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604 results on '"Shen, Huahao"'

5. Diagnosis and treatment practice of chest tightness variant asthma in China

Author

HUA Wen, SHEN Huahao

Subjects
chest tightness variant asthma, diagnosis and treatment, practice, inhale corticosteroids, peak expiratory flow, Medicine
Abstract

Chest tightness variant asthma (CTVA) is an atypical form of asthma, characterized by chest tightness as the primary symptom, without the typical asthma symptoms， such as recurrent wheezing and shortness of breath. Since it was first reported and named internationally in 2013, CTVA has gradually been recognized by clinical physicians in China and has undergone extensive clinical practice. As for diagnosis of CTVA ，doctors should integrate symptoms of chest tightness and objective evidence of variable airflow restriction, exclude chest tightness caused by other diseases, and find effective results of asthma treatment in patients. The treatment principle of CTVA is similar to that of typical asthma. An appropriate initial treatment level should be selected based on the patient's chest tightness attack, and the stepwise treatment plan should be followed for upgrade and downgrade treatment. Based on clinical diagnosis and treatment practices, this article systematically introduces the diagnostic criteria, diagnostic procedures, management evaluation, and treatment plans of CTVA,which is to help clinical physicians in standardizing the diagnosis and treatment of CTVA.

Published
2023
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6. Heterogeneities and impact profiles of early chronic obstructive pulmonary disease status: findings from the China Pulmonary Health Study

Author

Lei, Jieping, Huang, Ke, Wu, Sinan, Xu, Jianying, Xu, Yongjian, Zhao, Jianping, Zhang, Xiangyan, Bai, Chunxue, Song, Yuanlin, Kang, Jian, Ran, Pixin, Zhou, Yumin, Shen, Huahao, Wen, Fuqiandg, Huang, Kewu, Chen, Yahong, Yao, Wanzhen, Sun, Tieying, Lin, Yingxiang, Zhu, Jianguo, Shan, Guangliang, Yang, Ting, and Wang, Chen

Published
2024
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8. Identification of cough-variant asthma phenotypes based on clinical and pathophysiologic data

Author

Zhan, Wenzhi, Wu, Feng, Zhang, Yunhui, Lin, Lin, Li, Wen, Luo, Wei, Yi, Fang, Dai, Yuanrong, Li, Suyun, Lin, Jiangtao, Yuan, Yadong, Qiu, Chen, Jiang, Yong, Zhao, Limin, Chen, Meihua, Qiu, Zhongmin, Chen, Ruchong, Xie, Jiaxing, Guo, Chunxing, Jiang, Mei, Yang, Xiaohong, Shi, Guochao, Sun, Dejun, Chen, Rongchang, Zhong, Nanshan, Shen, Huahao, and Lai, Kefang

Published
2023
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12. Associations of residential greenness with lung function and chronic obstructive pulmonary disease in China

Author

Xiao, Yalan, Gu, Xiaoying, Niu, Hongtao, Meng, Xia, Zhang, Lina, Xu, Jianying, Yang, Lan, Zhao, Jianping, Zhang, Xiangyan, Bai, Chunxue, Kang, Jian, Ran, Pixin, Shen, Huahao, Wen, Fuqiang, Huang, Kewu, Chen, Yahong, Sun, Tieying, Shan, Guangliang, Lin, Yingxiang, Wu, Sinan, Zhu, Jianguo, Wang, Ruiying, Shi, Zhihong, Xu, Yongjian, Ye, Xianwei, Song, Yuanlin, Wang, Qiuyue, Zhou, Yumin, Ding, Liren, Li, Diandian, Yao, Wanzhen, Guo, Yanfei, Xiao, Fei, Lu, Yong, Peng, Xiaoxia, Zhang, Biao, Xiao, Dan, Wang, Zuomin, Zhang, Hong, Bu, Xiaoning, Zhang, Xiaolei, An, Li, Zhang, Shu, Cao, Zhixin, Zhan, Qingyuan, Yang, Yuanhua, Liang, Lirong, Cao, Bin, Dai, Huaping, Wu, Tangchun, He, Jiang, Kan, Haidong, Chen, Renjie, Yang, Ting, and Wang, Chen

Published
2022
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15. Characteristics of different asthma phenotypes associated with cough: a prospective, multicenter survey in China

Author

Zhou, Jianmeng, Yi, Fang, Wu, Feng, Xu, Pusheng, Chen, Meihua, Shen, Huahao, Lin, Lin, Zhang, Yunhui, Li, Suyun, Wu, Changgui, Yuan, Yadong, Wang, Gang, Ye, Xianwei, Zhang, Ping, Tang, Huaping, Ma, Qianli, Huang, Lanqing, Qiu, Zhongmin, Deng, Haiyan, Qiu, Chen, Shi, Guochao, Pan, Jiayu, Luo, Wei, Chung, Kian Fan, Zhong, Nanshan, and Lai, Kefang

Published
2022
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17. Association of fine particulate matter air pollution and its constituents with lung function: The China Pulmonary Health study

Author

Yang, Ting, Chen, Renjie, Gu, Xiaoying, Xu, Jianying, Yang, Lan, Zhao, Jianping, Zhang, Xiangyan, Bai, Chunxue, Kang, Jian, Ran, Pixin, Shen, Huahao, Wen, Fuqiang, Huang, Kewu, Chen, Yahong, Sun, Tieying, Shan, Guangliang, Lin, Yingxiang, Wu, Sinan, Zhu, Jianguo, Wang, Ruiying, Shi, Zhihong, Xu, Yongjian, Ye, Xianwei, Song, Yuanlin, Wang, Qiuyue, Zhou, Yumin, Ding, Liren, Yao, Wanzhen, Guo, Yanfei, Xiao, Fei, Lu, Yong, Peng, Xiaoxia, Zhang, Biao, Xiao, Dan, Wang, Zuomin, Zhang, Hong, Bu, Xiaoning, Zhang, Xiaolei, An, Li, Zhang, Shu, Cao, Zhixin, Zhan, Qingyuan, Yang, Yuanhua, Liang, Lirong, Cao, Bin, Dai, Huaping, van Donkelaar, Aaron, Martin, Randall V., Wu, Tangchun, He, Jiang, Kan, Haidong, and Wang, Chen

Published
2021
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19. Impact of Using Pre- and Postbronchodilator Spirometry Reference Values in a Chinese Population.

Author

Huang, Ke, Han, Xueyan, Pan, Zhaoyang, Xu, Jianying, Zhao, Jianping, Zhang, Xiangyan, Song, Yuanlin, Kang, Jian, Ran, Pixin, Zhou, Yumin, Shen, Huahao, Wen, Fuqiang, Huang, Kewu, Chen, Yahong, Guo, Yanfei, Shan, Guangliang, Wu, Sinan, Guan, Tianjia, Yang, Ting, and Wang, Chen

Subjects
CHRONIC obstructive pulmonary disease, REFERENCE values, CHINESE people, DISEASE prevalence, PROGNOSIS
Abstract

Rationale: Spirometry reference equations that are derived from a large, nationally representative general population are warranted in China, and the impact of using prebronchodilator (pre-BD) and post-BD spirometry reference values has yet to be assessed in Chinese populations. Objectives: To present the pre-BD and post-BD spirometry reference values for Chinese adults using the China Pulmonary Health (CPH) Study. Methods: A reference population of 17,969 healthy, nonsmoking participants in the CPH Study was used to calculate the pre- and post-BD reference values for FEV1, FVC, and FEV1/FVC ratio. Pre- and post-BD reference values were applied to the entire CPH population (N = 50,991) to illustrate the divergence between the use of different references in determining disease prevalence and severity grading. Measurements and Main Results: The prevalences of airflow limitation were 5.36% using the pre-BD reference and 8.02% using the post-BD reference. Individuals who had a post-BD FEV1/FVC ratio lower than the post-BD reference value but higher than the pre-BD reference value were found to have significantly higher rates of self-reported respiratory symptoms and significantly lower values on spirometry indicators than those whose post-BD FEV1/FVC ratio was greater than the post-BD reference value. An additional 3.51% of participants were identified as having grade II–IV chronic obstructive pulmonary disease using the post-BD FEV1 predicted values. Conclusions: This study generated and applied pre- and post-BD spirometry reference values in a nationally representative Chinese adult population. Post-BD reference values may serve as an additional criterion in identifying individuals at risk for obstructive pulmonary diseases, and their diagnostic and prognostic values should be further investigated. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Prevalence and risk factors of small airway dysfunction, and association with smoking, in China: findings from a national cross-sectional study

Author

Wang, Chen, He, Jiang, Xu, Jianying, Yang, Lan, Xu, Yongjian, Zhang, Xiangyan, Bai, Chenxue, Kang, Jian, Ran, Pixin, Shen, Huahao, Wen, Fuqiang, Huang, Kewu, Yao, Wanzhen, Shan, Guangliang, Yang, Ting, Lin, Yingxiang, Wu, Sinan, Zhu, Jianguo, Wang, Ruiying, Shi, Zhihong, Zhao, Jianping, Ye, Xianwei, Song, Yuanlin, Yang, Dong, Wang, Qiuyue, Hou, Gang, Zhou, Yumin, Li, Wen, Ding, Liren, Wan, Chun, Wang, Hao, Chen, Yahong, Guo, Yanfei, Xiao, Fei, Lu, Yong, Peng, Xiaoxia, Zhang, Biao, Xiao, Dan, Wang, Zuomin, Bu, Xiaoning, Zhang, Hong, Zhang, Xiaolei, An, Li, Zhang, Shu, Cao, Zhixin, Zhan, Qingyuan, Yang, Yuanhua, Cao, Bin, Dai, Huaping, Liang, Lirong, Wang, Chaolong, Tong, Xunliang, Wu, Tangchun, Kan, Haidong, Chen, Renjie, Cai, Hua, Xiong, Weining, Zhang, Pengjun, Li, Yong, Niu, Wenquan, Chen, Chung-Shiuan, Xu, Guodong, Zhang, Xinran, Gu, Xiaoying, Dong, Fen, Liu, Zhao, Cheng, Anqi, Pei, Zhengcun, Niu, Hongtao, Huang, Ke, Chen, Simiao, Chung, Kian Fan, Chen, Zhengming, Bai, Chunxue, and Sun, Tieying

Published
2020
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23. Impact of Using Pre- and Post-Bronchodilator Spirometry Reference Values in a Chinese Population

Author

Huang, Ke, primary, Han, Xueyan, additional, Pan, Zhaoyang, additional, Xu, Jianying, additional, Zhao, Jianping, additional, Zhang, Xiangyan, additional, Song, Yuanlin, additional, Kang, Jian, additional, Ran, Pixin, additional, Zhou, Yumin, additional, Shen, Huahao, additional, Wen, Fuqiang, additional, Huang, Kewu, additional, Chen, Yahong, additional, Guo, Yanfei, additional, Shan, Guangliang, additional, Wu, Sinan, additional, Guan, Tianjia, additional, Yang, Ting, additional, and Wang, Chen, additional

Published
2024
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25. MTOR Suppresses Cigarette Smoke-Induced Airway Inflammation and MMP12 Expression in Macrophage in Chronic Obstructive Pulmonary Disease

Author

Dong,Lingling, Wang,Yong, Chen,Haipin, Li,Zhouyang, Xu,Xuchen, Zhou,Jiesen, Shen,Huahao, Chen,Zhihua, Dong,Lingling, Wang,Yong, Chen,Haipin, Li,Zhouyang, Xu,Xuchen, Zhou,Jiesen, Shen,Huahao, and Chen,Zhihua

Abstract

Lingling Dong,1,* Yong Wang,1,* Haipin Chen,1 Zhouyang Li,1 Xuchen Xu,1 Jiesen Zhou,1 Huahao Shen,1,2 Zhihua Chen1 1Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhihua Chen, Department of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, People’s Republic of China, Tel +86-571-8898-1913, Fax +86-571-8778-3729, Email zhihuachen@zju.edu.cnBackground: Macrophage-derived matrix metalloproteinase 12 (MMP12) can cause destruction of lung tissue structure and plays a significant role in the development and progression of chronic obstructive pulmonary disease (COPD). MTOR is a serine/threonine kinase that plays a crucial role in cell growth and metabolism. The activity of MTOR in the lung tissues of COPD patients also shows significant changes. However, it is unclear whether MTOR can regulate the development and progression of COPD by controlling MMP12. This study primarily investigates whether MTOR in macrophages can affect the expression of MMP12 and participate in the progression of COPD.Methods: We tested the changes in MTOR activity in macrophages exposed to cigarette smoke (CS) both in vivo and in vitro. Additionally, we observed the effect of MTOR on the expression of MMP12 in macrophages and on lung tissue inflammation and structural damage in mice, both in vivo and in vitro, using MTOR inhibitors or gene knockout mice. Finally, we combined inhibitor treatment with gene knockout to demonstrate that MTOR primarily

Published
2024

29. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study

Author

Huang, Kewu, Yang, Ting, Xu, Jianying, Yang, Lan, Zhao, Jianping, Zhang, Xiangyan, Bai, Chunxue, Kang, Jian, Ran, Pixin, Shen, Huahao, Wen, Fuqiang, Chen, Yahong, Sun, Tieying, Shan, Guangliang, Lin, Yingxiang, Xu, Guodong, Wu, Sinan, Wang, Chaolong, Wang, Ruiying, Shi, Zhihong, Xu, Yongjian, Ye, Xianwei, Song, Yuanlin, Wang, Qiuyue, Zhou, Yumin, Li, Wen, Ding, Liren, Wan, Chun, Yao, Wanzhen, Guo, Yanfei, Xiao, Fei, Lu, Yong, Peng, Xiaoxia, Zhang, Biao, Xiao, Dan, Wang, Zuomin, Chen, Zhengming, Bu, Xiaoning, Zhang, Hong, Zhang, Xiaolei, An, Li, Zhang, Shu, Zhu, Jianguo, Cao, Zhixin, Zhan, Qingyuan, Yang, Yuanhua, Liang, Lirong, Tong, Xunliang, Dai, Huaping, Cao, Bin, Wu, Tangchun, Chung, Kian Fan, He, Jiang, and Wang, Chen

Published
2019
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32. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study

Author

Wang, Chen, Xu, Jianying, Yang, Lan, Xu, Yongjian, Zhang, Xiangyan, Bai, Chunxue, Kang, Jian, Ran, Pixin, Shen, Huahao, Wen, Fuqiang, Huang, Kewu, Yao, Wanzhen, Sun, Tieying, Shan, Guangliang, Yang, Ting, Lin, Yingxiang, Wu, Sinan, Zhu, Jianguo, Wang, Ruiying, Shi, Zhihong, Zhao, Jianping, Ye, Xianwei, Song, Yuanlin, Wang, Qiuyue, Zhou, Yumin, Ding, Liren, Chen, Yahong, Guo, Yanfei, Xiao, Fei, Lu, Yong, Peng, Xiaoxia, Zhang, Biao, Xiao, Dan, Chen, Chung-Shiuan, Wang, Zuomin, Zhang, Hong, Bu, Xiaoning, Zhang, Xiaolei, An, Li, Zhang, Shu, Cao, Zhixin, Zhan, Qingyuan, Yang, Yuanhua, Cao, Bin, Dai, Huaping, Liang, Lirong, and He, Jiang

Published
2018
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35. Pan‐Cancer Single‐Nucleus Total RNA Sequencing Using snHH‐Seq

Author

Chen, Haide, primary, Fang, Xiunan, additional, Shao, Jikai, additional, Zhang, Qi, additional, Xu, Liwei, additional, Chen, Jiaye, additional, Mei, Yuqing, additional, Jiang, Mengmeng, additional, Wang, Yuting, additional, Li, Zhouyang, additional, Chen, Zihang, additional, Chen, Yang, additional, Yu, Chengxuan, additional, Ma, Lifeng, additional, Zhang, Peijing, additional, Zhang, Tianyu, additional, Liao, Yuan, additional, Lv, Yuexiao, additional, Wang, Xueyi, additional, Yang, Lei, additional, Fu, Yuting, additional, Chen, Daobao, additional, Jiang, Liming, additional, Yan, Feng, additional, Lu, Wei, additional, Chen, Gao, additional, Shen, Huahao, additional, Wang, Jingjing, additional, Wang, Changchun, additional, Liang, Tingbo, additional, Han, Xiaoping, additional, Wang, Yongcheng, additional, and Guo, Guoji, additional

Published
2023
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41. Transient Receptor Potential Channels and Chronic Airway Inflammatory Diseases: A Comprehensive Review

Author

Xia, Yang, Xia, Lexin, Lou, Lingyun, Jin, Rui, Shen, Huahao, and Li, Wen

Subjects
Inflammation -- Complications and side effects -- Development and progression -- Genetic aspects -- Research, Lung diseases -- Development and progression -- Genetic aspects -- Research, Ion channels -- Physiological aspects -- Genetic aspects -- Research, Health
Abstract

Chronic airway inflammatory diseases remain a major problem worldwide, such that there is a need for additional therapeutic targets and novel drugs. Transient receptor potential (TRP) channels are a group of non-selective cation channels expressed throughout the body that are regulated by various stimuli. TRP channels have been identified in numerous cell types in the respiratory tract, including sensory neurons, airway epithelial cells, airway smooth muscle cells, and fibroblasts. Different types of TRP channels induce cough in sensory neurons via the vagus nerve. Permeability and cytokine production are also regulated by TRP channels in airway epithelial cells, and these channels also contribute to the modulation of bronchoconstriction. TRP channels may cooperate with other TRP channels, or act in concert with calcium-dependent potassium channels and calcium-activated chloride channel. Hence, TRP channels could be the potential therapeutic targets for chronic airway inflammatory diseases. In this review, we aim to discuss the expression profiles and physiological functions of TRP channels in the airway, and the roles they play in chronic airway inflammatory diseases., Author(s): Yang Xia [sup.1] , Lexin Xia [sup.1] , Lingyun Lou [sup.1] , Rui Jin [sup.1] , Huahao Shen [sup.1] , Wen Li [sup.1] Author Affiliations: (Aff1) 0000 0004 1759 [...]

Published
2018
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42. Mediating Effect of Tobacco Dependence on the Association Between Maternal Smoking During Pregnancy and Chronic Obstructive Pulmonary Disease: Case-Control Study.

Author

Li, Jinxuan, Xu, Jianying, Yang, Lan, Xu, Yongjian, Zhang, Xiangyan, Bai, Chunxue, Kang, Jian, Ran, Pixin, Shen, Huahao, Wen, Fuqiang, Huang, Kewu, Yao, Wanzhen, Sun, Tieying, Shan, Guangliang, Yang, Ting, Lin, Yingxiang, Zhu, Jianguo, Wang, Ruiying, Shi, Zhihong, and Zhao, Jianping

Published
2024
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44. Data from DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair

Author

Ying, Songmin, primary, Chen, Zhihui, primary, Medhurst, Annette L., primary, Neal, Jessica A., primary, Bao, Zhengqiang, primary, Mortusewicz, Oliver, primary, McGouran, Joanna, primary, Song, Xinming, primary, Shen, Huahao, primary, Hamdy, Freddie C., primary, Kessler, Benedikt M., primary, Meek, Katheryn, primary, and Helleday, Thomas, primary

Published
2023
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45. Supplementary Figure Legends from DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair

Author

Ying, Songmin, primary, Chen, Zhihui, primary, Medhurst, Annette L., primary, Neal, Jessica A., primary, Bao, Zhengqiang, primary, Mortusewicz, Oliver, primary, McGouran, Joanna, primary, Song, Xinming, primary, Shen, Huahao, primary, Hamdy, Freddie C., primary, Kessler, Benedikt M., primary, Meek, Katheryn, primary, and Helleday, Thomas, primary

Published
2023
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46. Supplementary Figures from DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair

Author

Ying, Songmin, primary, Chen, Zhihui, primary, Medhurst, Annette L., primary, Neal, Jessica A., primary, Bao, Zhengqiang, primary, Mortusewicz, Oliver, primary, McGouran, Joanna, primary, Song, Xinming, primary, Shen, Huahao, primary, Hamdy, Freddie C., primary, Kessler, Benedikt M., primary, Meek, Katheryn, primary, and Helleday, Thomas, primary

Published
2023
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47. Eligibility of C-BIOPRED severe asthma cohort for type-2 biologic therapies

Author

Deng, Zhenan, primary, Jin, Meiling, additional, Ou, Changxing, additional, Jiang, Wei, additional, Zhao, Jianping, additional, Liu, Xiaoxia, additional, Sun, Shenghua, additional, Tang, Huaping, additional, He, Bei, additional, Cai, Shaoxi, additional, Chen, Ping, additional, Wu, Penghui, additional, Liu, Yujing, additional, Kang, Jian, additional, Zhang, Yunhui, additional, Huang, Mao, additional, Xu, Jinfu, additional, Huang, Kewu, additional, Li, Qiang, additional, Zhang, Xiangyan, additional, Fu, Xiuhua, additional, Wang, Changzheng, additional, Shen, Huahao, additional, Zhu, Lei, additional, Shi, Guochao, additional, Qiu, Zhongmin, additional, Wen, Zhongguang, additional, Wei, Xiaoyang, additional, Gu, Wei, additional, Wei, Chunhua, additional, Wang, Guangfa, additional, Xie, Lixin, additional, Lin, Jiangtao, additional, Tang, Yuling, additional, Han, Zhihai, additional, Chung, Kian Fan, additional, Zhang, Qingling, additional, and Zhong, Nanshan, additional

Published
2023
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