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896 results on '"Shibuya, Kazutoshi"'

6. Intractable Nocardial mycetoma with possible colonisation by Candida species.

Author

Sumioki, Ayano, Saito, Kanami, Nishida, Haruto, Nishizono, Akira, Miyamoto, Yuji, Ishii, Norihisa, Hiruma, Masataro, Shibuya, Kazutoshi, Yaguchi, Takashi, and Hatano, Yutaka

Abstract

A Japanese male in his 30s with no underlying medical condition presented with painless nodules after being bitten by a dog during a stay in Bali, Indonesia, 7 years earlier. He was referred to our department with multiple ulcers, nodules, and masses on the right leg. The final diagnosis was mycetoma caused by Nocardia vulneris, which may have been exacerbated by colonization of Candida parapsilosis and C. tropicalis as these yeasts were isolated by culture from the tissue. Treatment with minocycline hydrochloride and sulfamethoxazole trimethoprim showed partial efficacy, but the addition of posaconazole achieved significant efficacy. This suggests that the surmised coexistence of pathogenic yeasts of lower virulency may have made mycetoma in this case intractable. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Clinicopathological importance of Bcl‐2 and p53 in postmenopausal triple‐negative breast carcinoma and association with age.

Author

Ito, Kei, Honma, Naoko, Ogata, Hideaki, Yamada, Akimitsu, Miyashita, Mika, Arai, Tomio, Sasaki, Eiichi, Shibuya, Kazutoshi, Mikami, Tetuo, and Sawaki, Masataka

Subjects
ANDROGEN receptors, BREAST cancer, TREATMENT effectiveness, ESTROGEN receptors, TRIPLE-negative breast cancer
Abstract

Appropriate biomarkers are required to predict the clinical outcome of triple‐negative breast cancer (TNBC). In this study, we focused on the clinical importance of two representative tumor‐associated proteins, Bcl‐2 and p53. Bcl‐2 expression is usually related to estrogen receptor expression and a favorable outcome in breast cancer. TNBC has been reported to show a high frequency of p53 positivity suggesting TP53 mutations. The expressions of Bcl‐2 and p53 were immunohistochemically examined in TNBC involving two age groups of postmenopausal women (≥75 y/o, n = 75; 55–64 y/o, n = 47), who underwent surgery without neoadjuvant therapy. We examined their associations with each other, or with clinicopathological factors including the outcome. Bcl‐2 expression was inversely correlated with androgen receptor, apocrine morphology, and p53 expressions, and was an independent predictor of a poor outcome in total or in younger women. p53 positivity was associated with a more favorable outcome than p53 negativity in the younger group. In combined analyzes, none of the twenty Bcl‐2‐negative/p53‐positive cases in the younger group exhibited recurrence, resulting in the independent favorable predictive value of Bcl‐2‐negative/p53‐positive. The anti‐apoptotic nature of Bcl‐2 may be apparent in TNBC. The excellent outcome of Bcl‐2‐negative/p53‐positive cases in the younger group warrants further combined investigation of Bcl‐2/p53 in TNBC. [ABSTRACT FROM AUTHOR]

Published
2024
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9. A Case of Leiomyosarcoma Arising in the Ischiorectal Fossa

Author

Yoshida, Kimihiko, Kaneko, Tomoaki, Tochigi, Naofumi, Miura, Yasuyuki, Kagami, Satoru, Suzuki, Takayuki, Ushigome, Mitsunori, Kurihara, Akiharu, Funahashi, Kimihiko, Shibuya, Kazutoshi, Yoshida, Kimihiko, Kaneko, Tomoaki, Tochigi, Naofumi, Miura, Yasuyuki, Kagami, Satoru, Suzuki, Takayuki, Ushigome, Mitsunori, Kurihara, Akiharu, Funahashi, Kimihiko, and Shibuya, Kazutoshi

Abstract

Case Report

Published
2024

11. Donor-Recipient Body Weight Mismatch May Affect Glomerular Basement Membrane Thinning in Electron Microscopic Examination of 1-Hour Renal Allograft Biopsy Specimens

Author

Kawaguchi, Yuki, Oguchi, Hideyo, Mikami, Tetuo, Yamaguchi, Yutaka, Kawamura, Takeshi, Muramatsu, Masaki, Itabashi, Yoshihiro, Shinoda, Kazunobu, Hyodo, Yoji, Takahashi, Yusuke, Onishi, Hiroka, Arai, Taichi, Ohashi, Yasushi, Hamasaki, Yuko, Shibuya, Kazutoshi, Shishido, Seiichiro, and Sakai, Ken

Published
2019
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14. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer

Author

Nishina, Takashi, Deguchi, Yutaka, Ohshima, Daisuke, Takeda, Wakami, Ohtsuka, Masato, Shichino, Shigeyuki, Ueha, Satoshi, Yamazaki, Soh, Kawauchi, Mika, Nakamura, Eri, Nishiyama, Chiharu, Kojima, Yuko, Adachi-Akahane, Satomi, Hasegawa, Mizuho, Nakayama, Mizuho, Oshima, Masanobu, Yagita, Hideo, Shibuya, Kazutoshi, Mikami, Tetuo, Inohara, Naohiro, Matsushima, Kouji, Tada, Norihiro, and Nakano, Hiroyasu

Published
2021
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18. 843. Prognostic Association of Liposomal Amphotericin B Doses Above 5 mg/kg in Mucormycosis: A Nationwide Epidemiologic and Treatment Analysis in Japan

Author

Tashiro, Masato, primary, Namie, Hotaka, additional, Ito, Yuya, additional, Takazono, Takahiro, additional, Kakeya, Hiroshi, additional, Miyazaki, Yoshitsugu, additional, Mukae, Hiroshi, additional, Mikamo, Hiroshige, additional, Tomoo, Fukuda, additional, Shibuya, Kazutoshi, additional, and Izumikawa, Koichi, additional

Published
2023
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21. Prognostic Association of Liposomal Amphotericin B Doses Above 5 mg/kg/d in Mucormycosis: A Nationwide Epidemiologic and Treatment Analysis in Japan

Author

Tashiro, Masato, primary, Namie, Hotaka, additional, Ito, Yuya, additional, Takazono, Takahiro, additional, Kakeya, Hiroshi, additional, Miyazaki, Yoshitsugu, additional, Mukae, Hiroshi, additional, Mikamo, Hiroshige, additional, Tomoo, Fukuda, additional, Shibuya, Kazutoshi, additional, and Izumikawa, Koichi, additional

Published
2023
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25. Prognostic Association of Liposomal Amphotericin B Doses Above 5 mg/kg/d in Mucormycosis: A Nationwide Epidemiologic and Treatment Analysis in Japan

Author

Tashiro, Masato, Namie, Hotaka, Ito, Yuya, Takazono, Takahiro, Kakeya, Hiroshi, Miyazaki, Yoshitsugu, Mukae, Hiroshi, Mikamo, Hiroshige, Tomoo, Fukuda, Shibuya, Kazutoshi, Izumikawa, Koichi, Tashiro, Masato, Namie, Hotaka, Ito, Yuya, Takazono, Takahiro, Kakeya, Hiroshi, Miyazaki, Yoshitsugu, Mukae, Hiroshi, Mikamo, Hiroshige, Tomoo, Fukuda, Shibuya, Kazutoshi, and Izumikawa, Koichi

Abstract

Background: Mucormycosis is a potentially fatal fungal infection, and there is limited information on its precise epidemiology and treatment practices, including the optimal dosage of liposomal amphotericin B. Methods: A retrospective, multicenter, nationwide analysis of 82 proven and probable cases of mucormycosis was performed. Cases between 2015 and 2022 were collected from 51 hospitals in Japan by hematologists and infectious disease specialists. The study included the epidemiology, treatment details, and association between the dose of liposomal amphotericin B and the outcome. Results: The lungs were the most commonly involved organ (70.7% of cases), and 35.4% of patients had disseminated disease. Rhizopus spp., Cunninghamella spp., and Mucor spp. were the most common organisms. Mortality at 4 weeks was 41.5%. The survivors had a shorter duration of neutropenia (P = .006) and less persistent hyperglycemia (P = .023). The site of infection and species of Mucorales had no detectable effect on survival. Survival did not differ between patients receiving liposomal amphotericin B at 5 mg/kg/d relative to those receiving >5 mg/kg/d (P = .625). Using Cox proportional hazards models and adjusting for confounders, the hazard ratio for the influence of >5 mg/kg/d liposomal amphotericin B on 4-week survival was 0.86 (95% CI, 0.28–2.68; P = .796) compared with 5 mg/kg/d. Conclusions: This study provides important insights into the precise epidemiology and treatment practices of mucormycosis. Treatment with liposomal amphotericin B at doses higher than 5 mg/kg/d did not improve outcomes relative to 5 mg/kg/d., Open Forum Infectious Diseases, 10(10), art. no. ofad480; 2023

Published
2023

28. Supplementary Figures 1-2 from Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer

Author

Haugen, Astrid C., primary, Goel, Ajay, primary, Yamada, Kanae, primary, Marra, Giancarlo, primary, Nguyen, Thuy-Phuong, primary, Nagasaka, Takeshi, primary, Kanazawa, Shinsaku, primary, Koike, Junichi, primary, Kikuchi, Yoshinori, primary, Zhong, Xiaoling, primary, Arita, Michitsune, primary, Shibuya, Kazutoshi, primary, Oshimura, Mitsuo, primary, Hemmi, Hiromichi, primary, Boland, C. Richard, primary, and Koi, Minoru, primary

Published
2023
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29. Supplementary Table 1 from Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer

Author

Haugen, Astrid C., primary, Goel, Ajay, primary, Yamada, Kanae, primary, Marra, Giancarlo, primary, Nguyen, Thuy-Phuong, primary, Nagasaka, Takeshi, primary, Kanazawa, Shinsaku, primary, Koike, Junichi, primary, Kikuchi, Yoshinori, primary, Zhong, Xiaoling, primary, Arita, Michitsune, primary, Shibuya, Kazutoshi, primary, Oshimura, Mitsuo, primary, Hemmi, Hiromichi, primary, Boland, C. Richard, primary, and Koi, Minoru, primary

Published
2023
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36. The efficacy of endoscopic ultrasound for preoperative diagnosis of epidermoid cyst in an intrapancreatic accessory spleen: a case report

Author

Iwata, Shuntaro, primary, Okano, Naoki, additional, Ujita, Wataru, additional, Mizutani, Saori, additional, Nakagawa, Hiroki, additional, Kimura, Yusuke, additional, Yamada, Yuto, additional, Watanabe, Koji, additional, Iwasaki, Susumu, additional, Takuma, Kensuke, additional, Ito, Ken, additional, Wakayama, Megumi, additional, Nagai, Hidenari, additional, Shibuya, Kazutoshi, additional, Igarashi, Yoshinori, additional, and Matsuda, Takahisa, additional

Published
2022
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39. Histopathologic profiles of coronary atherosclerosis by myocardial bridge underlying myocardial infarction

Author

Ishikawa, Yukio, Akasaka, Yoshikiyo, Akishima-Fukasawa, Yuri, Iuchi, Ami, Suzuki, Koyu, Uno, Mieko, Abe, Eriko, Yang, Yang, Li, Chin-Ping, Mukai, Kiyoshi, Niino, Hitoshi, Tanaka, Michio, Kawahara, Yutaka, Sugiura, Hitoshi, Shinagawa, Toshihito, Morinaga, Shojiroh, Ogata, Kentaro, Onuma, Junko, Yanagida-Iida, Maki, Taki, Kazuhiro, Komatsu, Akio, Satoh, Hideaki, Yamada, Kazuaki, Shimokawa, Reiko, Shibuya, Kazutoshi, Takahashi, Kei, and Ishii, Toshiharu

Published
2013
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42. Chronic Invasive Fungal Rhinosinusitis with Atypical Clinical Presentation in an Immunocompromised Patient

Author

Kawaji-Kanayama, Yuka, Nishimura, Ayako, Yasuda, Makoto, Sakiyama, Emiko, Shimura, Yuji, Tsukamoto, Taku, Kobayashi, Tsutomu, Mizutani, Shinsuke, Okamoto, Shota, Ohmura, Gaku, Hirano, Shigeru, Konishi, Eiichi, Shibuya, Kazutoshi, and Kuroda, Junya

Subjects
diabetes mellitus, nasal type, Case Report, chronic invasive fungal rhinosinusitis, extranodal natural killer/T cell lymphoma, maintenance dialysis
Abstract

Invasive fungal rhinosinusitis (FRS) is a rare but intractable infectious disease of the sinonasal region with destructive direct infiltration into surrounding tissues, such as the bone, orbit and brain, and potential dissemination to systemic organs. Symptomatic assessments and imaging are frequently not sufficiently diagnostic, and histopathological examination is essential for definite diagnosis of FRS. We herein report a case of chronic invasive FRS (CIFRS) in a 58-year-old Japanese male with end-stage diabetic nephropathy that required maintenance dialysis after graft rejection of living kidney transplantation. His initial main clinical presentation was sinus gangrene, which gradually progressed from the paranasal sinus to the nasal septum and oral palate, but not towards the intracranial or orbital region, for two months. The patient was first strongly suspected to have extranodal natural killer/T cell lymphoma (ENKTL), nasal type, a subtype of malignant lymphoma, based on the macroscopic appearance of the gangrene, expansion pattern and high serum soluble interleukin-2 level; however, repeated biopsies and eventual resection led to diagnosis of CIFRS due to Aspergillus niger and Mucor. The disease was improved by surgical resection in combination with antifungal pharmacologic treatment with liposomal amphotericin B and voriconazole. CIFRS typically occurs in immunocompetent patients and shows intracranial progression, but this case shows that atypical CIFRS with an uncommon expansion pattern can occur in an immunodeficient patient.

Published
2020

46. Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans

Author

Saijo, Shinobu, Ikeda, Satoshi, Yamabe, Keiko, Kakuta, Shigeru, Ishigame, Harumichi, Akitsu, Aoi, Fujikado, Noriyuki, Kusaka, Toshimasa, Kubo, Sachiko, Chung, Soo-hyun, Komatsu, Ryohei, Miura, Noriko, Adachi, Yoshiyuki, Ohno, Naohito, Shibuya, Kazutoshi, Yamamoto, Natsuo, Kawakami, Kazuyoshi, Yamasaki, Sho, Saito, Takashi, Akira, Shizuo, and Iwakura, Yoichiro

Published
2010
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47. Comparison Approach for Identifying Missed Invasive Fungal Infections in Formalin-Fixed, Paraffin-Embedded Autopsy Specimens

Author

Sadamoto, Sota, primary, Mitsui, Yurika, additional, Nihonyanagi, Yasuhiro, additional, Amemiya, Kazuki, additional, Shinozaki, Minoru, additional, Murayama, Somay Yamagata, additional, Abe, Masahiro, additional, Umeyama, Takashi, additional, Tochigi, Naobumi, additional, Miyazaki, Yoshitsugu, additional, and Shibuya, Kazutoshi, additional

Published
2022
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