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9 results on '"Shi, ChenKun"'

2. Single-cell transcriptome atlas of the human corpus cavernosum

Author

Zhao, LiangYu, Han, Sha, Su, HengChuan, Li, JianYing, Zhi, ErLei, Li, Peng, Yao, ChenCheng, Tian, RuHui, Chen, HuiXing, Chen, HuiRong, Luo, JiaQiang, Shi, ChenKun, Ji, ZhiYong, Hu, JianLin, Wu, Gang, Zhou, WeiDong, Tang, YuXin, Chen, YuZhuo, Lin, GuiTing, Lue, Tom F, Wu, DengLong, and Li, Zheng

Subjects
Contraception/Reproduction, Urologic Diseases, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Erectile Dysfunction, Humans, Male, Muscle, Smooth, Penile Erection, Penis, Transcriptome
Abstract

The corpus cavernosum is the most important structure for penile erection, and its dysfunction causes many physiological and psychological problems. However, its cellular heterogeneity and signalling networks at the molecular level are poorly understood because of limited access to samples. Here, we profile 64,993 human cavernosal single-cell transcriptomes from three males with normal erection and five organic erectile dysfunction patients. Cell communication analysis reveals that cavernosal fibroblasts are central to the paracrine signalling network and regulate microenvironmental homeostasis. Combining with immunohistochemical staining, we reveal the cellular heterogeneity and describe a detailed spatial distribution map for each fibroblast, smooth muscle and endothelial subcluster in the corpus cavernosum. Furthermore, comparative analysis and related functional experiments identify candidate regulatory signalling pathways in the pathological process. Our study provides an insight into the human corpus cavernosum microenvironment and a reference for potential erectile dysfunction therapies.

Published
2022

5. Preliminary experience with 3D digital image microscope system on the treatment of varicocele

Author

Yao, Chencheng, primary, Xu, Wang, additional, Liu, Nachuan, additional, Zhi, Erlei, additional, Shi, Chenkun, additional, Ji, Zhiyong, additional, Zhao, Jingpeng, additional, Tian, Ruhui, additional, Huang, Yuhua, additional, Zhao, Fujun, additional, Chen, Huirong, additional, Zhang, Pei, additional, Pu, Ying, additional, Dong, Jianjun, additional, Li, Zheng, additional, and Li, Peng, additional

Published
2022
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6. The Efficacy and Safety of Thrice Versus Twice Per Week Low-Intensity Pulsed Ultrasound Therapy for Erectile Dysfunction: A Randomized Clinical Trial

Author

Li, Zheng, primary, Chen, Huirong, additional, Li, Xianchen, additional, Yang, Yong, additional, Dai, Yutian, additional, Xie, Zuogang, additional, Xiao, Jiaquan, additional, Liu, Xiaoqiang, additional, Yang, Luo, additional, Shi, Chenkun, additional, Zhi, Erlei, additional, Tian, Ruhui, additional, Li, Peng, additional, Huang, Yuhuang, additional, Chen, Huixing, additional, Zhao, Fujun, additional, Hu, Jianlin, additional, Yao, Chengcheng, additional, Qiu, Yan, additional, Lin, Guiting, additional, Lue, Tom F., additional, and Xia, Shujie, additional

Published
2022
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7. Vasal vessel‐sparing microsurgical single‐armed vasoepididymostomy to epididymal obstructive azoospermia: A retrospective control study

Author

Li, Peng, primary, Liu, Nachuan, additional, Zhi, Erlei, additional, Yao, Chencheng, additional, Chen, Huixing, additional, Tian, Ruhui, additional, Huang, Yuhua, additional, Zhao, Liangyu, additional, Yang, Chao, additional, Zhao, Jingpeng, additional, Shi, Chenkun, additional, Liu, Ming, additional, Wang, Bo, additional, Chen, Huirong, additional, Li, Zheng, additional, and Xia, Shujie, additional

Published
2021
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8. An omni-directional rolling spherical robot with telescopic manipulator

Author

Jia Qingxuan, Shi Chenkun, Sun Hanxu, Zhao Kailiang, and Zheng Yili

Subjects
Engineering, Control theory, Mobile manipulator, business.industry, Obstacle avoidance, Snake-arm robot, Robot, Mobile robot, Bang-bang robot, business, Spherical robot, Simulation, Robot control
Abstract

In this paper, an omni-directional rolling spherical robot with telescopic manipulator (BYQ-IV) is presented. This robot is designed for territory or lunar exploration. It not only has features like straight line motion, circular motion, zero turning radius and obstacle avoidance, but also is able to accomplish tasks such as stably grabbing and delivering assemblies. The structure of the whole robot is divided into three sub-systems, including the motion driving system; the manipulator system and the stability maintain system. Moreover, the distribute control system of the robot based on ARM processor and wireless communication system are introduced and the software architecture of control system is analyzed. The experiment shows that the prototype of the spherical robot with telescopic manipulator (BYQ-IV) can stably grasp a static target and carry it to a new location.

Published
2008

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