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27 results on '"Sheng, Meixiao"'

9. Causal Effects of Specific Gut Microbiota on Chronic Kidney Diseases and Renal Function—A Two-Sample Mendelian Randomization Study

Author

Li, Ning, primary, Wang, Yi, additional, Wei, Ping, additional, Min, Yu, additional, Yu, Manshu, additional, Zhou, Guowei, additional, Yuan, Gui, additional, Sun, Jinyi, additional, Dai, Huibo, additional, Zhou, Enchao, additional, He, Weiming, additional, Sheng, Meixiao, additional, Gao, Kun, additional, Zheng, Min, additional, Sun, Wei, additional, Zhou, Dong, additional, and Zhang, Lu, additional

Published
2023
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13. The Efficacy of Tai Chi and Qigong Exercises on Blood Pressure and Blood Levels of Nitric Oxide and Endothelin-1 in Patients with Essential Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Author

Liu, Dingcheng, Yi, Lan, Sheng, Meixiao, Wang, Gang, and Zou, Yanqin

Subjects
Article Subject
Abstract

Objective. Tai Chi and Qigong are the two similar traditional Chinese wellness exercises. A strong body of published clinical randomized controlled trials (RCTs) has investigated the health benefits of Tai Chi and Qigong exercises (TCQE) in patients with essential hypertension (EH). This is the first meta-analysis to evaluate the efficacy of TCQE on blood pressure (BP) and blood levels of nitric oxide (NO) and endothelin-1 (ET-1) in EH patients and explore the potential antihypertensive mechanism of TCQE. Methods. We conducted a literature retrieval for Chinese and English studies in seven databases from their respective inceptions until January 14, 2020. All RCTs examining clinical efficacy of TCQE for EH patients were considered. The major therapeutic outcomes of TCQE were changes in the blood levels of NO, ET-1, and BP in EH patients. Methodological quality of the included RCTs was detected via The Cochrane Risk of Bias tool. We evaluated the data reported and performed the meta-analysis by Review Manager 5.3 software. Results. 9 RCTs involving 516 EH patients were included. The intervention duration lasted from 1.5 months to 6 months. The results of comprehensive analysis showed that compared with control interventions, experimental interventions were more effective in reducing the systolic blood pressure and the diastolic blood pressure and contributed higher blood levels of NO and lower blood levels of ET-1. Conclusions. TCQE could be an effective complementary and alternative therapy for EH. The lower BP in EH patients who practice TCQE may have some connection with exercise-related increased blood NO levels and decreased blood ET-1 levels. However, further research is needed to make clear the efficacy of TCQE in management of EH and the mechanism of lowering BP in TCQE.

Published
2020
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14. Allantoin induces pruritus by activating MrgprD in chronic kidney disease

Author

Yang, Yan, primary, Sun, Yulin, additional, Guan, Donglang, additional, Chen, Dan, additional, Wang, Dijun, additional, Liu, Tongtong, additional, Sheng, Meixiao, additional, Jing, Tao, additional, Jun, Shi, additional, Zhu, Chan, additional, Yu, Guang, additional, Dong, Xinzhong, additional, and Tang, Zongxiang, additional

Published
2020
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15. Efficacy and Safety of Chinese Herbal Formula Granules in Treating Chronic Kidney Disease Stage 3: A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial

Author

Zhao, Jing, primary, Sun, Wei, additional, Chen, Jihong, additional, Sun, Zhuxing, additional, Chen, Dai, additional, Cao, Chunhua, additional, Yang, Min, additional, Ma, Jipei, additional, Wang, Ling, additional, Xing, Changying, additional, Chen, Yan, additional, Sheng, Meixiao, additional, Zhou, Enchao, additional, Xu, Lingdong, additional, Gao, Kun, additional, Liu, Lihua, additional, Liu, Qiong, additional, Yi, Lan, additional, He, Weiming, additional, and Zhu, Yuanyuan, additional

Published
2020
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26. [Advances in the mechanism of extracellular vesicles action in macrophage-related tissue fibrosis].

Author

Shan Y, Zhu X, Tang L, Cao H, and Sheng M

Subjects
Fibrosis, Humans, Kidney pathology, Liver pathology, Extracellular Vesicles, Macrophages
Abstract

Fibrosis is a pathological healing process which occurs in the progression of various chronic diseases after tissue injury. Extracellular vesicles are involved in tissue fibrosis through communication between cells. Macrophages are important immune cells that maintain tissue integrity by eliminating or repairing damaged cells and matrix. Macrophages can directly regulate tissue fibrosis by secreting extracellular vesicles and transporting microRNAs, lncRNAs and fibrogenic factors to target cells of lungs, heart, liver, kidney and other organs. At the same time, chronic diseases are often accompanied by inflammation. A large number of macrophages are recruited to the site of injury, and local or distal cells transport extracellular vesicles to macrophages to regulate the polarization of macrophages, thus affecting the development and prognosis of tissue fibrosis.

Published
2022

27. The RhoA/ROCK signaling pathway affects the development of diabetic nephropathy resulting from the epithelial to mesenchymal transition.

Author

Yan Q, Wang X, Zha M, Yu M, Sheng M, and Yu J

Abstract

Diabetic nephropathy is a common complication of type 2 diabetes and is related to the epithelial to mesenchymal transition. In this study, we aimed to find whether the RhoA/ROCK pathway affects the development of diabetic nephropathy caused by the epithelial to mesenchymal transition both in vivo and in vitro. The results show that inhibition of the RhoA/ROCK signaling pathway improved the pathology and degree of fibrosis in diabetic nephropathy as determined by hematoxylin and eosin staining and Masson staining. We also found, using immunohistochemistry and quantitative reverse transcription polymerase chain reaction, that a RhoA/Rock inhibitor regulated relative protein and gene expression levels in a dose-dependent manner. Furthermore, the inhibitor improved fibrosis induced by high levels of glucose in HK-2 cells by suppressing E-cadherin, α-SMA, and FSP-1 expression. In conclusion, the RhoA/ROCK signaling pathway plays an important role in the development of diabetic nephropathy and could be a potential therapeutic target for type 2 diabetes., Competing Interests: None., (IJCEP Copyright © 2018.)

Published
2018

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