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Purpose: To validate Pediatric Refractive Error Profile 2 (PREP2) subscales that can be used to evaluate contact lens wearers and compare vision‐specific quality of life measurements between children wearing multifocal and single vision contact lenses for 2 weeks. Methods: Two hundred and ninety‐four myopic children aged 7–11 years (inclusive) were enrolled in the 3‐year, double‐masked Bifocal Lenses In Nearsighted Kids (BLINK) Study. Participants completed the PREP2 survey after having worn contact lenses for 2 weeks. The Vision, Symptoms, Activities and Overall PREP2 subscales were used to compare participants' subjective assessment while wearing +1.50 or +2.50 D add multifocal or single vision contact lenses. Rasch analysis was used to validate each subscale and to compare participants' subjective assessment of contact lens wear. Results: Item fit to the Rasch model was good for all scales, with no individual items having infit mean square statistics outside the recommended range (0.7–1.3). Response category function was acceptable for all subscales, with ordered category thresholds. Measurement precision, assessed by the Rasch person reliability statistic, was less than ideal (≥0.8) for three of the subscales, but met the minimum acceptable standard of 0.5. Scores for the Vision subscale differed by treatment assignment (p = 0.03), indicating that participants with the highest add power reported statistically worse quality of vision, although the difference was only 3.9 units on a scale of 1–100. Girls reported fewer symptoms than boys (p = 0.006), but there were no other differences between boys and girls. Conclusions: Rasch analysis demonstrates that the PREP2 survey is a valid instrument for assessing refractive error‐specific quality of life. These results suggest that vision‐related quality of life is not meaningfully affected by 2 weeks of soft multifocal contact lens wear for myopia control. [ABSTRACT FROM AUTHOR]