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5. Irradiated mononuclear cells express significant in vitro cytotoxic activity: Promise for in vivo clinical efficacy of irradiated mismatched donor lymphocytes infusion

Author

Tsirigotis, P. Resnick, I.B. Kapsimalli, V. Dray, L. Psarra, E. Samuel, S. Spyridonidis, A. Konsta, E. Vikentiou, M. Or, R. Slavin, S. Shapira, M.Y.

Abstract

Background: Relapse of the original disease remains the most common cause of treatment failure after allogeneic hematopoietic stem cell transplantation (allo-SCT). Patients who relapse post-allo-SCT can achieve prolonged remission after donor lymphocyte infusion. Donor lymphocyte infusion as well as other immunotherapeutic strategies are usually complicated by severe graft versus host disease. Aim: In the present study, we examined the effect of irradiation on the cytotoxic activity of mononuclear cells (MNCs). Materials & methods: Cytotoxic activity of fresh and irradiated MNCs from healthy donors was tested against the leukemic cell line K562 and against fresh leukemic cells from patients with acute myeloid leukemia. Cytotoxicity was assessed by using a flow-cytometry assay. Results & discussion: Interestingly, we observed that 25 Gy irradiated MNCs retain significant cytotoxic activity against K562. Based on these in vitro data, the safety and efficacy of irradiated haploidentical, IL-2-activated lymphocytes were tested in six patients after allo-SCT. Acute skin graft versus host disease developed in two patients and was resolved after a short course of steroids. One patient with mixed chimera converted to full donor chimera after infusion of irradiated donor cells. Conclusion: The efficacy of irradiated haploidentical lymphocytes should be further tested in a larger number of patients. © 2014 Future Medicine Ltd.

Published
2014

6. Basic oral care for hematology-oncology patients and hematopoietic stem cell transplantation recipients: a position paper from the joint task force of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT)

Author

Elad, S., Raber-Durlacher, J.E., Brennan, M.T., Saunders, D.P., Mank, A.P., Zadik, Y., Quinn, B., Epstein, J.B., Blijlevens, N.M.A., Waltimo, T., Passweg, J.R., Correa, M.E., Dahllof, G., Garming-Legert, K.U., Logan, R.M., Potting, C.M.J., Shapira, M.Y., Soga, Y., Stringer, J., Stokman, M.A., Vokurka, S., Wallhult, E., Yarom, N., Jensen, S.B., Elad, S., Raber-Durlacher, J.E., Brennan, M.T., Saunders, D.P., Mank, A.P., Zadik, Y., Quinn, B., Epstein, J.B., Blijlevens, N.M.A., Waltimo, T., Passweg, J.R., Correa, M.E., Dahllof, G., Garming-Legert, K.U., Logan, R.M., Potting, C.M.J., Shapira, M.Y., Soga, Y., Stringer, J., Stokman, M.A., Vokurka, S., Wallhult, E., Yarom, N., and Jensen, S.B.

Abstract

Contains fulltext : 154632.pdf (Publisher’s version ) (Open Access), PURPOSE: Hematology-oncology patients undergoing chemotherapy and hematopoietic stem cell transplantation (HSCT) recipients are at risk for oral complications which may cause significant morbidity and a potential risk of mortality. This emphasizes the importance of basic oral care prior to, during and following chemotherapy/HSCT. While scientific evidence is available to support some of the clinical practices used to manage the oral complications, expert opinion is needed to shape the current optimal protocols. METHODS: This position paper was developed by members of the Oral Care Study Group, Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT) in attempt to provide guidance to the health care providers managing these patient populations. RESULTS: The protocol on basic oral care outlined in this position paper is presented based on the following principles: prevention of infections, pain control, maintaining oral function, the interplay with managing oral complications of cancer treatment and improving quality of life. CONCLUSION: Using these fundamental elements, we developed a protocol to assist the health care provider and present a practical approach for basic oral care. Research is warranted to provide robust scientific evidence and to enhance this clinical protocol.

Published
2015

10. 305: Thymoglobulin® Rabbit Anti-thymocyte Globulins (r-ATG) Induces Faster Platelet Recovery and does not Suppress Granulocyte Engraftment in a Non-myeloablative Stem Cell Transplantation Setting

Author

Shapira, M.Y., primary, Resnick, I.B., additional, Gesundeheidt, B., additional, Bitan, M., additional, Ackerstein, A., additional, Samuel, S., additional, Drey, L., additional, Verkholevsky, Y., additional, Slavin, S., additional, and Or, R., additional

Published
2008
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