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Objective: To investigate the efficacy of artificial knee arthroplasty in conjunction with internal fracture fixation for treating knee osteoarthritis and a femoral condyle fracture., Methods: From January 2013 to June 2020, the researchers' department admitted 11 patients with femoral condyle fractures in combination with knee osteoarthritis. Three of the patients were males; 8 were females. They ranged in age from 62 to 76 years, with an average age of 69.2 years. Five patients were injured in traffic accidents, 6 were related to falls. Before the incidents, all patients had varying degrees of flexion inversion deformity and moderate to severe osteoarthritis in their knee joints. The fractures were of two types: 3 were epicondylar fractures, and 8 were medial femoral condyle fractures. To treat the combined condition of osteoarthritis and fractured femoral condyles, all patients underwent artificial knee joint replacement along with internal fixation with a single treatment. Knee radiographs and joint mobility assessments were performed during the follow-up period and were measured using the Hospital for Special Surgery (HSS) knee function score., Results: All patients were followed up from 18 to 105 months with a mean duration of (52.5±2.6) months. Significant differences in knee mobility and HSS ratings at 1 month and 1 year postoperatively compared favorably to the condition before surgery. HSS scores at the 1-year postoperative follow-up were excellent in 8 cases, good in 2, acceptable in 1, and poor in 0 cases., Conclusion: Artificial knee joint replacement combined with fracture internal fixation has good clinical efficacy in treating osteoarthritis of the knee joint combined with femoral condyle fracture. After surgery, patients resumed weight-bearing activities early, reducing the likelihood of complications and avoiding postoperative pain. This approach shortened the treatment period and enhanced the overall quality of life.