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1. A spatiotemporal atlas of mouse liver homeostasis and regeneration

Author

Xu, Jiangshan, Guo, Pengcheng, Hao, Shijie, Shangguan, Shuncheng, Shi, Quan, Volpe, Giacomo, Huang, Keke, Zuo, Jing, An, Juan, Yuan, Yue, Cheng, Mengnan, Deng, Qiuting, Zhang, Xiao, Lai, Guangyao, Nan, Haitao, Wu, Baihua, Shentu, Xinyi, Wu, Liang, Wei, Xiaoyu, Jiang, Yujia, Huang, Xin, Pan, Fengyu, Song, Yumo, Li, Ronghai, Wang, Zhifeng, Liu, Chuanyu, Liu, Shiping, Li, Yuxiang, Yang, Tao, Xu, Zhicheng, Du, Wensi, Li, Ling, Ahmed, Tanveer, You, Kai, Dai, Zhen, Li, Li, Qin, Baoming, Li, Yinxiong, Lai, Liangxue, Qin, Dajiang, Chen, Junling, Fan, Rong, Li, Yongyin, Hou, Jinlin, Ott, Michael, Sharma, Amar Deep, Cantz, Tobias, Schambach, Axel, Kristiansen, Karsten, Hutchins, Andrew P., Göttgens, Berthold, Maxwell, Patrick H., Hui, Lijian, Xu, Xun, Liu, Longqi, Chen, Ao, Lai, Yiwei, and Esteban, Miguel A.

Published
2024
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5. Contributors

Author

Abouhashem, Ahmed Safwat, primary, Ahmad, Aamir, additional, Ahmad, Shazia, additional, Ali, Saira R., additional, Anderson, Tyler, additional, Avitabile, Daniele, additional, Balakrishnan, Asha, additional, Balkhi, Mumtaz Yaseen, additional, Bao, Bin, additional, Bastaki, Nasma, additional, Beclin, Christophe, additional, Ben-Aicha, Soumaya, additional, Bosio, Andreas, additional, Bruch, Emily, additional, Calin, George A., additional, Cao, Yang, additional, Capogrossi, Maurizio C., additional, Caporali, Andrea, additional, Chan, Derryn Xin Hui, additional, Chan, Yuk Cheung, additional, Chavali, Pavithra L., additional, Chavali, Sreenivas, additional, Chen, Alex F., additional, Chen, Xiaona, additional, Cook, Charles, additional, Cremer, Harold, additional, Czeisler, Catherine, additional, Dakhlallah, Duaa, additional, Das, Amitava, additional, Delany, Anne M., additional, Dolezalova, Dasa, additional, Domínguez-Bendala, Juan, additional, EI Naggar, Manar A., additional, Emanueli, Costanza, additional, Ezzie, Michael, additional, Fathallah, Sara T., additional, Franceschetti, Tiziana, additional, Gambari, Roberto, additional, Ghatak, Subhadip, additional, Gleadle, Jonathan M., additional, Guan, Le Luo, additional, Guttridge, Denis C., additional, Gygli, Patrick Edwin, additional, Haider, Khawaja H., additional, Hampl, Aleš, additional, Han, Sen, additional, Harmsen, Martin C., additional, Hasegawa, Yoshinori, additional, Hashish, Sara A., additional, Hesse, Eric, additional, Houlé, John D., additional, Inoue, Kazuki, additional, Jagdeo, Jared, additional, Khan, Imran, additional, Khan, Mahmood, additional, Khorsandi, Shirin Elizabeth, additional, Klein, Dagmar, additional, Kong, Dejuan, additional, Krenning, Guido, additional, Kusumanchi, Praveen, additional, Li, Yiwei, additional, Li, Zhigang, additional, Liangpunsakul, Suthat, additional, Liechty, Kenneth W., additional, Louiselle, Amanda, additional, Lu, Leina, additional, Magenta, Alessandra, additional, Malmuthuge, Nilusha, additional, Mamalis, Andrew, additional, Marsh, Clay B., additional, Möbus, Selina, additional, Mohan, Ganesh, additional, Mohler, Peter J., additional, Moldovan, Leni, additional, Monroig, Paloma del C., additional, Mraz, Marek, additional, Nana-Sinkam, S. Patrick, additional, Neumann, Colby R., additional, Niemiec, Stephen, additional, Otero, José Javier, additional, Pal, Durba, additional, Pastori, Ricardo L., additional, Piper, Melissa G., additional, Pompilio, Giulio, additional, Qadir, Mirza Muhammed Fahd, additional, Ramsamy, Srinivas, additional, Rojas-Canales, Darling, additional, Rossini, Alessandra, additional, Roy, Sashwati, additional, Rustagi, Yashika, additional, Salama, Alaa A., additional, Salama, Mohamed, additional, Sampath, Prabha, additional, Sarkar, Fazlul H., additional, Sato, Mitsuo, additional, Sen, Chandan K., additional, Shames, David S., additional, Sharma, Amar Deep, additional, Singh, Anjali Kumari, additional, Singh, Kanhaiya, additional, Sinha, Mithun, additional, Srivastava, Prashant, additional, Sun, Hao, additional, Sun, Yeqing, additional, Tahara, Hidetoshi, additional, Taipaleenmäki, Hanna, additional, Trgovich, Joanne, additional, Tucker, Elise J., additional, Wang, Huating, additional, Wang, Jie-Mei, additional, Wang, Lijun, additional, Wang, Yijie, additional, Watson, Brandon, additional, Xu, Dan, additional, Xu, Junwang, additional, Xuan, Yi, additional, Yang, Dakai, additional, Yang, Zhihong, additional, Yonis, Nouran, additional, Zambrotta, Marina E., additional, Zgheib, Carlos, additional, Zhang, Ting, additional, Zhao, Baohong, additional, Zhao, Yu, additional, and Zhou, Liang, additional

Published
2023
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6. Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model

Author

Yang, Taihua, Poenisch, Marion, Khanal, Rajendra, Hu, Qingluan, Dai, Zhen, Li, Ruomeng, Song, Guangqi, Yuan, Qinggong, Yao, Qunyan, Shen, Xizhong, Taubert, Richard, Engel, Bastian, Jaeckel, Elmar, Vogel, Arndt, Falk, Christine S., Schambach, Axel, Gerovska, Daniela, Araúzo-Bravo, Marcos J., Vondran, Florian W.R., Cantz, Tobias, Horscroft, Nigel, Balakrishnan, Asha, Chevessier, Frédéric, Ott, Michael, and Sharma, Amar Deep

Published
2021
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9. MicroRNAs modulate SARS‐CoV‐2 infection of primary human hepatocytes by regulating the entry factors ACE2 and TMPRSS2.

Author

Khanal, Rajendra, Heinen, Natalie, Bogomolova, Alexandra, Meister, Toni L., Herrmann, Simon T., Westhoven, Saskia, Nocke, Maximilian K., Todt, Daniel, Jockenhövel, Freya, Klein, Isabel M., Hartmann, Laura, Vondran, Florian W. R., Steinmann, Eike, Zimmer, Gert, Ott, Michael, Brown, Richard J. P., Sharma, Amar Deep, and Pfaender, Stephanie

Subjects
COVID-19, ANGIOTENSIN converting enzyme, GENE expression, SARS disease, NON-coding RNA
Abstract

Background and Aims: Severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) preferentially infects the respiratory tract; however, several studies have implicated a multi‐organ involvement. Hepatic dysfunctions caused by SARS‐CoV‐2 infection have been increasingly recognized and described to correlate with disease severity. To elucidate molecular factors that could contribute towards hepatic infection, we concentrated on microRNAs (miRNAs), a class of small non‐coding RNAs that modulate various cellular processes and which are reported to be differentially regulated during liver injury. We aimed to study the infection of primary human hepatocytes (PHH) with SARS‐CoV‐2 and to evaluate the potential of miRNAs for modulating viral infection. Methods: We analysed liver autopsies from a coronavirus disease 19 (COVID‐19)‐positive cohort for the presence of viral RNA using Nanopore sequencing. PHH were used for the infection with SARS‐CoV‐2. The candidate miRNAs targeting angiotensin converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) were identified using in silico approaches. To discover the potential regulatory mechanism, transfection experiments, qRT‐PCRs, western blots and luciferase reporter assays were performed. Results: We could detect SARS‐CoV‐2 RNA in COVID‐19‐positive liver autopsies. We show that PHH express ACE2 and TMPRSS2 and can be readily infected with SARS‐CoV‐2, resulting in robust replication. Transfection of selected miRNA mimics reduced SARS‐CoV‐2 receptor expression and SARS‐CoV‐2 burden in PHH. In silico and biochemical analyses supported a potential direct binding of miR‐141‐3p to the SARS‐CoV‐2 genome. Conclusion: We confirm that PHH are susceptible to SARS‐CoV‐2 infection and demonstrate selected miRNAs targeting SARS‐CoV‐2 entry factors and/or the viral genome reduce viral loads. These data provide novel insights into hepatic susceptibility to SARS‐CoV‐2 and associated dysfunctions in COVID‐19. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Productive infection of primary human hepatocytes with SARSCoV-2 induces antiviral and proinflammatory responses.

Author

Heinen, Natalie, Khanal, Rajendra, Westhoven, Saskia, Klöhn, Mara, Herrmann, Simon T., Herrmann, Maike, Tuoc, Tran, Ulmke, Pauline Antonie, Hoang Duy Nguyen, Huu Phuc Nguyen, Steinmann, Eike, Todt, Daniel, Brown, Richard J. P., Sharma, Amar Deep, and Pfaender, Stephanie

Subjects
TRANSCRIPTION factors, MEDICAL virology, APOPTOSIS, HUMAN genetics, FALSE discovery rate, REVERSE genetics
Published
2024
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11. Ex Vivo/In vivo Gene Editing in Hepatocytes Using “All-in-One” CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template

Author

Krooss, Simon Alexander, Dai, Zhen, Schmidt, Florian, Rovai, Alice, Fakhiri, Julia, Dhingra, Akshay, Yuan, Qinggong, Yang, Taihua, Balakrishnan, Asha, Steinbrück, Lars, Srivaratharajan, Sangar, Manns, Michael Peter, Schambach, Axel, Grimm, Dirk, Bohne, Jens, Sharma, Amar Deep, Büning, Hildegard, and Ott, Michael

Published
2020
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13. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues

Author

Saunders, Laura R, Sharma, Amar Deep, Tawney, Jaime, Nakagawa, Masato, Okita, Keisuke, Yamanaka, Shinya, Willenbring, Holger, and Verdin, Eric

Subjects
Biochemistry and Cell Biology, Biological Sciences, Stem Cell Research, Biotechnology, Genetics, Stem Cell Research - Embryonic - Non-Human, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Animals, Cell Differentiation, Cellular Senescence, Down-Regulation, Drug Design, Embryonic Stem Cells, Genomic Instability, Mice, MicroRNAs, Organ Specificity, Protein Biosynthesis, RNA Processing, Post-Transcriptional, Sirtuin 1, SIRT1, mouse embryonic stem cells, miRNAs, differentiation, post-transcriptional regulation, reprogramming, Biochemistry and cell biology, Clinical sciences
Abstract

SIRT1 is increasingly recognized as a critical regulator of stress responses, replicative senescence, inflammation, metabolism, and aging. SIRT1 expression is regulated transcriptionally and post-transcriptionally, and its enzymatic activity is controlled by NAD+ levels and interacting proteins. We found that SIRT1 protein levels were much higher in mouse embryonic stem cells (mESCs) than in differentiated tissues. miRNAs post-transcriptionally downregulated SIRT1 during mESC differentiation and maintained low levels of SIRT1 expression in differentiated tissues. Specifically, miR-181a and b, miR-9, miR-204, miR-199b, and miR-135a suppressed SIRT1 protein expression. Inhibition of mir-9, the SIRT1-targeting miRNA induced earliest during mESC differentiation, prevented SIRT1 downregulation. Conversely, SIRT1 protein levels were upregulated post-transcriptionally during the reprogramming of mouse embryonic fibroblasts (MEFs) into induced pluripotent stem (iPS) cells. The regulation of SIRT1 protein levels by miRNAs might provide new opportunities for therapeutic tissue-specific modulation of SIRT1 expression and for reprogramming of somatic cells into iPS cells.

Published
2010

14. Productive infection of primary human hepatocytes with SARS-CoV-2 induces antiviral and proinflammatory responses

Author

Heinen, Natalie, primary, Khanal, Rajendra, additional, Westhoven, Saskia, additional, Klöhn, Mara, additional, Herrmann, Simon T, additional, Herrmann, Maike, additional, Tuoc, Tran, additional, Ulmke, Pauline Antonie, additional, Nguyen, Hoang Duy, additional, Nguyen, Huu Phuc, additional, Steinmann, Eike, additional, Todt, Daniel, additional, Brown, Richard J P, additional, Sharma, Amar Deep, additional, and Pfaender, Stephanie, additional

Published
2023
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16. Innovations, challenges, and minimal information for standardization of humanized mice

Author

Stripecke, Renata, Münz, Christian, Schuringa, Jan Jacob, Bissig, Karl‐Dimiter, Soper, Brian, Meeham, Terrence, Yao, Li‐Chin, Di Santo, James P, Brehm, Michael, Rodriguez, Estefania, Wege, Anja Kathrin, Bonnet, Dominique, Guionaud, Silvia, Howard, Kristina E, Kitchen, Scott, Klein, Florian, Saeb‐Parsy, Kourosh, Sam, Johannes, Sharma, Amar Deep, Trumpp, Andreas, Trusolino, Livio, Bult, Carol, and Shultz, Leonard

Published
2020
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17. Liver

Author

Cantz, Tobias, Sharma, Amar Deep, Manns, Michael P., Ott, Michael, and Steinhoff, Gustav, editor

Published
2016
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20. Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming

Author

Lim, Kyung Tae, Lee, Seung Chan, Gao, Yimeng, Kim, Kee-Pyo, Song, Guangqi, An, Su Yeon, Adachi, Kenjiro, Jang, Yu Jin, Kim, Jonghun, Oh, Kyoung-Jin, Kwak, Tae Hwan, Hwang, Seon In, You, Jueng Soo, Ko, Kinarm, Koo, Seung-Hoi, Sharma, Amar Deep, Kim, Jong-Hoon, Hui, Lijian, Cantz, Tobias, Schöler, Hans R., and Han, Dong Wook

Published
2016
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26. Liver

Author

Sharma, Amar Deep, Iacob, Razvan, Cantz, Tobias, Manns, Michael P., Ott, Michael, and Steinhoff, Gustav, editor

Published
2013
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27. Liver

Author

Sharma, Amar Deep, Iacob, Razvan, Bock, Michael, Cantz, Tobias, Manns, Michael P., Ott, Michael, and Steinhoff, Gustav, editor

Published
2011
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31. Corrigendum to ‘Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model’ [J Hepatol (2021) 1420-1433]

Author

Yang, Taihua, primary, Poenisch, Marion, additional, Khanal, Rajendra, additional, Hu, Qingluan, additional, Dai, Zhen, additional, Li, Ruomeng, additional, Song, Guangqi, additional, Yuan, Qinggong, additional, Yao, Qunyan, additional, Shen, Xizhong, additional, Taubert, Richard, additional, Engel, Bastian, additional, Jaeckel, Elmar, additional, Vogel, Arndt, additional, Falk, Christine S., additional, Schambach, Axel, additional, Gerovska, Daniela, additional, Araúzo-Bravo, Marcos J., additional, Vondran, Florian W.R., additional, Cantz, Tobias, additional, Horscroft, Nigel, additional, Balakrishnan, Asha, additional, Chevessier, Frédéric, additional, Ott, Michael, additional, and Sharma, Amar Deep, additional

Published
2022
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32. Corrigendum to: ‘Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis’ [J Hepatol (2019) 722-734]

Author

Tsay, Hsin-Chieh, primary, Yuan, Qinggong, additional, Balakrishnan, Asha, additional, Kaiser, Marina, additional, Möbus, Selina, additional, Kozdrowska, Emilia, additional, Farid, Marwa, additional, Tegtmeyer, Pia-Katharina, additional, Borst, Katharina, additional, Vondran, Florian W.R., additional, Kalinke, Ulrich, additional, Kispert, Andreas, additional, Manns, Michael P., additional, Ott, Michael, additional, and Sharma, Amar Deep, additional

Published
2022
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34. Contributors

Author

Ahmad, Aamir, primary, Alemdehy, Mir Farshid, additional, Anderson, Tyler, additional, Awad, Hamdy, additional, Balakrishnan, Asha, additional, Balkhi, Mumtaz Yaseen, additional, Bally-Cuif, Laure, additional, Banerjee, Jaideep, additional, Bao, Bin, additional, Barry, Christopher Taylor, additional, Beclin, Christophe, additional, Boison, Detlev, additional, Bosio, Andreas, additional, Brandi, Maria Luisa, additional, Brown, Melissa, additional, Calin, George A., additional, Cao, Yang, additional, Capogrossi, Maurizio C., additional, Caporali, Andrea, additional, Carulli, Christian, additional, Chan, Yuk Cheung, additional, Chavali, Pavithra L., additional, Chavali, Sreenivas, additional, Chen, Alex F., additional, Chen, Xiaona, additional, Cook, Charles, additional, Coolen, Marion, additional, Cremer, Harold, additional, Czeisler, Catherine, additional, Dakhlallah, Duaa, additional, Das, Amitava, additional, Delany, Anne M., additional, Dolezalova, Dasa, additional, Domínguez-Bendala, Juan, additional, Emanueli, Costanza, additional, Erkeland, Stefan J., additional, Ezzie, Michael, additional, Fasanaro, Pasquale, additional, Foinquinos, Ariana, additional, Franceschetti, Tiziana, additional, Gambari, Roberto, additional, Ahmad, Shazia, additional, Ghatak, Subhadip, additional, Guan, Le Luo, additional, Guttridge, Denis C., additional, Gygli, Patrick Edwin, additional, Haider, Khawaja H., additional, Hampl, Aleš, additional, Harmsen, Martin C., additional, Hasegawa, Yoshinori, additional, Hindges, Robert, additional, Hinsdale, Myron, additional, Houlé, John D., additional, Howard, Lynsey, additional, Hui Chan, Derryn Xin, additional, Ichi, Shunsuke, additional, Innocenti, Massimo, additional, Jagdeo, Jared, additional, Kagele, Dominique A., additional, Khan, Mahmood, additional, Klein, Dagmar, additional, Kobayashi, Tatsuya, additional, Kong, Dejuan, additional, Krenning, Guido, additional, Li, Yiwei, additional, Liechty, Kenneth W., additional, Lisse, Thomas, additional, Liu, Lin, additional, Lloyd, Pamela, additional, Lu, Leina, additional, Lusardi, Theresa A., additional, Luzi, Ettore, additional, Macera, Armando, additional, Magenta, Alessandra, additional, Maiorano, Nicola Antonio, additional, Malik, Obaid, additional, Mamalis, Andrew, additional, Mania-Farnell, Barbara, additional, Marsh, Clay B., additional, Mayanil, C. Shekhar, additional, McLone, David, additional, Möbus, Selina, additional, Mohler, Peter J., additional, Moldovan, Leni, additional, Monroig, Paloma del C., additional, Mraz, Marek, additional, Nana-Sinkam, S. Patrick, additional, Nguyen, Laurent, additional, O’Connell, Ryan M., additional, Otero, José Javier, additional, Pal, Durba, additional, Papaioannou, Garyfallia, additional, Pastori, Ricardo L., additional, Piper, Melissa G., additional, Pirotte, Sophie, additional, Pompilio, Giulio, additional, Ramsamy, Srinivas, additional, Romao, Josue Moura, additional, Rossini, Alessandra, additional, Roy, Sashwati, additional, Sampath, Prabha, additional, Sarkar, Fazlul H., additional, Sato, Mitsuo, additional, Sen, Chandan K., additional, Shames, David S., additional, Shantikumar, Saran, additional, Sharma, Amar Deep, additional, Siddiqui, M. Rizwan, additional, Sinha, Mithun, additional, Sun, Hao, additional, Sun, Yeqing, additional, Tahara, Hidetoshi, additional, Thum, Thomas, additional, Tili, Esmerina, additional, Tomita, Tadanori, additional, Trgovich, Joanne, additional, Viereck, Janika, additional, Volvert, Marie-Laure, additional, Wang, Jie-Mei, additional, Wang, Lijun, additional, Wang, Huating, additional, Wang, Yijie, additional, Xu, Dan, additional, Xu, Junwang, additional, Yang, Dakai, additional, Zambrotta, Marina E., additional, Zgheib, Carlos, additional, Zhao, Yu, additional, and Zhou, Liang, additional

Published
2015
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36. Functional genomic screening during somatic cell reprogramming identifies DKK3 as a roadblock of organ regeneration

Author

Arnold, Frank, Mahaddalkar, Pallavi, Kraus, Johann Michael, Zhong, Xiaowei, Srinivasan, Dharini, Gout, Johann, Roger, Elodie, Beutel, Alica K., Zizer, Eugen, Tharehalli, Umesh, Daiß, Nora, Russell, Ronan, Perkhofer, Lukas, Öllinger, Rupert, Lin, Qiong, Azoitei, Ninel, Weiss, Frank-Ulrich, Lerch, Markus M., Liebau, Stefan, Katz, Sarah-Fee, Lechel, André, Rad, Roland, Seufferlein, Thomas, Kestler, Hans A., Ott, Michael, Sharma, Amar Deep, Hermann, Patrick C., and Kleger, Alexander

Subjects
Pluripotent Stem Cells, ACINAR MORPHOGENESIS, ADULT LIVER, Reprogramming, Wnt-/Hedgehog-signaling, Expression, DICKKOPF-3, Hedgehog (Gen), Liver Regeneration, WNT, SELF-RENEWAL, Regeneration (Biology), DDC 570 / Life sciences, Hedgehogs, ddc:570, Functional shRNA screen, Regeneration, Cancer
Abstract

Somatic cell reprogramming and tissue repair share relevant factors and molecular programs. Here, Dickkopf-3 (DKK3) is identified as novel factor for organ regeneration using combined transcription-factor-induced reprogramming and RNA-interference techniques. Loss of Dkk3 enhances the generation of induced pluripotent stem cells but does not affect de novo derivation of embryonic stem cells, three-germ-layer differentiation or colony formation capacity of liver and pancreatic organoids. However, DKK3 expression levels in wildtype animals and serum levels in human patients are elevated upon injury. Accordingly, Dkk3-null mice display less liver damage upon acute and chronic failure mediated by increased proliferation in hepatocytes and LGR5+ liver progenitor cell population, respectively. Similarly, recovery from experimental pancreatitis is accelerated. Regeneration onset occurs in the acinar compartment accompanied by virtually abolished canonical-Wnt-signaling in Dkk3-null animals. This results in reduced expression of the Hedgehog repressor Gli3 and increased Hedgehog-signaling activity upon Dkk3 loss. Collectively, these data reveal Dkk3 as a key regulator of organ regeneration via a direct, previously unacknowledged link between DKK3, canonical-Wnt-, and Hedgehog-signaling., publishedVersion

Published
2021
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37. MicroRNA-221: A Fine Tuner and Potential Biomarker of Chronic Liver Injury

Author

Markovic, Jovana, Sharma, Amar Deep, Balakrishnan, Asha, and HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.

Subjects
NASH, noninvasive biomarker, HCC, liver fibrosis, miR-221
Abstract

The last decade has witnessed significant advancements in our understanding of how small noncoding RNAs, such as microRNAs (miRNAs), regulate disease progression. One such miRNA, miR-221, has been shown to play a key role in the progression of liver fibrosis, a common feature of most liver diseases. Many reports have demonstrated the upregulation of miR-221 in liver fibrosis caused by multiple etiologies such as viral infections and nonalcoholic steatohepatitis. Inhibition of miR-221 via different strategies has shown promising results in terms of the suppression of fibrogenic gene signatures in vitro, as well as in vivo, in independent mouse models of liver fibrosis. In addition, miR-221 has also been suggested as a noninvasive serum biomarker for liver fibrosis and cirrhosis. In this review, we discuss the biology of miR-221, its significance and use as a biomarker during progression of liver fibrosis, and finally, potential and robust approaches that can be utilized to suppress liver fibrosis via inhibition of miR-221.

Published
2020

39. Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration

Author

Arnold, Frank, primary, Mahaddalkar, Pallavi U, additional, Kraus, Johann M., additional, Zhong, Xiaowei, additional, Bergmann, Wendy, additional, Srinivasan, Dharini, additional, Gout, Johann, additional, Roger, Elodie, additional, Beutel, Alica K., additional, Zizer, Eugen, additional, Tharehalli, Umesh, additional, Daiss, Nora, additional, Russell, Ronan, additional, Perkhofer, Lukas, additional, Oellinger, Rupert, additional, Lin, Qiong, additional, Azoitei, Ninel, additional, Weiss, Frank‐Ulrich, additional, Lerch, Markus M., additional, Liebau, Stefan, additional, Katz, Sarah‐Fee, additional, Lechel, André, additional, Rad, Roland, additional, Seufferlein, Thomas, additional, Kestler, Hans A., additional, Ott, Michael, additional, Sharma, Amar Deep, additional, Hermann, Patrick C., additional, and Kleger, Alexander, additional

Published
2021
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42. Liver

Author

Sharma, Amar Deep, primary, Iacob, Razvan, additional, Bock, Michael, additional, Cantz, Tobias, additional, Manns, Michael P., additional, and Ott, Michael, additional

Published
2010
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49. Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells

Author

Dai, Zhen, primary, Song, Guangqi, additional, Balakrishnan, Asha, additional, Yang, Taihua, additional, Yuan, Qinggong, additional, Möbus, Selina, additional, Weiss, Carina, additional, Bentler, Martin, additional, Bantel, Heike, additional, Jaeckel, Elmar, additional, Kispert, Andreas, additional, Vogel, Arndt, additional, Saborowski, Anna, additional, Büning, Hildegard, additional, Manns, Michael P., additional, Cantz, Tobias, additional, Ott, Michael, additional, and Sharma, Amar Deep, additional

Published
2020
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