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Abstract: In an attempt to establish fundamental structure–activity relationships (SAR) of Pt/Pd-based anti-tumour compounds, we have recently designed monodentate pyridyl amide ligand containing central amide units which possess external metal co-ordinating pyridyl group and internal amide functionality. It was prepared in one step from commercially available compounds in moderate to good yield. Surprisingly, treatment of K2[MCl4] [M=Pt(II), Pd(II)] with ligand N-(4-chlorophenyl)-3-pyridinecarboxamide (L) in the same reaction condition affords two different hydrogen-bonded polymers: cis-[PtL2Cl2]·CH3OH·DMF (1) and trans-[PdL2Cl2]·2DMF (2). Fluorescence analysis indicates that the two complexes can bind to fish sperm DNA (FS-DNA) and gel electrophoresis assay demonstrates the ability of the complexes to cleave the pBR322 plasmid DNA. The two complexes exhibit cytotoxic specificity and significant cancer cell inhibitory rate. Furthermore, cytotoxicity values are higher in the case of cis-Pt(II) complex than trans-Pd(II) complex in four different cancer cell lines. [ABSTRACT FROM AUTHOR]

Abstract: Two new complexes, [Cu(L)2(CH3COO)2(H2O)]·6H2O (1) and [Cu2(L)2(CH3COO)4]·2C2H5OH (2) (where L N-(4-chlorophenyl)-3-pyridinecarboxamide), have been synthesized by altering the solvent of reaction system. For 1, the mononuclear complex is extended into a 3D supramolecular architecture through intricate non-covalent interactions. Unexpectedly, two scarcely reported cyclic water tetramers with C2h and D2h symmetries simultaneously exist in a 1D water chain. Whereas the dinuclear complex 2 represents a 2D framework by double hydrogen bonds with solvent ethanol molecules and π–π stacking interactions. In addition, the luminescent properties of them are also discussed. [Copyright &y& Elsevier]

Three new coordination polymers, namely, {[Cd(Hbptc)(IP)(HO)]·2HO} ( 1), {[Mn(IP)(dstc)]·6HO} ( 2) and {[Zn(IP)(dstc)]·3HO} ( 3) (IP = 1 H-imidazo[4,5- f][1,10]-phenanthroline, Hbptc = 3,3′,4,4′-benzophenonetetracarboxylic acid, and Hdstc = 3,3′,4,4′-diphenylsulfonetetracarboxylic acid) have rationally designed and characterized by single crystal X-ray diffraction. Polymer 1 shows a 1D ribbon-like structure. Although compounds 2 and 3 feature 2D grid networks, the coordinative modes of dstc ligand and the arrangements of IP ligand are very different. Furthermore, the luminescence properties for 1 and 3, as well as the magnetism of 2 are explored in detail. [ABSTRACT FROM AUTHOR]

Abstract: Two novel complexes, namely, [Pd(pdc)2]·(dmp)·6H2O (1) and [Pd(pdc)2K(H2O)5·3H2O]n (2) [H2pdc=pyridine-2,3-dicarboxylate acid, dmp=2,9-Dimethyl-1,10-phenanthroline] were synthesized and characterized as pH-dependent products. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the pBR 322 plasmid DNA. Values of IC50 calculated for complexes 1 and 2 show that the two complexes exhibit good cytotoxic activity against different cell lines tested in general, especially more effective against HL-60 and A2780cisR cell lines. [Copyright &y& Elsevier]

Abstract: Two dimensional coordination polymer [CdL2(NO3)2] n (where L=4,4′-bis(dimethylphosphonomethyl)biphenyl) has been achieved. The crystal structure and molecular composition are measured using elemental analysis and X-ray crystal structure. Two-dimensional square grid was formed by semi-rigid phosphonate ligands bridge metals, in which the metals adopt rare eight-coordinated geometry. Weak C–H⋯O hydrogen bonds which between coordinated nitrate anion and methyl group of phosphonate ligands link two dimensional grids generating three dimensional supramolecular networks without interpenetration. [Copyright &y& Elsevier]