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Lung cancer is one of the most common cancers worldwide and the leading cause of death. Early screening of lung cancer is exceptionally essential for later treatment. Abnormal lung cancer...

Mucin 1(MUC1) is an effective marker of breast cancer, so it is of great significance to develop a simple, sensitive and highly selective MUC1 detection sensor. Herein, we constructed a label-free nanopore biosensor for rapid and highly sensitive detection of MUC1. The presence of MUC1 triggered the modification of the DNAzyme walking chain on the surface of Fe

In this paper, a novel detection technique for tumor marker carcinoembryonic antigen (CEA) has been developed by using a solid-state nanopore as a tool. The system utilizes the specific affinity between aptamer-modified magnetic Fe

Endopeptidase activity of anthrax lethal factor (aLF) prevents the destroy of anthracis spore intracellularly by host macrophages, meanwhile disables the signaling pathways extracellularly that leads to host lethality. Hence, inhibitory of this activity is expected to be an alternative option to cure anthrax infection. Herein, we fabricated a nanopore platform via transmembrane pore construction in vitro, which allows precise mimics, monitoring of intercellular proteinic transport and enables the quantitative detection of aLF endopeptidase activity towards MAPKK signaling protein at single molecule level. Next, we inhibited the aLF activity via screening approaches of protein-metal ion acquisition and other condition controlment (proton/hydroxide strength, adapted temperature, ionizing irradiation), which were identified by nanopore electrokinetic study. Upon the results, we found that Ca

Ba 1− x Nd x Bi 4 Ti 4 O 14 (BNBT) ceramics were prepared by the convention solid state reaction method. Effect of neodymium substitution on the structural and dielectric properties of the BBT ceramic was investigated. Phase structure was characterized by using X-ray diffraction analysis (XRD). A broaden dielectric peak in frequency dependent dielectric spectrum is observed during the phase transition of the BNBT ceramics. The modified Curie-Weiss and Lorentz-type relationship were used to describe the phase transition behavior. The relaxor behavior could be described well by the Lorentz-type relationship. Effect of neodymium substitution on the Curie temperatures and degree of the diffuseness in the BNBT ceramics was discussed.

Sr1−x(Bi, Na)x/2Bi2Nb2O9 (SBNBNO, x = 0, 0.2, 0.4 and 0.6) ceramics were prepared by the conventional solid-state route. X-ray diffraction analyses (XRD) and Raman spectroscopy indicated that all specimens have a single phase with perovskite-type orthorhombic structure. The piezoelectric activity and Curie temperature of SrBi2Nb2O9 (SBN) ferroelectric ceramics are significantly improved by bismuth and sodium modification. The piezoelectric coefficient d33 of the Sr0.6(Bi, Na)0.2Nb2O9 (SBNBN4) specimen was found to be 22 pC/N, which is higher than the d33 values (about 12 pC/N) of SBN specimen. Moreover, the SBNBN4 specimen exhibited the excellent temperature stability of piezoelectric properties. In order to confirm the nature of the piezoelectric properties enhanced, the relationship between the structure and electrical properties was discussed.