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1,117 results on '"Sharma, Prem"'

21. Security Risk Analysis and Design Reengineering for Smart Healthcare

Author

Sharma Gaur, Madhu, Gaur, Navneet K., Kumar, Sanjeev, Sharma, Prem Sagar, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Sharma, Sanjeev, editor, Peng, Sheng-Lung, editor, Agrawal, Jitendra, editor, Shukla, Rajesh K., editor, and Le, Dac-Nhuong, editor

Published
2022
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32. Recalibrating the Non-Communicable Diseases risk prediction tools for the rural population of Western India

Author

Gupta, Manoj Kumar, Raghav, Pankaja, Tanvir, Tooba, Gautam, Vaishali, Mehto, Amit, Choudhary, Yachana, Mittal, Ankit, Singh, Gyanendra, Singh, Garima, Baskaran, Pritish, Rehana, V.R., Jabbar, Shaima Abdul, Sridevi, S., Goel, Akhil Dhanesh, Bhardwaj, Pankaj, Saurabh, Suman, Srikanth, S., Naveen, K.H., Prasanna, T., Rustagi, Neeti, and Sharma, Prem Prakash

Published
2022
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35. Linking demography and food consumption to project population growth and damage potential of Spodoptera frugiperda in India.

Author

Sharma, Shubham, Sharma, Prem Lal, Verma, Subhash Chander, Sharma, Deepika, Devi, Manju, Sharma, Nidhi, Sharma, Priyanka, Thakur, Shikha, and Sharma, Prajjval

Subjects
*POPCORN, *FALL armyworm, *SOYBEAN, *PEST control, *AGRICULTURAL productivity, *SWEET corn, *SORGHUM
Abstract

The fall armyworm, Spodoptera frugiperda (J. E. Smith), identified as an invasive pest worldwide, has severely threatened agricultural production and food security in India. To formulate eco‐friendly integrated pest management strategies for S. frugiperda in its new invasive habitat, the basic knowledge about demographic parameters and damage potential of this pest is crucial. The effects of five host crops viz. maize (Zea mays L.), popcorn (Zea mays everta Sturt), sweet corn (Zea mays saccharata Sturt), sorghum (Sorghum bicolor (L.)) and soybean (Glycine max (L.) Merr.) on the development and food consumption of S. frugiperda were examined. Population projection curves based on life table and consumption rates were drawn on different hosts using computer simulation. The pre‐adult development of S. frugiperda was fastest on popcorn (28.02 days), maize (28.04 days) and sweet corn (28.31 days) but slowest on soybean (34.83 days). The highest net reproductive rate, intrinsic rate of increase and finite rate of increase were observed on maize. The feeding potential of S. frugiperda was also highest on maize. The maximum consumption of the sixth larval instar was observed on maize (19470.47 mm2) while lowest on soybean (9033.67 mm2). In the simulation period of 90 days, the fastest growth of S. frugiperda was expected on maize, popcorn and sweet corn while the slowest on soybean. High larval and pupal survival recorded on the non‐maize hosts (sorghum and soybean) reflects that fall armyworm could be an obstacle in their production as well as in the success of maize‐soybean intercropping system. Simulations based on age‐stage, two‐sex life table could be helpful in predicting the most appropriate time for the pesticide application as well as augmentative releases of egg and larval parasitoids for the control of fall armyworm. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Toxicity and demographic effects of fungicides on Neoseiulus longispinosus (Evans) (Acari: Phytoseiidae).

Author

Sharma, Prajjval, Sharma, Prem Lal, Sharma, Shubham, Verma, Subhash Chander, Chandel, Rajeshwar Singh, Sharma, Nidhi, and Sharma, Priyanka

Abstract

Phytoseiids are an essential group of predators that feed on phytophagous mites. Studies on the detrimental impacts of plant protection chemicals on phytoseiids are crucial for their successful utilization as biocontrol agents. In the present study, the toxicity and side effects of fungicides on the predatory mite Neoseiulus longispinosus (Evans) (Acari: Phytoseiidae) were examined fed on Tetranychus urticae Koch (Acari: Tetranychidae) in tomato under laboratory conditions. Gravid females of N. longispinosus were exposed to fungicides using the leaf dip method for 48 hours. Results showed that the fungicide metalaxyl + mancozeb caused the highest mortality of 60%, followed by mancozeb (52.50%), copper oxychloride (35%), and thiophanate methyl (17.50%). Additionally, residual toxicity from metalaxyl + mancozeb and mancozeb treatments significantly affected the biological and life table parameters of the predatory mite. However, the effects of the other two fungicides were moderate to negligible, implying that the application of metalaxyl + mancozeb and mancozeb could negatively impact the biological performance of N. longispinosus in tomato fields. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Synthesis of alkynylated 1,2,4-oxadiazole/1,2,3-1H-triazole glycoconjugates: Discovering new compounds for use in chemotherapy against lung carcinoma and Mycobacterium tuberculosis

Author

Melo de Oliveira, Valentina Nascimento, Flávia do Amaral Moura, Cybele, Peixoto, Aline dos Santos, Gonçalves Ferreira, Vanessa Pinheiro, Araújo, Héverton Mendes, Lapa Montenegro Pimentel, Lilian Maria, Pessoa, Claudia do Ó, Nicolete, Roberto, Versiani dos Anjos, Janaína, Sharma, Prem Prakash, Rathi, Brijesh, Pena, Lindomar José, Rollin, Patrick, Tatibouët, Arnaud, and Nascimento de Oliveira, Ronaldo

Published
2021
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49. Discovery of low‐molecular‐weight phenylalanine derivatives as novel HIV capsid modulators with improved antiretroviral activity and metabolic stability.

Author

Jiang, Xiangyi, Gao, Zhen, Sharma, Prem Prakash, Kumar, Sumit, Rathi, Brijesh, Ji, Xiangkai, Dai, Jiaojiao, Xie, Minghui, Dong, Guanyu, Xu, Shujing, De Clercq, Erik, Pannecouque, Christophe, Dick, Alexej, Zhan, Peng, and Liu, Xinyong

Subjects
PHENYLALANINE, SURFACE plasmon resonance, HIV, MOLECULAR dynamics, MOLECULAR docking
Abstract

The HIV capsid (CA) protein is a promising target for anti‐AIDS treatment due to its critical involvement in viral replication. Herein, we utilized the well‐documented CA inhibitor PF74 as our lead compound and designed a series of low‐molecular‐weight phenylalanine derivatives. Among them, compound 7t exhibited remarkable antiviral activity with a high selection index (EC50 = 0.040 µM, SI = 2815), surpassing that of PF74 (EC50 = 0.50 µM, SI = 258). Furthermore, when evaluated against the HIV‐2 strain, 7t (EC50 = 0.13 µM) demonstrated approximately 14‐fold higher potency than that of PF74 (EC50 = 1.76 µM). Insights obtained from surface plasmon resonance (SPR) revealed that 7t exhibited stronger target affinity to the CA hexamer and monomer in comparison to PF74. The potential interactions between 7t and the HIV‐1 CA were further elucidated using molecular docking and molecular dynamics simulations, providing a plausible explanation for the enhanced target affinity with 7t over PF74. Moreover, the metabolic stability assay demonstrated that 7t (T1/2 = 77.0 min) significantly outperforms PF74 (T1/2 = 0.7 min) in human liver microsome, exhibiting an improvement factor of 110‐fold. In conclusion, 7t emerges as a promising drug candidate warranting further investigation. [ABSTRACT FROM AUTHOR]

Published
2024
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