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Your search keyword '"Shiami Jia"' showing total 4 results
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4 results on '"Shiami Jia"'

1. Bilayer microneedles based on Bletilla striata polysaccharide containing asiaticoside effectively promote scarless wound healing

Author

Jinying Lv, Hongyu Ma, Gengsheng Ye, Shiami Jia, Juan He, Wuni Jiaduo, Jie Ma, Yan Qu, Kaijun Gou, and Rui Zeng

Subjects
Bletilla striata polysaccharide, Asiaticoside, Microneedles, Scar, Wound healing, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

The repair of wounds is essential for overcoming injuries, but the process often leads to scars, and the formation mechanism is unclear. Interestingly, Bletilla striata polysaccharide (BSP) is a procoagulant and has anti-inflammatory properties to promote wound healing, which has great research value for scarless wound healing. Herein, we developed a transdermal drug delivery system of BSP/chitosan (CS) composite bilayer dissolvable microneedles (CS-AS-BSP MNs) containing asiaticoside (AS) based on a centrifugation method with a polydimethylsiloxane mould that fulfilled the requirements of wound healing and achieved a scar-free effect. The drug release results showed that this system improved the solubility of AS and maintained the stable release of the drug for a long time. Further experiments indicated that CS-AS-BSP MNs had a good antibacterial effect and reduced the proliferation of human scar fibroblasts. The wound healing effect of CS-AS-BSP MNs was evaluated in an experimental full-thickness-wound rat model, which demonstrated that the covered wound healed completely without scars within 3 weeks. Furthermore, CS-AS-BSP MNs downregulated TGF-β1 and COL Ⅰ, which are fibrosis-related genes, to inhibit scarring. In brief, this study provides a new strategy for meeting the clinical requirements of effective scarless wound dressings.

Published
2023
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2. Preparation of chitosan/peony (Paeonia suffruticosa Andr.) leaf extract composite film and its application in sustainable active food packaging

Author

Jie, Ma, Gengsheng, Ye, Shiami, Jia, Hongyu, Ma, Duowuni, Jia, Juan, He, Jinying, Lv, Xi, Chen, Fangyao, Liu, Kaijun, Gou, and Rui, Zeng

Subjects
Chitosan, Plant Extracts, Structural Biology, Food Packaging, General Medicine, Paeonia, Molecular Biology, Biochemistry, Antioxidants
Abstract

Considering the problem of food perishability and the environmental pollution of plastic packaging, the natural active packaging prepared by incorporating plant leaf (e.g. peony leaf) extract into biodegradable food packaging materials may be a key to addressing these issues. In the study, a novel green bioactive composite film (CS-PLE) with antioxidant and antibacterial propertiese was developed by blending peony leaf extract (PLE) into chitosan (CS) film through the solution casting method. The physical properties and biological activities of a series of films, including CS film and CS-PLEs incorporated with different concentrations of PLE, were studied by appropriate experimental protocols. The results demonstrated that addition of PLE improved thermal stability, the barrier performance of UV-A and total phenolic content of CS film, and the antioxidant activities of CS-PLEs increased by 60.6 % ~ 73.2 % with the appending proportion of PLE from 0.1 wt% ~ 0.7 wt% compared to CS film. Furthermore, CS-PLEs had better inhibiting effect on bacteria. Notably, CS-PLE (0.7 wt%) wrapping apples showed the least degree of browning among all the groups. Hence, the study of CS-PLEs can provide a new strategy for the preparation of food packaging materials that are green alternatives and reduce environmental pollution.

Published
2022
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