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The development of functional nanomaterials based on the unique structure and morphology of MXene for biosensing has aroused great interest. In this work, using thiourea as the doping source, a new structure composed of nitrogen and sulfur co-doped on the surface of Ti 3 C 2 nanosheets was synthesized through a simple one-step synthesis method. Fortunately, the obtained nitrogen and sulfur co-doped Ti 3 C 2 nanosheets (NS-Ti 3 C 2 NSs) showed excellent peroxidase-like activity and electrochemical activity. The catalytic mechanism of modified Ti 3 C 2 nanosheets was explored. It is revealed that the catalytic mechanism of NS-Ti 3 C 2 NSs is composed of two important parts: the dissociation and adsorption of H 2 O 2 and the protonation of TMB. In addition, the fabricated NS-Ti 3 C 2 NSs-based electrochemical biosensor is superior to the counterpart from Ti 3 C 2 nanosheets, indicating that the doping of nitrogen and sulfur elements provides more active sites and promotes electron transport efficiency. Combining the unique advantages of colorimetry and electrochemical technology, we have developed a fast, accurate, intuitive and efficient UA detection method for uric acid in the range of 2 μM-400 μM with a detection limit (LOD) of 0.19 μM. The established sensing platform in this study prove the possibility of the doping method for the development of MXene-based biosensors with high sensitivity and high performance, and pave the way for the future development of biosensors for biomedical fields., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)