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190 results on '"Shen, Yingbin"'

6. Sequential Targeting in Crosslinking Nanotheranostics for Tackling the Multibarriers of Brain Tumors

Author

Wu, Hao, Lu, Hongwei, Xiao, Wenwu, Yang, Jinfan, Du, Hongxu, Shen, Yingbin, Qu, Haijing, Jia, Bei, Manna, Suman K, Ramachandran, Mythili, Xue, Xiangdong, Ma, Zhao, Xu, Xiaobao, Wang, Zhongling, He, Yixuan, Lam, Kit S, Zawadzki, Robert J, Li, Yuanpei, and Lin, Tzu‐Yin

Subjects
Engineering, Chemical Sciences, Physical Sciences, Cancer, Brain Disorders, Bioengineering, Nanotechnology, Neurosciences, Brain Cancer, Orphan Drug, Rare Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Animals, Antineoplastic Agents, Blood-Brain Barrier, Boronic Acids, Brain, Brain Neoplasms, Carbocyanines, Cell Line, Tumor, Disaccharides, Drug Carriers, Gadolinium DTPA, Glioma, Humans, Hydrogen-Ion Concentration, Kaplan-Meier Estimate, Mice, Mice, Inbred BALB C, Nanoparticles, Transcytosis, Xenograft Model Antitumor Assays, blood-brain barrier, diffuse intrinsic pontine glioma, pH response, sequential targeting, Nanoscience & Nanotechnology, Chemical sciences, Physical sciences
Abstract

The efficacy of therapeutics for brain tumors is seriously hampered by multiple barriers to drug delivery, including severe destabilizing effects in the blood circulation, the blood-brain barrier/blood-brain tumor barrier (BBB/BBTB), and limited tumor uptake. Here, a sequential targeting in crosslinking (STICK) nanodelivery strategy is presented to circumvent these important physiological barriers to improve drug delivery to brain tumors. STICK nanoparticles (STICK-NPs) can sequentially target BBB/BBTB and brain tumor cells with surface maltobionic acid (MA) and 4-carboxyphenylboronic acid (CBA), respectively, and simultaneously enhance nanoparticle stability with pH-responsive crosslinkages formed by MA and CBA in situ. STICK-NPs exhibit prolonged circulation time (17-fold higher area under curve) than the free agent, allowing increased opportunities to transpass the BBB/BBTB via glucose-transporter-mediated transcytosis by MA. The tumor acidic environment then triggers the transformation of the STICK-NPs into smaller nanoparticles and reveals a secondary CBA targeting moiety for deep tumor penetration and enhanced uptake in tumor cells. STICK-NPs significantly inhibit tumor growth and prolong the survival time with limited toxicity in mice with aggressive and chemoresistant diffuse intrinsic pontine glioma. This formulation tackles multiple physiological barriers on-demand with a simple and smart STICK design. Therefore, these features allow STICK-NPs to unleash the potential of brain tumor therapeutics to improve their treatment efficacy.

Published
2020

15. Dietary polyphenols: regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases.

Author

Li, Yueqin, Peng, Yao, Shen, Yingbin, Zhang, Yunzhen, Liu, Lianliang, and Yang, Xinquan

Subjects
ADVANCED glycation end-products, NEURODEGENERATION, POLYPHENOLS, DIETARY supplements, MAILLARD reaction, GUT microbiome
Abstract

Advanced glycation end products (AGEs) are formed in non-enzymatic reaction, oxidation, rearrangement and cross-linking between the active carbonyl groups of reducing sugars and the free amines of amino acids. The Maillard reaction is related to sensory characteristics in thermal processed food, while AGEs are formed in food matrix in this process. AGEs are a key link between carbonyl stress and neurodegenerative disease. AGEs can interact with receptors for AGEs (RAGE), causing oxidative stress, inflammation response and signal pathways activation related to neurodegenerative diseases. Neurodegenerative diseases are closely related to gut microbiota imbalance and intestinal inflammation. Polyphenols with multiple hydroxyl groups showed a powerful ability to scavenge ROS and capture α-dicarbonyl species, which led to the formation of mono- and di- adducts, thereby inhibiting AGEs formation. Neurodegenerative diseases can be effectively prevented by inhibiting AGEs production, and interaction with RAGEs, or regulating the microbiota-gut-brain axis. These strategies include polyphenols multifunctional effects on AGEs inhibition, RAGE-ligand interactions blocking, and regulating the abundance and diversity of gut microbiota, and intestinal inflammation alleviation to delay or prevent neurodegenerative diseases progress. It is a wise and promising strategy to supplement dietary polyphenols for preventing neurodegenerative diseases via AGEs-RAGE axis and microbiota-gut-brain axis regulation. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Rotatable Aggregation‐Induced‐Emission/Aggregation‐Caused‐Quenching Ratio Strategy for Real‐Time Tracking Nanoparticle Dynamics

Author

Wu, Hao, primary, Zhang, Lu, additional, Yang, Jinfan, additional, Bo, Ruonan, additional, Du, Hongxu, additional, Lin, Kai, additional, Zhang, Dalin, additional, Ramachandran, Mythili, additional, Shen, Yingbin, additional, Xu, Yangxi, additional, Xue, Xiangdong, additional, Ma, Zhao, additional, Lindstrom, Aaron Raymond, additional, Carney, Randy, additional, Lin, Tzu‐Yin, additional, and Li, Yuanpei, additional

Published
2020
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38. The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology

Author

Chen, Chaoran, Xie, Zhenxing, Shen, Yingbin, and Xia, Shu Fang

Subjects
Article Subject
Abstract

It is widely accepted that thyroid hormones (THs), secreted from the thyroid, play important roles in energy metabolism. It is also known that THs also alter the functioning of other endocrine glands; however, their effects on pancreatic function have not yet been reviewed. One of the main functions of the pancreas is insulin secretion, which is altered in diabetes. Diabetes, therefore, could be related to thyroid dysfunction. Earlier research on this subject focused on TH regulation of pancreas function (such as insulin secretion) or on insulin function through TH-mediated increase of energy metabolism. Afterwards, epidemiological investigations and animal test research found a link between autoimmune diseases, thyroid dysfunction, and pancreas pathology; however, the underlying mechanisms remain unknown. Furthermore, recent studies have shown that THs also play important roles in pancreas development and on islet pathology, both in diabetes and in pancreatic cancer. Therefore, an overview of the effects of thyroid and THs on pancreas physiology and pathology is presented. The topics contained in this review include a summary of the relationship between autoimmune thyroid dysfunction and autoimmune pancreas lesions and the effects of THs on pancreas development and pancreas pathology (diabetes and pancreatic cancer).

Published
2018
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39. Isolation, Structures, and Bioactivities of the Polysaccharides from Gynostemma pentaphyllum (Thunb.) Makino: A Review

Author

Ji, Xiaolong, Shen, Yingbin, and Guo, Xudan

Subjects
Article Subject
Abstract

Polysaccharides obtained from Gynostemma pentaphyllum (Thunb.) Makino have promising prospects in functional food and nutraceuticals due to its broad range of biological activities including antioxidant, immunomodulatory, antitumor, hepatoprotective, neuroprotective, and antifatigue activities. These beneficial biological activities are related to chemical composition and structure of the G. pentaphyllum polysaccharides. The molecular weight, monosaccharide composition, and chemical structures could be influenced by both different extraction/purification techniques employed to obtain polysaccharide enriched products. The purpose of this article is to review previous and current literature regarding the extraction, purification, structural characterization, and biological activity of G. pentaphyllum polysaccharides. This review provides a useful bibliography for the further investigation, production, and application of G. pentaphyllum polysaccharides as functional foods and nutraceuticals.

Published
2018
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47. Characteristics of Pitaya After Radio Frequency Treating: Structure, Phenolic Compounds, Antioxidant, and Antiproliferative Activity.

Author

Shen, Yingbin, Zheng, Luyao, Gou, Min, Xia, Tianyu, Li, Wenhao, Song, Xun, and Jiang, Hao

Subjects
*RADIO frequency, *PHENOLS, *ENZYME inactivation, *HEAT treatment, *ANTIOXIDANTS
Abstract

The performances of radio frequency (RF) heating treatment of pitaya fruits, with varying distances between the electrode plates, were investigated. The data indicated that a large gap between the electrode plates would reduce the highest temperature and the temperature rising rates. Contrarily, Smaller gap between the electrode plates always resulted in non-uniform heating. However, the RF heating treatment method was effective for enzyme inactivation. The results of the antiproliferative activity and cellular antioxidant activity (CAA) assay indicated that the RF heat treatment had limited effects on the functional features of the samples. However, the functional features of the pitaya samples obtained from the 100-mm and 120-mm gap RF heat treatments were better than those of the 140-mm and 160-mm gap RF heat-treated pitaya samples. The results suggested that RF heat treatment is an efficient method for enzyme inactivation. [ABSTRACT FROM AUTHOR]

Published
2020
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