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18 results on '"Shevtsova, Yulia A."'

1. Extracellular vesicles of human glial cells exert neuroprotective effects via brain miRNA modulation in a rat model of traumatic brain injury

Author

Salikhova, Diana I., Timofeeva, Angelika V., Golovicheva, Victoria V., Fatkhudinov, Timur Kh., Shevtsova, Yulia A., Soboleva, Anna G., Fedorov, Ivan S., Goryunov, Kirill V., Dyakonov, Alexander S., Mokrousova, Victoria O., Shedenkova, Margarita O., Elchaninov, Andrey V., Makhnach, Oleg V., Kutsev, Sergey I., Chekhonin, Vladimir P., Silachev, Denis N., and Goldshtein, Dmitry V.

Published
2023
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3. Characteristics of the Follicular Fluid Extracellular Vesicle Molecular Profile in Women in Different Age Groups in ART Programs

Author

Sysoeva, Anastasia, primary, Akhmedova, Zumriyat, additional, Nepsha, Oksana, additional, Makarova, Natalya, additional, Silachev, Denis, additional, Shevtsova, Yulia, additional, Goryunov, Kirill, additional, Karyagina, Victoria, additional, Bugrova, Anna, additional, Starodubtseva, Natalya, additional, Novoselova, Anastasia, additional, Chagovets, Vitaliy, additional, and Kalinina, Elena, additional

Published
2024
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5. Metabolite Biomarkers for Early Ischemic–Hypoxic Encephalopathy: An Experimental Study Using the NeoBase 2 MSMS Kit in a Rat Model

Author

Shevtsova, Yulia, primary, Starodubtseva, Natalia, additional, Tokareva, Alisa, additional, Goryunov, Kirill, additional, Sadekova, Alsu, additional, Vedikhina, Irina, additional, Ivanetz, Tatiana, additional, Ionov, Oleg, additional, Frankevich, Vladimir, additional, Plotnikov, Egor, additional, Sukhikh, Gennady, additional, Zorov, Dmitry, additional, and Silachev, Denis, additional

Published
2024
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7. Dried Blood Spot Metabolome Features of Ischemic–Hypoxic Encephalopathy: A Neonatal Rat Model.

Author

Eldarov, Chupalav, Starodubtseva, Natalia, Shevtsova, Yulia, Goryunov, Kirill, Ionov, Oleg, Frankevich, Vladimir, Plotnikov, Egor, Sukhikh, Gennady, Zorov, Dmitry, and Silachev, Denis

Subjects
TREATMENT effectiveness, LABORATORY rats, THERAPEUTIC hypothermia, LIPID metabolism, NEONATOLOGY, ASPHYXIA neonatorum
Abstract

Hypoxic–ischemic encephalopathy (HIE) is a severe neurological disorder caused by perinatal asphyxia with significant consequences. Early recognition and intervention are crucial, with therapeutic hypothermia (TH) being the primary treatment, but its efficacy depends on early initiation of treatment. Accurately assessing the HIE severity in neonatal care poses challenges, but omics approaches have made significant contribution to understanding its complex pathophysiology. Our study further explores the impact of HIE on the blood metabolome over time and investigated changes associated with hypothermia's therapeutic effects. Using a rat model of hypoxic–ischemic brain injury, we comprehensively analyzed dried blood spot samples for fat-soluble compounds using HPLC-MS. Our research shows significant changes in the blood metabolome after HIE, with a particularly rapid recovery of lipid metabolism observed. Significant changes in lipid metabolites were observed after 3 h of HIE, including increases in ceramides, carnitines, certain fatty acids, phosphocholines, and phosphoethanolamines, while sphingomyelins and N-acylethanolamines (NAEs) decreased (p < 0.05). Furthermore, NAEs were found to be significant features in the OPLS-DA model for HIE diagnosis, with an area under the curve of 0.812. TH showed a notable association with decreased concentrations of ceramides. Enrichment analysis further corroborated these observations, showing modulation in several key metabolic pathways, including arachidonic acid oxylipin metabolism, eicosanoid metabolism via lipooxygenases, and leukotriene C4 synthesis deficiency. Our study reveals dynamic changes in the blood metabolome after HIE and the therapeutic effects of hypothermia, which improves our understanding of the pathophysiology of HIE and could lead to the development of new rapid diagnostic approaches for neonatal HIE. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Metabolite Biomarkers for Early Ischemic Hypoxic Encephalopathy: An Experimental Study Using the NeoBase 2 MSMS Kit in a Rat Model

Author

Shevtsova, Yulia, primary, Starodubtseva, Natalia, additional, Tokareva, Alisa, additional, Goryunov, Kirill, additional, Sadekova, Alsu, additional, Vedikhina, Irina, additional, Ivanetz, Tatiana, additional, Ionov, Oleg, additional, Frankevich, Vladimir, additional, Plotnikov, Egor, additional, Sukhikh, Gennady, additional, Zorov, Dmitry, additional, and Silachev, Denis, additional

Published
2023
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10. Therapeutic Efficiency of Proteins Secreted by Glial Progenitor Cells in a Rat Model of Traumatic Brain Injury

Author

Salikhova, Diana I., primary, Golovicheva, Victoria V., additional, Fatkhudinov, Timur Kh., additional, Shevtsova, Yulia A., additional, Soboleva, Anna G., additional, Goryunov, Kirill V., additional, Dyakonov, Alexander S., additional, Mokroysova, Victoria O., additional, Mingaleva, Natalia S., additional, Shedenkova, Margarita O., additional, Makhnach, Oleg V., additional, Kutsev, Sergey I., additional, Chekhonin, Vladimir P., additional, Silachev, Denis N., additional, and Goldshtein, Dmitry V., additional

Published
2023
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11. Development of an In Vitro Model of SARS-CoV-Induced Acute Lung Injury for Studying New Therapeutic Approaches

Author

Shevtsova, Yulia A., primary, Goryunov, Kirill V., additional, Babenko, Valentina A., additional, Pevzner, Irina B., additional, Vtorushina, Valentina V., additional, Inviyaeva, Evgeniya V., additional, Krechetova, Lyubov V., additional, Zorova, Ljubava D., additional, Plotnikov, Egor Y., additional, Zorov, Dmitry B., additional, Sukhikh, Gennady T., additional, and Silachev, Denis N., additional

Published
2022
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12. Human Multipotent Mesenchymal Stromal Cell–Derived Extracellular Vesicles Enhance Neuroregeneration in a Rat Model of Sciatic Nerve Crush Injury

Author

Demyanenko, Svetlana V., primary, Pitinova, Maria A., additional, Kalyuzhnaya, Yulia N., additional, Khaitin, Andrey M., additional, Batalshchikova, Svetlana A., additional, Dobaeva, Natalya M., additional, Shevtsova, Yulia A., additional, Goryunov, Kirill V., additional, Plotnikov, Egor Y., additional, Pashkevich, Svetlana G., additional, Sukhikh, Gennady T., additional, and Silachev, Denis N., additional

Published
2022
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13. Do Extracellular Vesicles Derived from Mesenchymal Stem Cells Contain Functional Mitochondria?

Author

Zorova, Ljubava D., primary, Kovalchuk, Sergei I., additional, Popkov, Vasily A., additional, Chernikov, Valery P., additional, Zharikova, Anastasia A., additional, Khutornenko, Anastasia A., additional, Zorov, Savva D., additional, Plokhikh, Konstantin S., additional, Zinovkin, Roman A., additional, Evtushenko, Ekaterina A., additional, Babenko, Valentina A., additional, Pevzner, Irina B., additional, Shevtsova, Yulia A., additional, Goryunov, Kirill V., additional, Plotnikov, Egor Y., additional, Silachev, Denis N., additional, Sukhikh, Gennady T., additional, and Zorov, Dmitry B., additional

Published
2022
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15. Mesenchymal stromal cell-derived extracellular vesicles afford neuroprotection by modulating PI3K/AKT pathway and calcium oscillations

Author

Turovsky, Egor A., primary, Golovicheva, Victoria V., additional, Varlamova, Elena G., additional, Danilina, Tatyana I., additional, Goryunov, Kirill V., additional, Shevtsova, Yulia A., additional, Pevzner, Irina B., additional, Zorova, Ljubava D., additional, Babenko, Valentina A., additional, Evtushenko, Ekaterina A., additional, Zharikova, Anastasia A., additional, Khutornenko, Anastasia A., additional, Kovalchuk, Sergey I., additional, Plotnikov, Egor Y., additional, Zorov, Dmitry B., additional, Sukhikh, Gennady T., additional, and Silachev, Denis N., additional

Published
2022
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16. Research tasks design in the 'Circle' topic

Author

Shevtsova Yulia Segeevna and Malinnikova Natalia Alekseevna

Subjects
этапы конструирования, исследовательские задачи, классификация исследовательских задач, базовая задача
Abstract

статья посвящена методике конструирования исследовательских задач по геометрии на основе базовых задач, выделенных в теме «Окружность». Отмечено, что конструирование исследовательских задач в процессе обучения вместе с учащимися позволяет не только увеличить их количество на уроке, но и более активно вовлекать учащихся в исследовательскую деятельность, что и формирует исследовательские умения школьников.

Published
2017
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17. О конструировании исследовательских задач в теме «Окружность»

Author

Шевцова Юлия Сергеевна, ФГБОУ ВО «Брянский государственный университет им. академика И.Г. Петровского», Shevtsova Yulia Segeevna, FSFEI of HE "Bryansk State University named after Academician Ivan Georgiyevich Petrovsky", Малинникова Наталья Алексеевна, Malinnikova Natalia Alekseevna, Шевцова Юлия Сергеевна, ФГБОУ ВО «Брянский государственный университет им. академика И.Г. Петровского», Shevtsova Yulia Segeevna, FSFEI of HE "Bryansk State University named after Academician Ivan Georgiyevich Petrovsky", Малинникова Наталья Алексеевна, and Malinnikova Natalia Alekseevna

Abstract

статья посвящена методике конструирования исследовательских задач по геометрии на основе базовых задач, выделенных в теме «Окружность». Отмечено, что конструирование исследовательских задач в процессе обучения вместе с учащимися позволяет не только увеличить их количество на уроке, но и более активно вовлекать учащихся в исследовательскую деятельность, что и формирует исследовательские умения школьников.

Published
2017

18. The Republic of Belarus Country Report / European Neighborhood and Partnership Instrument – Shared Environmental Information System

Author

Titov, Konstantin, Komosko, Irina, Panteleyeva, Olga, Shevtsova, Yulia, Snetkov, Aleksander, Novakovskaya, Elena, Bushmovich, Alina, Kuzmin, Saveliy, Utochkina, Svetlana, Stankevich, Alexander, Denisov, Nickolai, and Nikolayeva, Lesya

Subjects
ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::География [ЭБ БГУ], МЕЖОТРАСЛЕВЫЕ ПРОБЛЕМЫ::Охрана окружающей среды. Экология человека [ЭБ БГУ]
Abstract

This project is financed through a service contract ENPI/2009/210/629 managed by DG EuropeAid. This publication has been produced with the assistance of the European Union. The contents of this publication are the sole responsibility of Zoï Environment Network, sub-contracted by EEA for this work, and can in no way be taken to reflect the views of the European Union.

Published
2012

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