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1,612 results on '"Shi, Run"'

4. Strong Neel ordering and luminescence correlation in a two-dimensional antiferromagnet

Author

Zhou, Yongheng, He, Kaiyue, Hu, Huamin, Ouyang, Gang, Zhu, Chao, Wang, Wei, Qin, Sichen, Tao, Ye, Chen, Runfeng, Zhang, Le, Shi, Run, Cheng, Chun, Wang, Han, Liu, Yanjun, Liu, Zheng, Wang, Taihong, Huang, Wei, Wang, Lin, and Chen, Xiaolong

Subjects
Physics - Optics, Condensed Matter - Materials Science
Abstract

Magneto-optical effect has been widely used in light modulation, optical sensing and information storage. Recently discovered two-dimensional (2D) van der Waals layered magnets are considered as promising platforms for investigating novel magneto-optical phenomena and devices, due to the long-range magnetic ordering down to atomically-thin thickness, rich species and tunable properties. However, majority 2D antiferromagnets suffer from low luminescence efficiency which hinders their magneto-optical investigations and applications. Here, we uncover strong light-magnetic ordering interactions in 2D antiferromagnetic MnPS3 utilizing a newly-emerged near-infrared photoluminescence (PL) mode far below its intrinsic bandgap. This ingap PL mode shows strong correlation with the Neel ordering and persists down to monolayer thickness. Combining the DFT, STEM and XPS, we illustrate the origin of the PL mode and its correlation with Neel ordering, which can be attributed to the oxygen ion-mediated states. Moreover, the PL strength can be further tuned and enhanced using ultraviolet-ozone treatment. Our studies offer an effective approach to investigate light-magnetic ordering interactions in 2D antiferromagnetic semiconductors.

Published
2022

14. Bridging the gap between atomically thin semiconductors and metal leads

Author

Cai, Xiangbin, Wu, Zefei, Han, Xu, Xu, Shuigang, Lin, Jiangxiazi, Han, Tianyi, He, Pingge, Feng, Xuemeng, An, Liheng, Shi, Run, Wang, Jingwei, Ying, Zhehan, Cai, Yuan, Hua, Mengyuan, Liu, Junwei, Pan, Ding, Cheng, Chun, and Wang, Ning

Subjects
Condensed Matter - Materials Science
Abstract

Electrically interfacing atomically thin transition metal dichalcogenide semiconductors (TMDSCs) with metal leads is challenging because of undesired interface barriers, which have drastically constrained the electrical performance of TMDSC devices for exploring their unconventional physical properties and realizing potential electronic applications. Here we demonstrate a strategy to achieve nearly barrier-free electrical contacts with few-layer TMDSCs by engineering interfacial bonding distortion. The carrier-injection efficiency of such electrical junction is substantially increased with robust ohmic behaviors from room to cryogenic temperatures. The performance enhancements of TMDSC field-effect transistors are well reflected by the ultralow contact resistance (down to 90 Ohm um in MoS2, towards the quantum limit), the ultrahigh field-effect mobility (up to 358,000 cm2V-1s-1 in WSe2) and the prominent transport characteristics at cryogenic temperatures. This method also offers new possibilities of the local manipulation of structures and electronic properties for TMDSC device design.

Published
2021
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16. Radiotherapy of oligometastatic prostate cancer: a systematic review

Author

Rogowski, Paul, Roach, Mack, Schmidt-Hegemann, Nina-Sophie, Trapp, Christian, von Bestenbostel, Rieke, Shi, Run, Buchner, Alexander, Stief, Christian, Belka, Claus, and Li, Minglun

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Urologic Diseases, Prostate Cancer, Biomedical Imaging, Cancer, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Bone Neoplasms, Humans, Lymph Nodes, Lymphatic Metastasis, Male, Prostatic Neoplasms, Radiosurgery, Radiotherapy Dosage, ENRT, Metastasis‐directed therapy, Oligometastatic prostate cancer, Radiotherapy, SBRT, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

BackgroundDue to improved imaging sensitivity, the term "oligometastatic" prostate cancer disease is diagnosed more often, leading to an increasing interest in metastasis-directed therapy (MDT). There are two types of radiation based MDT applied when treating oligometastatic disease: (1) stereotactic body radiation therapy (SBRT) generally used for bone metastases; or (2) SBRT for isolated nodal oligometastases combined with prophylactic elective nodal radiotherapy. This review aims to summarize current evidence data, which may shed light on the optimal management of this heterogeneous group of patients.MethodsA systematic review of the Medline database through PubMed was performed according to PRISMA guidelines. All relevant studies published up to November 2020 were identified and screened. Fifty-six titles were included. Besides outcome parameters, different prognostic and predictive factors were assessed, including site of metastases, time between primary treatment and MDT, use of systemic therapies, hormone sensitivity, as well as pattern of recurrence.FindingsEvidence consists largely of retrospective case series and no consistent precise definition of oligometastasis exists, however, most investigators seem to acknowledge the need to distinguish between patients presenting with what is frequently called "synchronous" versus "metachronous" oligometastatic disease. Available data on radiotherapy as MDT demonstrate high local control rates and a small but relevant proportion of patients without progressive disease after 2 years. This holds true for both hormone sensitive and castration resistant prostate cancer diseases. The use of 68Ga-PSMA PET/CT for staging increased dramatically. Radiation doses and field sizes varied considerably among the studies. The search for relevant prognostic and predictive factors is ongoing.ConclusionsTo our best knowledge this review on oligometastatic prostate cancer included the largest number of original articles. It demonstrates the therapeutic potential and challenges of MDT for oligometastatic prostate cancer. Prospective studies are under way and will provide further high-level evidence.

Published
2021

33. Cycloheximide promotes type I collagen maturation mainly via collagen prolyl 4-hydroxylase subunit α2

Author

Shi Run, Xu Miao, Ye Huazhe, Gao Shanshan, Li Jingfeng, Li Huan, and Li Chaoyang

Subjects
cycloheximide, type I collagen, collagen prolyl 4-hydroxylases, proline hydroxylation, Biochemistry, QD415-436, Genetics, QH426-470
Abstract

Aberrant deposition of collagen is associated with cancer development and tissue fibrosis. Proline hydroxylation, catalyzed by collagen prolyl 4-hydroxylases (C-P4Hs), is necessary for collagen maturation and secretion. Here, we try to evaluate the mechanism of the regulation of CHX on collagen maturation. Using pepsin digestion, liquid chromatograph mass spectrometry and gene knockout, we find that treatment of mouse embryonic fibroblasts with cycloheximide (CHX) increases type I collagen proline hydroxylation partially via P4HA1 and mainly via P4HA2. Western blot analysis results show that CHX treatment reduces type I collagen but does not obviously impact the level of P4HA1/2 protein in the endoplasmic reticulum, which enhances the molar ratio of P4HA1/2 to type I collagen, and coimmunoprecipitation results confirm that more P4HA1/2 can bind to each type I collagen. Since C-P4Hs possess the capability to hydroxylate proline independent of ascorbate for a few cycles, this enhanced binding between P4HA1/2 and type I collagen can partially explain how CHX stimulates type I collagen maturation.

Published
2022
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