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5 results on '"Sheng-Nan Cheng"'

1. Discrepancies between total and anterior corneal high-order aberrations at measured and theoretical pupil diameter

Author

Li-Jun Zhao, Yu-Kan Huang, Sheng-Nan Cheng, Ming-Feng Wu, and Yu-Zhi Li

Subjects
cornea, high-order aberration, pupil diameter, Ophthalmology, RE1-994
Abstract

AIM: To compare the difference between total and anterior corneal high-order aberrations(HOA)calculated based on the pupil diameters of 4.0mm and the actual measurements in different age groups.METHODS: A cross sectional study. A Total of 100 subjects between March, 31th and May, 31th in 2019 were included. Their total corneal high-order aberrations(THOA)and anterior corneal high-order aberrations(AHOA)were detected on the basis of different machine-provided pupil diameters(2.0-7.0mm)and their photopic pupil diameters were recorded as measured pupil diameters in the room with normal illumination. THOA and AHOA based on the machine-measured pupil diameter was calculated through fitting curves, and compared to the THOA and AHOA at a theoretical 4mm pupil diameter.RESULTS: The measured pupil diameter was negatively correlated with age(r= -0.587, Pr= -0.191, P=0.002; r=-0.181, P=0.004). At 4mm pupil diameter, THOA was positively correlated with age(r=0.282, PPPP=0.006), but higher than AHOA in 60-69 years old groups(P=0.039). In the aged group(include 60-69 and 70-79 years old groups), the proportion of observed value of THOA ≥0.3μm at the measured pupil diameters were significantly lower than those at 4mm pupil diameter(χ2=4.300, P=0.038).CONCLUSION: THOA and AHOA at the measured pupil diameters in the old subjects are significantly lower than those at 4mm pupil diameter, which could be ascribed to their relatively small actual mean pupil sizes. Our study suggested that the THOA rather than AHOA should be used for the selection of multifocal intraocular lens for cataract patients at measured pupil diameter, so that more aged patients will satisfy the inclusion criteria.

Published
2020
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2. Intense Pulsed Light Therapy for Patients with Meibomian Gland Dysfunction and Ocular Demodex Infestation

Author

Yu-Kan Huang, Sheng-Nan Cheng, Fa-Gang Jiang, Hui Gao, and Hua Chen

Subjects
Adult, Male, medicine.medical_specialty, Mite Infestations, medicine.medical_treatment, Meibomian gland, Intense pulsed light, Biochemistry, Ophthalmology, parasitic diseases, Genetics, medicine, Animals, Humans, Ocular Surface Disease Index, Demodex infestation, Meibomian Gland Dysfunction, Aged, Retrospective Studies, Aged, 80 and over, Mites, biology, business.industry, Intense Pulsed Light Therapy, Meibomian gland dysfunction, Eyelids, Meibomian Glands, Middle Aged, biology.organism_classification, eye diseases, medicine.anatomical_structure, Tears, Female, sense organs, Eyelid, business, Demodex
Abstract

To observe the clinical changes of meibomian gland dysfunctipn (MGD) and ocular Demodex infestation after intense pulsed light (IPL) treatment to further examine the mechanism of IPL treating patients with MGD and ocular Demodex infestation. The medical records of 25 patients (49 eyes) with MGD treated with IPL, were retrospectively examined to determine outcomes. Associated ocular-surface parameters (ocular surface disease index, OSDI; lipid layer thickness, LLT; noninvasive first breakup time, NIF-BUT; noninvasive average breakup time, NIAvg-BUT; tear film breakup area, TBUA; Schirmer I Test, SIT; corneal fluorescein staining, CFS), eyelid margin abnormalities, meibum quality and expressibility, MG morphological parameters (macrostructure and microstructure), and the number of Demodex infestation were examined before and after treatment. The MG microstructure and the Demodex infestation were examined via in vivo confocal microscopy (IVCM). The results showed that there were statistically significant differences in associated ocular-surface parameters (all P

Published
2019

3. Comparison of 2-wall versus 3-wall orbital decompression against dysthyroid optic neuropathy in visual function

Author

Xinghua Wang, Xiao-Huan Pi, Fagang Jiang, Ya-Yan You, Yueqi Yu, Jin Chen, and Sheng-Nan Cheng

Subjects
Adult, Male, musculoskeletal diseases, medicine.medical_specialty, Visual acuity, genetic structures, Decompression, Visual Acuity, Observational Study, dysthyroid optic neuropathy, Thyroid Function Tests, Optic neuropathy, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Ophthalmology, Tobacco Smoking, medicine, Humans, 030212 general & internal medicine, Evoked potential, Aged, Retrospective Studies, Diplopia, business.industry, Age Factors, Retrospective cohort study, General Medicine, Middle Aged, Decompression, Surgical, 3-wall orbital decompression, medicine.disease, eye diseases, Visual field, Graves Ophthalmopathy, 2-wall orbital decompression, P100 Latency, 030220 oncology & carcinogenesis, Visual Perception, Evoked Potentials, Visual, Female, pattern-reversed visual evoked potential, Visual Fields, medicine.symptom, business, Orbit, Research Article
Abstract

To compare visual function of 2-wall (medial and lateral) versus 3-wall (medial, lateral, and inferior) orbital decompression in patients with dysthyroid optic neuropathy (DON). A total of 52 eyes of 37 patients underwent orbital decompression for DON between 2013 and 2019 were retrospectively reviewed. Two- or 3-wall decompression was performed in 31 eyes of 23 patients and 21 eyes of 14 patients, respectively. We examined best-corrected visual acuity (BCVA), visual field mean deviation (MD) and pattern standard deviation (PSD), pattern-reversed visual evoked potential (PVEP) for P100 latency and amplitude at 60 and 15 arcmin stimulation checkerboard size, as well as proptosis using Hertel exophthalmometry. Whether 2-wall or 3-wall decompression, all parameters of visual function were improved after surgery (all P .05). Proptosis reduction was higher after 3-wall decompression (P = .011). Mean increase in P100 amplitude after 3-wall decompression was statistically higher than that of after 2-wall decompression at 60 and 15 arcmin (P = .045 and .020, respectively), while the mean decrease in P100 latency was similar between the groups (P = .821 and .655, respectively). Six patients (66.67%) had persistent postoperative diplopia and 1 patient (20%) had new-onset diplopia in 3-wall decompression group, which were higher than in 2-wall decompression group (46.15% persistent postoperative diplopia and no new-onset diplopia). Both 2-wall and 3-wall decompression can effectively improve visual function of patients with DON. Three-wall decompression provides better improvement in P100 amplitude and proptosis, however new-onset diplopia is more common with this surgical technique.

Published
2021
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5. The correlation between the microstructure of meibomian glands and ocular Demodex infestation

Author

Hua Chen, Wanlin Fan, Mingchang Zhang, Sheng-Nan Cheng, and Yu-Kan Huang

Subjects
Adult, Male, China, Mite Infestations, meibomian glands, medicine.medical_specialty, Adolescent, In vivo confocal microscopy, microstructure, Observational Study, Meibomian gland, meibomian glands dysfunction, Demodex, Gastroenterology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, parasitic diseases, Humans, Medicine, Eye Infections, Parasitic, 030212 general & internal medicine, Demodex infestation, Aged, Retrospective Studies, Aged, 80 and over, Chinese population, Microscopy, Confocal, biology, business.industry, Significant difference, Case-control study, General Medicine, Middle Aged, Eye infection, biology.organism_classification, medicine.anatomical_structure, Case-Control Studies, correlation, 030220 oncology & carcinogenesis, Eyelid Diseases, Female, business, Research Article
Abstract

Meibomian gland dysfunction (MGD) is a common disease in ophthalmic clinic. This study aimed to explore ocular Demodex infestation on the microstructure changes of the meibomian glands (MGs) in patients with MGD by in vivo confocal microscopy (IVCM). We retrospectively reviewed 103 eyes of 52 patients with MGD and 62 eyes of 31 non-MGD patients. All enrolled patients underwent IVCM examination. The following IVCM parameters were recorded: the MG acinar density (MAD), MG acinar longest diameter (MALD), MG acinar shortest diameter (MASD), MG orifice area (MOA), severity of MG fibrosis (MF), MG acinar irregularity (MAI), meibum secretion reflectivity (MSR), inhomogeneous appearance of walls of acinar units (AWI) and periglandular interstices of acinar units (API), and the number of Demodex. The positive rate of Demodex infestation in MGDs was 89.32%, and statistically higher than control group (controls; P

Published
2019
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