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958 results on '"Shi, Linqi"'

16. Biomedical polymers: synthesis, properties, and applications

Author

Chen, Wei-Hai, Chen, Qi-Wen, Chen, Qian, Cui, Chunyan, Duan, Shun, Kang, Yongyuan, Liu, Yang, Liu, Yun, Muhammad, Wali, Shao, Shiqun, Tang, Chengqiang, Wang, Jinqiang, Wang, Lei, Xiong, Meng-Hua, Yin, Lichen, Zhang, Kuo, Zhang, Zhanzhan, Zhen, Xu, Feng, Jun, Gao, Changyou, Gu, Zhen, He, Chaoliang, Ji, Jian, Jiang, Xiqun, Liu, Wenguang, Liu, Zhuang, Peng, Huisheng, Shen, Youqing, Shi, Linqi, Sun, Xuemei, Wang, Hao, Wang, Jun, Xiao, Haihua, Xu, Fu-Jian, Zhong, Zhiyuan, Zhang, Xian-Zheng, and Chen, Xuesi

Published
2022
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41. Electrostatic and hydrophobic interaction cooperative nanochaperone regulates protein folding.

Author

Wu, Xiaohui, Deng, Fei, Chen, Yujie, Xu, Mengchen, Ma, Feihe, and Shi, Linqi

Subjects
PROTEIN folding, HYDROPHOBIC interactions, ELECTROSTATIC interaction, DENATURATION of proteins, MOLECULAR chaperones, SINGLE molecules
Abstract

Natural molecular chaperones utilize spatially ordered multiple molecular forces to effectively regulate protein folding. However, synthesis of such molecules is a big challenge. The concept of "aggregate science" provides insights to construct chemical entities (aggregates) beyond molecular levels to mimic both the structure and function of natural chaperone. Inspired by this concept, herein we fabricate a novel multi‐interaction (i.e., electrostatic and hydrophobic interaction) cooperative nanochaperone (multi‐co‐nChap) to regulating protein folding. This multi‐co‐nChap is fabricated by rationally introducing electrostatic interactions to the surface (corona) and confined hydrophobic microdomains (shell) of traditional single‐hydrophobic interaction nanochaperone. We demonstrate that the corona electrostatic attraction facilitates the diffusion of clients into the hydrophobic microdomains, while the shell electrostatic interaction balances the capture and release of clients. By finely synergizing corona electrostatic attraction with shell electrostatic repulsion and hydrophobic interaction, the optimized multi‐co‐nChap effectively facilitated de novo folding of nascent polypeptides. Moreover, the synergy between corona electrostatic attraction, shell electrostatic attraction and shell hydrophobic interaction significantly enhanced the capability of multi‐co‐nChap to protect native proteins from denaturation at harsh temperatures. This work provides important insights for understanding and design of nanochaperone, which is a kind of ordered aggregate with chaperone‐like activity that beyond the level of single molecule. [ABSTRACT FROM AUTHOR]

Published
2024
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44. A High-Throughput Platform for Formulating and Screening Multifunctional Nanoparticles Capable of Simultaneous Delivery of Genes and Transcription Factors.

Author

Liu, Yang, Du, Juanjuan, Choi, Jin-sil, Chen, Kuan-Ju, Hou, Shuang, Yan, Ming, Lin, Wei-Yu, Chen, Kevin Sean, Ro, Tracy, Lipshutz, Gerald S, Wu, Lily, Shi, Linqi, Lu, Yunfeng, Tseng, Hsian-Rong, and Wang, Hao

Subjects
Transcription Factors, Drug Delivery Systems, Microfluidic Analytical Techniques, Gene Transfer Techniques, Genes, Nanoparticles, High-Throughput Screening Assays, biomolecular delivery, microfluidics, nanoparticles, supramolecular chemistry, transcription factors, Biotechnology, Nanotechnology, Genetics, Stem Cell Research, Bioengineering, 5.2 Cellular and gene therapies, Development of treatments and therapeutic interventions, Generic health relevance, Chemical Sciences, Organic Chemistry
Abstract

Simultaneous delivery of multiple genes and proteins (e.g., transcription factors; TFs) is an emerging issue surrounding therapeutic research due to their ability to regulate cellular circuitry. Current gene and protein delivery strategies, however, are based on slow batch synthesis, which is ineffective, poorly controlled, and incapable of simultaneous delivery of both genes and proteins with synergistic functions. Consequently, advances in this field have been limited to in vitro studies. Here, by integrating microfluidic technologies with a supramolecular synthetic strategy, we present a high-throughput approach for formulating and screening multifunctional supramolecular nanoparticles (MFSNPs) self-assembled from a collection of functional modules to achieve simultaneous delivery of one gene and TF with unprecedented efficiency both in vitro and in vivo. We envision that this new approach could open a new avenue for immunotherapy, stem cell reprogramming, and other therapeutic applications.

Published
2016

48. Recent advances and prospects in nanomaterials for bacterial sepsis management.

Author

Zhou, Chaoyang, Liu, Yong, Li, Yuanfeng, and Shi, Linqi

Abstract

Bacterial sepsis is a life-threatening condition caused by bacteria entering the bloodstream and triggering an immune response, underscoring the importance of early recognition and prompt treatment. Nanomedicine holds promise for addressing sepsis through improved diagnostics, nanoparticle biosensors for detection and imaging, enhanced antibiotic delivery, combating resistance, and immune modulation. However, challenges remain in ensuring safety, regulatory compliance, scalability, and cost-effectiveness before clinical implementation. Further research is needed to optimize design, efficacy, safety, and regulatory strategies for effective utilization of nanomedicines in bacterial sepsis diagnosis and treatment. This review highlights the significant potential of nanomedicines, including improved drug delivery, enhanced diagnostics, and immunomodulation for bacterial sepsis. It also emphasizes the need for further research to optimize design, efficacy, safety profiles, and address regulatory challenges to facilitate clinical translation. [ABSTRACT FROM AUTHOR]

Published
2023
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