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319 results on '"Shi, Baolu"'

42. Propagation instabilities of the oblique detonation wave in partially prevaporized n -heptane sprays.

Author

Tian, Cheng, Teng, Honghui, Shi, Baolu, Yang, Pengfei, Wang, Kuanliang, and Zhao, Majie

Subjects
DETONATION waves, SHOCK waves, MAGNETOHYDRODYNAMIC instabilities, MULTIPHASE flow, BLAST effect
Abstract

Two-dimensional oblique detonation wave (ODW) propagations in partially prevaporized n -heptane sprays are numerically simulated with a skeletal chemical mechanism. The influences of the droplet diameter and total equivalence on oblique detonation are considered. The initiation length is found to increase first and then decrease with increasing initial droplet diameter, and the effect of droplet size is maximized when the initial droplet diameter is approximately $10\ \mathrm {\mu } {\rm m}$. As the initial droplet diameter varies, unsteady and steady ODWs are observed. In the cases of unsteady ODWs, temperature gradients and non-uniform distributions of the reactant mixture due to droplet evaporation lead to formation of unsteady detonation propagation, therefore leading to fluctuations in the initiation length. The fluctuations in initiation length decrease as the pre-evaporation gas equivalence ratio increases for the unsteady cases. The results further suggest that the relationship between the evaporation layer thickness along the streamline and the corresponding theoretical initiation length can be used to identify an unsteady or steady ODW in cases with large droplets that evaporate behind an oblique shock wave or ODW under the effects of different initial droplet diameters. [ABSTRACT FROM AUTHOR]

Published
2024
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43. CCDC157 is essential for sperm differentiation and shows oligoasthenoteratozoospermia‐related mutations in men.

Author

Zheng, Huimei, Gong, Chenjia, Li, Jingping, Hou, Jiaru, Gong, Xinhan, Zhu, Xinhai, Deng, Huan, Wu, Haoyue, Zhang, Fengbin, Shi, Qinghua, Zhou, Jianteng, Shi, Baolu, Yang, Xiaohang, and Xi, Yongmei

Abstract

Oligoasthenoteratospermia (OAT), characterized by abnormally low sperm count, poor sperm motility, and abnormally high number of deformed spermatozoa, is an important cause of male infertility. Its genetic basis in many affected individuals remains unknown. Here, we found that CCDC157 variants are associated with OAT. In two cohorts, a 21‐bp (g.30768132_30768152del21) and/or 24‐bp (g.30772543_30772566del24) deletion of CCDC157 were identified in five sporadic OAT patients, and 2 cases within one pedigree. In a mouse model, loss of Ccdc157 led to male sterility with OAT‐like phenotypes. Electron microscopy revealed misstructured acrosome and abnormal head–tail coupling apparatus in the sperm of Ccdc157‐null mice. Comparative transcriptome analysis showed that the Ccdc157 mutation alters the expressions of genes involved in cell migration/motility and Golgi components. Abnormal Golgi apparatus and decreased expressions of genes involved in acrosome formation and lipid metabolism were detected in Ccdc157‐deprived mouse germ cells. Interestingly, we attempted to treat infertile patients and Ccdc157 mutant mice with a Chinese medicine, Huangjin Zanyu, which improved the fertility in one patient and most mice that carried the heterozygous mutation in CCDC157. Healthy offspring were produced. Our study reveals CCDC157 is essential for sperm maturation and may serve as a marker for diagnosis of OAT. [ABSTRACT FROM AUTHOR]

Published
2024
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