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In this paper, we investigate a time two-grid algorithm to get the numerical solution of nonlinear generalized viscous Burgers' equation, which is the first time that the two-grid method is used to solve this problem. Based on Crank–Nicolson finite difference scheme, we establish the time two-grid difference (TTGD) scheme which consists of three computational procedures to reduce the computational cost compared with the general finite difference (GFD) scheme. The cut-offf function method is applied to prove the conservation, unique solvability, the prior estimate and convergence in L 2 -norm and L ∞ -norm of the TTGD scheme on the coarse grid and fine grid, respectively. Comparing our TTGD scheme with GFD scheme in Zhang et al. (Appl Math Lett 112:106719, 2021), we provided the proof the uniqueness the solution of the nonlinear scheme, direct proof of convergence in L 2 -norm and the prior estimate both on the coarse mesh and fine mesh. The numerical results show that our TTGD scheme is more efficient than the GDF scheme in Zhang et al. (2021) in terms of the CPU time. Particularly, our method not only improves the efficiency, but also preserves the energy conservation of the original model. [ABSTRACT FROM AUTHOR]

Hexagonal MAB phases （h‐MAB） have attracted attention due to their potential to exfoliate into MBenes, similar to MXenes, which are predicted to be promising for Li‐ion battery applications. However, the high cost of synthesizing MBenes poses challenges for their use in batteries. This study presents a novel approach where a simple ball‐milling treatment is employed to enhance the purity of the h‐MAB phase Ti2InB2 and introduce significant indium defects, resulting in improved conductivity and the creation of abundant active sites. The synthesized Ti2InB2 with indium defects (VIn‐Ti2InB2) exhibits excellent electrochemical properties, particularly exceptional long‐cycle stability at current densities of 5 A g−1 (5000 cycles, average capacity decay of 0.0018%) and 10 A g−1 (15 000 cycles, average capacity decay of 0.093%). The charge storage mechanism of VIn‐Ti2InB2, involving a dual redox reaction, is proposed, where defects promote the In‐Li alloy reaction and a redox reaction with Li in the TiB layer. Finally, a Li‐ion full cell demonstrates cycling stability at 0.5 A g−1 after 350 cycles. This work presents the first accessible and scalable application of VIn‐Ti2InB2 as a Li‐ion anode, unlocking a wealth of possibilities for sustainable electrochemical applications of h‐MAB phases. [ABSTRACT FROM AUTHOR]

High-pressure sintering (HPS) is a promising technique for producing nanocrystalline ceramics with unique properties. However, the densification mechanisms of HPS for nanocrystalline ceramics at different sintering stages remain controversial. This study focuses on Gd 2 Zr 2 O 7 (GZO) nanocrystalline ceramics, investigating their microstructure evolution and densification behavior under varying pressures, temperatures, and dwelling times. The HPS process involves distinct stages: cold compaction, hot compaction, and isothermal progression. During cold compaction, densification is driven by the breakdown of aggregates, particle rearrangement, and local plastic deformation, resulting in a relative density of 84.8 %. The intermediate stage achieves an increase to ∼93.7 % in relative density by grain boundary-mediated plastic deformation mechanism. The final isothermal stage, held at 500 °C/5 GPa, achieves nearly full density (∼99.2 %) through diffusion creep, eliminating microstructural defects. This comprehensive understanding of HPS densification mechanisms, exemplified by GZO ceramics, contributes to advancing nanocrystalline ceramic applications. [ABSTRACT FROM AUTHOR]

Artificial microswarms with a collective intelligence that can execute cooperative tasks will serve as intelligent micro/nanorobot systems for many biomedical and microengineering applications. However, it remains challenging to construct microswarms with 3D dynamic and reconfigurable structures that can execute complex spatiotemporal‐dependent tasks. Here, simply using a tapered optical fiber (TOF) with 1.55 µm wavelength light irradiation, a convenient opto‐hydrodynamic strategy for 3D dynamic microswarm actuation based on photothermal gradient‐induced Marangoni effect is reported. With light irradiation at the water‐air interface, randomly distributed microparticles are reorganized into firework‐like 3D swarms with four petals. Such petals in the microswarm are controllably reconfigurable by adjusting the angle between TOF and water‐air interface. These microswarms are also deformable and capable of performing stable migration by simply moving the TOF. Importantly, this opto‐hydrodynamic strategy is applicable for the formation of artificial 3D‐dynamic bio‐microswarms using different biological cells, which further facilitate the regulation of biological processes such as bacteria growth/division. This opto‐hydrodynamic strategy provides a new solution for 3D dynamic microswarm formation, with many potentials for biomedical and microengineering applications that need spatiotemporal‐dependent individual cooperation. [ABSTRACT FROM AUTHOR]

Studies in shift workers and model organisms link circadian disruption to breast cancer. However, molecular circadian rhythms in noncancerous and cancerous human breast tissues and their clinical relevance are largely unknown. We reconstructed rhythms informatically, integrating locally collected, time-stamped biopsies with public datasets. For noncancerous breast tissue, inflammatory, epithelial-mesenchymal transition (EMT), and estrogen responsiveness pathways show circadian modulation. Among tumors, clock correlation analysis demonstrates subtype-specific changes in circadian organization. Luminal A organoids and informatic ordering of luminal A samples exhibit continued, albeit dampened and reprogrammed rhythms. However, CYCLOPS magnitude, a measure of global rhythm strength, varied widely among luminal A samples. Cycling of EMT pathway genes was markedly increased in high-magnitude luminal A tumors. Surprisingly, patients with high-magnitude tumors had reduced 5-y survival. Correspondingly, 3D luminal A cultures show reduced invasion following molecular clock disruption. This study links subtype-specific circadian disruption in breast cancer to EMT, metastatic potential, and prognosis. [ABSTRACT FROM AUTHOR]

Nanoengineering the composition and morphology of functional nanoparticles endows them to perform multiple tasks and functions. An intriguing strategy for creating multifunctional nanomaterials involves the construction of core–shell nanostructures, which have enabled promising applications in biomedicine, energy, sensing, and catalysis. Here, a straightforward nanoengineering approach is presented utilizing liquid metal nanoparticles and galvanic replacement to create diverse core–shell nanostructures. Controlled nanostructures including liquid metal core‐gold nanoparticle shell (LM@Au), gold nanoparticle core‐gallium oxide shell (Au@Ga oxide), and hollow Ga oxide nanoparticles are successfully fabricated. Remarkably, these investigations reveal that LM@Au exhibits exceptional photothermal performance, achieving an impressive conversion efficiency of 65.9%, which is five times that of gold nanoparticles. By leveraging the high photothermal conversion efficiency and excellent biocompatibility of LM@Au, its promising application in hyperthermia cancer therapy is demonstrated. This simple yet powerful nanoengineering strategy opens new avenues for the controlled synthesis of complex core–shell nanostructures, advancing various fields beyond biomedicine. [ABSTRACT FROM AUTHOR]

Droplet‐based microfluidics represents a disruptive technology in the field of chemistry and biology through the generation and manipulation of sub‐microlitre droplets. To avoid droplet coalescence, fluoropolymer‐based surfactants are commonly used to reduce the interfacial tension between two immiscible phases to stabilize droplet interfaces. However, the conventional preparation of fluorosurfactants involves multiple steps of conjugation reactions between fluorinated and hydrophilic segments to form multiple‐block copolymers. In addition, synthesis of customized surfactants with tailored properties is challenging due to the complex synthesis process. Here, we report a highly efficient synthetic method that utilizes living radical polymerization (LRP) to produce fluorosurfactants with tailored functionalities. Compared to the commercialized surfactant, our surfactants outperform in thermal cycling for polymerase chain reaction (PCR) testing, and exhibit exceptional biocompatibility for cell and yeast culturing in a double‐emulsion system. This breakthrough synthetic approach has the potential to revolutionize the field of droplet‐based microfluidics by enabling the development of novel designs that generate droplets with superior stability and functionality for a wide range of applications. [ABSTRACT FROM AUTHOR]

Droplet‐based microfluidics represents a disruptive technology in the field of chemistry and biology through the generation and manipulation of sub‐microlitre droplets. To avoid droplet coalescence, fluoropolymer‐based surfactants are commonly used to reduce the interfacial tension between two immiscible phases to stabilize droplet interfaces. However, the conventional preparation of fluorosurfactants involves multiple steps of conjugation reactions between fluorinated and hydrophilic segments to form multiple‐block copolymers. In addition, synthesis of customized surfactants with tailored properties is challenging due to the complex synthesis process. Here, we report a highly efficient synthetic method that utilizes living radical polymerization (LRP) to produce fluorosurfactants with tailored functionalities. Compared to the commercialized surfactant, our surfactants outperform in thermal cycling for polymerase chain reaction (PCR) testing, and exhibit exceptional biocompatibility for cell and yeast culturing in a double‐emulsion system. This breakthrough synthetic approach has the potential to revolutionize the field of droplet‐based microfluidics by enabling the development of novel designs that generate droplets with superior stability and functionality for a wide range of applications. [ABSTRACT FROM AUTHOR]

Herein, we report that bulky alkylphosphines such as PtBu3 can switch the roles from actor to spectator ligands to promote the FeCl2‐catalyzed N‐amidation reaction of arylamines with dioxazolones, giving hydrazides in high efficiency and chemoselectivity. Mechanistic studies indicated that the phosphine ligands could facilitate the decarboxylation of dioxazolones on the Fe center, and the hydrogen bonding interactions between the arylamines and the ligands on Fe nitrenoid intermediates might play a role in modulating the delicate interplay between the phosphine ligand, arylamine, and acyl nitrene N, favoring N−N coupling over N−P coupling. The new ligand‐promoted N‐amidation protocols offer a convenient way to access various challenging triazane compounds via double or sequential N‐amidation of primary arylamines. [ABSTRACT FROM AUTHOR]

Herein, we report that bulky alkylphosphines such as PtBu3 can switch the roles from actor to spectator ligands to promote the FeCl2‐catalyzed N‐amidation reaction of arylamines with dioxazolones, giving hydrazides in high efficiency and chemoselectivity. Mechanistic studies indicated that the phosphine ligands could facilitate the decarboxylation of dioxazolones on the Fe center, and the hydrogen bonding interactions between the arylamines and the ligands on Fe nitrenoid intermediates might play a role in modulating the delicate interplay between the phosphine ligand, arylamine, and acyl nitrene N, favoring N−N coupling over N−P coupling. The new ligand‐promoted N‐amidation protocols offer a convenient way to access various challenging triazane compounds via double or sequential N‐amidation of primary arylamines. [ABSTRACT FROM AUTHOR]

This study focuses on the synthesis of novel vinpocetine derivatives (2–25) and their biological evaluation. The chemical structures of the synthesized compounds were fully characterized using techniques such as 1H NMR, 13C NMR, and HRMS. The inhibitory activity of the synthesized compounds on PDE1A was evaluated, and the results revealed that compounds 3, 4, 5, 12, 14, 21, and 25 exhibited superior inhibitory activity compared to vinpocetine. Compound 4, with a para-methylphenyl substitution, showed a 5-fold improvement in inhibitory activity with an IC50 value of 3.53 ± 0.25 μM. Additionally, compound 25, with 3-chlorothiazole substitution, displayed an 8-fold increase in inhibitory activity compared to vinpocetine (IC50 = 2.08 ± 0.16 μM). Molecular docking studies were conducted to understand the binding models of compounds 4 and 25 within the active site of PDE1A. The molecular docking study revealed additional binding interactions, such as π–π stacking and hydrogen bonding, contributing to the enhanced inhibitory activity and stability of the ligand–protein complexes. Overall, the synthesized vinpocetine derivatives demonstrated promising inhibitory activity on PDE1A, and the molecular docking studies provided insights into their binding modes, supporting further development of these compounds as potential candidates for drug research and development. [ABSTRACT FROM AUTHOR]

Developing all‐perovskite tandem solar cells is an effective approach to extend the limit of power conversion efficiency. However, fast preparation of large‐area and high‐quality narrow‐bandgap Sn‐based perovskite films still remains a major challenge in fabricating all‐perovskite tandem modules. Here high‐crystalline and compact narrow‐bandgap perovskite films with an area over 100 cm2 are well prepared by combining compositional, solvent and additive engineering. The use of 2‐methoxyethanol as a solvent enables the fast deposition of narrow‐bandgap perovskite films. Adding proper amounts of dimethyl sulfoxide and surfactant L‐α‐phosphatidylcholine into the narrow‐bandgap perovskite precursor effectively enhances the crystallinity and coverage of the resulting perovskite films, respectively. Based on these studies, narrow‐bandgap perovskite and all‐perovskite tandem mini‐modules with an aperture area of 10.4 cm2 are constructed and exhibit high efficiencies of 13.2% and 16.4%, respectively. This study provides an option for fast deposition of high‐quality narrow‐bandgap perovskite films, which is beneficial for the scalable production of all‐perovskite tandem solar modules. [ABSTRACT FROM AUTHOR]

A new type of gust generator generates the airflow oscillation in the wind tunnel through the Coanda effect of the unsteady trailing edge blowing, which has been shown to have strong potential for accurately simulating discrete gusts. It is necessary to study the relationship between the generated gust characteristics and the control parameters of such devices in order to optimize the design performance and improve gust simulation capabilities. By solving the compressible unsteady Reynolds-averaged Navier–Stokes (URANS) equations, the computational fluid dynamics model of the subsonic airflow past the gust generator in the wind tunnel was presented. The effects of jet momentum, frequency, and spanwise blowing ratio on gust intensity, shape, and spatial uniformity were investigated. Results indicate that the intensity of gusts is positively correlated with jet momentum and frequency. The gust shape matches well with the normalized jet momentum coefficient curve. However, when the frequency increases to above 10 Hz, the gust shape differs significantly from expectation due to the appearance of reverse wave peaks. In addition, the mechanism of the impact of the sidewall and partial spanwise blowing on gusts was revealed. In the three-dimensional situation, streamwise vortices are formed on the sidewall and at the spanwise position where the blowing stops, respectively. This results in an increase and noticeable nonuniformity in gust amplitude. When the blowing with a 15% spanwise length near the sidewall is turned off, the gust amplitude at the symmetry plane increases by nearly 40% due to the main vortex being closer to the main flow. The result provides a physical explanation for the availability of this operation to reduce gust attenuation. [ABSTRACT FROM AUTHOR]

This paper presents an analytical model for the near-field radiation of acoustically actuated magnetoelectric (ME) antennas considering a fully magneto-elastic coupled magnetostrictive constitutive relation. The nonlinearity of the magnetostrictive phase is introduced into the governing equation of the ME antennas using the equivalent parameter method, resulting in analytical expressions of the near-field radiation. The strain distribution in the ME antenna is calculated first and then extracted as a source for solving the magnetic flux density, energies, average radiated power, and radiation impedance. The predictions for the admittance and impedance show good agreement with simulation and experimental data, respectively. The effects of the external stimuli on the radiation performance are investigated, to theoretically evaluate the ME antennas operated in complex magnetic and stress conditions. The required magnetic bias corresponding to the maximum radiation of the ME antennas is determined, which is changed with the pre-stress. In addition, the radiation power can be improved by tensile stress before the required magnetic bias or by compressive stress after the required magnetic bias. The present model may provide a basis for the evaluation and regulation of acoustically actuated ME antenna. [ABSTRACT FROM AUTHOR]

A series of epoxy vitrimers (EVs) with enhanced glass transition temperatures (Tgs) were synthesized by curing epoxy resin E51 with different ratios of phthalic anhydride and sebacic acid as curing agents, and 1,5,7-triazabicyclic [4.4.0] dece-5-ene as a transesterification catalyst, and their curing dynamics, rheological properties, mechanical properties, and thermal stability were comprehensively investigated. By adjusting the molar ratio of the anhydride to the carboxylic acid in the curing agent, the Tgs of the EVs increased from 79 to 143 °C with the increase in the anhydride content. In particular, the material EV-5.5 with a high usable Tg of 98 °C could undergo stress relaxation through the transesterification reaction when exposed to high temperatures (160 to 200 °C), and the correlation between the relaxation time and temperature follows the Arrhenius equation. Moreover, EV-5.5 exhibited elastomeric behavior, where brittle fractures occurred before yielding, which demonstrated a tensile strength of 52 MPa. EV-5.5 also exhibited good thermal stability with a decomposition temperature (Td5) of 322 °C. This study introduces new possibilities for practical applications of thermoset epoxy resins under special environmental conditions. [ABSTRACT FROM AUTHOR]

Background: As one of the major food crops in the world, rice is vulnerable to cadmium (Cd) pollution. Understanding of the molecular mechanisms of Cd uptake, transport and detoxification in rice is essential for the breeding of low-Cd rice. However, the molecular mechanisms underlying the response of rice to Cd stress remains to be further clarified. Results: In this study, a novel Cd-responsive gene OsHARBI1-1 was identified in the rice genome and its expression pattern and function were characterized. Bioinformatics analysis showed that the promoter region of OsHARBI1-1 had multiple cis-acting elements in response to phytohormones and stress, and the expression of OsHARBI1-1 was induced by phytohormones. OsHARBI1-1 protein was targeted to the nucleus. qRT-PCR analysis results showed that the expression of OsHARBI1-1 in the roots was repressed while the expression in the shoots was increased under Cd stress. Heterologous expression of OsHARBI1-1 in yeast conferred tolerance to Cd and reduced Cd content in the cells. Meanwhile, the expression of OsHARBI1-1 in Arabidopsis thaliana (A. thaliana) enhanced the tolerance of A. thaliana to Cd stress. In addition, compared with the wild type plants, the POD activity of transgenic plants was increased, while the SOD and CAT activities were decreased. Interestingly, the accumulation of Cd in the roots of A. thaliana expressing OsHARBI1-1 was significantly increased, whereas the Cd accumulation in the shoots was slightly decreased. Compared to the WT plants, the expression of genes related to Cd absorption and chelation was upregulated in transgenic A. thaliana under Cd stress, while the expression of genes responsible for the translocation of Cd from the roots to the shoots was downregulated. Moreover, the expression of phytohormone-related genes was significantly influenced by the expression of OsHARBI1-1 with and without Cd treatment. Conclusions: Findings of this study suggest that OsHARBI1-1 might play a role in the response of plants to Cd response by affecting antioxidant enzyme activities, Cd chelation, absorption and transport, and phytohormone homeostasis and signaling. [ABSTRACT FROM AUTHOR]

Recycled fibre composites are made of discontinuous fibres that are not of the same length. Their mechanical behaviour depends on the load transfer between fibres and in particular on the overlaps between fibres of different lengths. The objective of the study is to show the influence of the architecture on the failure of a discontinuous reinforcement composite. A numerical model was developed to simulate different overlap lengths between fibres. The influence of defects, in this study small overlap length between fibres, and of their distribution in the architecture, was thus highlighted. Experimental tests allowed to validate the model. The model makes it possible to calculate a critical overlap length, length from which the composite strength reaches its maximum. In particular, simulations showed that discontinuous fibre architectures with small overlap lengths at the edge strongly decrease the strength of the composite. On the contrary, defects in the core of the architecture are tolerable. These results open perspectives for the choice of architectures based on recycled fibre in order to optimize the final properties of the composite. [ABSTRACT FROM AUTHOR]

Near-surface seismic shear wave is a basic tool for seismic investigations. However, its frequency-dependent property is not fully investigated, especially by the in situ observation method. Here, we develop the seismic interferometry with a moving frequency window to process the natural seismic signals recorded by the KiK-net network. It is observed that the phase velocity of the shear wave decreases sharply as the frequency increases in the low-frequency range, and remains constant in the high-frequency range. The observed dispersion phenomenon presents a challenge to existing site effect prediction theories, while also providing an observational reference for understanding how the shear wave propagates in near-surface sediment. Key points: Moving-frequency-window seismic interferometry is developed to extract the frequency-varying information of the ground motion. It is firstly observed that the shear wave velocity in near-surface sediment is strongly frequency-dependent. The phase velocity of the shear wave decreases sharply in the low-frequency range as the frequency increases. [ABSTRACT FROM AUTHOR]

An ideal craniofacial bone repair graft shall not only focus on the repair ability but also the regeneration of natural architecture with occlusal loads‐related function restoration. However, such functional bone tissue engineering scaffold has rarely been reported. Herein, a hierarchical 3D graft is proposed for rebuilding craniofacial bone with both natural structure and healthy biofunction reconstruction. Inspired by the bone healing process, an organic–inorganic nanoink with ultrasmall calcium phosphate oligomers and bone morphogenetic protein‐2 incorporated is developed for spatiotemporal guidance of new bone. Based on such homogeneous nanoink, a biomimetic graft, including a cortical layer containing Haversian system, and a cancellous layer featured with triply periodic minimum surface macrostructures, is fabricated via projection‐based 3D printing method, and the layers are loaded with distinct concentrations of bioactive factors for regenerating new bone with gradient density. The graft exhibits excellent osteogenic and angiogenic potential in vitro, and accelerates revascularization and reconstructs neo‐bone with original morphology in vivo. Benefiting from such natural architecture, loading force is widely transferred with reduced stress concentration around the inserted dental implant. Taken from native physiochemical and structural cues, this wstudy provides a novel strategy for functional tissue engineering through designing function‐oriented biomaterials. [ABSTRACT FROM AUTHOR]

Background and aims : The problem of desertification is becoming increasingly serious in the Zoige Plateau. How to carry out vegetation restoration more efficiently in desertified area has been a hotspot. This study aims to improve the vegetation restoration capacity in the desertified area of Zoige Plateau. Methods: In this study, Elymus sibiricus, Elymus dahuricus Turcz and Avena sativa were used as restoration plants in desertified areas. The application concentrations of palygorskite fertilizers (PF), bacterial fertilizers (BF) and phyto-hormones were determined by orthogonal test. The restoration effects were determined based on the fractional vegetation cover (FVC), soil physicochemical properties and soil microbial community after restoration. Results: The results showed that FVC was improved in desertified lands through the addition of PF, BF and phyto-hormones, and the best performance of the combined application improved the FVC up to 67.9%. Meanwhile, the contents of available phosphorus and available nitrogen were also significantly increased compared with the control. Moreover, 16S sequencing analysis showed that Flavobacteria and Herbaspirillum were increased in the plots with high FVC compared to the ones in the control (p < 0.05). Functional prediction by using Tax4Fun revealed that the KEGG pathways of bacteria in the plots with high FVC were enriched for oxidation and amino associated enzymes. Conclusion: The addition of fertilizers and phytohormones improves FVC in desertified areas, and this improvement may be caused by increased soil nutrients and some functional soil microorganisms. [ABSTRACT FROM AUTHOR]

In the fields of artificial intelligence and control engineering, generalized-Sylvester matrix equation is considered as an important mathematic problem, and its solving process is usually viewed as a challenge that deserves particular attention. In this paper, a creative discrete-form recurrent neural network (RNN) model is developed, analyzed and investigated for solving discrete-form time-variant generalized-Sylvester matrix equation (DF-TV-GSME), which is derived by a direct discretization numerical method. Specifically, first of all, DF-TV-GSME, which includes the well-known Lyapunov matrix equation and Sylvester matrix equation, is presented as the target problem of this research. Secondly, for solving such problem, different from the traditional discrete-form RNN design philosophy, second-order Taylor expansion is applied to derive the discrete-form RNN model. This creative process avoids involving the continuous time-variant environment and continuous-form model. Then, theoretical properties analyses are presented, which present the convergence and precision of the discrete-form RNN model. Abundant numerical experiments are further carried out with different perspectives of DF-TV-GSME, which further confirm the excellent properties of discrete-form RNN model. [ABSTRACT FROM AUTHOR]

Discrete time-variant nonlinear optimization (DTVNO) problems are commonly encountered in various scientific researches and engineering application fields. Nowadays, many discrete-time recurrent neurodynamics (DTRN) methods have been proposed for solving the DTVNO problems. However, these traditional DTRN methods currently employ an indirect technical route in which the discrete-time derivation process requires to interconvert with continuous-time derivation process. In order to break through this traditional research method, we develop a novel DTRN method based on the inspiring direct discrete technique for solving the DTVNO problem more concisely and efficiently. To be specific, firstly, considering that the DTVNO problem emerging in the discrete-time tracing control of robot manipulator, we further abstract and summarize the mathematical definition of DTVNO problem, and then we define the corresponding error function. Secondly, based on the second-order Taylor expansion, we can directly obtain the DTRN method for solving the DTVNO problem, which no longer requires the derivation process in the continuous-time environment. Whereafter, such a DTRN method is theoretically analyzed and its convergence is demonstrated. Furthermore, numerical experiments confirm the effectiveness and superiority of the DTRN method. In addition, the application experiments of the robot manipulators are presented to further demonstrate the superior performance of the DTRN method. [ABSTRACT FROM AUTHOR]

To meet the fast iteration speed and high computing power requirements of deep learning models, mainstream hardware vendors are increasingly inclined towards heterogeneous systems consisting of general-purpose processors and AI-specific accelerator cores. However, AI-specific accelerator ores only support certain core operators and do not have general programming capabilities. Therefore, how to efficiently deploy deep learning tasks on such heterogeneous architectures is worth further research. Based on the domestically developed FT-Matrix DSP+MatrixZone heterogeneous system platform, this paper designs and implements a deep learning programming framework, called KaiSa. KaiSa analyzes the input parameters of the deep learning model, identifies the operator type, and assigns it to the corresponding computing core. For complex operators, KaiSa automatically completes the optimal search for the block size based on a performance model, improving the performance of dual-core parallel computing. At the same time, KaiSa shields all low-level hardware details to provide users with a friendly programming environment for efficient program development. Experimental results show that KaiSa can achieve performance improvements of up to 39.0%. [ABSTRACT FROM AUTHOR]

Contamination of nano‐biothreats, such as viruses, mycoplasmas, and pathogenic bacteria, is widespread in cell cultures and greatly threatens many cell‐based bio‐analysis and biomanufacturing. However, non‐invasive trapping and removal of such biothreats during cell culturing, particularly many precious cells, is of great challenge. Here, inspired by the wake‐riding effect, a biocompatible opto‐hydrodynamic diatombot (OHD) based on optical trapping navigated rotational diatom (Phaeodactylum tricornutum Bohlin) for non‐invasive trapping and removal of nano‐biothreats is reported. Combining the opto‐hydrodynamic effect and optical trapping, this rotational OHD enables the trapping of bio‐targets down to sub‐100 nm. Different nano‐biothreats, such as adenoviruses, pathogenic bacteria, and mycoplasmas, are first demonstrated to be effectively trapped and removed by the OHD, without affecting culturing cells including precious cells such as hippocampal neurons. The removal efficiency is greatly enhanced via reconfigurable OHD array construction. Importantly, these OHDs show remarkable antibacterial capability, and further facilitate targeted gene delivery. This OHD serves as a smart micro‐robotic platform for effective trapping and active removal of nano‐biothreats in bio‐microenvironments, and especially for cell culturing of many precious cells, with great promises for benefiting cell‐based bio‐analysis and biomanufacturing. [ABSTRACT FROM AUTHOR]

The mesoscale ensemble prediction system based on the Tropical Regional Atmosphere Model for the South China Sea (CMA-TRAMS (EPS)) has been pre-operational since April 2020 at South China Regional Meteorological Center (SCRMC), which was developed by the Guangzhou Institute of Tropical and Marine Meteorology (GITMM). To better understand the performance of the CMA-TRAMS (EPS) and provide guidance to forecasters, we assess the performance of this system on both deterministic and probabilistic forecasts from April to September 2020 in this study through objective verification. Compared with the control (deterministic) forecasts, the ensemble mean of the CMATRAMS (EPS) shows advantages in most non-precipitation variables. In addition, the threat score indicates that the CMA-TRAMS (EPS) obviously improves light and heavy rainfall forecasts in terms of the probability-matched mean. Compared with the European Center for Medium-range Weather Forecasts operational ensemble prediction system (ECMWF-EPS), the CMA-TRAMS (EPS) improves the probabilistic forecasts of light rainfall in terms of accuracy, reliability and discrimination, and this system also improves the heavy rainfall forecasts in terms of discrimination. Moreover, two typical heavy rainfall cases in south China during the pre-summer rainy season are investigated to visually demonstrate the deterministic and probabilistic forecasts, and the results of these two cases indicate the differences and advantages (deficiencies) of the two ensemble systems. [ABSTRACT FROM AUTHOR]

As an essential material carrier of cultural heritage, the accurate identification and effective monitoring of buildings in traditional Chinese villages are of great significance to the sustainable development of villages. However, along with rapid urbanization in recent years, many towns have experienced problems such as private construction, hollowing out, and land abuse, destroying the traditional appearance of villages. This study combines deep learning technology and UAV remote sensing to propose a high-precision extraction method for conventional village architecture. Firstly, this study constructs the first sample database of traditional village architecture based on UAV remote sensing orthophotos of eight representative villages in Beijing, combined with fine classification; secondly, in the face of the diversity and complexity of the built environment in traditional villages, we use the Mask R-CNN instance segmentation model as the basis and Path Aggregate Feature Pyramid Network (PAFPN) and Atlas Space Pyramid Pool (ASPP) as the main strategies to enhance the backbone model for multi-scale feature extraction and fusion, using data increment and migration learning as auxiliary means to overcome the shortage of labeled data. The results showed that some categories could achieve more than 91% accuracy, with average precision, recall, F1-score, and Intersection over Union (IoU) values reaching 71.3% (+7.8%), 81.9% (+4.6%), 75.7% (+6.0%), and 69.4% (+8.5%), respectively. The application practice in Hexi village shows that the method has good generalization ability and robustness, and has good application prospects for future traditional village conservation. [ABSTRACT FROM AUTHOR]

The hepatitis B virus core protein (HBcAg) is a highly immunogenic particulate antigen. Nearly all patients with persistent or resolved hepatitis B virus (HBV) infection show seropositivity for hepatitis B core antibody (anti-HBc), which appears in the early stage of infection and is mostly present for life. Traditionally, the anti-HBc is regarded as an evidential serological marker of HBV infections. In the last ten years, several studies revealed the predictive value of quantitative anti-HBc (qAnti-HBc) level in the treatment response and clinical outcome of chronic HBV infections, implying new insights into this classic marker. Overall, qAnti-HBc should be regarded as an indicator of the host's immune response specific to HBV, which correlates with HBV-related hepatitis activity and liver pathology. This review summarized the latest understanding of the clinical values of qAnti-HBc for differentiating the CHB phase, predicting treatment response, and providing disease prognosis. Moreover, we also discussed the possible mechanism of qAnti-HBc regulation during different courses of HBV infection. [ABSTRACT FROM AUTHOR]

In this study, we present a novel low-frequency magnetic field energy harvester (EH) employing beryllium bronze/Pb(Zr,Ti)O3 ceramic composited dual-beam structures with tip magnets attached to the inner and outer beams. This design incorporates the internal magnetic-coupled (IMC) effect, resulting in significantly enhanced coupling ability and a wide bandwidth. The validity of the IMC mechanism is confirmed through theoretical formulas and numerical simulations. By leveraging the IMC condition, the EH achieves an expanded bandwidth, which increases from 22 to 43 Hz. Moreover, the total output voltages at the inherent resonance and internal resonance are boosted by 15.4% and 32%, respectively. The performance of the IMC-EH can be further improved by increasing the number of the endmost magnets. Experimental investigations reveal that the IMC-EH generates a maximum RMS output power density of 56.25 μW Oe−2 cm−3, surpassing existing magnetically coupled piezoelectric energy harvesters. Remarkably, even under an ambient magnetic field as low as 1 Oe, the proposed IMC-EH still yields a total output power of 185 μW, sufficient to continuously power 26 LEDs in real time. This demonstrates its potential as a promising solution for low-power consumption small electronics. Furthermore, the implications of this work extend beyond its immediate benefits, as it inspires the design of future self-powered wireless sensor networks in the context of the Internet of Things. [ABSTRACT FROM AUTHOR]

Suicide is the fourth leading cause of death for individuals aged 15–29 years, and early intervention on suicidal ideation and risk factors should be priortized. Brief mindfulness meditation (BMM) is convenient and cost-effective in improving physical and mental well-being, but less is known about its efficacy for suicidal ideation, stress and sleep quality. We investigated the effects of BMM on suicidal ideation, stress, and sleep quality for individuals with suicide risk. Sixty-four college students with high suicidal ideation (aged 18–30 years) were randomly allocated to either a BMM (n = 32) or control group (n = 32). The BMM was based on Anapanasati and core mindfulness concepts. Sixty participants completed all scheduled sessions including pretest, one month of intervention or waiting, and posttest. Suicidal ideation was measured with the Beck Scale for Suicidal Ideation. Stress was evaluated using the Perceived Stress Scale and salivary cortisol levels. Sleep was measured using the Pittsburgh Sleep Quality Index and actigraphy accompanied with 7-day sleep diaries. Post-intervention, the BMM group showed significant decrease in suicidal ideation with a large effect size; the decrease showed a medium effect size in the control group. The BMM group, but not the control group, showed significant decrease in morning salivary cortisol and sleep latency, and improved sleep efficiency. BMM could help reduce suicidal ideation, stress, and sleep disturbance for individuals with high suicidal ideation and it may implicate effective suicide prevention strategy. [ABSTRACT FROM AUTHOR]

Malignant gliomas are a type of primary brain tumour that originates in glial cells. Among them, glioblastoma multiforme (GBM) is the most common and the most aggressive brain tumour in adults, classified as grade IV by the World Health Organization. The standard care for GBM, known as the Stupp protocol includes surgical resection followed by oral chemotherapy with temozolomide (TMZ). This treatment option provides a median survival prognosis of only 16–18 months to patients mainly due to tumour recurrence. Therefore, enhanced treatment options are urgently needed for this disease. Here we show the development, characterization, and in vitro and in vivo evaluation of a new composite material for local therapy of GBM post-surgery. We developed responsive nanoparticles that were loaded with paclitaxel (PTX), and that showed penetration in 3D spheroids and cell internalization. These nanoparticles were found to be cytotoxic in 2D (U-87 cells) and 3D (U-87 spheroids) models of GBM. The incorporation of these nanoparticles into a hydrogel facilitates their sustained release in time. Moreover, the formulation of this hydrogel containing PTX-loaded responsive nanoparticles and free TMZ was able to delay tumour recurrence in vivo after resection surgery. Therefore, our formulation represents a promising approach to develop combined local therapies against GBM using injectable hydrogels containing nanoparticles. [ABSTRACT FROM AUTHOR]

Developing digital inclusive finance is one of the most effective ways to alleviate financial exclusion in the agriculture sector. For empirical investigation, data from 30 provinces of Rural China is collected from the period 2011 to 2020. The study constructs five dimensions and 22 indicators in total to critically conduct the impact of digital inclusive finance on high-quality agricultural development. The level of agricultural development is measured by entropy weight TOPSIS, and the impact of digital inclusive finance on its high-quality development is empirically tested. The results show that digital inclusive finance has significantly improved the agricultural sector and, particularly, the Eastern region of China has the greatest impact. Three dimensions of digital inclusion finance have regional heterogeneity in terms of impact on agricultural development in Rural China. Data does not show the simple linear relationship between digital inclusion finance and agricultural development quality. The impact of the former on the latter is characterized by the double thresholds. The digital inclusive finance index is the weakest when it is lower than the first threshold that is 4.7704, and the impact of the second threshold that is 5.3186 on high-quality agricultural development is gradually enhanced. After crossing the second threshold, the impact of digital inclusive finance on high-quality agricultural development in Rural China is significantly enhanced. The development of digital inclusive finance should be strengthened in the Central and Western regions to compensate for regional financial imbalances and promote synergy in the high-quality development of agriculture across the country. [ABSTRACT FROM AUTHOR]

For perovskite manganites, their colossal magnetoresistance (CMR) requires a large field, which limits their potential applications. In order to uncover the path to achieve low-field CMR, it is crucial to understand the microscopic process of the field driven insulator-to-metal transition (IMT) in manganites. This is particularly true considering the fact that the IMT is of a percolative type, in which the interplay between nucleation and growth of the electronic phase separation domains under magnetic field is not well investigated. In this work, we investigate the magnetic field driven percolative IMT in a model system of La1−x−yPrxCayMnO3 in real space via magnetic force microscopy (MFM). Our experimental observations show unambiguously three stages of the IMT phase transition where domain nucleation and domain growth exhibit distinctly different features in the global initial magnetization measurements. Moreover, MFM reveals that domain growth requires a much lower field than domain nucleation, which provides critical information on how to achieve low-field CMR. It is believed that the exchange field provided by ferromagnetic metallic domains at the boundary with antiferromagnetic insulating domains plays a critical role in assisting the domain growth process. Optimizing such internal exchange fields in manganites is a potential route to achieve CMR without the need of a large external field. [ABSTRACT FROM AUTHOR]

Simple Summary: Fish adapt to changes in their external light environment by adjusting their visual system. Fish that live at different depths can perceive different spectral ranges, leading to differences in the type and expression of their optic proteins. The Japanese flounder (Paralichthys olivaceus) is a valuable cold temperate benthic marine fish that undergoes a series of metamorphoses during its juvenile stage. The vision of flounder larvae is reshaped to adapt to changes in their light environment. Previous studies have shown that thyroid hormone (TH) signaling is critical for flounder metamorphosis. In the present study, we investigated the tissue composition and the metamorphosis temporal expression profile of five opsin genes in flounder larvae. We also investigated the effect of TH on the opsin genes' expression levels by adding TH and thiourea (a TH inhibitor, TU) to the culture water. In addition, we investigated the thyroid hormone receptor (TR)-mediated targeting regulatory relationship between TH and the opsin genes to further explore the function of TH in visual remodeling during flounder metamorphosis. In the present study, we investigated the function of thyroid hormones (TH) in visual remodeling during Japanese flounder (Paralichthys olivaceus) metamorphosis through cellular molecular biology experiments. Our results showed that the expression of the five opsin genes of the flounder were highest in eye tissue and varied with the metamorphosis process. The expression of rh1, sws2aβ and lws was positively regulated by exogenous TH, but inhibited by thiourea (TU) compared to the control group. In addition, there was a significant increase in sws2aβ and lws in the rescue experiments performed with TU-treated larvae (p < 0.05). Meanwhile, T3 levels in flounder larvae were increased by TH and decreased by TU. Based on the differences in the expression of the three isoforms of the thyroid hormone receptor (TR) (Trαa, Trαb and Trβ), we further hypothesized that T3 may directly or indirectly regulate the expression of sws2aβ through Trαa. This study demonstrates the regulatory role of TH in opsins during flounder metamorphosis and provides a basis for further investigation on the molecular mechanisms underlying the development of the retinal photoreceptor system in flounders. [ABSTRACT FROM AUTHOR]

Since acoustic agglomeration is an effective pre-treatment technique for removing fine particles, it can be considered as a potential technology for applications in aerosol pollution control, industrial dust and mist removal, and cloud and precipitation interference. In this study, the cloud-precipitation interference effect was evaluated in situ based on a multi-dimensional multi-scale monitoring system. The variations in the spatial and temporal distribution of rainfall near the surface and the characteristics of precipitation droplets in the air were investigated. The results indicate that strong low-frequency acoustic waves had a significant impact on the macro-characteristics of rainfall clouds, the microphysical structure of rain droplets and near-surface precipitation, and various microwave parameters. In terms of physical structure, the precipitation cloud's base height decreased significantly upon opening the acoustic device, while agglomeration and de-agglomeration of raindrops were in a dynamic equilibrium. When the sound generator was on, the particle concentration at a sampling attitude of 500−1700 m and the proportion of particles with diameters of 1–1.5 mm decreased significantly (by 1–5 ln [1/m3·mm]). In contrast, the particle concentration increased by 1–3 ln [1/m3·mm] at a sampling attitude below 400 m. Moreover, during acoustic interference, the reflectivity factor surged by 2.71 dBZ within 1200 m of the operation centre. Overall, the spatial and temporal distributions of rainfall rates and cumulative precipitation within 5 km of acoustic operation were uneven and influenced by local terrain and background winds. [ABSTRACT FROM AUTHOR]

Since the early days of foundational studies of nucleic acids, many chemical moieties have been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one of these chemical modifications, N6-methyl adenosine (m6A), is unique in a way that it is highly abundant not only on RNA polymerase II (RNAPII) transcribed, protein-coding transcripts but also on non-coding RNAs, such as ribosomal RNAs and snRNAs, mediated by distinct, evolutionarily conserved enzymes. Here, we review RNA m6A modification in the light of the recent appreciation of nuclear roles for m6A in regulating chromatin states and gene expression, as well as the recent discoveries of the evolutionarily conserved methyltransferases, which catalyze methylation of adenosine on diverse sets of RNAs. Considering that the substrates of these enzymes are involved in many important biological processes, this modification warrants further research to understand the molecular mechanisms and functions of m6A in health and disease. [Display omitted] In this review, Sendinc and Shi discuss the recent appreciation of nuclear roles for m6A in regulating chromatin states and gene expression, as well as the recent discoveries of the evolutionarily conserved methyltransferases, which catalyze methylation of adenosine on diverse sets of RNAs. [ABSTRACT FROM AUTHOR]

In this paper, we discuss the exact solutions of linear homogeneous and nonhomogeneous fractional differential equations with double delays. Firstly, a new concept of double-delayed Mittag-Leffler type matrix function is introduced, which is the promotion of the double-delayed matrix exponential. Secondly, we apply the double-delayed Mittag-Leffler type matrix function and Laplace transform approach to obtain the exact solutions of fractional differential equations with double delays. Furthermore, the solution is used to investigate the Hyers-Ulam stability of the system. Lastly, we illustrate our techniques by an example. [ABSTRACT FROM AUTHOR]

Taxus cuspidata S. et Z. is a precious species of frigid zone plant belonging to the Taxaceae family, which possesses anticancer, anti-inflammatory, hypoglycemic, and antibacterial pharmacological properties. While taxane extracted from Taxus chinensis has been reported to elicit antioxidant activities, whether Taxus cuspidata S. et Z. has skin-protective actions against injuries remained unknown. This study aims to explore the pharmacological effects of three Taxus extracts on skin melanin deposition, oxidation, inflammation, and allergy so as to provide new ideas for the prevention and treatment of various diseases related to skin damage. Skin melanin deposition was evaluated by measuring melanin content in the skin of guinea pigs by alkali lysis method. Antioxidant capacity was evaluated by measuring superoxide dismutase (SOD) concentration and glutathione (GSH) content in skin tissue homogenates of Kunming mice by SOD assay kit and micro reduced GSH assay kit. The quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting were used to examine the levels of both SOD and recombinant glutathione peroxidase 4 (GPX4). Skin inflammation was evaluated by xylene-induced ear swelling test and egg-white-induced paw swelling test in mice. In a mouse model of skin allergy induced by 4-aminopyridine (4-AP), allergy was determined by licking body counts and histamine concentrations in tissue homogenates using enzyme-linked immunosorbent assay (ELISA) kits. Two proinflammatory factors tumor necrosis factor (TNF)-α and interleukin (IL)-1β were measured by qRT-PCR. Hematoxylin and eosin (HE) staining was conducted to assess the degree of skin lesion. All three Taxus extracts including Taxus chinensis essential oil, Taxus chinensis extract and Taxus chinensis extract compound reduced the melanin deposits in the back skin relative to the non-treated control animals, of which Taxus chinensis essential oil produced the greatest effect. In contrast, the three Taxus extracts elevated SOD and GSH levels in the skin tissues, and the highest increase was seen with Taxus chinensis essential oil. Three Taxus extracts, especially Taxus chinensis essential oil, effectively reduce the rate of ear and paw swelling. All three Taxus extracts reduced the number of body licks, the levels of TNF-α and IL-1β, and the histamine content in tissue homogenates of mice and alleviated skin damage. Consistently, Taxus chinensis essential oil yielded the greatest magnitude of decreases. While all three Taxus extracts possessed the anti-skin melanin deposition, oxidation, and allergy properties, Taxus chinensis essential oil produced the superior effects. [ABSTRACT FROM AUTHOR]

Background: A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) is involved in inflammation and fertility in women with polycystic ovary syndrome (PCOS). This study aims to assess the role of ADAMTS level in the outcomes of in vitro fertilization and embryo transfer (IVF-ET) in women with PCOS, using a meta-analytic approach. Methods: We systematically searched Web of Science, PubMed, EmBase, and the Cochrane library to identify potentially eligible studies from inception until December 2021. Study assess the role of ADAMTS levels in patients with PCOS was eligible in this study. The pooled effect estimates for the association between ADAMTS level and IVF-ET outcomes were calculated using the random-effects model. Results: Five studies involving a total of 181 patients, were selected for final analysis. We noted that ADAMTS-1 levels were positively correlated to oocyte maturity (r = 0.67; P = 0.004), oocyte recovery (r = 0.74; P = 0.006), and fertilization (r = 0.46; P = 0.041) rates. Moreover, ADAMTS-4 levels were positively correlated to oocyte recovery (r = 0.91; P = 0.001), and fertilization (r = 0.85; P = 0.017) rates. Furthermore, downregulation of ADAMTS-1, ADAMTS-4, ADAMTS-5, and ADAMTS-9 was associated with elevated follicle puncture (ADAMTS-1: weighted mean difference [WMD], 7.24, P < 0.001; ADAMTS-4: WMD, 7.20, P < 0.001; ADAMTS-5: WMD, 7.20, P < 0.001; ADAMTS-9: WMD, 6.38, P < 0.001), oocytes retrieval (ADAMTS-1: WMD, 1.61, P < 0.001; ADAMTS-4: WMD, 3.63, P = 0.004; ADAMTS-5: WMD, 3.63, P = 0.004; ADAMTS-9: WMD, 3.20, P = 0.006), and Germinal vesicle oocytes levels (ADAMTS-1: WMD, 2.89, P < 0.001; ADAMTS-4: WMD, 2.19, P < 0.001; ADAMTS-5: WMD, 2.19, P < 0.001; ADAMTS-9: WMD, 2.89, P < 0.001). Finally, the oocytes recovery rate, oocyte maturity rate, fertilization rate, cleavage rate, good-quality embryos rate, blastocyst formation rate, and clinical pregnancy rate were not affected by the downregulation of ADAMTS-1, ADAMTS-4, ADAMTS-5, and ADAMTS-9 (P > 0.05). Conclusions: This study found that the outcomes of IVF-EF in patients with PCOS could be affected by ADAMTS-1 and ADAMTS-4; further large-scale prospective studies should be performed to verify these results. [ABSTRACT FROM AUTHOR]

Background: A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) is involved in inflammation and fertility in women with polycystic ovary syndrome (PCOS). This study aims to assess the role of ADAMTS level in the outcomes of in vitro fertilization and embryo transfer (IVF-ET) in women with PCOS, using a meta-analytic approach. Methods: We systematically searched Web of Science, PubMed, EmBase, and the Cochrane library to identify potentially eligible studies from inception until December 2021. Study assess the role of ADAMTS levels in patients with PCOS was eligible in this study. The pooled effect estimates for the association between ADAMTS level and IVF-ET outcomes were calculated using the random-effects model. Results: Five studies involving a total of 181 patients, were selected for final analysis. We noted that ADAMTS-1 levels were positively correlated to oocyte maturity (r = 0.67; P = 0.004), oocyte recovery (r = 0.74; P = 0.006), and fertilization (r = 0.46; P = 0.041) rates. Moreover, ADAMTS-4 levels were positively correlated to oocyte recovery (r = 0.91; P = 0.001), and fertilization (r = 0.85; P = 0.017) rates. Furthermore, downregulation of ADAMTS-1, ADAMTS-4, ADAMTS-5, and ADAMTS-9 was associated with elevated follicle puncture (ADAMTS-1: weighted mean difference [WMD], 7.24, P < 0.001; ADAMTS-4: WMD, 7.20, P < 0.001; ADAMTS-5: WMD, 7.20, P < 0.001; ADAMTS-9: WMD, 6.38, P < 0.001), oocytes retrieval (ADAMTS-1: WMD, 1.61, P < 0.001; ADAMTS-4: WMD, 3.63, P = 0.004; ADAMTS-5: WMD, 3.63, P = 0.004; ADAMTS-9: WMD, 3.20, P = 0.006), and Germinal vesicle oocytes levels (ADAMTS-1: WMD, 2.89, P < 0.001; ADAMTS-4: WMD, 2.19, P < 0.001; ADAMTS-5: WMD, 2.19, P < 0.001; ADAMTS-9: WMD, 2.89, P < 0.001). Finally, the oocytes recovery rate, oocyte maturity rate, fertilization rate, cleavage rate, good-quality embryos rate, blastocyst formation rate, and clinical pregnancy rate were not affected by the downregulation of ADAMTS-1, ADAMTS-4, ADAMTS-5, and ADAMTS-9 (P > 0.05). Conclusions: This study found that the outcomes of IVF-EF in patients with PCOS could be affected by ADAMTS-1 and ADAMTS-4; further large-scale prospective studies should be performed to verify these results. [ABSTRACT FROM AUTHOR]

Microswarms have shown great potential in biomedical applications at small scales due to their features of wireless actuation and collective microrobotic behaviors. However, actuation of microswarms with strong universality and intelligent biomimetic behaviors is always a great challenge. Here, photothermal damage‐free actuation of an intelligent microswarm based on light‐induced cold Marangoni flow (CMF) is reported, along with collective drug delivery and targeted cell chemotherapy. This microswarm actuation shows strong universality and high controllability for both abiotic particles and living materials. Importantly, this microswarm exhibits intelligent biomimetic behaviors, such as collective migration, size‐based self‐organization, and group rejection, due to the synergy between cold flow with individual agents. The distinctive photothermal isolation capability of CMF ensures the microswarm to perform photothermal damage‐free biomedical tasks such as collective gene delivery and targeted single‐cell chemotherapy. This light‐induced CMF provides an optical strategy for photothermal damage‐free actuation of intelligent biomimetic microswarm robots, with great promises to perform many collective and cognitive tasks in biomedical applications such as cooperative grasping, collective drug delivery, and precise chemotherapy. [ABSTRACT FROM AUTHOR]

High-density (∼99.34%), fine-grained (∼685 nm) ZnO ceramic was successfully fabricated by the high-pressure cold sintering. The influences of solvent (liquid phase) fraction and the applied pressure on densification in this process have been carefully studied. The excess solvent can result in grain refinement, but impedes the densification of ceramic. Significantly, the role of pressure is unlike that in the traditional pressure-assisted sintering, which can improve the densification and inhibit grain growth. There is a critical pressure (∼1 GPa) that can be associated with the transition of recrystallization from heterogeneous nucleation to homogeneous nucleation. When the pressure is lower than this critical value, the applied pressure can improve densification, but cannot inhibit grain growth. Above the critical value, the densification is dramatically weakened and many small crystals in the interstitial space between grains can be found. [ABSTRACT FROM AUTHOR]

The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop of international experts to discuss new research opportunities for the prevention, detection, and intervention of myocarditis in May 2021. These experts reviewed the current state of science and identified key gaps and opportunities in basic, diagnostic, translational, and therapeutic frontiers to guide future research in myocarditis. In addition to addressing community-acquired myocarditis, the workshop also focused on emerging causes of myocarditis including immune checkpoint inhibitors and SARS-CoV-2 related myocardial injuries and considered the use of systems biology and artificial intelligence methodologies to define workflows to identify novel mechanisms of disease and new therapeutic targets. A new priority is the investigation of the relationship between social determinants of health (SDoH), including race and economic status, and inflammatory response and outcomes in myocarditis. The result is a proposal for the reclassification of myocarditis that integrates the latest knowledge of immunological pathogenesis to refine estimates of prognosis and target pathway-specific treatments. [ABSTRACT FROM AUTHOR]

Background: Both Response Evaluation Criteria in Solid Tumors (RECIST) and tumor regression grade (TRG) play key roles in evaluating tumor response. We analyzed the consistency of TRG and RECIST 1.1 for gastric cancer (GC) patients and compared their prognostic values.Methods: Patients with GC who received preoperative chemotherapy or chemoimmunotherapy and had records of TRG from December 2013 to October 2021 were enrolled retrospectively. TRG 0-1 and 2-3 are considered as corresponding to complete response (CR)/partial response (PR) and stable disease (SD)/progress disease (PD) in RECIST 1.1, respectively. The primary endpoints were disease-free survival (DFS) and overall survival (OS). The consistency of RECIST and TRG was examined by kappa statistics. Survival analysis was performed using the Kaplan Meier method.Result: One hundred fifty seven GC patients were enrolled, including 125 with preoperative chemotherapy and 32 with chemoimmunotherapy. Among them, 56 patients had measurable lesions. Only 19.6% (11/56) of the patients had consistent results between RECIST 1.1 and TRG. TRG was correlated with both OS and DFS (P = 0.02 and 0.03, respectively) while response according to RECIST1.1 was not (P = 0.86 and 0.23, respectively). The median DFS had not reached in the TRG 0-1 group and was 16.13 months in TRG 2-3 group. TRG 2-3 was associated with young age and peritoneal or liver metastasis. Besides, preoperative chemoimmunotherapy had a significantly higher pCR rate than chemotherapy alone (34.4% vs 8.0%, P < 0.001).Conclusion: TRG was in poor agreement with RECIST 1.1. TRG was better than RECIST 1.1 in predicting DFS and OS for GC patients who received preoperative therapy. [ABSTRACT FROM AUTHOR]

Working in isotropic coordinates, we get some maximally symmetric nonrotating solutions of the Einstein-aether theory in 2 + 1 dimensions, all in analytical forms. Curvature singularities are not found in the Ricci and Kretschmann scalars, while conical singularities are avoidable by fixing some integration constants. In Schwarzschild type coordinates, most line elements become the metric of a black hole or a massive particle in the 2 + 1 -dimensional de Sitter or anti-de Sitter spacetime, but in some solutions the aether field cannot be written in closed forms. [ABSTRACT FROM AUTHOR]

Inflammation, oxidative stress, and copper (Cu) play an important role in cardiovascular disease, including atherosclerosis. We previously reported that cytosolic Cu chaperone antioxidant-1 (Atox1) translocates to the nucleus in response to inflammatory cytokines or exogenous Cu and that Atox1 is localized at the nucleus in the endothelium of inflamed atherosclerotic aorta. However, the roles of nuclear Atox1 and their function are poorly understood. Here we showed that Atox1 deficiency in ApoE−/− mice with a Western diet exhibited a significant reduction of atherosclerotic lesion formation. In vitro, adenovirus-mediated overexpression of nuclear-targeted Atox1 (Ad-Atox1-NLS) in cultured human endothelial cells (ECs) increased monocyte adhesion and reactive oxygen species (ROS) production compared to control cells (Ad-null). To address the underlying mechanisms, we performed genome-wide mapping of Atox1-regulated targets in ECs, using an unbiased systemic approach integrating sequencing data. Combination of ChIP-Seq and RNA-Seq analyses in ECs transfected with Ad-Atox1-NLS or Ad-null identified 1387 differentially expressed genes (DEG). Motif enrichment assay and KEGG pathway enrichment analysis revealed that 248 differentially expressed genes, including inflammatory and angiogenic genes, were regulated by Atox1-NLS, which was then confirmed by real-time qPCR. Among these genes, functional analysis of inflammatory responses identified CD137, CSF1, and IL5RA as new nuclear Atox1-targeted inflammatory genes, while CD137 is also a key regulator of Atox1-NLS-induced ROS production. These findings uncover new nuclear Atox1 downstream targets involved in inflammation and ROS production and provide insights into the nuclear Atox1 as a potential therapeutic target for the treatment of inflammatory diseases such as atherosclerosis. [ABSTRACT FROM AUTHOR]

Supercapacitors have played an important role in electrochemical energy storage. Recently, researchers have found many effective methods to improve electrode materials with more robust performances through the increasing volume of scientific publications in this field. Though nickel cobaltite (NiCo2O4), as a promising electrode material, has substantially demonstrated potential properties for supercapacitors, its composites usually show much better performances than the pristine NiCo2O4. The combination of carbon-based materials and NiCo2O4 has been implemented recently due to the dual mechanisms for energy storage and the unique advantages of carbon materials. In this paper, we review the recent research on the hybrids of NiCo2O4 and carbon nanomaterials for supercapacitors. Typically, we focused on the reports related to the composites containing graphene (or reduced graphene oxide), carbon nanotubes, and amorphous carbon, as well as the major synthesis routes and electrochemical performances. Finally, the prospect for the future work is also discussed. [ABSTRACT FROM AUTHOR]

Objective: To determine the ability of conventional ultrasound (US) combined with shear wave elastography (SWE) to reveal axillary status after neoadjuvant chemotherapy (NAC) in breast cancer patients. Methods: From September 2016 to December 2021, 201 patients with node-positive breast cancer who underwent NAC were enrolled in this prospective study. Conventional US features of axillary lymph nodes and SWE characteristics of breast lesions after NAC were analyzed. The diagnostic performances of US, SWE, and their combination were assessed using multivariate logistic regression and receiver operator characteristic curve (ROC) analyses. Results: The area under the ROC curve (AUC) for the ability of conventional US features to determine axillary status after NAC was 0.82, with a sensitivity of 85.23%, a specificity of 67.39%, and an accuracy of 76.11%. Shear wave velocity (SWV) displayed moderate performance for predicting axilla status after NAC with SWVmean demonstrating an AUC of 0.85. Cortical thickness and shape of axillary nodes and SWVmean of breast tumors were independently associated with axillary nodal metastasis after NAC. Compared to conventional US, the combination of conventional US of axillary lymph nodes with SWE of breast lesions achieved a significantly higher AUC (0.90 vs 0.82, p < 0.01, Delong's test) with a sensitivity of 87.50%, improved specificity of 82.61% and accuracy of 85.00%. Conclusions: Breast SWE was independently associated with residual metastasis of axillary node after NAC in patients with initially diagnosed positive axilla. Combining SWE with conventional US showed good diagnostic performance for axillary node disease after NAC. Key Points: • Breast SWE can serve as a supplement to axilla US for the evaluation of the axilla after NAC. • The combination of axilla US with breast SWE may be a promising method to facilitate less-invasive treatment in patients receiving NAC. [ABSTRACT FROM AUTHOR]

The study aims at the problems of rough edges and low accuracy in processing cell nucleus image segmentation in existing image segmentation methods. The use of a generative adversarial network (GAN) and a fully convolutional network (FCN) model to segment cell nuclei is suggested. First, the FCN model is used to perform preliminary segmentation of the cell nucleus image, in which the fully connected layer convolution and skip connection are used to improve the accuracy of image segmentation, then improve the GAN, introduce splitting branches into the discriminator structure, and combine the GAN and the splitting network into one. At the same time, pixel loss is introduced in the generator to obtain a nucleus image that is visually more similar to the real image. Finally, the segmented image output by the FCN model is used as the input of the GAN to achieve high-precision segmentation of the nucleus image. The proposed method is experimentally demonstrated based on the 2018 data science bowl data set. The results show that it can achieve rapid convergence, and the mean intersection over union (MIoU) is 85.34%, which is better than other comparison methods. [ABSTRACT FROM AUTHOR]