obesity and 3819 (82.1%) males and 778 (14.6%) females didn’t have abdominal obesity. Based on the adjusted multiple logistic regression, overweight/obesity (BMI > 25) was associated with age > 45, female gender, education ≥ 13 years, heavy physical activity, wealth status index (WSI), alcohol consumption, current cigarette smoking and opium consumption compared to reference group. Also, odds of abdominal obesity displayed a significant association with age > 45, female gender, education > 5 years, physical activity, WSI, current cigarette smoking, alcohol and opium consumption compared to reference group. Conclusions Our results recommend local public health strategies that promote training the society on the health benefits of avoiding alcohol, getting more physical exercise and gaining more personal education on the health-threatening lifestyle.

In this study, we show that automata theory is also a suitable tool for analyzing a more complex type of the k-forcing process. First, the definition of k-forcing automata is presented according to the definition of k-forcing for graphs. Moreover, we study and discuss the language of k-forcing automata for particular graphs. Also, for some graphs with different k-forcing sets, we study the languages of their k-forcing automata. In addition, for some given recognizable languages, we study the structure of graphs. After that, we show that k-forcing automata arising from isomorph graphs are also isomorph. Also, we present the style of words that can be recognized with k-forcing automata. Moreover, we introduce the structure of graphs the k-forcing automata arising from which recognize some particular languages. To clarify the notions and the results obtained in this study, some examples are submitted as well.

Abstract Background Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is still among the leading causes of disease burden and mortality in sub-Saharan Africa (SSA), and the world is not on track to meet targets set for ending the epidemic by the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the United Nations Sustainable Development Goals (SDGs). Precise HIV burden information is critical for effective geographic and epidemiological targeting of prevention and treatment interventions. Age- and sex-specific HIV prevalence estimates are widely available at the national level, and region-wide local estimates were recently published for adults overall. We add further dimensionality to previous analyses by estimating HIV prevalence at local scales, stratified into sex-specific 5-year age groups for adults ages 15–59 years across SSA. Methods We analyzed data from 91 seroprevalence surveys and sentinel surveillance among antenatal care clinic (ANC) attendees using model-based geostatistical methods to produce estimates of HIV prevalence across 43 countries in SSA, from years 2000 to 2018, at a 5 × 5-km resolution and presented among second administrative level (typically districts or counties) units. Results We found substantial variation in HIV prevalence across localities, ages, and sexes that have been masked in earlier analyses. Within-country variation in prevalence in 2018 was a median 3.5 times greater across ages and sexes, compared to for all adults combined. We note large within-district prevalence differences between age groups: for men, 50% of districts displayed at least a 14-fold difference between age groups with the highest and lowest prevalence, and at least a 9-fold difference for women. Prevalence trends also varied over time; between 2000 and 2018, 70% of all districts saw a reduction in prevalence greater than five percentage points in at least one sex and age group. Meanwhile, over 30% of all districts saw at least a five percentage point prevalence increase in one or more sex and age group. Conclusions As the HIV epidemic persists and evolves in SSA, geographic and demographic shifts in prevention and treatment efforts are necessary. These estimates offer epidemiologically informative detail to better guide more targeted interventions, vital for combating HIV in SSA.

Introduction: Lack of high-quality sleep causes severe side effects like anxiety and changes in plasma concentration of oxalate. The current study investigated the impact of local extremely low-frequency magnetic fields (ELF-MFs) on inducing sleep (sleepiness) and anxiety in male rats. Methods: In this experimental study, 40 male rats were divided into four groups (n=10 for each group). The ELF-MF exposure (0, 10, and 18 Hz) was applied with an intensity of 200µT for three days (10 min/d). The sham-treated animal did not receive ELF-MF. Serum levels of oxalic acid (OA) and sleepiness were measured before and after the last exposure to ELF-MF or sham. Anxiety, sleepiness, and OA were measured using the elevated plus maze, open-field test (OFT), and ELISA test. Results: A comparison of oxalate levels before and after exposure to ELF-MF revealed that ELF-MF (10 Hz) decreased the serum level of oxalate (P

Background and Objectives: Nurses are at higher risk of insomnia due to changes in their work shifts. This study aims to investigate the effect of extremely low-frequency magnetic field (ELF-MF) exposure on the sleepiness of night-shift nurses during rest time. Methods: This is a randomized crossover clinical trial that was conducted on 28 night-shift nurses, randomly divided into two groups of exposure (n=14) and sham (n=14). The central areas of the brain of nurses in the exposure group was exposed to a magnetic field with 200-μT intensity at a frequency of 10Hz for 10 minutes after each night shift for eight night shifts and four weeks. The executive protocol for the sham group was the same, except that the nurses were not exposed to a magnetic field. After exposure, there was no intervention for two weeks to wash out the effects. Then, the groups exchanged their roles and the protocol was repeated. Stanford sleepiness scale (SSS) was used to measure the sleepiness of nurses. Findings were analyzed in SPSS software. Results: No significant difference was observed in the mean SSS score in the first and second periods between the two groups (P=0.30). No significant difference was observed in the mean SSS score between the periods and the order of placement in each period, either (carryover effect=0.97, period effect=0.96). Conclusion: The local ELF-MF exposure has no significant effect on the sleepiness of night-shift nurses during rest time. It may be due to their disturbed circadian rhythm or the disturbance by the noise and light (not by work-related anxiety). Further investigation is needed.

In this paper, first of all, considering the notions of single-valued neutrosophic and general fuzzy automata we present the concept of single-valued neutrosophic general machine, to simplicity, SVNGM. Also, for a given SVNGM M, we give the concept of single-valued neutrosophic sub-general machine (SVNSGM) of M. Moreover, we show that if there exists a strong homomorphism between two SVNGM, then there is a connection between the SVNSGM of them. Further, we give the notion of single-valued neutrosophic strong sub-general machine (SVNSSGM). In addition, we show that for a given SVNGM M if M′ is a SVNSSGM of M, then M′ is a SVNSGM of M, but the converse does not hold.

Objective(s): Delayed tissue plasminogen activator (tPA) thrombolysis is accompanied by different complications in stroke patients. Studies reported sex differences in stroke therapy. Ischemic postconditioning (PC) unveils neuroprotection in stroke models. In this study, we investigate the combined effect of delayed tPA therapy and PC procedure during an embolic stroke experimental model in female rats. Materials and Methods: Female Wistar rats were randomly divided into control (saline), tPA, PC, and tPA+PC groups after stroke induction via clot injection to the middle cerebral artery. tPA treatment was initiated 6 hr after stroke, and PC procedure was performed 6.5 hr post-ischemia induction (occlusion: 10 sec; reopening: 30 sec; 5 cycles). The cerebral blood flow (CBF) was recorded up to 60 min from IV tPA injection time. The parameters of brain edema, infarct volume, disruption of the blood-brain barrier (BBB), behavioral tests, and matrix metalloproteinases-9 (MMP-9) were evaluated.Results: This study revealed that PC conduction prevents excessive CBF increase by tPA and played a protective role in infarct volume reduction (P

Introduction: Memantine as N-Methyl-D-Aspartic Acid (NMDA) receptor antagonist is used in some neurological disorders. Moreover, memantine presents modulatory effects on the somatosensory information processing in healthy subjects. This study investigated the effects of memantine on electrophysiological properties of barrel cortex neurons in male rats. Methods: Single unit recording was used to evaluate the electrophysiological properties of barrel cortex neurons. The neural responses to the Principal Whisker (PW), Adjacent Whisker (AW), and combined displacement of two whiskers [20 ms Inter-Stimulus Intervals (ISIs)] were recorded before and 2 hours after memantine gavage (10 mg/kg). A Condition Test Ratio (CTR) was calculated for assessing inhibitory interactions. Results: Two hours after memantine gavage, neuronal ON and OFF responses to PW deflection were decreased. Furthermore, CTR for both ON and OFF responses was decreased following memantine administration. Conclusion: The current study demonstrated that memantine modified neural response properties in the rat barrel cortex.

Considering high concentrations of multidrug-resistant bacteria and antibiotic resistance genes (ARGs) in wastewater, agricultural reuse of treated wastewater may be a public health threat due to ARG dissemination in different environmental compartments, including soil and edible parts of crops. We investigated the presence of antibiotic-resistant Escherichia coli as an indicator bacterium from secondary treated wastewater (STWW), water- or wastewater-irrigated soil and crop samples. ARGs including blaCTX-m-32, blaOXA-23, tet-W, sul1, cml-A, erm-B, along with intI1 gene in E. coli isolates were detected via molecular methods. The most prevalent ARGs in 78 E. coli isolates were sul1 (42%), followed by blaCTX-m-32 (19%), and erm-B (17%). IntI1 as a class 1 integrons gene was detected in 46% of the isolates. Cml-A was detected in STWW isolates but no E. coli isolate from wastewater-irrigated soil and crop samples contained this gene. The results also showed no detection of E. coli in water-irrigated soil and crop samples. Statistical analysis showed a correlation between sul1 and cml-A with intI1. The results suggest that agricultural reuse of wastewater may contribute to the transmission of antibiotic-resistant bacteria to soil and crop. Further research is needed to determine the potential risk of ARB associated with the consumption of wastewater-irrigated crops. HIGHLIGHTS Antibiotic-resistant E. coli presented different abundance in STWW, irrigated soil and crops.; Antibiotic resistance genes were detected in high numbers of E. coli isolates.; sul1 was the most abundant ARG in the E. coli isolates.; Wastewater irrigation could aggravate antibiotic resistance in soil and crops.;