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15 results on '"Shi, Huibo"'

2. Gene signatures of endoplasmic reticulum stress and mitophagy for prognostic risk prediction in lung adenocarcinoma.

Author

Lin, Xiong, Yang, Miaoling, Huang, Yuanling, Huang, Xiaoli, Shi, Huibo, Chen, Binbin, Kang, Jianle, and Ke, Sunkui

Subjects
ENDOPLASMIC reticulum, GENE expression, LUNGS, OVERALL survival, GENES
Abstract

Genes associated with endoplasmic reticulum stress (ERS) and mitophagy can be conducive to predicting solid tumour prognosis. The authors aimed to develop a prognosis prediction model for these genes in lung adenocarcinoma (LUAD). Relevant gene expression and clinical information were collected from public databases including Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA). A total of 265 differentially expressed genes was finally selected (71 up‐regulated and 194 downregulated) in the LUAD dataset. Among these, 15 candidate ERS and mitophagy genes (ATG12, CSNK2A1, MAP1LC3A, MAP1LC3B, MFN2, PGAM5, PINK1, RPS27A, SQSTM1, SRC, UBA52, UBB, UBC, ULK1, and VDAC1) might be critical to LUAD based on the expression analysis after crossing with the ERS and mitochondrial autophagy genes. The prediction model demonstrated the ability to effectively predict the 5‐, 3‐, and 1‐year prognoses of LUAD patients in both GEO and TCGA databases. Moreover, high VDAC1 expression was associated with poor overall survival in LUAD (p < 0.001), suggesting it might be a critical gene for LUAD prognosis prediction. Overall, the prognosis model based on ERS and mitophagy genes in LUAD can be useful for evaluating the prognosis of patients with LUAD, and VDAC1 may serve as a promising biomarker for LUAD prognosis. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Viral Shedding Prolongation in a Kidney Transplant Patient with COVID‐19 Pneumonia

Author

Liu Bin, Zhang Jing, Shi Huibo, Zhang Man, and Zeng Fanjun

Subjects
Transplantation, medicine.medical_specialty, Kidney, Coronavirus disease 2019 (COVID-19), business.industry, 030230 surgery, medicine.disease, Tacrolimus, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Prednisone, Internal medicine, Pandemic, medicine, Immunology and Allergy, Pharmacology (medical), Permanent resident, Viral shedding, business, Letters to the Editor, Letter to the Editor, Kidney transplantation, medicine.drug
Abstract

Coronavirus disease 2019 (COVID‐19) pandemic sweeps the globe. The information regarding the kinetic changes of SARS‐CoV‐2 in immunosuppressed patients is unclear. Herein, we present a case of prolonged viral shedding in a transplant patient with COVID‐19 pneumonia. A 49‐year‐old male kidney recipient was admitted to the hospital on February 7, 2020, for fever and fatigue. He was a permanent resident in Wuhan, China, and began having symptoms on January 29 (day 1 of illness). His maintenance immunosuppressive regime was consisted of tacrolimus (TAC, 1mg twice a day, orally), mycophenolate mofetil (MMF, 0.5g twice a day, orally) and prednisone (Pred, 5mg daily, orally) triple combination.

Published
2020

15. Early De Novo Donor Specific Antibody Involvement in Delayed Graft Function After Kidney Transplantation: A Report of 2 Cases.

Author

Zhu L, Chen G, Zhang W, Guo H, Lin Z, Du D, Chen S, Shi H, Liu S, and Chen Z

Subjects
Adult, Biomarkers blood, Delayed Graft Function blood, Delayed Graft Function diagnosis, Delayed Graft Function physiopathology, Delayed Graft Function therapy, Desensitization, Immunologic methods, Drug Therapy, Combination, Female, Humans, Immunosuppressive Agents therapeutic use, Kidney Transplantation methods, Living Donors, Middle Aged, Recovery of Function, Renal Dialysis, Time Factors, Treatment Outcome, Delayed Graft Function immunology, HLA Antigens immunology, Histocompatibility, Isoantibodies blood, Kidney Transplantation adverse effects
Abstract

Kidney tubular damage caused by ischemia-reperfusion injury is considered the major cause of delayed graft function (DGF) after renal transplantation. It is not clear whether early generated de novo donor specific antibodies (DSA) play a role in DGF. Here, we report 2 cases of renal transplant with DGF, which seems to be associated with de novo DSA. When the early produced de novo DSA are not potent enough to mediate acute rejection, they may cause mild intra-graft injury, which has a significant impact on the degree of DGF and its recovery. Antibody-targeted therapy seems to be beneficial to the recovery of patients with DGF.

Published
2014

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