Search

Background: Magnetic particle imaging (MPI) is a recently developed, non‐invasive in vivo imaging technique to map the spatial distribution of superparamagnetic iron oxide nanoparticles (SPIONs) in animal tissues with high sensitivity and speed. It is a challenge to reconstruct images directly from the received signals of MPI device due to the complex physical behavior of the nanoparticles. System matrix and X‐space are two commonly used MPI reconstruction methods, where the former is extremely time‐consuming and the latter usually produces blurry images. Purpose: Currently, we proposed an end‐to‐end machine learning framework to reconstruct high‐resolution MPI images from 1‐D voltage signals directly and efficiently. Methods: The proposed framework, which we termed "MPIGAN", was trained on a large MPI simulation dataset containing 291 597 pairs of high‐resolution 2‐D phantom images and each image's corresponding voltage signals, so that it was able to accurately capture the nonlinear relationship between the spatial distribution of SPIONs and the received voltage signal, and realized high‐resolution MPI image reconstruction. Results: Experiment results showed that, MPIGAN exhibited remarkable abilities in high‐resolution MPI image reconstruction. MPIGAN outperformed the traditional methods of system matrix and X‐space in recovering the fine‐scale structure of magnetic nanoparticles' spatial distribution and achieving enhanced reconstruction performance in both visual effects and quantitative assessments. Moreover, even when the received signals were severely contaminated with noise, MPIGAN could still generate high‐quality MPI images. Conclusion: Our study provides a promising AI solution for end‐to‐end, efficient, and high‐resolution magnetic particle imaging reconstruction. [ABSTRACT FROM AUTHOR]

Magnetic particle imaging (MPI) is a tomographic imaging method that quantitatively determines the distribution of magnetic nanoparticles (MNPs). However, the performance of MPI is primarily limited by the noise in the receive coil and electronic devices, which causes quantification errors for MPI images. Existing methods cannot efficiently eliminate noise while preserve structural details in MPI images. To address this problem, we propose a Content-Noise Feature Fusion Neural Network equipped with tailored modules of noise learning and content learning. It can simultaneously learn content and noise features of raw MPI images. Experimental results show that the proposed method outperforms the state-of-the-art methods on structural details preservation and image noise reduction of different levels.