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22 results on '"Shi, Willa"'

8. Prognostic value of pretreatment circulating neutrophils, monocytes, and lymphocytes in oropharyngeal cancer stratified by human papillomavirus status

Author

Huang, Shao Hui, Waldron, John N., Milosevic, Michael, Shen, Xiaowei, Ringash, Jolie, Su, Jie, Tong, Li, Perez-Ordonez, Bayardo, Weinreb, Ilan, Bayley, Andrew J., Kim, John, Hope, Andrew, Cho, John B.C., Giuliani, Meredith, Razak, Albiruni, Goldstein, David, Shi, Willa, Liu, Fei-Fei, Xu, Wei, and OʼSullivan, Brian

Published
2015
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9. 85: The Role of Cytokine Signaling in the Reversal of Chronic Lymphedema

Author

Kwan, Jennifer Yin Yee, primary, Xu, Wenxi, additional, Sandhu, Vandana, additional, Demidov, Valentin, additional, Shi, Willa, additional, Vitkin, Alex, additional, Jones, Jennifer, additional, Williams, Justin, additional, Haykal, Siba, additional, Haibe-Kains, Benjamin, additional, Brooks, David G., additional, Yip, Kenneth W., additional, and Liu, Fei-Fei, additional

Published
2020
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10. Proteomic Analysis of Cancer-Associated Fibroblasts Reveals a Paracrine Role for MFAP5 in Human Oral Tongue Squamous Cell Carcinoma

Author

Principe, Simona, primary, Mejia-Guerrero, Salvador, additional, Ignatchenko, Vladimir, additional, Sinha, Ankit, additional, Ignatchenko, Alexandr, additional, Shi, Willa, additional, Pereira, Keira, additional, Su, Susie, additional, Huang, Shao Hui, additional, O’Sullivan, Brian, additional, Xu, Wei, additional, Goldstein, David P., additional, Weinreb, Ilan, additional, Ailles, Laurie, additional, Liu, Fei-Fei, additional, and Kislinger, Thomas, additional

Published
2018
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12. Association of fatigue and insomnia with inflammatory cytokine and hematopoetic stem cell levels in breast cancer patients undergoing adjuvant radiation therapy.

Author

Liu, Fei-Fei, primary, Shi, Willa Wei, additional, McCusker, M, additional, Li, Madeline, additional, Su, Jie, additional, Williams, Justin, additional, Spence, Tara, additional, Xu, Wei, additional, Han, Kathy Chai-Zung, additional, Bratman, Scott Victor, additional, and Yip, Kenneth, additional

Published
2017
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15. Prognostic value of pretreatment circulating neutrophils, monocytes, and lymphocytes in oropharyngeal cancer stratified by human papillomavirus status

Author

Huang, Shao Hui, primary, Waldron, John N., additional, Milosevic, Michael, additional, Shen, Xiaowei, additional, Ringash, Jolie, additional, Su, Jie, additional, Tong, Li, additional, Perez-Ordonez, Bayardo, additional, Weinreb, Ilan, additional, Bayley, Andrew J., additional, Kim, John, additional, Hope, Andrew, additional, Cho, B.C. John, additional, Giuliani, Meredith, additional, Razak, Albiruni, additional, Goldstein, David, additional, Shi, Willa, additional, Liu, Fei-Fei, additional, Xu, Wei, additional, and O'Sullivan, Brian, additional

Published
2014
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17. Potentially Novel Candidate Biomarkers for Head and Neck Squamous Cell Carcinoma Identified Using an Integrated Cell Line-based Discovery Strategy

Author

Sepiashvili, Lusia, primary, Hui, Angela, additional, Ignatchenko, Vladimir, additional, Shi, Willa, additional, Su, Susie, additional, Xu, Wei, additional, Huang, Shao Hui, additional, O'Sullivan, Brian, additional, Waldron, John, additional, Irish, Jonathan C., additional, Perez-Ordonez, Bayardo, additional, Liu, Fei-Fei, additional, and Kislinger, Thomas, additional

Published
2012
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21. Did the addition of concurrent chemotherapy to conventional radiotherapy improve survival for patients with HPV+ve and HPV-ve Oropharynx cancer? A population-based study.

Author

Hall, Stephen F, Liu, Fei-Fei, O'Sullivan, Brian, Shi, Willa, Rohland, Susan, Griffiths, Rebecca, and Groome, Patti

Subjects
DNA analysis, HEAD tumors, IMMUNOHISTOCHEMISTRY, IN situ hybridization, MULTIVARIATE analysis, NECK tumors, PAPILLOMAVIRUS diseases, PAPILLOMAVIRUSES, RADIOTHERAPY, SQUAMOUS cell carcinoma, SURVIVAL, TREATMENT effectiveness, PROPORTIONAL hazards models, RETROSPECTIVE studies, CASE-control method, DISEASE complications, OROPHARYNGEAL cancer, CANCER treatment, TUMOR treatment
Abstract

Background: In the absence of clear evidence on the efficacy of concurrent chemoradiotherapy (CRT) over conventional radiotherapy (RT) for HPV+ve and for HPV-ve oropharyngeal cancer (OPC), this study compares the treatments and outcomes from pre-CRT years to post-CRT years.Methods: A population-based retrospective treatment-effectiveness study based on all patients with OPC treated in Ontario Canada in 1998, 1999, 2003 and 2004. Charts were reviewed, tissue samples were requested and tissue was tested for p16 or in situ hybridisation. Overall survival (OS) and disease-specific survival (DSS) were compared by treatment era and by treatment type for all 1028 patients, for 865 treated for cure and for 610 with HPV status.Results: There was no improvement in OS comparing pre-CRT to post-CRT eras for the HPV+ve patients (P=0.147) or for the HPV-ve patients (P=0.362). There was no difference in OS comparing CRT to RT for the HPV+ve cohort (HR=0.948 (0.642-1.400)) or for the HPV-ve patients (HR=1.083 (0.68-1.727)).Conclusions: In these 'real-world' patients what appeared to be improvements in OS with CRT in clinical trials were confounded by HPV status in Ontario. CRT did not improve outcomes for HPV+ve or for HPV-ve patients. [ABSTRACT FROM AUTHOR]

Published
2017
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22. p16 gene therapy: a potentially efficacious modality for nasopharyngeal carcinoma.

Author

Lee AW, Li JH, Shi W, Li A, Ng E, Liu TJ, Klamut HJ, and Liu FF

Subjects
Adenoviridae genetics, Animals, Apoptosis, Blotting, Western, Carcinoma genetics, Cell Cycle, Cell Line, Tumor, Cytomegalovirus genetics, DNA Fragmentation, Flow Cytometry, Genes, Reporter, Humans, Kinetics, Mice, Mice, SCID, Nasopharyngeal Neoplasms genetics, Necrosis, Neoplasm Transplantation, Retinoblastoma Protein metabolism, beta-Galactosidase metabolism, Carcinoma therapy, Cyclin-Dependent Kinase Inhibitor p16 genetics, Genetic Therapy methods, Nasopharyngeal Neoplasms therapy
Abstract

p16 is an important regulator of the cell cycle at the G(1) phase. Frequent aberration of p16 in nasopharyngeal carcinoma (NPC) suggests a role for this tumor suppressor gene in disease development. p16 gene transfer has been demonstrated to be effective in various human cancer models, including breast, lung, and prostate, causing cell cycle arrest, apoptosis, and tumor growth delay. We investigated the potential of adenoviral-mediated p16 therapy, in combination with ionizing radiation (RT), in two distinct NPC models. Two deltaE1 adenoviral vectors were employed: one carrying the human p16 gene (adv.p16), and the other a beta-galactosidase reporter gene (adv.beta-gal), both driven by the cytomegalovirus (CMV) promoter. Two NPC cell lines with differential endogenous p16 expression, CNE-1 (low) and CNE-2Z (high), were evaluated for protein expression, cytotoxicity, cell cycle analysis, apoptosis, and senescence. The CNE-1 cells were exquisitely sensitive to adv.p16, with 0.1% survival level after gene therapy [25 plaque-forming unit (pfu)/cell], which further decreased to 0.01% with the addition of RT (2 Gy). This reduction in survival was effected through necrosis, G1 arrest, and senescence. In contrast, CNE-2Z cells were resistant to adv.p16 gene transfer, with 75% surviving at an equivalent viral dose. This differential sensitivity was recapitulated in vivo in that adv.p16-treated CNE-1 cells formed no tumors in severe-combined-immunodeficiency (SCID) mice, followed for over 100 days. In contrast, tumor formation was detected 40 days after implantation of adv.p16-treated CNE-2Z cells. In conclusion, adv.p16 gene transfer appears to be highly effective against NPC that lack functional p16, which is the situation in the majority of NPC patients.

Published
2003

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