Search

Your search keyword '"Shen, Zhenhuang"' showing total 8 results
Start Over Author "Shen, Zhenhuang"
8 results on '"Shen, Zhenhuang"'

3. Safety Evaluation of an Apitherapy Formulation, Bao-Yuan-Ling: Acute and Sub-acute Oral Toxicity in Wistar Rats

Author

Shen Zhenhuang, Sun Yanru, Miao Xiaoqing, and Jia Zhe

Subjects
Apitherapy, Nutrition and Dietetics, Traditional medicine, business.industry, Medicine (miscellaneous), Medicine, Sub acute, Oral toxicity, business
Abstract

Bao-Yuan-Ling (BYL) is an apitherapy formulation which is composed of royal jelly, propolis and bee venom. Cardioprotective effects of BYL has been demonstrated, while the toxicity of BYL was not clear. In this study, acute and sub-acute toxicity test of BYL was processed following Organization for Economic Co-operation and Development (OECD) 423 and OECD 407, respectively, in Wistar rats. In acute toxicity test, rats were orally treated with BYL at the single dose of 2000 mg/kg and 5000 mg/kg. No death occurred in the acute toxicity test for 7 days, which indicated the lethal dose 50% value exceeded 5000 mg/kg. In sub-acute toxicity study, rats were treated with BYL at the dose of 250 mg/kg, 500 mg/kg and 1000 mg/kg in a daily base for continuous 28 days. Results showed that female rats were more likely to be affected by BYL in body weight changes, while biochemical indicators of blood serum in male rats were more susceptible to drug effects. However, neither female nor male rats were affected by BYL administration significantly on the organs via hematoxylin-eosin staining analysis. Results suggested that BYL was slightly toxic and clinical use was safe and reliable.

Published
2017
Full Text
View/download PDF

8. Protective effect of scutellarin on myocardial infarction induced by isoprenaline in rats.

Author

Huang H, Geng Q, Yao H, Shen Z, Wu Z, Miao X, and Shi P

Abstract

Objectives: Scutellarin ( Scu ) is the main effective constituent of Erigeron breviscapus which has anti-oxidant, anti-apoptotic, anti-inflammatory and other therapeutic properties. The purpose of this study was to investigate the protective effect of Scu on myocardial infarction (MI) induced by isoprenaline (ISO)., Materials and Methods: The rats were subcutaneously injected with ISO (45 mg/kg) on the first day, then single tail-intravenously injected with different doses of Scu (10 mg/kg, 20 mg/kg, 40 mg/kg) for 7 consecutive days. The protective effect of Scu on ISO-induced MI was evaluated by measuring markers of heart injury in serum, levels of lipid peroxidation, and antioxidants in heart tissue, observing pathological changes of tissue, and detecting quantified expression of apoptotic-related family members and inflammation., Results: Compared with the model group, the concentration of troponin T (CTn-T) and troponin I (CTn-I), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) in the serum all decreased in the Scu high dose group. The activities of superoxide dismutase (SOD), catalase (CAT), and the content of reduced glutathione (GSH) in heart increased, and the content of malondialdehyde (MDA) and inducible nitric oxide synthase (iNOS) decreased. In addition, the histopathologic aspects showed that pathological heart change was found in the model group, and was reduced to varying degrees in the Scu group. Moreover, the expression of Bax, P53, Caspase3, Caspase9, cytochrome C, NGAL, NFκB, IL-1β and IL-6 in the heart decreased, while the expression of Bcl 2 increased., Conclusion: Scu could reduce the degree of MI induced by ISO by improving the antioxidant, anti-apoptotic, and anti-inflammatory capacities of the body.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results