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4. Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy

Author

M. Naeini, Marjan, Newell, Felicity, Aoude, Lauren G., Bonazzi, Vanessa F., Patel, Kalpana, Lampe, Guy, Koufariotis, Lambros T., Lakis, Vanessa, Addala, Venkateswar, Kondrashova, Olga, Johnston, Rebecca L., Sharma, Sowmya, Brosda, Sandra, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Xu, Qinying, Thomas, Janine, Walpole, Euan, Tao Mai, G., Ackland, Stephen P., Martin, Jarad, Burge, Matthew, Finch, Robert, Karapetis, Christos S., Shannon, Jenny, Nott, Louise, Bohmer, Robert, Wilson, Kate, Barnes, Elizabeth, Zalcberg, John R., Mark Smithers, B., Simes, John, Price, Timothy, Gebski, Val, Nones, Katia, Watson, David I., Pearson, John V., Barbour, Andrew P., and Waddell, Nicola

Published
2023
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7. Prospective Optimization of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Lymph Node Assessment for Lung Cancer: Three Needle Agitations Are Noninferior to 10 Agitations for Adequate Tumor Cell and DNA Yield

Author

Fielding, David, Dalley, Andrew J., Singh, Mahendra, Nandakumar, Lakshmy, Nones, Katia, Lakis, Vanessa, Chittoory, Haarika, Ferguson, Kaltin, Bashirzadeh, Farzad, Bint, Michael, Pahoff, Carl, Son, Jung Hwa, Hodgson, Alan, Sharma, Sowmya, Godbolt, David, Coleman, Kylie, Whitfield, Lenore, Waddell, Nicola, Lakhani, Sunil R., Hartel, Gunter, and Simpson, Peter T.

Published
2022
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8. Vitamin B12 status and skeletal muscle function among elderly: A literature review and pilot study on the effect of oral vitamin B12 supplementation in improving muscle function.

Author

Sharma, Sowmya, Bhadra, Rohini, Selvam, Sumithra, and Sambashivaiah, Sucharita

Subjects
SKELETAL muscle physiology, CROSS-sectional method, PEARSON correlation (Statistics), RESEARCH funding, T-test (Statistics), PATIENT safety, PILOT projects, MULTIPLE regression analysis, VITAMIN B12, ORAL drug administration, MANN Whitney U Test, DESCRIPTIVE statistics, MUSCLE strength, NUTRITIONAL status, RESEARCH methodology, COMPARATIVE studies, DATA analysis software, DIETARY supplements, WELL-being, OLD age
Abstract

Objectives: The objective of this study is to understand the role of vitamin B12 supplementation in improving skeletal muscle function among the elderly. Methods: A literature review in the Medline database was conducted to understand the association between vitamin B12 and muscle function in Section A. In Section B, 28 healthy elderly participants aged ≥60 years were recruited in a cross‐sectional design for estimation of plasma vitamin B12 status and assessment of upper limb muscle strength Maximal voluntary contraction (MVC) and muscle quality (expressed as MVC/total muscle mass). Participants were grouped based on vitamin B12 status into vitamin B12‐depleted (<148 pmol/L) and replete (≥148 pmol/L) groups. In a quasi‐experimental study design, the vitamin B12‐depleted group (n = 14) received daily oral vitamin B12 supplementation of 100 μg for 3 months. All the study measures were repeated post‐supplementation. Results: Vitamin B12 deficiency was identified to contribute adversely to muscle strength, quality, and physical performance among older people in the extensive literature review. The pilot intervention study showed significant improvement in MVC and muscle quality (p < 0.050) post‐vitamin B12 supplementation, comparable to the vitamin B12‐replete group. Conclusions: Vitamin B12 may have a crucial role in the maintenance of muscle function. 3‐month oral vitamin B12 supplementation among subclinical vitamin B12 deficient elderly improved muscle strength and quality and reached levels similar to the vitamin B12 replete group. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Discrepancies in tumor mutation burden reporting from sequential endobronchial ultrasound transbronchial needle aspiration samples within single lymph node stations - brief report

Author

Fielding, David, primary, Dalley, Andrew J., additional, Singh, Mahendra, additional, Nandakumar, Lakshmy, additional, Lakis, Vanessa, additional, Chittoory, Haarika, additional, Fairbairn, David, additional, Patch, Ann-Marie, additional, Kazakoff, Stephen H., additional, Ferguson, Kaltin, additional, Bashirzadeh, Farzad, additional, Bint, Michael, additional, Pahoff, Carl, additional, Son, Jung Hwa, additional, Ryan, Kimberley, additional, Hodgson, Alan, additional, Sharma, Sowmya, additional, Pearson, John V., additional, Waddell, Nicola, additional, Lakhani, Sunil R., additional, Hartel, Gunter, additional, Simpson, Peter T., additional, and Nones, Katia, additional

Published
2023
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13. The oesophageal adenocarcinoma tumour immune microenvironment dictates outcomes with different modalities of neoadjuvant therapy – results from the AGITG DOCTOR trial and the cancer evolution biobank

Author

Lonie, James M., primary, Brosda, Sandra, additional, Bonazzi, Vanessa F., additional, Aoude, Lauren G., additional, Patel, Kalpana, additional, Brown, Ian, additional, Sharma, Sowmya, additional, Lampe, Guy, additional, Addala, Venkateswar, additional, Koufariotis, Lambros T., additional, Wood, Scott, additional, Waddell, Nicola, additional, Dolcetti, Riccardo, additional, and Barbour, Andrew P., additional

Published
2023
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15. Antibody Kinetics after Three Doses of SARS-CoV-2 mRNA Vaccination in Patients with Inflammatory Bowel Disease

Author

Tsipotis, Evangelos, primary, Maremanda, Ankith, additional, Zeiser, Laura Bowles, additional, Connolly, Caoilfhionn, additional, Sharma, Sowmya, additional, Dudley-Brown, Sharon, additional, Frey, Sarah, additional, Lazarev, Mark, additional, Melia, Joanna M., additional, Parian, Alyssa M., additional, Segev, Dorry L., additional, Truta, Brindusa, additional, Yu, Huimin, additional, Werbel, William A., additional, and Selaru, Florin M., additional

Published
2023
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16. PSMA-Targeted PET Radiotracer [18F]DCFPyL as an Imaging Biomarker in Inflammatory Bowel Disease.

Author

Ismail, Mohamed Saleh, Peters, Diane E, Rowe, Steven P, Salavati, Ali, Sharma, Sowmya, Anders, Robert A, Pomper, Martin, Slusher, Barbara S, and Selaru, Florin M

Subjects
INFLAMMATORY bowel diseases, POSITRON emission tomography, BIOMARKERS, RADIOACTIVE tracers, COMPUTED tomography
Abstract

Background: Prostate-specific membrane antigen (PSMA) is highly and specifically upregulated in active-inflamed mucosa of patients with inflammatory bowel disease (IBD). We hypothesized that this upregulation would be detectable using a PSMA-targeted positron emission tomography/computed tomography (PET/CT) imaging agent, [18F]DCFPyL, enabling non-invasive visualization of inflammation. A noninvasive means of detecting active inflammation would have high clinical value in localization and management of IBD.Study: We performed [18F]DCFPyL imaging in three IBD patients with active disease. Abnormally increased gastrointestinal [18F]DCFPyL uptake was observed in areas with endoscopic, histologic, and immunohistochemical inflammation, demonstrating partial overlap of segments of bowel with abnormal [18F]DCFPyL uptake and active inflammation.Conclusion: This study demonstrates that PSMA-targeted [18F]DCFPyL PET can effectively detect regions of inflamed mucosa in patients with IBD, suggesting its utility as a non-invasive imaging agent to assess location, extent, and disease activity in IBD. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Evaluating Diff‐Quik cytology smears for large‐panel mutation testing in lung cancer—Predicting DNA content and success with low‐malignant‐cellularity samples

Author

Fielding, David I., primary, Dalley, Andrew J., additional, Singh, Mahendra, additional, Nandakumar, Lakshmy, additional, Lakis, Vanessa, additional, Chittoory, Haarika, additional, Fairbairn, David, additional, Patch, Ann‐Marie, additional, Kazakoff, Stephen H., additional, Ferguson, Kaltin, additional, Bashirzadeh, Farzad, additional, Bint, Michael, additional, Pahoff, Carl, additional, Son, Jung Hwa, additional, Hodgson, Alan, additional, Sharma, Sowmya, additional, Waddell, Nicola, additional, Lakhani, Sunil R., additional, Hartel, Gunter, additional, Nones, Katia, additional, and Simpson, Peter T., additional

Published
2023
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19. 280. MULTI-OMIC FEATURES OF OESOPHAGEAL ADENOCARCINOMA PATIENTS PRE-TREATED WITH PREOPERATIVE NEOADJUVANT THERAPY

Author

Naeini, Marjan, primary, Newell, Felicity, additional, Aoude, Lauren G, additional, Bonazzi, Vanessa F, additional, Patel, Kalpana, additional, Lampe, Guy, additional, Koufariotis, Lambros T, additional, Lakis, Vanessa, additional, Addala, Venkateswar, additional, Kondrashova, Olga, additional, Johnston, Rebecca L, additional, Sharma, Sowmya, additional, Brosda, Sandra, additional, Holmes, Oliver, additional, Leonard, Conrad, additional, Wood, Scott, additional, Xu, Qinying, additional, Thomas, Janine, additional, Walpole, Euan, additional, Mai, G Tao, additional, Ackland, Stephen P, additional, Martin, Jarad, additional, Burge, Matthew, additional, Finch, Robert, additional, Karapetis, Christos S, additional, Shannon, Jenny, additional, Nott, Louise, additional, Bohmer, Robert, additional, Wilson, Kate, additional, Barnes, Elizabeth, additional, Zalcberg, John R, additional, Smithers, B Mark, additional, Simes, John, additional, Price, Timothy, additional, Gebski, Val, additional, Nones, Katia, additional, Watson, David I, additional, Pearson, John V, additional, Barbour, Andrew P, additional, and Waddell, Nicola, additional

Published
2022
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23. Generalising uncertainty improves accuracy and safety of deep learning analytics applied to oncology

Author

MacDonald, Samual, primary, Foley, Helena, additional, Yap, Melvyn, additional, Johnston, Rebecca L, additional, Steven, Kaiah, additional, Koufariotis, Lambros T, additional, Sharma, Sowmya, additional, Wood, Scott, additional, Addala, Venkateswar, additional, Pearson, John, additional, Roosta, Fred, additional, Waddell, Nicola, additional, Kondrashova, Olga, additional, and Trzaskowski, Maciej, additional

Published
2022
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24. Heart Rate Variability and its Modulation Across Lifecycle Among Healthy Individuals

Author

Thomas Tinku, Sharma Sowmya, and S Sucharita

Subjects
Aging, medicine.medical_specialty, business.industry, Health Professions (miscellaneous), Biochemistry, Genetics and Molecular Biology (miscellaneous), General Biochemistry, Genetics and Molecular Biology, Modulation, Internal medicine, Healthy individuals, General Health Professions, Cardiology, Heart rate variability, Medicine, Dentistry (miscellaneous), business, General Dentistry
Published
2021

25. Classification of esophageal adenocarcinoma into subgroups that are associated with patient survival using RNA-seq and immunohistochemistry.

Author

Sharma, Sowmya, primary, Naeini, Marjan, additional, Aoude, Lauren G, additional, Bonazzi, Vanessa F, additional, Gartside, Michael G, additional, Loffler, Kelly A, additional, Patel, Kalpana, additional, Newell, Felicity, additional, Lampe, Guy, additional, Brosda, Sandra, additional, Thomas, Janine, additional, Smithers, Mark, additional, Simes, John, additional, Watson, David I., additional, Pearson, John, additional, Barbour, Andrew, additional, and Waddell, Nic, additional

Published
2022
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32. A Body Shape Index and Heart Rate Variability in Healthy Indians with Low Body Mass Index

Author

Sharma Sowmya, Tinku Thomas, Ankalmadagu Venkatsubbareddy Bharathi, and Sambashivaiah Sucharita

Subjects
Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Background. One third of Indian population is said to be suffering from chronic energy deficiency (CED), with increased risk of developing chronic diseases. A new anthropometric measure called A Body Shape Index (ABSI) is said to be a better index in predicting risks for premature mortality. ABSI is also in part said to be a surrogate of visceral fat. Objective. The present study aimed to explore the association between indices of HRV (heart rate variability), BMI, WC, and ABSI in healthy Indian males with low BMI (BMI < 18.5 kg/m2) and to compare with normal BMI group (BMI 18.5 to 24.9 kg/m2). Methodology. ABSI and BMI were derived from anthropometric parameters, namely, height, weight, and waist circumference in 178 males aged 18 to 78 years. Subjects were categorized into two groups based on their BMI. Results and Conclusions. Power spectral analysis of HRV demonstrated a significant negative correlation between Log HF (high frequency) and ABSI in both low BMI [−24.2 (9.4), P

Published
2014
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33. Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home

Author

Tsien, Cynthia, primary, Tan, Huey, additional, Sharma, Sowmya, additional, Palaniyappan, Naaventhan, additional, Wijayasiri, Pramudi, additional, Leung, Kristel, additional, Hayre, Jatinder, additional, Mowlem, Elizabeth, additional, Kang, Rachel, additional, Eddowes, Peter J, additional, Wilkes, Emilie, additional, Venkatachalapathy, Suresh V, additional, Guha, Indra N, additional, Antonova, Lilia, additional, Cheung, Angela C, additional, Griffiths, William JH, additional, Butler, Andrew J, additional, Ryder, Stephen D, additional, James, Martin W, additional, Aithal, Guruprasad P, additional, and Aravinthan, Aloysious D, additional

Published
2021
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35. Su1813 INCIDENCE OF ANTI-DRUG ANTIBODY DEVELOPMENT IN OLDER ADULTS WITH INFLAMMATORY BOWEL DISEASE TREATED WITH TUMOR NECROSIS FACTOR ALPHA INHBITORS: A LARGE MULTICENTER COHORT STUDY

Author

Frost, Spencer, Sauk, Jenny S., Patel, Devin B., Roney, Andrew R., Park, Sunhee, Rangel-Garcia, Maricela, Chang, Christopher C., Parian, Alyssa, Suchan, Andrew, Moughames, Eric, Krishna, Mahesh, Lazarev, Mark, Chowdhury, Reezwana, Sharma, Sowmya, Maas, Laura, Ho, Andrew, Limketkai, Berkeley N., Limsui, David, and Keyashian, Kian

Published
2023
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40. A Mycobacteriumspecies for Crohn's disease?

Author

Aitken, John M., Phan, Khoi, Bodman, Samantha E., Sharma, Sowmya, Watt, Anthony, George, Peter M., Agrawal, Gaurav, and Tie, Andrew B.M.

Abstract

In ruminants Mycobacterium aviumsubspecies paratuberculosis(MAP) is the causative organism of a chronic granulomatous inflammatory bowel disease called Johne's disease (JD). Some researchers have hypothesised that MAP is also associated with Crohn's disease (CD), an inflammatory bowel disease in humans that shares some histological features of JD. Despite numerous attempts to demonstrate causality by researchers, direct microbiological evidence of MAP involvement in CD remains elusive. Importantly, it has not been possible to reliably and reproducibly demonstrate mycobacteria in the tissue of CD patients. Past attempts to visualise mycobacteria in tissue may have been hampered by the use of stains optimised for Mycobacterium tuberculosiscomplex (MTB) and the lack of reliable bacteriological culture media for both non-tuberculous mycobacteria (NTM) and cell-wall-deficient mycobacteria (CWDM).

Published
2021
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41. Subclinical Vitamin B12 Deficiency and Heart Rate Variability Across Life Cycle

Author

Anura V Kurpad, Mario Vaz, S Sucharita, Tinku Thomas, Srinivasan Krishnamachari, and Sharma Sowmya

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, Pediatrics, medicine.medical_specialty, Aging, Population, Physiology, India, 01 natural sciences, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Heart Rate, Prevalence, Heart rate variability, Medicine, Humans, 030212 general & internal medicine, Vitamin B12, 0101 mathematics, Young adult, education, Child, Subclinical infection, Aged, education.field_of_study, Analysis of Variance, business.industry, 010102 general mathematics, Vitamin B 12 Deficiency, Healthy elderly, Anthropometry, Middle Aged, Vitamin B 12, Child, Preschool, Pediatrics, Perinatology and Child Health, Inclusion and exclusion criteria, Female, business
Abstract

The present study aimed to evaluate association between plasma vitamin B12 and heart rate variability in clusters of population of various ages across life cycle.47 healthy children from an ongoing pregnancy and birth cohort, 32 young adults and 47 healthy elderly subjects were recruited following inclusion and exclusion criteria. All subjects underwent plasma vitamin B12, anthropometry and heart rate variability (HRV).The prevalence of vitamin B12 deficiency (lt;148 pmol/l) across age groups were 51.1 % for children, 56.2 % for young adults and 61.7 % for the elderly group respectively. There was large variability in vitamin B12 status across the age groups. Frequency distribution of low frequency (LF) absolute units HRV in the elderly was skewed, whereas in children and young adult group there was wide distribution of LF HRV. Association between Log LF absolute units HRV and plasma vitamin B12 across groups were tested using curve fit models. In children a linear curve estimation best fitted and explained 9.3 % of the association (n=47, .=0.003, P=0.03, R2=0.09). There was no association between log LF absolute units HRV and plasma vitamin B12 in the young adult group. In the elderly group a power curve fit model best fitted and explained 8.9 % of the association. Inspection of the power curve fit model demonstrated a curvilinear pattern; there was a linear association in the elderly with vitamin B12 levels less than 200 pmol/l. However, elderly with vitamin B12 valuesgt;200 pmol/l demonstrated saturation (plateauing) of log LF HRV.The study demonstrated varied pattern of responses between vitamin B12 status and LF power of HRV across age groups. Thus, it is important to consider these associations before planning supplementation of vitamin B12.

Published
2015

43. Plasma vitamin B12, methylmalonic acid and heart rate variability in healthy young Indian adults

Author

Mario Vaz, Tinku Thomas, S Sucharita, Sharma Sowmya, and Anura V Kurpad

Subjects
Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Population, Methylmalonic acid, Medicine (miscellaneous), India, chemistry.chemical_compound, Young Adult, Heart Rate, Internal medicine, medicine, Heart rate variability, Humans, Vitamin B12, Young adult, education, Homocysteine, education.field_of_study, Nutrition and Dietetics, Chemistry, Indian population, Vitamin B 12 Deficiency, General Medicine, Autonomic nervous system, Vitamin B 12, Endocrinology, Methylmalonic Acid
Abstract

Prevalence of vitamin B12 deficiency in the Indian population is not known, however; it is considered to be higher than in the Western population. Vitamin B12 deficiency is generally diagnosed by the plasma vitamin B12 level. Metabolites of vitamin B12 such as homocysteine (Hcy) and methylmalonic acid (MMA) are considered to be better markers to diagnose vitamin B12 deficiency at the tissue level. Autonomic neuropathy in vitamin B12 deficiency appears to precede other neurological signs. One of the recent techniques to evaluate autonomic neuropathy is heart rate variability (HRV). We evaluated 14 healthy young adults to explore the association of plasma vitamin B12, MMA, and Hcy levels with HRV. Resting lead II ECG was recorded and power spectral analyses were performed. Plasma MMA level was significantly and negatively correlated with the log-transformed low frequency (r = - 0.74, p = 0.002) and total power spectra (r = - 0.55, p = 0.03) of HRV in absolute units. Low frequency (LF) (r = - 0.56, p = 0.03) and high frequency (HF) (r = 0.57, p = 0.03), when represented in normalized units, were also correlated significantly with plasma MMA. In summary, plasma MMA but not vitamin B12 was significantly associated with HRV indices in a young adult population, suggesting that a tissue-level marker of vitamin B12 deficiency is more closely correlated with functional changes.

Published
2014

44. Multimodal diagnostic approach to brain abscess

Author

Husain, Nuzhat, Sharma, Sowmya, Verma, Ritu, Shukla, Nitin, Gupta, R.K., Prasad, K.N., and Husain, Mazhar

Subjects
Magnetic resonance imaging -- Usage, CT imaging -- Usage, Brain -- Abscess, Brain -- Diagnosis, Health
Abstract

Table of Contents Abstract Introduction Materials And Methods Results Discussion Conclusion References Abstract A tertiary hospital based study comprising of a case series of 25 patients was carried out to [...]

Published
2007

49. Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice

Author

Kum Kum Khanna, Behnam Rashidieh, Amanda Bain, Simon Tria, Sowmya Sharma, Cameron Stewart, Jacinta Simmons, Pirjo Apaja, Pascal Duijf, John Finnie, Rashidieh, Behnam, Bain, Amanda Louise, Tria, Simon Manuel, Sharma, Sowmya, Stewart, Cameron Allan, Simmons, Jacinta Ley, Apaja, Pirjo M, Duijf, Pascal HG, Finnie, John, and Khanna, Kum Kum

Subjects
Cancer Research, tumorigenesis, angiogenesis, Oncology, metastasis, Hematology, heat-shock protein, Cryab mouse model
Abstract

Background αB-Crystallin is a heat shock chaperone protein which binds to misfolded proteins to prevent their aggregation. It is overexpressed in a wide-variety of cancers. Previous studies using human cancer cell lines and human xenograft models have suggested potential tumor promoter (oncogene) roles for αB-Crystallin in a wide-spectrum of cancers. Methods To determine the causal relationship between CRYAB overexpression and cancer, we generated a Cryab overexpression knock-in mouse model and monitor them for development of spontaneous and carcinogen (DMBA)-induced tumorigenesis. In order to investigate the mechanism of malignancies observed in this model multiple techniques were used such as immunohistochemical characterizations of tumors, bioinformatics analysis of publically available human tumor datasets, and generation of mouse embryonic fibroblasts (MEFs) for in vitro assays (clonogenic survival and migration assays and proteome analysis by mass-spectrometry). Results This model revealed that constitutive overexpression of Cryab results in the formation of a variety of lethal spontaneous primary and metastatic tumors in mice. In vivo, the overexpression of Cryab correlated with the upregulation of epithelial-to-mesenchymal (EMT) markers, angiogenesis and some oncogenic proteins including Basigin. In vitro, using E1A/Ras transformed MEFs, we observed that the overexpression of Cryab led to the promotion of cell survival via upregulation of Akt signaling and downregulation of pro-apoptotic pathway mediator JNK, with subsequent attenuation of apoptosis as assessed by cleaved caspase-3 and Annexin V staining. Conclusions Overall, through the generation and characterization of Cryab overexpression model, we provide evidence supporting the role of αB-Crystallin as an oncogene, where its upregulation is sufficient to induce tumors, promote cell survival and inhibit apoptosis.

Published
2023

50. PSMA-Targeted PET Radiotracer [ 18 F]DCFPyL as an Imaging Biomarker in Inflammatory Bowel Disease.

Author

Ismail MS, Peters DE, Rowe SP, Salavati A, Sharma S, Anders RA, Pomper M, Slusher BS, and Selaru FM

Abstract

Background: Prostate-specific membrane antigen (PSMA) is highly and specifically upregulated in active-inflamed mucosa of patients with inflammatory bowel disease (IBD). We hypothesized that this upregulation would be detectable using a PSMA-targeted positron emission tomography/computed tomography (PET/CT) imaging agent, [ 18 F]DCFPyL, enabling non-invasive visualization of inflammation. A noninvasive means of detecting active inflammation would have high clinical value in localization and management of IBD., Study: We performed [ 18 F]DCFPyL imaging in three IBD patients with active disease. Abnormally increased gastrointestinal [ 18 F]DCFPyL uptake was observed in areas with endoscopic, histologic, and immunohistochemical inflammation, demonstrating partial overlap of segments of bowel with abnormal [ 18 F]DCFPyL uptake and active inflammation., Conclusion: This study demonstrates that PSMA-targeted [ 18 F]DCFPyL PET can effectively detect regions of inflamed mucosa in patients with IBD, suggesting its utility as a non-invasive imaging agent to assess location, extent, and disease activity in IBD., Competing Interests: M.P. is a coinventor on a US patent covering [18F]DCFPyL and as such is entitled to a portion of any licensing fees and royalties generated by this technology. B.S.S. and D.E.P. are coinventors on Johns Hopkins patent applications covering the use and novel compositions of PSMA inhibitors as IBD therapeutics. These arrangements have been reviewed and approved by the Johns Hopkins University in accordance with its conflict-of-interest policies. D.E.P. also reports NIH T32 training grant (T32 OD011089). S.P.R. is a consultant to Progenics Pharmaceuticals, the licensee of [18F]DCFPyL. S.P.R. and M.P. receive research funding from Progenics Pharmaceuticals. M.P. is a founder of Precision Molecular, Inc. S.P.R. and M.P. are consultants to Precision Molecular, Inc. The authors report no other conflicts of interest in this work., (© 2023 Ismail et al.)

Published
2023
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