Search

RNA modifications, including N6-methyladenosine (m6A), have been reported to regulate fundamental RNA processes and properties, and directly linked to various human diseases. Methods enabling temporal and transcript/locus-specific editing of specific RNA modifications are essential, but still limited, to dissect the dynamic and context-dependent functions of these epigenetic modifications. Here, we develop a chemically inducible and reversible RNA m6A modification editing platform integrating chemically induced proximity (CIP) and CRISPR methods. We show that m6A editing can be temporally controlled at specific sites of individual RNA transcripts by the addition or removal of the CIP inducer, abscisic acid (ABA), in the system. By incorporating a photo-caged ABA, a light-controlled version of m6A editing platform can be developed. We expect that this platform and strategy can be generally applied to edit other RNA modifications in addition to m6A.RNA modifications, including N6-methyladenosine (m6A), have been reported to regulate fundamental RNA processes and properties, and directly linked to various human diseases. Here, the authors develop a chemically inducible and reversible RNA m6A modification editing platform integrating chemically induced proximity (CIP) and CRISPR methods. [ABSTRACT FROM AUTHOR]

Correction for 'Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy' by Huaxia Shi et al., J. Mater. Chem. B, 2016, 4, 113–120, https://doi.org/10.1039/C5TB02041G. [ABSTRACT FROM AUTHOR]

Abstract: Uniform and well-defined CuO cauliflowers have been prepared via a simple hydrothermal route, which form through the “oriented attachment (OA)–preferential growth–Ostwald ripening (OR)” processes. Furthermore, the CuO cauliflowers show a much higher activity than the irregular CuO for the degradation of rhodamine B (RhB). Its apparent rate constant (0.0156min−1) is 5.24 times higher than that (0.0025min−1) of the latter. The higher activity is mainly attributed to its higher crystallinity (84.02% vs. 62.86%), which can reduce the recombination rate of photogenerated electrons and holes. [Copyright &y& Elsevier]

Abstract: CdS nanoparticles were in situ deposited on TiO2 nanosheets and nanorods under hydrothermal conditions, respectively. The effect of CdS–TiO2 interface structure on hydrogen production activity was mainly investigated under visible light irradiation. The results showed that the TiO2 nanosheet-based CdS/TiO2 showed a higher activity and a higher cyclability than the nanorod-based sample due to the stronger interaction of CdS with the (001) facets of TiO2 than with the (101) facets. It was proposed that the strong interaction between CdS nanoparticles and TiO2 nanosheets effectively refrains the recombination of electrons and holes. [Copyright &y& Elsevier]

Three-dimensional graphene foam (3DGF) is a superior sensing material because of its high conductivity, large specific surface area and wide electrochemical potential windows. In this work, hexagonal Ni(OH)2 nanosheets are deposited on the surface of chemical vapor deposition-grown 3DGF through a facial hydrothermal process without any auxiliary reagents. The morphology and structure of the composite are characterized by scanning electron microscopy (SEM), transmission electron microscope (TEM), Raman spectroscopy, and X-ray diffraction (XRD). Based on the Ni(OH)2/3DGF composite, a free-standing electrochemical electrode is fabricated. Being employed as a nonenzymatic glucose detection electrochemical electrode, it exhibits a high sensitivity (∼2.65 mA mM(-1) cm(-2)), low detection limit (0.34 μM) and excellent selectivity with a linear response from 1 μM to 1.17 mM. The excellent sensing properties of the Ni(OH)2/3DGF electrode may be attributed to the synergistic effect of the high electrocatalytic activity of Ni(OH)2 nanosheets and the high conductivity and large surface area of 3DGF.