Search

Your search keyword '"Shanmugan, Sheila"' showing total 32 results
Start Over Author "Shanmugan, Sheila"
32 results on '"Shanmugan, Sheila"'

2. Personalized functional brain network topography is associated with individual differences in youth cognition

Author

Keller, Arielle S., Pines, Adam R., Shanmugan, Sheila, Sydnor, Valerie J., Cui, Zaixu, Bertolero, Maxwell A., Barzilay, Ran, Alexander-Bloch, Aaron F., Byington, Nora, Chen, Andrew, Conan, Gregory M., Davatzikos, Christos, Feczko, Eric, Hendrickson, Timothy J., Houghton, Audrey, Larsen, Bart, Li, Hongming, Miranda-Dominguez, Oscar, Roalf, David R., Perrone, Anders, Shetty, Alisha, Shinohara, Russell T., Fan, Yong, Fair, Damien A., and Satterthwaite, Theodore D.

Published
2023
Full Text
View/download PDF

3. Linking Individual Differences in Personalized Functional Network Topography to Psychopathology in Youth

Author

Cui, Zaixu, Pines, Adam R., Larsen, Bart, Sydnor, Valerie J., Li, Hongming, Adebimpe, Azeez, Alexander-Bloch, Aaron F., Bassett, Dani S., Bertolero, Max, Calkins, Monica E., Davatzikos, Christos, Fair, Damien A., Gur, Ruben C., Gur, Raquel E., Moore, Tyler M., Shanmugan, Sheila, Shinohara, Russell T., Vogel, Jacob W., Xia, Cedric H., Fan, Yong, and Satterthwaite, Theodore D.

Published
2022
Full Text
View/download PDF

4. Dissociable multi-scale patterns of development in personalized brain networks

Author

Pines, Adam R., Larsen, Bart, Cui, Zaixu, Sydnor, Valerie J., Bertolero, Maxwell A., Adebimpe, Azeez, Alexander-Bloch, Aaron F., Davatzikos, Christos, Fair, Damien A., Gur, Ruben C., Gur, Raquel E., Li, Hongming, Milham, Michael P., Moore, Tyler M., Murtha, Kristin, Parkes, Linden, Thompson-Schill, Sharon L., Shanmugan, Sheila, Shinohara, Russell T., Weinstein, Sarah M., Bassett, Danielle S., Fan, Yong, and Satterthwaite, Theodore D.

Published
2022
Full Text
View/download PDF

6. XCP-D: A Robust Pipeline for the post-processing of fMRI data

Author

Mehta, Kahini Pankaj, primary, Salo, Taylor, additional, Madison, Thomas, additional, Adebimpe, Azeez, additional, Bassett, Danielle S, additional, Bertolero, Max, additional, Cieslak, Matthew, additional, Covitz, Sydney, additional, Houghton, Audrey, additional, Keller, Arielle S, additional, Luo, Audrey, additional, Miranda Dominguez, Oscar, additional, Nelson, Steve, additional, Shafiei, Golia, additional, Shanmugan, Sheila, additional, Shinohara, Russell, additional, Sydnor, Valerie Jill, additional, Feczko, Eric, additional, Fair, Damien A, additional, and Satterthwaite, Theodore D, additional

Published
2023
Full Text
View/download PDF

7. Generalizable links between symptoms of borderline personality disorder and functional connectivity

Author

Shafiei, Golia, primary, Keller, Arielle S., additional, Bertolero, Maxwell, additional, Shanmugan, Sheila, additional, Bassett, Dani S., additional, Chen, Andrew A., additional, Covitz, Sydney, additional, Houghton, Audrey, additional, Luo, Audrey, additional, Mehta, Kahini, additional, Salo, Taylor, additional, Shinohara, Russell T., additional, Fair, Damien, additional, Hallquist, Michael N., additional, and Satterthwaite, Theodore D., additional

Published
2023
Full Text
View/download PDF

10. Personalized Functional Brain Network Topography Predicts Individual Differences in Youth Cognition

Author

Keller, Arielle S., primary, Pines, Adam R., additional, Sydnor, Valerie J., additional, Cui, Zaixu, additional, Bertolero, Maxwell A., additional, Barzilay, Ran, additional, Alexander-Bloch, Aaron F., additional, Byington, Nora, additional, Chen, Andrew, additional, Conan, Gregory M., additional, Davatazikos, Christos, additional, Feczko, Eric, additional, Hendrickson, Timothy J., additional, Houghton, Audrey, additional, Larsen, Bart, additional, Li, Hongming, additional, Miranda-Dominguez, Oscar, additional, Roalf, David R., additional, Perrone, Anders, additional, Shanmugan, Sheila, additional, Shinohara, Russell T., additional, Fan, Yong, additional, Fair, Damien A., additional, and Satterthwaite, Theodore D., additional

Published
2022
Full Text
View/download PDF

11. Sex differences in the functional topography of association networks in youth

Author

Shanmugan, Sheila, primary, Seidlitz, Jakob, additional, Cui, Zaixu, additional, Adebimpe, Azeez, additional, Bassett, Danielle S., additional, Bertolero, Maxwell A., additional, Davatzikos, Christos, additional, Fair, Damien A., additional, Gur, Raquel E., additional, Gur, Ruben C., additional, Larsen, Bart, additional, Li, Hongming, additional, Pines, Adam, additional, Raznahan, Armin, additional, Roalf, David R., additional, Shinohara, Russell T., additional, Vogel, Jacob, additional, Wolf, Daniel H., additional, Fan, Yong, additional, Alexander-Bloch, Aaron, additional, and Satterthwaite, Theodore D., additional

Published
2022
Full Text
View/download PDF

12. P683. Sex Differences in the Functional Topography of Association Networks in Youths

Author

Shanmugan, Sheila, primary, Seidlitz, Jakob, additional, Cui, Zaixu, additional, Adebimpe, Azeez, additional, Bassett, Danielle S., additional, Bertolero, Maxwell A., additional, Davatzikos, Christos, additional, Fair, Damien A., additional, Gur, Raquel E., additional, Gur, Ruben C., additional, Larsen, Bart, additional, Li, Hongming, additional, Pines, Adam, additional, Raznahan, Armin, additional, Roalf, David R., additional, Shinohara, Russell T., additional, Vogel, Jacob, additional, Wolf, Daniel H., additional, Fan, Yong, additional, Alexander-Bloch, Aaron, additional, and Satterthwaite, Theodore D., additional

Published
2022
Full Text
View/download PDF

14. Linking Individual Differences in Personalized Functional Network Topography to Psychopathology in Youth

Author

Cui, Zaixu, primary, Pines, Adam R., additional, Larsen, Bart, additional, Sydnor, Valerie J., additional, Li, Hongming, additional, Adebimpe, Azeez, additional, Alexander-Bloch, Aaron F., additional, Bassett, Dani S., additional, Bertolero, Max, additional, Calkins, Monica E., additional, Davatzikos, Christos, additional, Fair, Damien A., additional, Gur, Ruben C., additional, Gur, Raquel E., additional, Moore, Tyler M., additional, Shanmugan, Sheila, additional, Shinohara, Russell T., additional, Vogel, Jacob W., additional, Xia, Cedric H., additional, Fan, Yong, additional, and Satterthwaite, Theodore D., additional

Published
2021
Full Text
View/download PDF

15. Dissociable Multi-scale Patterns of Development in Personalized Brain Networks

Author

Pines, Adam R., primary, Larsen, Bart, additional, Cui, Zaixu, additional, Sydnor, Valerie J., additional, Bertolero, Maxwell A., additional, Adebimpe, Azeez, additional, Alexander-Bloch, Aaron F., additional, Davatzikos, Christos, additional, Fair, Damien A., additional, Gur, Ruben C., additional, Gur, Raquel E., additional, Li, Hongming, additional, Milham, Michael P., additional, Moore, Tyler M., additional, Murtha, Kristin, additional, Parkes, Linden, additional, Thompson-Schill, Sharon L., additional, Shanmugan, Sheila, additional, Shinohara, Russell T., additional, Weinstein, Sarah M., additional, Bassett, Danielle S., additional, Fan, Yong, additional, and Satterthwaite, Theodore D., additional

Published
2021
Full Text
View/download PDF

16. Sex Differences in Functional Topography of Association Networks

Author

Shanmugan, Sheila, primary, Seidlitz, Jakob, additional, Cui, Zaixu, additional, Adebimpe, Azeez, additional, Bassett, Danielle S., additional, Bertolero, Maxwell A., additional, Davatzikos, Christos, additional, Fair, Damien A., additional, Gur, Raquel E., additional, Gur, Ruben C., additional, Larsen, Bart, additional, Li, Hongming, additional, Pines, Adam, additional, Raznahan, Armin, additional, Roalf, David R., additional, Shinohara, Russell T., additional, Vogel, Jacob, additional, Wolf, Daniel H., additional, Fan, Yong, additional, Alexander-Bloch, Aaron, additional, and Satterthwaite, Theodore D., additional

Published
2021
Full Text
View/download PDF

18. Linking Individual Differences in Personalized Functional Network Topography to Psychopathology in Youth

Author

Cui, Zaixu, Pines, Adam, Li, Hongming, Moore, Tyler, Adebimpe, Azeez, Vogel, Jacob, Shanmugan, Sheila, Larsen, Bart, Bertolero, Maxwell, Gur, Raquel, Gur, Ruben, Oathes, Desmond, Alexander-Bloch, Aaron, Roalf, David, Shinohara, Russell, Wolf, Daniel, Davatzikos, Christos, Bassett, Danielle, Fair, Damien, Fan, Yong, and Satterthwaite, Theodore

Published
2021
Full Text
View/download PDF

19. Sex Differences in Functional Topography of Association Networks

Author

Shanmugan, Sheila, Seidlitz, Jakob, Cui, Zaixu, Adebimpe, Azeez, Bassett, Danielle S., Bertolero, Maxwell A., Davatzikos, Christos, Fair, Damien A., Gur, Raquel E., Gur, Ruben C., Li, Hongming, Pines, Adam, Raznahan, Armin, Roalf, David R., Shinohara, Russell T., Vogel, Jacob, Wolf, Daniel H., Fan, Yong, Alexander-Bloch, Aaron, and Satterthwaite, Theodore D.

Published
2021
Full Text
View/download PDF

22. Impact of Adverse Childhood Experiences on Behavioral and Neural Markers of Executive Function in Menopausal Women

Author

Shanmugan, Sheila and Shanmugan, Sheila

Abstract

Many healthy women with no history of cognitive dysfunction experience subjective executive difficulties during menopause. Indicators of risk for executive function difficulties at menopause are lacking, as is a mechanistic understanding of how loss of estradiol unmasks this vulnerability. We hypothesized that adverse childhood experiences (ACE) increase the risk of executive dysfunction during menopause via alterations in monoaminergic neurotransmission. To test this hypothesis, we evaluated the effect of ACE on subjective and objective measures of executive function as well as executive activation, functional connectivity, and neurochemistry. We used tryptophan depletion (TD) and lisdexamfetamine (LDX) to probe serotonergic and catecholaminergic function, respectively. High ACE women endorsed greater symptoms of executive dysfunction and performed worse on tasks probing sustained attention and working memory. These negative ACE effects were partially mediated by anxiety and depressive symptoms. ACE moderated the impact of TD on DLPFC activation in hypogonadal women such that TD increased activation in high ACE participants but decreased activation in low ACE participants. Importantly, treatment with estradiol attenuated the effects of both ACE and TD. ACE similarly moderated the impact of TD on within-network connectivity. While ACE was associated with lower within-network connectivity regardless of depletion condition, TD increased connectivity in the high ACE group but had no effect on connectivity in the low ACE group. ACE also moderated response to LDX. In the high ACE group, LDX (vs placebo) increased activation in the insula and reduced symptoms related to difficulty with organization and activation for work. In contrast, response to LDX was not significantly different from placebo in the low ACE group. These results have several clinical and mechanistic implications. First, they highlight that addressing concurrent mood changes is a critical step in treatin

Published
2017

24. Lisdexamfetamine Effects on Executive Activation and Neurochemistry in Menopausal Women with Executive Function Difficulties

Author

Shanmugan, Sheila, primary, Loughead, James, additional, Nanga, Ravi Prakash Reddy, additional, Elliott, Mark, additional, Hariharan, Hari, additional, Appleby, Dina, additional, Kim, Deborah, additional, Ruparel, Kosha, additional, Reddy, Ravinder, additional, Brown, Thomas E, additional, and Epperson, C Neill, additional

Published
2016
Full Text
View/download PDF

26. Common and Dissociable Mechanisms of Executive System Dysfunction Across Psychiatric Disorders in Youth

Author

Shanmugan, Sheila, primary, Wolf, Daniel H., additional, Calkins, Monica E., additional, Moore, Tyler M., additional, Ruparel, Kosha, additional, Hopson, Ryan D., additional, Vandekar, Simon N., additional, Roalf, David R., additional, Elliott, Mark A., additional, Jackson, Chad, additional, Gennatas, Efstathios D., additional, Leibenluft, Ellen, additional, Pine, Daniel S., additional, Shinohara, Russell T., additional, Hakonarson, Hakon, additional, Gur, Ruben C., additional, Gur, Raquel E., additional, and Satterthwaite, Theodore D., additional

Published
2016
Full Text
View/download PDF

28. Lisdexamfetamine Effects on Executive Activation and Neurochemistry in Menopausal Women with Executive Function Difficulties

Author

Shanmugan, Sheila, Loughead, James, Nanga, Ravi Prakash Reddy, Elliott, Mark, Hariharan, Hari, Appleby, Dina, Kim, Deborah, Ruparel, Kosha, Reddy, Ravinder, Brown, Thomas E, and Epperson, C Neill

Abstract

Many women with no history of executive dysfunction report difficulties in this domain during the menopause transition. Lisdexamfetamine (LDX) has been suggested to be a safe and effective treatment option for these women. However, the mechanism by which LDX improves executive functioning in these women is not known. Here we investigated the effects of LDX on brain activation and neurochemistry, hypothesizing that LDX would be associated with increased activation and decreased glutamate in executive regions. Fourteen women underwent multimodal neuroimaging at 7T at three time points in this baseline-corrected, double-blind, placebo-controlled, crossover study. Effects of LDX on symptom severity, blood-oxygen-level-dependent (BOLD) signal, and dorsolateral prefrontal cortex (DLPFC) glutamate+glutamine (Glx) were measured using a clinician-administered questionnaire, fMRI during performance of a fractal n-back task, and 1H-MRS, respectively. The effect of treatment (LDX minus baseline vs placebo minus baseline) on these behavioral and neural markers of executive function was examined using repeated measures mixed effects models. LDX treatment was associated with decreased symptom severity, increased activation in the insula and DLPFC, and decreased DLPFC Glx. In addition, the magnitude of LDX-induced improvement in symptom severity predicted both direction and magnitude of LDX-induced change in insular and DLPFC activation. Moreover, symptom severity was positively correlated with Glx concentration in the left DLPFC at baseline. These findings provide novel evidence that the neural mechanisms by which LDX acts to improve self-reported executive functioning in healthy menopausal women with midlife onset of executive difficulties include modulation of insular and DLPFC recruitment as well as decrease in DLPFC Glx concentration.

Published
2017
Full Text
View/download PDF

29. Reproducible Sex Differences in Personalized Functional Network Topography in Youth.

Author

Keller AS, Sun KY, Francisco A, Robinson H, Beydler E, Bassett DS, Cieslak M, Cui Z, Davatzikos C, Fan Y, Gardner M, Kishton R, Kornfield SL, Larsen B, Li H, Linder I, Pines A, Pritschet L, Raznahan A, Roalf DR, Seidlitz J, Shafiei G, Shinohara RT, Wolf DH, Alexander-Bloch A, Satterthwaite TD, and Shanmugan S

Abstract

Background: A key step towards understanding psychiatric disorders that disproportionately impact female mental health is delineating the emergence of sex-specific patterns of brain organization at the critical transition from childhood to adolescence. Prior work suggests that individual differences in the spatial organization of functional brain networks across the cortex are associated with psychopathology and differ systematically by sex., Aims: We aimed to evaluate the impact of sex on the spatial organization of person-specific functional brain networks., Method: We leveraged person-specific atlases of functional brain networks defined using non-negative matrix factorization in a sample of n = 6437 youths from the Adolescent Brain Cognitive Development Study. Across independent discovery and replication samples, we used generalized additive models to uncover associations between sex and the spatial layout ("topography") of personalized functional networks (PFNs). Next, we trained support vector machines to classify participants' sex from multivariate patterns of PFN topography. Finally, we leveraged transcriptomic data from the Allen Human Brain Atlas to evaluate spatial correlations between sex differences in PFN topography and gene expression., Results: Sex differences in PFN topography were greatest in association networks including the fronto-parietal, ventral attention, and default mode networks. Machine learning models trained on participants' PFNs were able to classify participant sex with high accuracy. Brain regions with the greatest sex differences in PFN topography were enriched in expression of X-linked genes as well as genes expressed in astrocytes and excitatory neurons., Conclusions: Sex differences in PFN topography are robust, replicate across large-scale samples of youth, and are associated with expression patterns of X-linked genes. These results suggest a potential contributor to the female-biased risk in depressive and anxiety disorders that emerge at the transition from childhood to adolescence.

Published
2024
Full Text
View/download PDF

30. ComBatLS: A location- and scale-preserving method for multi-site image harmonization.

Author

Gardner M, Shinohara RT, Bethlehem RAI, Romero-Garcia R, Warrier V, Dorfschmidt L, Shanmugan S, Thompson P, Seidlitz J, Alexander-Bloch AF, and Chen AA

Abstract

Recent work has leveraged massive datasets and advanced harmonization methods to construct normative models of neuroanatomical features and benchmark individuals' morphology. However, current harmonization tools do not preserve the effects of biological covariates including sex and age on features' variances; this failure may induce error in normative scores, particularly when such factors are distributed unequally across sites. Here, we introduce a new extension of the popular ComBat harmonization method, ComBatLS, that preserves biological variance in features' locations and scales. We use UK Biobank data to show that ComBatLS robustly replicates individuals' normative scores better than other ComBat methods when subjects are assigned to sex-imbalanced synthetic "sites". Additionally, we demonstrate that ComBatLS significantly reduces sex biases in normative scores compared to traditional methods. Finally, we show that ComBatLS successfully harmonizes consortium data collected across over 50 studies. R implementation of ComBatLS is available at https://github.com/andy1764/ComBatFamily.

Published
2024
Full Text
View/download PDF

31. XCP-D: A Robust Pipeline for the post-processing of fMRI data.

Author

Mehta K, Salo T, Madison T, Adebimpe A, Bassett DS, Bertolero M, Cieslak M, Covitz S, Houghton A, Keller AS, Luo A, Miranda-Dominguez O, Nelson SM, Shafiei G, Shanmugan S, Shinohara RT, Sydnor VJ, Feczko E, Fair DA, and Satterthwaite TD

Abstract

Functional neuroimaging is an essential tool for neuroscience research. Pre-processing pipelines produce standardized, minimally pre-processed data to support a range of potential analyses. However, post-processing is not similarly standardized. While several options for post-processing exist, they tend not to support output from disparate pre-processing pipelines, may have limited documentation, and may not follow BIDS best practices. Here we present XCP-D, which presents a solution to these issues. XCP-D is a collaborative effort between PennLINC at the University of Pennsylvania and the DCAN lab at the University at Minnesota. XCP-D uses an open development model on GitHub and incorporates continuous integration testing; it is distributed as a Docker container or Singularity image. XCP-D generates denoised BOLD images and functional derivatives from resting-state data in either NifTI or CIFTI files, following pre-processing with fMRIPrep, HCP, and ABCD-BIDS pipelines. Even prior to its official release, XCP-D has been downloaded >3,000 times from DockerHub. Together, XCP-D facilitates robust, scalable, and reproducible post-processing of fMRI data.

Published
2023
Full Text
View/download PDF

32. Generalizable links between symptoms of borderline personality disorder and functional connectivity.

Author

Shafiei G, Keller AS, Bertolero M, Shanmugan S, Bassett DS, Chen AA, Covitz S, Houghton A, Luo A, Mehta K, Salo T, Shinohara RT, Fair D, Hallquist MN, and Satterthwaite TD

Abstract

Background |: Symptoms of borderline personality disorder (BPD) often manifest in adolescence, yet the underlying relationship between these debilitating symptoms and the development of functional brain networks is not well understood. Here we aimed to investigate how multivariate patterns of functional connectivity are associated with symptoms of BPD in a large sample of young adults and adolescents., Methods |: We used high-quality functional Magnetic Resonance Imaging (fMRI) data from young adults from the Human Connectome Project: Young Adults (HCP-YA; N = 870, ages 22-37 years, 457 female) and youth from the Human Connectome Project: Development (HCP-D; N = 223, age range 16-21 years, 121 female). A previously validated BPD proxy score was derived from the NEO Five Factor Inventory (NEO-FFI). A ridge regression model with 10-fold cross-validation and nested hyperparameter tuning was trained and tested in HCP-YA to predict BPD scores in unseen data from regional functional connectivity, while controlling for in-scanner motion, age, and sex. The trained model was further tested on data from HCP-D without further tuning. Finally, we tested how the connectivity patterns associated with BPD aligned with age-related changes in connectivity., Results |: Multivariate functional connectivity patterns significantly predicted out-of-sample BPD proxy scores in unseen data in both young adults (HCP-YA; p perm = 0.001) and older adolescents (HCP-D; p perm = 0.001). Predictive capacity of regions was heterogeneous; the most predictive regions were found in functional systems relevant for emotion regulation and executive function, including the ventral attention network. Finally, regional functional connectivity patterns that predicted BPD proxy scores aligned with those associated with development in youth., Conclusion |: Individual differences in functional connectivity in developmentally-sensitive regions are associated with the symptoms of BPD., Competing Interests: Financial Disclosures The authors report no biomedical financial interests or potential conflicts of interest.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results