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4. Vascular wall microenvironment: Endothelial cells original exosomes mediated melatonin-suppressed vascular calcification and vascular ageing in a m6A methylation dependent manner

Author

Shan, Su-Kang, Lin, Xiao, Wu, Feng, Li, Chang-Chun, Guo, Bei, Li, Fu-Xing-Zi, Zheng, Ming-Hui, Wang, Yi, Xu, Qiu-Shuang, Lei, Li-Min, Tang, Ke-Xin, Wu, Yun-Yun, Duan, Jia-Yue, Cao, Ye-Chi, Wu, Yan-Lin, Tan, Chang-Ming, Liu, Zi-Han, Zhou, Zhi-Ang, Liao, Xiao-Bo, Xu, Feng, and Yuan, Ling-Qing

Published
2024
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10. Assessment of causal association between the socio-economic status and osteoporosis and fractures: a bidirectional Mendelian randomization study in European population

Author

Duan, Jia-Yue, primary, You, Rui-Xuan, additional, Zhou, Yong, additional, Xu, Feng, additional, Lin, Xiao, additional, Shan, Su-Kang, additional, Zheng, Ming-Hui, additional, Lei, Li-Min, additional, Li, Fu-Xing-Zi, additional, Guo, Bei, additional, Wu, Yun-Yun, additional, Chen, Xi, additional, Tang, Ke-Xin, additional, Cao, Ye-Chi, additional, Wu, Yan-Lin, additional, He, Si-Yang, additional, Xiao, Rong, additional, and Yuan, Ling-Qing, additional

Published
2024
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12. Adipose exosomal noncoding RNAs: Roles and mechanisms in metabolic diseases.

Author

Wu, Yan‐Lin, Lin, Zheng‐Jun, Li, Chang‐Chun, Lin, Xiao, Shan, Su‐Kang, Guo, Bei, Zheng, Ming‐Hui, Wang, Yi, Li, Fuxingzi, and Yuan, Ling‐Qing

Subjects
NON-coding RNA, METABOLIC disorders, EXOSOMES, LINCRNA, EXTRACELLULAR vesicles
Abstract

Summary: Exosomes are extracellular vesicles, measuring 40–160 nm in diameter, that are released by many cell types and tissues, including adipose tissue. Exosomes are critical mediators of intercellular communication and their contents are complex and diverse. In recent years, accumulating evidence has proved that multiple adipose tissue‐derived exosomal noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), play pivotal roles in the pathogenesis of diverse metabolic diseases, such as obesity. In this narrative review, we focus on the adipose tissue‐derived exosomal ncRNAs, especially exosomal miRNAs, and their dysregulation in multiple types of metabolic diseases. A deeper understanding of the role of adipose tissue‐derived exosomal ncRNAs may help provide new diagnostic and treatment methods for metabolic diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Global publication trends and research trends of necroptosis application in tumor: A bibliometric analysis

Author

Wu, Yun-Yun, primary, Li, Chang-chun, additional, Lin, Xiao, additional, Xu, Feng, additional, Shan, Su-Kang, additional, Guo, Bei, additional, Li, Fu-Xing-Zi, additional, Zheng, Ming-Hui, additional, Xu, Qiu-Shuang, additional, Lei, Li-Min, additional, Duan, Jia-Yue, additional, Tang, Ke-Xin, additional, Cao, Ye-Chi, additional, and Yuan, Ling-Qing, additional

Published
2023
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20. Histone Lysine Methylation Modification and Its Role in Vascular Calcification

Author

Cao, Ye-Chi, primary, Shan, Su-Kang, additional, Guo, Bei, additional, Li, Chang-Chun, additional, Li, Fu-Xing-Zi, additional, Zheng, Ming-Hui, additional, Xu, Qiu-Shuang, additional, Wang, Yi, additional, Lei, Li-Min, additional, Tang, Ke-Xin, additional, Ou-Yang, Wen-Lu, additional, Duan, Jia-Yue, additional, Wu, Yun-Yun, additional, Ullah, Muhammad Hasnain Ehsan, additional, Zhou, Zhi-Ang, additional, Xu, Feng, additional, Lin, Xiao, additional, Wu, Feng, additional, Liao, Xiao-Bo, additional, and Yuan, Ling-Qing, additional

Published
2022
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21. Cellular Crosstalk in the Vascular Wall Microenvironment: The Role of Exosomes in Vascular Calcification

Author

Wu, Yun-Yun, primary, Shan, Su-Kang, additional, Lin, Xiao, additional, Xu, Feng, additional, Zhong, Jia-Yu, additional, Wu, Feng, additional, Duan, Jia-Yue, additional, Guo, Bei, additional, Li, Fu-Xing-Zi, additional, Wang, Yi, additional, Zheng, Ming-Hui, additional, Xu, Qiu-Shuang, additional, Lei, Li-Min, additional, Ou-Yang, Wen-Lu, additional, Tang, Ke-Xin, additional, Li, Chang-Chun, additional, Ullah, Muhammad Hasnain Ehsan, additional, and Yuan, Ling-Qing, additional

Published
2022
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22. H19 Promotes Osteoblastic Transition by Acting as ceRNA of miR-140-5p in Vascular Smooth Muscle Cells

Author

Xu, Feng, primary, Zhong, Jia-Yu, additional, Guo, Bei, additional, Lin, Xiao, additional, Wu, Feng, additional, Li, Fu-Xing-Zi, additional, Shan, Su-Kang, additional, Zheng, Ming-Hui, additional, Wang, Yi, additional, Xu, Qiu-Shuang, additional, Lei, Li-Min, additional, Tan, Chang-Ming, additional, Liao, Xiao-Bo, additional, and Yuan, Ling-Qing, additional

Published
2022
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24. Additional file 1 of Protective role of small extracellular vesicles derived from HUVECs treated with AGEs in diabetic vascular calcification

Author

Guo, Bei, Shan, Su-Kang, Xu, Feng, Lin, Xiao, Li, Fu-Xing-zi, Wang, Yi, Xu, Qiu-Shuang, Zheng, Ming-Hui, Lei, Li-Min, Li, Chang-Chun, Zhou, Zhi-Ang, Ullah, Muhammad Hasnain Ehsan, Wu, Feng, Liao, Xiao-Bo, and Yuan, Ling-Qing

Subjects
embryonic structures, cardiovascular system, musculoskeletal system
Abstract

Additional file 1: Fig. S1. AGEs Reduce the Viability of HUVEC in a Dose/Time-Dependent Manner. Fig. S2 Identification of HA-VSMCs. Fig. S3. AGEsstimulated HUVECs reduce the protein level of Runx2 and BMP2 in VSMCs by secreting sEVs rather than other soluble mediators. Fig. S4. miR-126-5p was delivered into VSMCs by sEVs. Fig. S5. miR-126-5p overexpression significantly reduced the transcript level of BMPR1B Fig. S6. A-EC/sEVs decreased BMPR1B expression and phosphorylation and nuclear translocation of smad1/5/9 in calcified HA-VSMCs. Fig. S7. A-EC/sEVs did not affect levels of Runx2, BMP2, total-p-smad1/5/9 and intranuclear p-smad1/5/9 in BMPR1B-silenced HA-VSMCs. Fig. S8. Random blood glucose levels of ND and DVC mice.

Published
2022
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25. The Role of Mesenchymal Stromal Cells-Derived Small Extracellular Vesicles in Diabetes and Its Chronic Complications

Author

Li, Fu-Xing-Zi, Lin, Xiao, Xu, Feng, Shan, Su-Kang, Guo, Bei, Lei, Li-Min, Zheng, Ming-Hui, Wang, Yi, Xu, Qiu-Shuang, and Yuan, Ling-Qing

Subjects
Endocrinology, Diabetes and Metabolism, Mesenchymal Stem Cells, Review, diabetic complication, RC648-665, Endoplasmic Reticulum Stress, Mesenchymal Stem Cell Transplantation, Diseases of the endocrine glands. Clinical endocrinology, microRNAs, Diabetes Complications, Extracellular Vesicles, Endocrinology, insulin resistance, Chronic Disease, Diabetes Mellitus, Animals, Humans, mesenchymal stromal cells
Abstract

Mesenchymal stromal cells (MSCs) are applied in regenerative medicine of several tissues and organs nowadays by virtue of their self-renewal capabilities, multiple differentiation capacity, potent immunomodulatory properties, and their ability to be favourably cultured and manipulated. With the continuous development of “cell-free therapy” research, MSC-derived small extracellular vesicles (MSC-sEVs) have increasingly become a research hotspot in the treatment of various diseases. Small extracellular vesicles (SEVs) are membrane vesicles with diameters of 30 to 150 nm that mediate signal transduction between adjacent or distal cells or organs by delivering non-coding RNA, protein, and DNA. The contents and effects of sEVs vary depending on the properties of the originating cell. In recent years, MSC-sEVs have been found to play an important role in the occurrence and development of diabetes mellitus as a new way of communication between cells. Diabetes mellitus is a common metabolic disease in clinic. Its complications of the heart, brain, kidney, eyes, and peripheral nerves are a serious threat to human health and has been a hot issue for clinicians. MSC-sEVs could be applied to repair or prevent damage from the complications of diabetes mellitus through anti-inflammatory effects, reduction of endoplasmic reticulum-related protein stress, polarization of M2 macrophages, and increasing autophagy. Therefore, we highly recommend that MSC-sEVs-based therapies to treat diabetes mellitus and its chronic complication be further explored. The analysis of the role and molecular mechanisms of MSC-sEVs in diabetes and its related complications will provide new idea and insights for the prevention and treatment of diabetes.

Published
2021

26. Ferroptosis and Its Potential Role in Metabolic Diseases: A Curse or Revitalization?

Author

Duan, Jia-Yue, primary, Lin, Xiao, additional, Xu, Feng, additional, Shan, Su-Kang, additional, Guo, Bei, additional, Li, Fu-Xing-Zi, additional, Wang, Yi, additional, Zheng, Ming-Hui, additional, Xu, Qiu-Shuang, additional, Lei, Li-Min, additional, Ou-Yang, Wen-Lu, additional, Wu, Yun-Yun, additional, Tang, Ke-Xin, additional, and Yuan, Ling-Qing, additional

Published
2021
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28. The Multi-Therapeutic Role of MSCs in Diabetic Nephropathy

Author

Wang, Yi, primary, Shan, Su-Kang, additional, Guo, Bei, additional, Li, Fuxingzi, additional, Zheng, Ming-Hui, additional, Lei, Li-Min, additional, Xu, Qiu-Shuang, additional, Ullah, Muhammad Hasnain Ehsan, additional, Xu, Feng, additional, Lin, Xiao, additional, and Yuan, Ling-Qing, additional

Published
2021
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29. Exosomes and Obesity-Related Insulin Resistance

Author

Lei, Li-Min, primary, Lin, Xiao, additional, Xu, Feng, additional, Shan, Su-Kang, additional, Guo, Bei, additional, Li, Fu-Xing-Zi, additional, Zheng, Ming-Hui, additional, Wang, Yi, additional, Xu, Qiu-Shuang, additional, and Yuan, Ling-Qing, additional

Published
2021
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30. Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease

Author

Wang, Yi, Xu, Feng, Zhong, Jia-Yu, Lin, Xiao, Shan, Su-Kang, Guo, Bei, Zheng, Ming-Hui, and Yuan, Ling-Qing

Subjects
Article Subject
Abstract

Exosomes are a type of extracellular vehicle, formed by budding cell membranes, containing proteins, DNA, and RNA. Concentrated cargoes from parent cells are enveloped in exosomes, which are cell specific and may have functions in the recipient cell, reflecting a novel physiological and pathological mechanism in disease development. As a transmitter, exosomes shuttle to different cells or tissues and mediate communications among these organelles. To date, several studies have demonstrated that exosomes play crucial roles in disease pathogenesis and development, such as breast and prostate cancer. However, studies investigating connections between exosomes and thyroid disease are limited. In this review, recent research advances on exosomes in thyroid cancer and Graves’ disease are reviewed. These studies suggest that exosomes are involved in thyroid disease and appear as impressive potentials in thyroid therapeutic areas.

Published
2020
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31. Plasma Exosomes Derived From Patients With End-Stage Renal Disease and Renal Transplant Recipients Have Different Effects on Vascular Calcification

Author

Lin, Xiao, primary, Zhu, Ting, additional, Xu, Feng, additional, Zhong, Jia-Yu, additional, Li, Fuxingzi, additional, Shan, Su-Kang, additional, Wu, Feng, additional, Guo, Bei, additional, Zheng, Ming-Hui, additional, Wang, Yi, additional, Xu, Qiu-Shuang, additional, Liao, Xiao-Bo, additional, Lu, Hong-Yu, additional, Xie, Xu-Biao, additional, and Yuan, Ling-Qing, additional

Published
2021
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33. New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions

Author

Guo, Bei, primary, Zhuang, Tongtian, additional, Xu, Feng, additional, Lin, Xiao, additional, Li, Fuxingzi, additional, Shan, Su-Kang, additional, Wu, Feng, additional, Zhong, Jia-Yu, additional, Wang, Yi, additional, Zheng, Ming-Hui, additional, Xu, Qiu-Shuang, additional, Ehsan, Ullah Muhammad Hasnain, additional, and Yuan, Ling-Qing, additional

Published
2020
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34. Plasma exosomes derived from patients with end-stage renal disease and renal transplant recipients have different effects on vascular calcification

Author

lin, xiao, primary, Zhu, Ting, additional, Xu, Feng, additional, Zhong, Jia-Yu, additional, Li, Fuxingzi, additional, Shan, Su-Kang, additional, Wu, Feng, additional, Guo, Bei, additional, Zheng, Ming-Hui, additional, Wang, Yi, additional, Xu, Qiu-Shuang, additional, Liao, Xiao-Bo, additional, Xie, Xu-Biao, additional, and Yuan, Ling-Qing, additional

Published
2020
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37. Melatonin alleviates vascular calcification and ageing through exosomal miR‐204/miR‐211 cluster in a paracrine manner

Author

Xu, Feng, primary, Zhong, Jia‐Yu, additional, Lin, Xiao, additional, Shan, Su‐Kang, additional, Guo, Bei, additional, Zheng, Ming‐Hui, additional, Wang, Yi, additional, Li, Fuxingzi, additional, Cui, Rong‐Rong, additional, Wu, Feng, additional, Zhou, En, additional, Liao, Xiao‐Bo, additional, Liu, You‐Shuo, additional, and Yuan, Ling‐Qing, additional

Published
2020
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38. Exosomes and Bone Disease

Author

Shan, Su-Kang, primary, Lin, Xiao, additional, Li, Fuxingzi, additional, Xu, Feng, additional, Zhong, Jia-Yu, additional, Guo, Bei, additional, Wang, Yi, additional, Zheng, Ming-Hui, additional, Wu, Feng, additional, and Yuan, Ling-Qing, additional

Published
2020
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43. Exosomes and Bone Disease

Author

Shan, Su-Kang, Lin, Xiao, Li, Fuxingzi, Xu, Feng, Zhong, Jia-Yu, Guo, Bei, Wang, Yi, Zheng, Ming-Hui, Wu, Feng, and Yuan, Ling-Qing

Abstract

Exosomes, which mediate cell-to-cell communications and provide a novel insight into information exchange, have drawn increasing attention in recent years. The homeostasis of bone metabolism is critical for bone health. The most common bone diseases such as osteoporosis, osteoarthritis and bone fractures have apparent correlations with exosomes. Accumulating evidence has suggested the potential regenerative capacities of stem cell-derived exosomes. In this review, we summarise the pathophysiological mechanism, clinical picture and therapeutic effects of exosomes in bone metabolism. We introduce the advantages and challenges in the application of exosomes. Although the exact mechanisms remain unclear, miRNAs seem to play major roles in the exosome.

Published
2019
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44. Cold Exposure Alleviates T2DM Through Plasma-Derived Extracellular Vesicles.

Author

Li FX, Xu F, Li CC, Lei LM, Shan SK, Zheng MH, Lin X, Guo B, Tang KX, Duan JY, Wu YY, Cao YC, Liu JJ, and Yuan LQ

Subjects
Animals, Mice, Male, Diabetes Mellitus, Experimental therapy, Mice, Inbred C57BL, Insulin blood, Signal Transduction, Proto-Oncogene Proteins c-akt metabolism, Insulin Receptor Substrate Proteins metabolism, Liver metabolism, Extracellular Vesicles, Diabetes Mellitus, Type 2 metabolism, Diabetes Mellitus, Type 2 therapy, Cold Temperature, Insulin Resistance, Blood Glucose
Abstract

Purpose: Anecdotal reports have praised the benefits of cold exposure, exemplified by activities like winter swimming and cold water immersion. Cold exposure has garnered acclaim for its potential to confer benefits and potentially alleviate diabetes. We posited that systemic cold temperature (CT, 4-8°C) likely influences the organism's blood components through ambient temperature, prompting our investigation into the effects of chronic cold exposure on type 2 diabetic (T2DM) mice and our initial exploration of how cold exposure mitigates the incidence of T2DM., Methods: The effects of CT (4-8°C) or room temperature (RT, 22-25°C) on T2DM mice were investigated. Mice blood and organ specimens were collected for fully automated biochemical testing, ELISA, HE staining, immunohistochemistry, and immunofluorescence. Glucose uptake was assessed using flow cytometry with 2-NBDG. Changes in potential signaling pathways such as protein kinase B (AKT), phosphorylated AKT (p-AKT), insulin receptor substrates 1 (IRS1), and phosphorylated IRS1 (p-IRS1) were evaluated by Western blot., Results: CT or CT mice plasma-derived extracellular vesicles (CT-EVs) remarkably reduced blood glucose levels and improved insulin sensitivity in T2DM mice. This treatment enhanced glucose metabolism, systemic insulin sensitivity, and insulin secretion function while promoting glycogen accumulation in the liver and muscle. Additionally, CT-EVs treatment protected against the streptozocin (STZ)-induced destruction of islets in T2DM mice by inhibiting β-cell apoptosis. CT-EVs also shielded islets from destruction and increased the expression of p-IRS1 and p-AKT in adipocytes and hepatocytes. In vitro experiments further confirmed its pro-insulin sensitivity effect., Conclusion: Our data indicate that cold exposure may have a potentially beneficial effect on the development of T2DM, mainly through the anti-diabetic effect of plasma-derived EVs released during cold stimulation. This phenomenon could significantly contribute to understanding the lower prevalence of diabetes in colder regions., Competing Interests: The authors declare no conflicts of interest in this work., (© 2024 Li et al.)

Published
2024
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