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2. Sensory neurons promote immune homeostasis in the lung

Author

Tamari, Masato, Del Bel, Kate L., Ver Heul, Aaron M., Zamidar, Lydia, Orimo, Keisuke, Hoshi, Masato, Trier, Anna M., Yano, Hiroshi, Yang, Ting-Lin, Biggs, Catherine M., Motomura, Kenichiro, Shibuya, Rintaro, Yu, Chuyue D., Xie, Zili, Iriki, Hisato, Wang, Zhen, Auyeung, Kelsey, Damle, Gargi, Demircioglu, Deniz, Gregory, Jill K., Hasson, Dan, Dai, Jinye, Chang, Rui B., Morita, Hideaki, Matsumoto, Kenji, Jain, Sanjay, Van Dyken, Steven, Milner, Joshua D., Bogunovic, Dusan, Hu, Hongzhen, Artis, David, Turvey, Stuart E., and Kim, Brian S.

Published
2024
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5. Sensory neurons promote immune homeostasis in the lung

Author

Tamari, Masato, primary, Del Bel, Kate L., additional, Ver Heul, Aaron M., additional, Zamidar, Lydia, additional, Orimo, Keisuke, additional, Hoshi, Masato, additional, Trier, Anna M., additional, Yano, Hiroshi, additional, Yang, Ting-Lin, additional, Biggs, Catherine M., additional, Motomura, Kenichiro, additional, Shibuya, Rintaro, additional, Yu, Chuyue D., additional, Xie, Zili, additional, Iriki, Hisato, additional, Wang, Zhen, additional, Auyeung, Kelsey, additional, Damle, Gargi, additional, Demircioglu, Deniz, additional, Gregory, Jill K., additional, Hasson, Dan, additional, Dai, Jinye, additional, Chang, Rui B., additional, Morita, Hideaki, additional, Matsumoto, Kenji, additional, Jain, Sanjay, additional, Van Dyken, Steven, additional, Milner, Joshua D., additional, Bogunovic, Dusan, additional, Hu, Hongzhen, additional, Artis, David, additional, Turvey, Stuart E., additional, and Kim, Brian S., additional

Published
2023
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10. Alopecia areata in a patient with cytotoxic T lymphocyte antigen‐4 haploinsufficiency successfully treated with topical delgocitinib ointment.

Author

Senda, Akiyoshi, Shibuya, Rintaro, Miyake, Toshiya, Nomura, Takashi, Dainichi, Teruki, and Kabashima, Kenji

Subjects
*CYTOTOXIC T lymphocyte-associated molecule-4, *ALOPECIA areata, *REGULATORY T cells, *TREATMENT effectiveness, *PRIMARY immunodeficiency diseases
Abstract

This article discusses a case study of a patient with alopecia areata (AA) and cytotoxic T lymphocyte antigen-4 (CTLA-4) haploinsufficiency. AA is an autoimmune disease characterized by non-scarring hair loss. CTLA-4 haploinsufficiency is a primary immunodeficiency that can lead to various immunodeficient and autoimmune disorders. The patient in this case study had a familial history of CTLA-4 haploinsufficiency and presented with significant hair loss. Histopathological analysis confirmed the diagnosis of AA, and treatment with topical delgocitinib ointment resulted in complete hair regrowth. The article suggests that dysfunctional regulatory T cells in CTLA-4 haploinsufficiency may contribute to the development of AA, and further research is needed to understand the underlying mechanisms. [Extracted from the article]

Published
2024
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11. Single‐incision laparoscopic partial cecectomy for appendiceal mucocele in a patient with porphyria photosensitivity

Author

Takami, Takuya, primary, Itatani, Yoshiro, additional, Shibuya, Rintaro, additional, Kiyasu, Yoshiyuki, additional, Kasahara, Keiko, additional, Nishizaki, Daisuke, additional, Okamura, Ryosuke, additional, Okada, Tomoaki, additional, Nishigori, Tatsuto, additional, Hoshino, Nobuaki, additional, Hisamori, Shigeo, additional, Tsunoda, Shigeru, additional, Hida, Koya, additional, Kawada, Kenji, additional, and Obama, Kazutaka, additional

Published
2022
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12. Circadian rhythm affects the magnitude of contact hypersensitivity response in mice

Author

Miyake, Toshiya, primary, Egawa, Gyohei, additional, Chow, Zachary, additional, Asahina, Ryota, additional, Otsuka, Masayuki, additional, Nakajima, Saeko, additional, Nomura, Takashi, additional, Shibuya, Rintaro, additional, Ishida, Yoshihiro, additional, Nakamizo, Satoshi, additional, Murata, Teruasa, additional, Kitoh, Akihiko, additional, and Kabashima, Kenji, additional

Published
2022
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13. Decidualization of Stromal Cells Promotes Involvement of Mast Cells in Successful Human Pregnancy by Increasing Stem Cell Factor Expression

Author

Ueshima, Chiyuki, primary, Kataoka, Tatsuki R., additional, Osakabe, Mitsumasa, additional, Sugimoto, Akihiko, additional, Ushirokawa, Akihiko, additional, Shibata, Yuji, additional, Nakamura, Hiroya, additional, Shibuya, Rintaro, additional, Minamiguchi, Sachiko, additional, Sugai, Tamotsu, additional, and Haga, Hironori, additional

Published
2022
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15. Single‐incision laparoscopic partial cecectomy for appendiceal mucocele in a patient with porphyria photosensitivity.

Author

Takami, Takuya, Itatani, Yoshiro, Shibuya, Rintaro, Kiyasu, Yoshiyuki, Kasahara, Keiko, Nishizaki, Daisuke, Okamura, Ryosuke, Okada, Tomoaki, Nishigori, Tatsuto, Hoshino, Nobuaki, Hisamori, Shigeo, Tsunoda, Shigeru, Hida, Koya, Kawada, Kenji, and Obama, Kazutaka

Subjects
APPENDIX (Anatomy), PHOTOSENSITIVITY, ERYTHROPOIETIC protoporphyria, PORPHYRIA, LAPAROSCOPIC surgery, SURGICAL site
Abstract

Erythropoietic protoporphyria (EPP) is a rare hereditary subtype of cutaneous porphyria characterized by photosensitivity. Increased exposure to light irradiation may precipitate acute liver failure, and surgical light‐induced intestinal burns and perforations are known to occur. We report a case of EPP in a patient who underwent laparoscopic partial cecectomy for appendiceal mucocele. A 55‐year‐old man with EPP was presented for treatment of appendiceal mucocele. A light test using two types of laparoscopes (Companies O and S) was performed preoperatively. Light from the laparoscope manufactured by Company O caused photosensitivity; this effect was not observed with light from the laparoscope manufactured by Company S. Therefore, we performed laparoscopic partial cecectomy through a single umbilical incision using the laparoscope from Company S. Except for the incision site, the patient's skin was completely covered using surgical drapes. No intra‐ or postoperative complications were observed. Histopathological examination of the resected specimen revealed a low‐grade appendiceal mucinous neoplasm. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis

Author

Nakamizo, Satoshi, primary, Dutertre, Charles-Antoine, additional, Khalilnezhad, Ahad, additional, Zhang, Xiao Meng, additional, Lim, Shawn, additional, Lum, Josephine, additional, Koh, Geraldine, additional, Foong, Charlene, additional, Yong, Pearly Jean Ai, additional, Tan, Kahbing Jasmine, additional, Sato, Reiko, additional, Tomari, Kaori, additional, Yvan-Charvet, Laurent, additional, He, Helen, additional, Guttman-Yassky, Emma, additional, Malleret, Benoit, additional, Shibuya, Rintaro, additional, Iwata, Masashi, additional, Janela, Baptiste, additional, Goto, Tsuyoshi, additional, Lucinda, Tan Siyun, additional, Tang, Mark B.Y., additional, Theng, Colin, additional, Julia, Valerie, additional, Hacini-Rachinel, Feriel, additional, Kabashima, Kenji, additional, and Ginhoux, Florent, additional

Published
2021
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19. Granuloma Caused by Carbon Deposition in the Dermis

Author

Shibuya, Rintaro, Endo, Yuichiro, Fujisawa, Akihiro, Tanioka, Miki, and Miyachi, Yoshiki

Subjects
genetic structures, Article Subject, education
Abstract

Pencil core granuloma is characterized by a delayed foreign-body reaction against retained fragments of pencil lead. Previous case reports presented pencil core granuloma resembling malignant melanoma, haemangioma, or soft tissue sarcoma. We present a case of pencil core granuloma arising from the palm 25 years after the initial injury. The patient presented a bluish nodule that had been present over 25 years before. The nodule initially measured 5 mm in diameter. However, five years before presentation, it suddenly enlarged to the size of 30 mm during six months. Computed tomography (CT) of the lesion revealed a linear radiopaque structure of 8 mm long with a mass on its distal end. Surgical resection revealed a bluish muddy mass and pencil lead. Histological examination revealed degenerative tissue with calcification surrounded by massive amounts of black granular material in the middle and lower dermis.

Published
2014
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23. CCL2‒CCR2 Signaling in the Skin Drives Surfactant-Induced Irritant Contact Dermatitis through IL-1β‒Mediated Neutrophil Accumulation

Author

Shibuya, Rintaro, Ishida, Yoshihiro, Hanakawa, Sho, Kataoka, Tatsuki R., Takeuchi, Yasuhide, Murata, Teruasa, Akagi, Arisa, Chow, Zachary, Kogame, Toshiaki, Nakamizo, Satoshi, Nakajima, Saeko, Egawa, Gyohei, Nomura, Takashi, Kambe, Naotomo, Kitoh, Akihiko, and Kabashima, Kenji

Abstract

Surfactant-induced cumulative irritant contact dermatitis (ICD) is a common and clinically important skin disorder. CCL2 is known to mediate inflammation after tissue damage in various organs. Thus, we investigated whether and how CCL2 contributes to the development of murine cumulative ICD induced by a common surfactant, SDS. Wild-type mice treated topically with SDS for 6 consecutive days developed skin inflammation that recapitulated the features of human cumulative ICD, including barrier disruption, epidermal thickening, and neutrophil accumulation. CCL2 was upregulated in SDS-treated skin, and local CCL2 blockade attenuated SDS-induced ICD. SDS-induced ICD and neutrophil accumulation were also attenuated in mice deficient in CCR2, the receptor for CCL2. Neutrophil depletion alleviated SDS-induced ICD, suggesting that impaired neutrophil accumulation was responsible for the amelioration of ICD in Ccr2-deficient mice. In RNA-sequencing analyses of SDS-treated skin, the expression levels of Il1bin Ccr2-deficient mice were highly downregulated compared with those in wild-type mice. Furthermore, the intradermal administration of IL-1β in the SDS-treated skin of Ccr2-deficient mice restored the local accumulation of neutrophils and the development of ICD. Collectively, our results suggest that CCL2‒CCR2 signaling in the skin critically promotes the development of SDS-induced ICD by inducing IL-1β expression for neutrophil accumulation.

Published
2021
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24. Dual CD4/CD8-positive Ichthyosiform Mycosis Fungoides with Lymph Node, Peripheral Blood and Cardiac Involvement: A Case Report.

Author

Kaku Y, Otsuka A, Tanizaki H, Shibuya R, Endo Y, Nonomura Y, Hirata M, Fujimoto M, Ohmori K, Sakurai T, and Kabashima K

Subjects
Adult, Antineoplastic Agents therapeutic use, Biomarkers, Tumor analysis, Biopsy, Cord Blood Stem Cell Transplantation, Heart Neoplasms secondary, Heart Neoplasms therapy, Humans, Immunohistochemistry, Immunophenotyping, Lymphatic Metastasis, Male, Mycosis Fungoides blood, Mycosis Fungoides pathology, Mycosis Fungoides therapy, Neoplasm Staging, Phenotype, Skin Neoplasms blood, Skin Neoplasms pathology, Skin Neoplasms therapy, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology, Heart Neoplasms immunology, Lymphocytes, Tumor-Infiltrating immunology, Mycosis Fungoides immunology, Skin Neoplasms immunology
Published
2016
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25. DIHS/DRESS with remarkable eosinophilic pneumonia caused by zonisamide.

Author

Shibuya R, Tanizaki H, Nakajima S, Koyanagi I, Kataoka TR, Miyachi Y, and Kabashima K

Subjects
Adrenal Cortex Hormones administration & dosage, Biopsy, Drug Hypersensitivity Syndrome diagnosis, Drug Hypersensitivity Syndrome drug therapy, Female, Humans, Middle Aged, Prednisolone administration & dosage, Pulmonary Eosinophilia diagnosis, Pulmonary Eosinophilia drug therapy, Tomography, X-Ray Computed, Treatment Outcome, Zonisamide, Drug Hypersensitivity Syndrome etiology, Isoxazoles adverse effects, Pulmonary Eosinophilia chemically induced
Published
2015
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