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22 results on '"Shen, Ziyin"'

11. Study of different patterns of immuno-modulatory mechanism by tonifying Kidney and Invigorating Spleen drugs

Author

Cai Dingfang, Zhong Liyong, Shen Ziyin, Zhang Lingjuan, and Chen Xiaohong

Subjects
Kidney, chemistry.chemical_compound, medicine.anatomical_structure, Immune system, Chemistry, Mechanism (biology), Corticosterone, Medicine public health, Rat model, medicine, Spleen, General Medicine, Pharmacology
Abstract

Objective: To observe the acting pattern on the immune system by Kidney tonifying (KT) drugs.Methods: Three composite recipes were used on the 7- and 14-day corticosterone rat model to study the effect of recipes on the different patterns of immuno-modulatory and neuro-endocrinological systems.Results: The immune system of Spleen Invigorating (SI) group was well protected in either 7- or 14-day experiments, with the SI recipe showing no effect on the neuroendocrine system. It suggested that SI recipe might have direct action on immune system. On the other hand, KT group with no effect on neuroendocrine-immune (NEI) system in 7-day experiment, but showed a remarkable protective effect of the whole NEI system in 14-day experiment.Conclusion: The results indicated that KT recipe acts on the neuroendocrine system first, and then influence the immune system. It means that the action took place through down pathway of NEI network.

Published
1998

19. Effect of three composite recipes on content of monoamine transmitters in hypothalamus induced by intracerebroventricular injection of interleukin-1 in rats

Author

Duan Yuanli, Zhang Xinmin, Shen Ziyin, Wang Wenjian, and Chen Weihua

Subjects
medicine.medical_specialty, Kidney, Chemistry, medicine.medical_treatment, Interleukin, Decoction, General Medicine, Norepinephrine, medicine.anatomical_structure, Endocrinology, Cytokine, Monoamine neurotransmitter, Hypothalamus, Internal medicine, medicine, Neuron, medicine.drug
Abstract

OBJECTIVE To explore the different effects of Youguiyin decoction, Sijunzi decoction, Taohong Siwu decoction on the content of monoamine transmitters in the hypothalamus induced by cytokines. METHODS A reactive status of hypothalamic monoamine transmitters to cytokine in rat was built by observing the content change of monoamine transmitters in hypothalamic homogenate after intracerebroventricular (icv) injection of human recombinant interleukin-1 beta(IL-1 beta). On this basis, the different effect of three composite recipes on this status was observed. RESULTS The content of norepinephrine (NE) declined significantly compared with control group after icv injection of IL-1. Compared with IL-1 group, Youguiyin further reduced the content of NE induced by icv injection of IL-1, while Taohong Siwu decoction and Sijunzi decoction did not show any effect on this status. CONCLUSIONS It seems that Youguiyin for tonifying Kidney could increase the reactivity of hypothalamic NE neuron, Sijunzi decoction for invigorating Spleen and Taohong Siwu decoction for promoting blood circulation did not show this effect.

Published
1999

20. The Spatial Association of Gene Expression Evolves from Synchrony to Asynchrony and Stochasticity with Age.

Author

Qi Wang, Huang, Jianhua, Zhang, Xinmin, Bin Wu, Liu, Xiaoyu, and Shen, Ziyin

Subjects
GENE expression, STOCHASTIC analysis, LABORATORY mice, TISSUE analysis, NEURODEGENERATION, AGING prevention, DNA damage, CANCER risk factors
Abstract

For multicellular organisms, different tissues coordinate to integrate physiological functions, although this systematically and gradually declines in the aging process. Therefore, an association exists between tissue coordination and aging, and investigating the evolution of tissue coordination with age is of interest. In the past decade, both common and heterogeneous aging processes among tissues were extensively investigated. The results on spatial association of gene changes that determine lifespan appear complex and paradoxical. To reconcile observed commonality and heterogeneity of gene changes among tissues and to address evolution feature of tissue coordination with age, we introduced a new analytical strategy to systematically analyze genome-wide spatio-temporal gene expression profiles. We first applied the approach to natural aging process in three species (Rat, Mouse and Drosophila) and then to anti-aging process in Mouse. The results demonstrated that temporal gene expression alteration in different tissues experiences a progressive association evolution from spatial synchrony to asynchrony and stochasticity with age. This implies that tissue coordination gradually declines with age. Male mice showed earlier spatial asynchrony in gene expression than females, suggesting that male animals are more prone to aging than females. The confirmed anti-aging interventions (resveratrol and caloric restriction) enhanced tissue coordination, indicating their underlying anti-aging mechanism on multiple tissue levels. Further, functional analysis suggested asynchronous DNA/protein damage accumulation as well as asynchronous repair, modification and degradation of DNA/protein in tissues possibly contributes to asynchronous and stochastic changes of tissue microenvironment. This increased risk for a variety of age-related diseases such as neurodegeneration and cancer that eventually accelerate organismal aging and death. Our study suggests a novel molecular event occurring in aging process of multicellular species that may represent an intrinsic molecular mechanism of aging. [ABSTRACT FROM AUTHOR]

Published
2011
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21. Simultaneous determination of nine flavonoids and qualitative evaluation of Herba Epimediiby high performance liquid chromatography with ultraviolet detection

Author

Huang, Hao, Liang, Mingjin, Zhang, Xinmin, Zhang, Chuan, Shen, Ziyin, and Zhang, Weidong

Abstract

A simple high performance liquid chromatographic method has been developed for the determination of nine flavonoids inHerba Epimedii, including quercetin‐3‐O‐glucoside, epimedin A, hexandraside A, epimedin B, epimedin C, icariin, icariside I, icariside II, and icaritin. The chromatographic separation was performed on a Diamonsil C18column (5 μm, 250×4.6 mm) with gradient elution by acetonitrile–0.5% acetic buffer (adjusted to pH 5.00 with triethylamine). Methodological validation gave acceptable linearities (r2>0.9992) and recoveries (ranging from 98.9 to 102.4%). The limits of detection of these flavonoids ranged from 16.3 to 83.3 ng. The results indicated that the contents of flavonoids in Herba Epimediivaried significantly from habitat to habitat with contents ranging from 0.05 to 39.0 mg/g. Twenty fiveHerba Epimedii samples prepared from five different botanical materials were investigated by the established method, and the results showed the influence of the botanical material and the habitat on the quality of Herba Epimedii. The proposed method is simple, effective, and suitable for the evaluation of this traditional Chinese medicine.

Published
2007
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