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Objective: To explore the synergistic mechanism of salvia miltiorrhiza and Pueraria lobata of multi-component, multi-target and multi-pathway in the treatment of type 2 diabetes mellitus (T2DM). Methods: The chemical components of Salvia miltiorrhiza and Pueraria lobata were queried and screened through the pharmacological database and analysis platform of traditional Chinese medicine system, and the chemical components were predicted by SwissTargetPrediction database. At the same time, the related targets of T2DM were searched and screened from GeneCards, TTD, DrugBank and Disgenet databases. The chemical composition targets and disease targets are intersected, and the PPI network of intersection targets is constructed by using STRING11.0 database, and the PPI network nodes are screened to get the key targets. The GO function and KEGG pathway enrichment analysis of the key targets are carried out. Results: A total of 70 chemical constituents and 51 key targets for the interaction between chemical components and diseases were obtained through retrieval and screening. After enrichment and analysis of 51 key targets, a total of 71 cellular components, 85 molecular functions, 559 biological processes and 137 signal pathways were obtained. The treatment of T2DM with Salvia miltiorrhiza and Pueraria lobata may be related to AGE-RAGE, P13K-Akt, ErbB, insulin resistance, HIF-1 and other signal pathways. Conclusion: This study preliminarily reveals the action mechanism of Salvia miltiorrhiza and Pueraria lobata on the treatment of T2DM with multi-components, multi-targets and multi-pathways, which provides a certain basis for the study of the molecular mechanism of Salvia miltiorrhiza and Pueraria lobata pairs.

Background: Type 2 Diabetes Mellitus (T2DM) is a complex metabolic disease caused by complicated factors, the pathogenesis of which has not been determined. Traditional Chinese medicine(TCM) could effectively regulate blood sugar and influence gut microbiota in T2DM patients. Preliminary studies showed that the coptis root and ginseng (RG) formula could relieve insulin resistance and regulate the progression of diabetes in mice. The purpose of this study is to explore the efficacy and safety of RG formula in the treatment of adult patients with T2DM, as well as observing its effects on gut microbiota.Methods and analysis: This trial is a randomized, double-blind, placebo-controlled study. A total of 60 participants will be randomized in a 1:1 ratio into an experiment group (RG formula) and a control group (placebo). Patients in both groups will be given diabetes education and basic blood glucose control. Glucose-lowering drugs with significant influence on gut microbiota will be avoided. This trial will last 25 weeks including 1 week run-in, 12 weeks intervention and 12 weeks follow-up visit. The primary outcome is the change in the HbA1c. The secondary outcomes comprise the change in the fasting blood glucose(FBG), postprandial blood glucose(PBG) fasting insulin(FIL), fasting C-peptide(C-P), insulin resistance index(IRI), inflammatory factors and species abundance of gut microbiota between the two groups. Safety in medication will also be evaluated. The correlation analysis will be explored between the glycemic indicators,inflammatory factors and abundance of gut microbiota.Discussion: This study will provide the clinical evidence for the efficacy of RG formula in regulating blood sugar and influencing gut microbiota, which will be beneficial to form the integrated therapeutic regimen in T2DM with TCM.Trial registration: “Clinical Study on the Intervention of Coptis Root and Ginseng”, Chinese Clinical Trials Registry ChiCTR 2100042126. Registered on 14 January, 2021, http://www.chictr.org.cn/edit.aspx?pid=42669&htm=4

Purpose The objective of this study was to retrospectively research the clinical characteristics, pathogen distribution, prognosis of nosocomial bloodstream infection (nBSI), and the associated risk factors for nBSI. Materials and methods The clinical and microbiological data of patients with nBSI were retrospectively studied. Patients were treated at the First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Hangzhou, China) between January 2013 and December 2016. Results Our study spanned a four-year period and included 704 episodes of nBSI. The incidence rate was 4.11 per 1000 admissions. Of these cases, 96.7% were monomicrobial: gram-negative bacteria (56.4%), gram-positive bacteria (33.4%), and fungal (7%). Of all the Escherichia coli isolates, 41.5% were extended-spectrum β-lactamase-producing (ESBL)-positive. Of the Klebsiella pneumoniae isolates, 50.9% were resistant to imipenem. Of the Staphylococcus aureus isolates, 42.1% were methicillin-resistant. The overall 28-day mortality rate in all patients with nBSI was 24.4%. Parenteral nutrition (PN) and sequential organ failure assessment (SOFA) scores (≥5) were closely related to the 28-day mortality rate of nBSI, while removal of venous catheters and appropriate empirical therapy were protective factors of 28-day mortality. Conclusions Gram-negative bacteria predominantly developed in nBSI. Timely removal of venous catheters (catheter retention time ≥ 7 days) and implementation of appropriate empirical therapy improved the nBSI outcomes.

Objective: To compare the efficacy of traditional Chinese medicine (TCM) based on Zheng differentiation with angiotensin receptor blocker/angiotensin-converting enzyme inhibitor (ARB/ACEI) in treating diabetic kidney disease (DKD) from the aspects of decreasing urinary microalbumin, declining 24-h urinary protein, reducing endpoint events, and renal function protection. Methods: The Chinese Biomedical Literature Database (CBM), the Chinese Academy of Sciences database (CNKI), the VIP Chinese journal database, Wanfang DATA, Medline database, Cochrane library, excerpt medical database (Embase), and Web of science were used for literature searching. The reviewer manager 5.3 software was utilized to analyze the data. Results: Twenty-four studies including 1956 participants were involved in this review. Results showed that TCM had a better effect (mean difference [MD], −23.20, 95% confidence interval [CI], −30.60 to −15.79, P < 0.00001) than ARB/ACEI on lowering urinary albumin excretion rate (UAER) and urine albumin-to-creatinine ratio (MD −4.56 mg/mmol, 95% CI, −5.76 to −3.36, P < 0.00001). Moreover, the advantage of decreasing UAER was greater as the follow-up period become longer (P = 0.04). TCM also had a better effect in 24-h urinal protein, decreasing 0.36 g/24 h (95% CI, −0.45 to −0.27, P < 0.00001) more than the control in shorter follow-up period (ranged from 12 to 24 weeks) subgroup but only 0.08 g/24 h (95% CI, −0.13 to −0.03, P = 0.0006) in the longer follow-up period (>24 weeks) subgroup. TCM worked as well as ACEI/ARB in reducing endpoint events (relative risk, 0.67, 95% CI, 0.20–2.224, P = 0.51) and decreasing urinary albumin concentration (UAC) (MD, −16.50, 95% CI, −46.28–13.28, P = 0.28). As for protecting renal function, TCM had an equal effect to AECI/ARB in improving creatinine clearance ratio (MD, −3.30, 95% CI, −6.66–0.03, P = 0.05) or estimated glomerular filtration rate (MD, 1.00, 95% CI, −0.59–2.58, P = 0.22). However, TCM had a better effect in releasing the glomerular hyperfiltration state (MD, −9.64, 95% CI, −14.45 to −4.84, P < 0.0001). Conclusions: TCM based on Zheng differentiation can work as well as ACEI/ARB in treating DKD and even better in decreasing urinary microalbumin and releasing glomerular hyperfiltration. It is a good alternative treatment of DKD.

Objective. To evaluate the efficacy of the Qingre Yiqi method in the treatment of type 2 diabetes mellitus (T2DM) with meta-analysis. Method. The randomized controlled trials (RCTs) of the Qingre Yiqi method in the treatment of T2DM in the PubMed, Medline, EMBase, Cochrane Library, Web of Science, Weipu Journal, China Knowledge Network (CNKI), and Wanfang database were conducted. Three reviewers independently conducted the screening, extracted the data, and assessed methodological quality. Data analysis was performed using Rev Man 5.3 software for statistical analysis. Results. A total of 15 RCTs, including 1440 patients, were included. The results showed that compared with oral hypoglycemic drugs alone, the add-on treatment of the Qingre Yiqi method could significantly improve Chinese medicine syndrome (OR (95%CI) = 3.66 [2.47,5.42], P < 0.00001 ) and lower the level of HbA1c (MD (95%CI) = −0.68 [0.91, −0.45], P < 0.00001 ), triglyceride (TG) (MD (95%CI) = −0.38 [−0.58,-0.17], P = 0.0004 ), low-density lipoprotein cholesterol (LDL-C) (MD (95%CI) = −0.25 [−0.37, −0.13], P < 0.0001 ), and total cholesterol(TC) (MD(95%CI) = −0.40[−0.67, −0.13], P = 0.003 ). In terms of fasting blood glucose (FBG) and postprandial blood sugar (PBG), subgroup analysis showed that the baseline of FBG and the number of combined oral hypoglycemic drugs of PBG were the major sources of heterogeneity. Conclusion. Compared with the standard treatment, the Qingre Yiqi method along with oral hypoglycemic drugs showed the more beneficial effects for T2DM on improving TCM syndromes and reducing the blood glucose and partial lipid parameter.

Background: Diabetic peripheral neuropathy (DPN) is a common complication in patients (pts) with diabetes. However, multinational data do not support any convincing efficacy of the current therapies for treating DPN. This necessitated the evaluation of safety and efficacy of alternative medicine to tackle DPN. Methods: A double-blinded RCT was conducted in 8 Chinese medicine hospitals in China, evaluating the safety and efficacy of 190 g Tangbi Waixi decoction (TW, intervention (Int)) compared with 19 g TW (control (Cont)). Change in Toronto Clinical Scoring System - Total Score (TCSS-TS) at 12 and 24 weeks follow-up was the primary outcome, with treatment ceasing at 12 weeks. Secondary outcomes included change in bilateral motor velocity (BMV) and sensory nerve conduction velocity (SNCV) of the common peroneal nerve (CPN). All pts received standard care for glycaemic management. The pts in the Int (n=317) and Cont (n=315) groups were analysed on ITT principle. All adverse events (AEs) were recorded. Results: The pts were mean 60 years old with median 10 yrs and 2 yrs of diabetes and DPN duration respectively at randomisation. With median TCSS-TS of 10 at randomisation in both groups, the median (95% CI) reduction in Int and Cont: at 12 weeks 2 (1.7, 2.3) and 3 (2.7, 3.3) respectively (median between group difference (MBGD): 1.0, p=0.011); at 24 weeks 3 (2.6, 3.4) in both groups. At 12 weeks, median (95% CI) CPN velocity increased in both Int and Cont - BMV Int vs. Cont: 2.7 (1.9, 4.9) m/s vs. 4.9 (2.7, 5.5) m/s, MBGD - 2.5 m/s (p=0.044); SNCV Int vs. Cont: 1.4 (0, 2) m/s vs. 2.7 (1.9, 4.9) m/s, MBGD - 0.7 m/s (p=0.26). Similar increase in CPN velocity was observed at 24 weeks in both groups. Overall 12% pts experienced at least one AE, with no difference between groups. Conclusion: Treatment of DPN with TW decoction significantly benefitted the pts and is safe, while lower dose of TW appears to be more effective than the higher does. Disclosure F. Guanjie: None. Y. Lin: None. S.K. Paul: Advisory Panel; Self; Sanofi. Research Support; Self; AstraZeneca, Genentech, Inc. H. Huang: None. T. Xianyu: None. Z. Yuehong: None. F. Zhaohui: None. Q. Xiaotang: None. D. Fang: None. S. Wang: None. M. Wang: None. H. Wei: None. Z. Ling: None. L. Zhenjie: None. Y. Fu: None. M. Wu: None. L. Anxiang: None. H. Jinzhu: None. Q. Li: None. Funding National Science and Technology Support Program (2015BAI04B09)

Diabetic nephropathy (DN) is a common but intractable diabetic microvascular complication. Tripterygium, a Chinses herb, has been proven to be effective for DN treatment. In this review, the efficacy and pharmacological mechanism of tripterygium and its extracts on DN is elucidated. Tripterygium and its extracts could effectively reduce urine protein and protect renal function. Its pharmacological mechanism involves anti-inflammation, anti-oxidation, anti-glomerulosclerosis and anti-fibrosis, which is achieved by balancing the Th1/Th2 cells, regulating macrophage infiltration, and regulating the following pathways: p38 MAPK, NF-κB, TGF-β, Wnt/β-catenin, Akt and Notch1. Although tripterygium and its extracts may result in some adverse effects, including liver-function damage, gastrointestinal reaction, menstrual disorders, and reproductive problems, they are considered good alternative medicines for DN if used with caution and in the proper manner.

Civil engineering structures inevitably suffer from nonstationary ambient excitations in practice, which make conventional damage identification methods relying on the stationary assumption ineffective. This study presents a novel method based on unthresholded assembled recurrence distance matrix (UARDM) and multi-label convolutional neural network (CNN) for structural damage identification under nonstationary excitations. UARDM is a new type of recurrence plot (RP) that is proposed to integrate information of multiple channels and dispense with the artificially selected threshold. It reveals intrinsic dynamic characteristics of the structure using its vibration responses from the perspective of global probabilistic autocorrelation. After that, CNN is applied to automatically extract damage-sensitive features of UARDMs and classify them for the identification of damage cases. Instead of the traditional single-label CNN model that labels each combination of damage location and level as an objective class, the multi-label CNN model is developed to decouple the identification processes of damage locations and levels in order to improve the identification accuracy and computational efficiency. It evaluates the damage level at each location through a sub-branch with an independent set of labels and detects the damage locations by fusing information of all the sub-branches. A comprehensive comparison was conducted among single-label and multi-label CNN models input with raw accelerations, unthresholded multivariate recurrence plots (UMRPs), unthresholded recurrence plots (URPs) and UARDMs through numerical simulation and experimental test. It was demonstrated that the proposed structural damage identification method based on UARDM and multi-label CNN was able to identify multiple damage locations and levels under various stationary and nonstationary excitations with higher accuracy, efficiency and robustness, and even able to detect multiple-damage cases that were not measured beforehand and involved in the training dataset.

CaO-based CO 2 sorbents play a significant role in sorption enhanced methane steam reforming process for hydrogen production and CO 2 emission reduction. In this work, pretreatment of CaO/Ca 3 Al 2 O 6 sorbents in CO 2 atmosphere at different temperatures was investigated for its influence on CO 2 sorption capacity and cyclic stability. The sorbents were synthesized to contain a CaO to Al 2 O 3 mass ratios of 9:1, and then subjected to cycling tests with repeated carbonation and calcination process. Results showed that the sorbents pretreated by CO 2 at 650 oC obtained a minimum CaO grain size of 40.7 nm and a maximum surface area of 13.1 m 2 ·g -1 . This resulted in an increase in CO 2 sorption capacity, up to 7.60 mmol CO 2 ·g -1 sorbent. After 50 cycles, the CO 2 sorption capacity decreased, but still remained 10% above those for the original (no pretreatment) sample. The mechanism about the improved CO 2 sorption performance of the pretreated sorbents was also postulated.

Being able to accurately estimate and map forest biomass at large scales is important for a better understanding of the terrestrial carbon cycle and for improving the effectiveness of forest management. In this study, forest plot sample data, forest resources inventory (FRI) data, and SPOT Vegetation (SPOT-VGT) normalized difference vegetation index (NDVI) data were used to estimate total forest biomass and spatial distribution of forest biomass in northeast China (with 1 km resolution). Total forest biomass at both county and provincial scales was estimated using FRI data of 11 different forest types obtained by sampling 1156 forest plots, and newly-created volume to biomass conversion models. The biomass density at the county scale and SPOT-VGT NDVI data were used to estimate the spatial distribution of forest biomass. The results suggest that the total forest biomass was 2.4 Pg (1 Pg = 1015 g), with an average of 77.2 Mg ha−1, during the study period. Forests having greater biomass density were located in the middle mountain ranges in the study area. Human activities affected forest biomass at different elevations, slopes and aspects. The results suggest that the volume to biomass conversion models that could be developed using more plot samples and more detailed forest type classifications would be better suited for the study area and would provide more accurate biomass estimates. Use of both FRI and remote sensing data allowed the down-scaling of regional forest biomass statistics to forest cover pixels to produce a relatively fine-resolution biomass map.

CaO-based CO2 sorbents play a significant role in sorption enhanced methane steam reforming process for hydrogen production and CO2 emission reduction. However, the sorbents suffer from decreasing CO2 sorption capacity and stability due to the sintering of CaO grains. In this study, we modified CaO sorbents by incorporating Al to obtain CaO/Ca3Al2O6 sorbents via a modified sol-gel method. CO2 sorption evaluation shows that the relative quantity of CaO to Al2O3 plays an overwhelming role in the CO2 sorption capacity and stability of the CaO/Ca3Al2O6 sorbents. Superior CO2 sorption ratio (51.92% for sorbent C8A2 at 500 °C) is achieved, which is 5 times higher than that of the as-synthesized pure CaO sorbent. The high CO2 sorption ratio is due to the existence of inert Ca3Al2O6, which decreases the diffusion resistance of CO2 through product layer during the carbonation reaction. Meanwhile, the superior CO2 cyclic sorption stability is ascribed to the small original surface free energy of the as-synthesized sorbents.

CO2 enhanced sorption methane steam reforming for hydrogen production is a potential approach to economically provide hydrogen and to reduce CO2 emission. The key point for this process is to develop a composite catalyst with high catalytic and adsorptive capacity. Considering the tunable structure of hydrotalcite-like compounds, co-precipitation method was employed to synthesize Ni/CaO-Al2O3 composite catalysts by varying the molar ratio of Ca to Al. The results show that the specific surface area and Ni dispersion of the as-synthesized composite catalysts are greatly influenced by molar ratio of Ca to Al, which derives from the variable interaction between Ni and the support. When the molar ratio of Ca to Al is 3, the composite catalyst obtains a specific surface area of 12.92 m2/g and Ni dispersion of 1.07%. Catalytic evaluation shows that the composite catalyst possesses a H2 concentration of 95% and a CH4 conversion of 88%, and H2 concentration exceeds 93% even after 10 cyclic runs.

18β-Glycyrrhetinic acid (GRA), a major component ofGlycyrrhiza glabra, is widely used therapeutically in clinic. In this study, the effect of GRA onHelicobacter pylori- (H. pylori-) infected gastritis was investigated in Mongolian gerbilsin vivo. The gerbils were randomly divided into groups: uninfected;H. pylori-infected;H. pylori+ antibiotics (clarithromycin, amoxicillin, and esomeprazole); andH. pylori+ GRA. The gastric intraluminal pH value, histopathological changes, and the expression levels of inflammation-related cytokines (IL-1β, TNF-α, COX-2, and iNOS) were investigated. The results showed that, in theH. pylori+ GRA group, the intraluminal gastric pH value was lower (2.14±0.08versus3.17±0.23,P<0.05), erosion and hyperplasia were alleviated, the infiltration of neutrophils and mononuclear cells was attenuated (P<0.05), and the expression levels of TNF-α, IL-1β, COX-2, and iNOS were decreased (P<0.05) compared with theH. pylori-infected group. There was no significant difference in results between theH. pylori+ GRA group and theH. pylori+ antibiotics group. This study indicated that GRA significantly attenuatedH. pylori-infected gastritis in gerbils and has the potential to be developed as a new therapeutic drug.

Background As a common complication of diabetes, the incidence of diabetic peripheral neuropathy (DPN) is 60–70% worldwide. DPN is a major risk factor for diabetic foot, which may lead to foot ulceration and even amputation. The treatment of DPN remains challenging. Our preliminary study demonstrated that the external application of Tangbi Waixi (TW) decoction to the lower extremities relieved clinical symptoms and improved nerve conduction velocity in DPN patients. The aim of this study was to verify the efficacy of TW among DPN patients and evaluate the herb mixture’s safety using rigorous methodological designs. Methods/design This study is a multicenter, double-blind, randomized controlled trial. A total of 640 DPN patients will be recruited and randomized to receive a foot bath with either the TW decoction or control drug. Participants will be assessed at baseline and 12 and 24 weeks after treatment. The primary outcome was the change of the Toronto Clinical Scoring System (TCSS). Secondary outcomes were nerve conduction velocity, blood glucose, blood lipids, serum inflammatory cytokines, and the European Quality of Life Five-Dimension Scale (EQ-5D) and TCM symptom scores. Discussion This multicenter, prospective, randomized clinical trial will provide valuable data regarding the efficacy and safety of foot bath treatment with TW decoction. Positive results would provide a novel treatment regimen for DPN patients. Trial registration Chinese Clinical Trial Registry, ChiCTR-IOR-16009331. Registered on 8 October 2016. Electronic supplementary material The online version of this article (10.1186/s13063-018-2856-4) contains supplementary material, which is available to authorized users.

WDR5 is a chromatin-regulatory scaffold protein overexpressed in various cancers and a potential epigenetic drug target for the treatment of mixed-lineage leukemia. Here, we describe the discovery of potent and selective WDR5-WIN-site inhibitors using fragment-based methods and structure-based design. NMR-based screening of a large fragment library identified several chemically distinct hit series that bind to the WIN site within WDR5. Members of a 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole fragment class were expanded using a structure-based design approach to arrive at lead compounds with dissociation constants

Qufengtongluo (QFTL) decoction is an effective treatment for diabetic nephropathy (DN). However, the underlying molecular mechanism is still unclear. In this study, we try to investigate whether QFTL decoction acts via inhibiting PI3K/Akt signaling pathway. Twenty-four GK rats were randomly divided into 3 groups: blank group, sham-operated group, and QFTL group. After model establishment, rats in QFTL group were given QFTL decoction by gavage, while the rest were given pure water. During the 8-week intervention, 24 hr urinal protein was measured every 2-3 weeks. After intervention, kidneys were removed for pathological smear, quantitative real-time PCR, and western blotting to detect expression levels of p-PI3K, p-Akt, PTEN, TGF-β, PI3K mRNA, Akt mRNA, PTEN mRNA, and TGF-β mRNA. QFTL group showed a slighter degree of renal fibrosis in Masson and PASM staining and a greater reduction of 24 hr urinal protein than blank group. Compared to blank group, expression levels of p-PI3K, p-Akt, PI3K mRNA, and Akt mRNA were lower in QFTL group, while expression levels of PTEN and PTEN mRNA were higher. Besides, TGF-β was downregulated by QFTL decoction. In conclusion, this study suggests that QFTL decoction might inhibit PI3K/Akt signaling pathway via activating PTEN and inhibiting TGF-β.

The oncogenic mechanisms of overnutrition, a confirmed independent cancer risk factor, remain poorly understood. Herein, we report that enoyl-CoA hydratase-1 (ECHS1), the enzyme involved in the oxidation of fatty acids (FAs) and branched-chain amino acids (BCAAs), senses nutrients and promotes mTOR activation and apoptotic resistance. Nutrients-promoted acetylation of lys101 of ECHS1 impedes ECHS1 activity by impairing enoyl-CoA binding, promoting ECHS1 degradation and blocking its mitochondrial translocation through inducing ubiquitination. As a result, nutrients induce the accumulation of BCAAs and FAs that activate mTOR signaling and stimulate apoptosis, respectively. The latter was overcome by selection of BCL-2 overexpressing cells under overnutrition conditions. The oncogenic effects of nutrients were reversed by SIRT3, which deacetylates lys101 acetylation. Severely decreased ECHS1, accumulation of BCAAs and FAs, activation of mTOR and overexpression of BCL-2 were observed in cancer tissues from metabolic organs. Our results identified ECHS1, a nutrients-sensing protein that transforms nutrient signals into oncogenic signals., Overnutrition has been linked to increased risk of cancer. Here, the authors show that exceeding nutrients suppress Enoyl-CoA hydratase-1 (ECHS1) activity by inducing its acetylation resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR activation.

This paper describes the types and characteristics of ionic liquids, synthesis and application of ionic liquids in chemical and environmental applications, and naphthenic acid corrosion problems and research on ionic liquids are organically combined together, using properties, good stability and easy separating from crude oil, of ionic liquid generated by imidazole and naphthenic acid, exploring the ionic liquid deacidification process conditions and acid removal effect. The naphthenic acid and imidazole react in acetone solvent, synthesis a series of ionic liquids in different reaction ratio, reaction temperature, reaction time and stirring speed conditions,makesome physical measurements and calculation of the yield of these ionic liquids and. The results show that, in naphthenic acid and imidazole molar ratio of 1:1, reaction temperature 70°C, reaction time 7h, stirring speed 400R / min, stand half hour after reaction, the yield of naphthenic acid type ionic liquid is maximum, namely, the deacidification effect is best. At the same time measured in the ionic liquid density is 1.179g / mL, and pH is 5.8. Obtained optimum synthesis condition of naphthenic acid type ionic liquid, greatly improving the deacidification rate of high acid crude oil, more importantly, the method does not cause any pollution to the environment.

This paper uses a metal hung weight loss method, acidic ionic liquid desulfurizer as the media, by adding different inhibitor (Polyethylene Glycol, SDBS, Functional ionic liquids), contrast to carbon steel corrosion in the absence of inhibitor, understanding of their respective inhibition effect. In the experiment, the carbon steel material, different kinds and concentrations of the inhibitor in the medium, the corrosion rate measured by weight loss method. Contrast to the blank experiment the inhibition rate can be calculated. The experiment proved that the inhibition effect of several inhibitor at room temperature, and calculate their respective optimal concentration. The experiment also investigated the compound of several corrosion inhibition synergies, confirm the good corrosion inhibiting effect of polyethylene Glycol and SDBS complex, the inhibition rate reached 69.2%.Excellent inhibition effect of the ionic liquid corrosion inhibitor and the inhibition rate reached 88.3%, showing a clear advantage.

Two new imidazole ionic liquid salts, 1-allyl-3-methylimidazolium chloride ([AMIM]Cl) and 1-allyl-3-methy-imidazolium hydrogen sulfate ([EMIM]HSO4), were synthesized with direct synthesis and two-step synthesis method, using a viscosity meter, PH meter, conductivity meter, densitometer, infrared spectrometer determined its chemical structure and properties. The results show that two ionic liquids in the range is slightly different, the trend is roughly same. As the temperature increases, the viscosity decreases, PH gradually increased, the density decreases slightly, can be regarded as constant, the conductivity gradually increased. Ionic liquids of the two IR spectra analysis show its structure and synthetic route consistent with the structure of matter.

The macroporous resin is one kind of new non-ionic organic high polymer absorbent with nearly 20 years development. It takes the styrene and the acrylic ester as the monomer, divinyl benzene as the crosslinking agent, the toluene and the xylene as aperture reagents. They intersectantly linked the polymerization to form the porous skeleton structure mutually. This experiment is the utilization of aerosol polymerization method in preparation of rhenium concerned polymeric adsorbent. On research of monomer and crosslinking agent allocated proportion, dispersing agent amount used, temperature and mixing speed control, the different monomer and the crosslinking agent separately affected the synthesis different macroporous polymeric adsorbent. Also we investigated the adsorption performance quality of the different macroporous polymeric adsorbent in order to make the best particle size.

Mg–La alloys were prepared by constant voltage electrolysis in the molten salt system of MgCl2–LaCl3–KCl at 750 °C, with a graphite crucible as the anode and a tungsten rod as the cathode. The effect of oxide and fluoride addition on the electrolysis was investigated comprehensively. X-ray diffraction (XRD) was used to characterize some of the Mg–La alloy products and the sludges. As the content of MgO or La2O3 in the electrolyte increased, both the current efficiency and the mass of alloy product decreased, indicating that both MgO and La2O3 may take part in the reactions in the electrolyte. When the same mass of the oxide was added, compared with La2O3, MgO had a more pronounced effect on both the current efficiency and the mass of alloy product. XRD studies confirmed the formation of LaOCl when MgO or La2O3 was added into the electrolyte. The formation of LaOCl sludge would be the main reason for the negative effect of the oxide addition on both the current efficiency and the mass of alloy. In the electrolytic system, the addition of CaF2 was not helpful to suppress the negative effect of MgO on the electrolysis, probably due to the complex reactions of the La compounds in the electrolyte.

Bone morphogenetic protein receptors (BMPRs) are multifunctional proteins; they have indispensible roles in the process of BMP signaling. However, their function in dedifferentiated chondrosarcoma is uncertain. It has been reported that BMPR2 is associated with chondrosarcoma. Moreover, the detection of BMPR2 is more frequent in dedifferentiated chondrosarcomas (DDCS) than in conventional chondrosarcomas (CCS). BMPR2, phospho-SMAD1/5 (pSMAD1/5), and runt-related transcription factor 2 (RUNX2) expressions were found to be associated with the pathological grades of chondrosarcoma and could be a promising target of treatment outcome. Moreover, BMPR2 was found to induce the RUNX2 expression via pSmad1/5. Knockdown of BMPR2 and pSmad1/5 results in the downregulation of RUNX2 expression in DDCS cells, while the upregulation of BMPR2 and Smad1/5 in CCS cells leads to increased RUNX2 expression. The luciferase reporter gene assay suggested that BMPR2 can induce the RUNX2 expression at the transcriptional level. By chromatin immunoprecipitation (ChIP) and electrophoresis mobility shift assay (EMSA), it was found that pSmad1/5 combined directly to RUNX2. The in vivo tumorigenicity assay in mice showed that the inhibition of BMPR2 or Smad1/5 in DDCS cell line reduced tumor growth, while the upregulation of BMPR2 or Smad1/5 in CCS cell line increased tumor growth. Furthermore, a BMPR signaling inhibitor, LDN-193189, was introduced to investigate its role as a potential drug to treat DDCS. Taken together, the present-study results suggest that BMPR2-pSmad1/5 signaling pathway has an important role in regulating not only the RUNX2 expression but also the tumorigenesis of DDCS.

The electrochemical corrosion behavior of 409 stainless steel after cyclic oxidation below 400 °C was investigated in the simulated muffler condensates by using surface analysis and electrochemical measurement techniques. In the cyclic processes of condensate-dipping and oxidation, specimens may form defective oxide films and weak Cr depletion underlying the oxide films. Sulfate from the condensate-dipping will give rise to sulfidation during the cyclic oxidation, being detrimental to both the oxidation and corrosion properties of stainless steel. The oxidation above 300 °C deteriorates the corrosion resistance, even leading to active corrosion in the acidic condensate solutions. Comparatively, specimens oxidized cyclically without condensate-dipping show much higher condensate corrosion resistance. It is suggested that the acidic condensate corrosion is accelerated by the synergetic effect of oxidation and condensation in the mufflers, and then may result in perforation through the defects such as cracks and nodules in oxide films on the stainless steel surface.

Suitability evaluation plays an important role in land reclamation because the choice of evaluation methods affects the accuracy and objectivity of the suitability evaluation results. Furthermore, it influences the decision-making related to land reclamation. An improved method, which is called limit comprehensive conditions method, was developed after different suitability evaluation methods were studied. Based on this method, the reclaimed land of the Gaoqiao bauxite mining area was evaluated. The Gaoqiao mining area was divided into seven evaluation units that were evaluated respectively by selecting evaluation factors and establishing grade standards. The results show that the proposed method is more applicable and easier to handle. Moreover, its evaluation results are more scientific compared with the traditional evaluation methods. The improved method can be beneficial to the rapid monitoring and the effective management of reclaimed land in the opencast mine area.

Postoperative adhesions are a common cause of adhesive small bowel obstruction (ASBO), and recognition of intestinal strangulation is important. The aim of this study is to analyze the clinical factors for strangulating obstruction and to identify the predictors for recurrence of ASBO. A retrospective study was conducted using the database in our department. Patients with ASBO from January 2013 to April 2016 were included in the study and were subject to follow-up. The clinical factors associated with strangulating obstruction and recurrence after treatment were analyzed by using univariate and multivariate logistic regression model. In total, 288 ASBO patients were included in the study. Of these, 37 (12.9%) patients had occurred strangulating obstructions, and 251 (87.1%) patients had simple obstructions. Four clinical parameters, including increasing heart rate (>100 bpm), increasing WBC count (>15 × 109/L), CT findings of thickening or swelling of the mesentery, and CT showing seroperitoneum were detected as independent clinical factors for intestinal strangulation. Eighty-four (29.2%) patients experienced recurrence of obstruction during the median 24 months of follow-up. Recurrence rates were reduced in patients who underwent surgical treatment compared with those who received conservative management [21.3% (26/122) vs 34.9% (58/166) (P = .010)]. Nevertheless, the recurrence rates were not significantly increased in patients with strangulating obstructions compared with those with simple ASBO [34.3% (12/35) vs 27.7% (72/253) (P = .186)]. Four clinical parameters including tachycardia, leukocytosis, along with CT findings of thickening or swelling of the mesentery and CT showing seroperitoneum, associated with occurrence of intestinal strangulation in ASBO. ASBO patients who underwent surgical treatment had a reduced recurrence rate, but ASBO patients with strangulating obstructions had not increase the recurrence rates than those of patients with simple ASBO.

Background Recognition of the intermuscular spaces within lumbar paraspinal muscles is critically important for using the paramedian muscle-splitting approach to the lumbar spine. As such, it is important to determine the intermuscular spaces within the lumbar paraspinal muscles by utilizing modern medical imaging such as computed tomography (CT) and magnetic resonance imaging (MRI). Methods A total of 30 adult cadavers were studied by sectional anatomic dissection, and 60 patients were examined using CT (16 slices, 3-mm thickness, 3-mm intersection gap, n = 30) and MRI (3.0T, T2-WI, 5-mm thickness, 1-mm intersection gap, n = 30). The distances between the midline and the superficial points of the intermuscular spaces at different intervertebral disc levels were measured. Results Based on study of our cadavers, the mean distances from the midline to the intermuscular space between multifidus and longissimus, from intervertebral disc levels L1–L2 to L5–S1, were 0.9, 1.1, 1.7, 3.0, and 3.5 cm, respectively. Compared with the upper levels (L1–L3), the superficial location at the lower level (L4–S1) is more laterally to the midline (P

According to the strictest water resources management system and three red lines of water resources management, with the precondition of strictly controlling water rights and maximum emissions rights, and improving water use efficiency, the bi-level diagnosis and optimal model was developed, based on the principles of interactive negotiation and coordinated and sustainable development of different regions and water sectors within a basin, the optimal function of soc-economy comprehensive benefits, the goal function and diagnosis principle were given between the first and the second levels of the hierarchy in order to allocate initial water rights interactively. To promote fair and coordinated development across different regions of the basin and coordinated and efficient water use across different water sectors, realize the maximum comprehensive benefits to the basin, promote the unity of quantity and quality of initial water rights allocation, and eliminate water conflict across different regions and water sectors. A case study further verified the validity of the model.

To provide anatomic evidence for identification of "holy plane" between fascia propria and its adjacent fascia in total mesorectal excision.A total of 26 pelvic specimens of adult male preserved in 10% formalin solution were used in this study. Twenty pelvis were employed for topographic anatomy, six for sectional anatomy.Rectovesical septum was formed by the ventral part of the fascia propria and Denonvilliers' fascia, with no blood vessel and nerve coursed between two layers. Dorsal part of the fascia propria parallelled with the presacral fascia, with no blood vessel and nerve coursed between two layers in 80% of the pelvis. However, anatomic variations was encountered occasionally--with muscle-like tissue or fusion of presacral fascia interposed between them for 20%. The lateral space of rectum was between lateral part of the fascia propria and parietal fascia which witnessed pelvic nerve plexus and lateral ligament of the rectum traveling. Pelvic nerve plexus was categorized as two types according the relation between fascia propria and nerve plexus: fusion type accounting for 85% and rarefaction type for 15%.'holy plane' is sandwiched between the fascia propria and its adjacent fascia--ventrally Denonvilliers fascia, dorsally presacral fascia and laterally parietal fascia.

The chromium plating layer shows excellent wear resistance under lubrication at low speed and light load. However, its wear resistance is not very good at high speed and heavy load. The newly developed substitute chromium brush plating layer behaves satisfactorily under both sets of conditions. Friction and wear tests were conducted and average and flash temperatures of substitute chromium plating layer were calculated. The microstructures of plating layer before and after the wear process were analysed by SEM, AES and XPS. The mechanism of its excellent wear resistance at high speed and heavy load is described.

Aiming at complexity of hydrogeological conditions of coal mine, this paper brought forward the improved chaos-genetic optimization method based on the chaos optimization method and genetic algorithm method. Using the optimization method, this paper have carried out the back analysis of earth temperature field of coal mine, then predicted the earth temperature field using the parameters of the back analysis, which provided a scientific basis for control of heat-harm. Through engineering example, the result showed that the improved chaos and genetic optimization method on the back analysis of earth temperature field in coal mine was feasible.

The paper mainly studies the development of assistant and decision-making system of site selection for supermarket, including development environment, overall design, design and realization of every function module, etc. The system adopts MapX5.0 and VB6.0 as the development platform, uses SQL Server 2005 as the back database. The establishment of the system offers an important means for site selection of supermarket, increases the efficiency of site selection of supermarket.

To build and apply Temporal Geographic Information System (TGIS), to manage mining land spatio-temporal data is a key research aspect for present production administration and ecological environment protection. Spatio-temporal database, whose foundation is spatio-temporal data model, is th e core of TGIS. Considering the feature of land use to change, this paper builds up a model of mining land spatio-temporal data based on ground-state amended model with some improvements. This data model stores space informati on and time information of mining land in spatial database. From judging the spatio-temporal information in historical and current database, the land use situation at different historical period can be recurred very conveniently. At the same time, the mutual transforming situation among lands at different periods can be educed from overlaying the lands by use of the related analyzed function of GIS. Accordingly, that will give an important reference to open out the rule of mining land evolution. Keywords: mining land; mining-land use change; spatio-temporal data model; ground-state amended model

in order to predict gas content of coal seam accurately in binchang mining, we use core data to build the BP neural network. We select the important controlling factors which impacted gas content of coal seam, coal bed thickness, ash and max vitrinite reflectance as the basic features of the BP neural network model, and establish the BP neural network prediction model between coal bed methane content and the main controlling factors. The testing results show that the BP neural network model could truly reflect the non-linear relationship between the gas content and the controlling factors, and obtain minimal error between the predicted results and the measured ones. This method provides the probability for using geological, logging and seismic information to predict gas content of coal seam. Key word- CBM content, geologic parameter, BP neural networks model

MapInfo is current a popular GIS software. This paper introduces characters of MapInfo and GIS second development methods offered by MapInfo, which include three ones based on MapBasic, OLE automation, and MapX control usage respectively. Taking development of land management information system in mine area for example, in the paper, the method of developing GIS applications based on MapX has been discussed, as well as development of land management information system in mine area has been introduced in detail, including development environment, overall design, design and realization of every function module, and simple application of system, etc. The system uses MapX 5.0 and Visual Basic 6.0 as development platform, takes SQL Server 2005 as back-end database, and adopts Matlab 6.5 to calculate number in back-end. On the basis of integrated design, the system develops eight modules including start-up, layer control, spatial query, spatial analysis, data editing, application model, document management, results output. The system can be used in mine area for cadastral management, land use structure optimization, land reclamation, land evaluation, analysis and forecasting for land in mine area and environmental disruption, thematic mapping, and so on.