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Acne vulgaris is a chronic inflammatory disorder of the pilo-sebaceous follicles characterised by comedones, papules, pustules, nodules and often scars mainly seen on cheeks, chin, nose, forehead and upper trunk during adolescence. The symptoms of Acne vulgaris resemble Mukhadushika as per Ayurvedic classics. Acharya Sushruta has mentioned Mukhadushika as one of the Kshudra Rogas. In Mukhadushika, there are Shalmali kantak like eruptions on the face which are impregnated with Meda caused due to vitiation of Kaphadosha, Vatadosha and Raktadhatu which destroy the beauty of the face and makes the appearance ugly. The disease almost take place in adolescent and young age group prominently therefore is also known as Yuvanapidika. Acharya Sushruta stated Jalaukavacharana is the preferred method of bloodletting in Sukumara. Aim: To evaluate the efficacy of Jalaukavacharana in the management of Acne vulgaris w.s.r. to Mukhadushika. Methodology: Fourteen patients of age group 15-30 years having signs and symptoms of Mukhadushika were selected and four sittings of Jalaukavacharana on a seven day interval were given. Apart from treatment duration of 28 days, a follow-up was also done after 30 days. Results: Intervention was found to be highly significant (p0.05) was found in Srava. Conclusion: The results are satisfactory. Jalaukavacharana is proved to be an effective, time saving, affordable and acceptable treatment in Mukhadushika without causing any adverse effect.

Mutrakrichha is a disease in which Mutra is voided with much Dukha (discomfort). The word Mutrakrichha comprises of two words, Mutra and Krichha, which means Krichha pravritti of Mutravahana (difficulty in micturition). Mutrakrichha comes under the disorders of Mutravaha srotas and mainly deals with Shool (pain) and Krichhata (dysuria). Mutrakrichha can be an independent disease as well as associated symptom in other disease. In the contemporary science, the disease with similar signs and symptoms are Lower urinary tract infection. Lower urinary tract infection is the most common infection known to mankind and a common condition seen in general practice. Urinary tract infection affects more than 150 million people every year worldwide. It is well explained by all the Acharyas. Charaka has described eight types of Mutrakrichha. Acharya Sushruta in Uttra-Tantra has separately described Mutraghata and Mutrakrichha. Acharyas have mentioned drugs having antibacterial and diuretic property in Mutrakrichha chikitsa. Paniya kshara is an age old treatment modality used since ancient times. To evaluate the role of Paniya kshara in Mutrakrichha, a total of thirty patients were selected with complaints of painful micturation, fever, urgency and tenderness. Patients were given Paniya Kshara. The study revealed highly significant results in terms of pain, fever, urgency and tenderness.

Skin is the general covering of the entire external surface of the body. Because of a large number of its functions, the skin is regarded as an important organ of the body. There are so many skin disorders of which Tenia pedis is a very common fungal infection that affects a significantly large number of people globally. This fungal infection is called Athlete’s foot because it is commonly seen in athletes. In Ayurveda, various skin disorders are described under the heading of kshudraroga. A brief description about Kshudraroga has been given in many Ayurvedic classics. Alasa is a variety of Kshudraroga occurring in between the skin of toes manifesting with Kleda, Kandu, Daha and Ruja. Talisadi tailam mentioned in Sushruta Samhita is an excellent formulation prepared of drugs which are effective against this disease. Current study includes 30 patients from OPD Department of Shalya Tantra, Jammu Institute of Ayurveda and Research, Jammu and Sri Sain Charitable Hospital, Janipur, Jammu diagnosed to have Tenia pedis based on signs and symptoms. Therapeutic effect was evaluated before and after treatment. The present clinical study has shown symptoms of Kandu, Daha, Ruja, Kleda significantly reduced after application of Talisadi tailam.

Selenium (Se) is an essential trace element involved in different physiological functions of the human body and plays a role in cancer prevention and treatment. Induction of apoptosis is considered an important cellular event that can account for the cancer preventive effects of Se. The mechanisms of Se-induced apoptosis are associated with the chemical forms of Se and their metabolism as well as the type of cancer studied. So, some selenocompounds, such as SeO2 involve the activation of caspase-3 while sodium selenite induces apoptosis in the absence of the activation of caspases. Modulation of mitochondrial functions has been reported to play a key role in the regulation of apoptosis and also to be one of the targets of Se compounds. Other mechanisms for apoptosis induction are the modulation of glutathione and reactive oxygen species levels, which may function as intracellular messengers to regulate signaling pathways, or the regulation of kinase, among others. Emerging evidence indicates the overlaps between the apoptosis and other types of cell death such as autophagy. In this review we report different processes of cell death induced by Se compounds in cancer treatment and prevention.