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5. Efficacy and Safety of First-Line Platinum-Based Doublet Chemotherapy in Advanced Primary Pulmonary Salivary Gland Tumors (PSGTs).

Author

Shi, Zheng, Zeng, Xiaohong, Sun, Wei, Xu, Manyi, Shao, Keda, Wei, Jingwen, Xu, Chunwei, and Song, Zhengbo

Subjects
PLATINUM compounds, PATIENT safety, RESEARCH funding, ANTINEOPLASTIC agents, SALIVARY gland tumors, RETROSPECTIVE studies, DESCRIPTIVE statistics, CANCER chemotherapy, KAPLAN-Meier estimator, LOG-rank test, LUNG tumors, DRUG efficacy, MEDICAL records, ACQUISITION of data, LUNG cancer, SURVIVAL analysis (Biometry), PACLITAXEL
Abstract

Primary pulmonary salivary gland tumors (PSGT) constitute a rare subtype of non-small cell lung cancer (NSCLC). Currently, no established treatment guidelines exist for advanced PSGT. The efficacy of platinum-based chemotherapy for PSGT within the context of NSCLC remains uncertain. Therefore, we retrospectively collected 37 PSGT patients who underwent first-line platinum-based chemotherapy from 2010 to 2023. Survival analysis, employing the Kaplan–Meier method, and group comparisons via the log rank test were conducted. Our results show that first-line platinum-based chemotherapy demonstrates favorable efficacy and manageable safety in advanced PSGT, with the combination of Paclitaxel + Platinum emerging as a preferred option. [ABSTRACT FROM AUTHOR]

Published
2024
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