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BACKGROUND Negative emotions such as anxiety and depression may have a bearing on patients' psychological resilience and quality of life (QoL) following surgery. Cognitive bias modification (CBM) for attention and interpretation has been confirmed to alleviate anxiety and depression. However, the psychological effects of CBM attention and interpretation on Chinese patients with pituitary adenoma have hardly received research attention. METHODS This prospective interventional study enrolled 100 patients undergoing surgical treatment for pituitary adenoma. Participants were divided into an experimental group and a control group, with 50 cases in each group. Baseline characteristics of included patients were collected. Patients in the control group were given routine training, and those in experimental group received routine training plus CBM attention and interpretation training. The Connor-Davidson Resilience Scale (CD-RISC) was used to assess patients' psychological resilience. The patients' levels of anxiety and depression were assessed using the Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS). QoL was assessed based on the European Organization for Research and Treatment of Cancer QoL Questionnaire (EORTC QLQ-C30). RESULTS No statistical difference was found between the 2 groups in CD-RISC, SAS, SDS, or QoL score at baseline (P>0.05). After CBM training, psychological resilience and QoL in the experimental group improved, and the levels of anxiety and depression decreased (P

Background Gliomas, particularly high-grade gliomas, are the most common primary brain tumors. From the Chinese Glioma Genome Atlas (CGGA) database, the relationships between the altered molecular pathways and gliomas could be easily observed. A close connection in the occurrence of the pathogenesis exists between the microenvironment, the glioma, and the associated genes. Methods Validation of the role of ZNF311 oncogene was confirmed by data from the CGGA dataset on glioblastoma and low-grade glioma. Furthermore, we used CIBERSORT to analyze the correlation between ZNF311 and cancer immune infiltrates. Results According to our analysis, ZNF311 was expressed higher in patients with grade-depended glioma with poor prognosis. In addition, we obtained valuable prognostic results between isocitrate dehydrogenase 1 (IDH1) and ZNF311 through the analysis of integrated correlations. Similarly, we simultaneously revealed the prognostic results between 1p/19q and ZNF311. In addition, we found that ZNF311 is correlated with a large number of tumor-infiltrating immune cells. Conclusions Based on the study findings, we conclude that ZNF311 is potentially a novel biomarker for assessing prognosis and immune infiltration in glioblastoma and diffuse glioma cases.

Nervus intermedius neuralgia (NIN) is a rare craniofacial neuralgia with features of paroxysmal pain in the deep ear. Because of sensory nerves overlap in the ear, the diagnosis of NIN is often difficult and not definitive. Here, we present the case of a 70-year-old woman who had deep-ear pain for more than 4 years and was diagnosed with trigeminal neuralgia and treated with carbamazepine without relief in another hospital. Magnetic resonance tomographic angiography revealed no neurovascular conflict with the trigeminal nerve, whereas the anterior inferior cerebellar artery (AICA) was close to the VII/VIII complex. We performed left-sided suboccipital retrosigmoid craniotomy. Surgical exploration under endoscopy clearly showed that the nervus intermedius was compressed by the AICA from behind. The ear pain was completely relieved immediately after nervus intermedius sectioning. The intraoperative findings and postoperative results confirmed that the compression of the nervus intermedius by the AICA caused the otalgia. A patient's specific pain, combined with preoperative imaging examination, is useful in the diagnosis of NIN. Neuroendoscopy has the advantages of enabling a clear field of view and close observation, thus aiding in the identification and accurate cutting of the nervus intermedius during the operation.

DNA methylation is a key epigenetic modification which confers phenotypic plasticity and adaptation. Cyst-forming strains of Toxoplasma gondii undergo tachyzoite to bradyzoite conversion after initial acute infection of a host, and the reverse conversion may occur in immune-suppressed hosts. The formation of m5C is catalyzed by DNA methyltransferase (DNMT). We identified two functional DNA methyltransferases, TgDNMTa and TgDNMTb, in T. gondii that may mediate DNA methylation. The recombinant proteins showed intrinsic methyltransferase activity; both have higher transcription levels in bradyzoites than that in tachyzoites. We performed genome-wide analysis of DNA methylation in tachyzoites and bradyzoites. The results showed more methylation sites in bradyzoites than that in tachyzoites. The most significantly enriched GO-terms of genes with DNA methylation were associated with basal cellular processes such as energy metabolism and parasite resistance to host immunity. Tachyzoite proliferation in parasitophorous vacuoles (PV) can be inhibited by the DNA methyltransferase inhibitor 5-azacytidine, a chemical analogue of the nucleotide cytosine that can inactivate DNA methyltransferases. These findings provide the first confirmation of DNA methylation in T. gondii.

The multi-channel scanning imager is one of the main payloads of a Geostationary earth orbit satellite of China, which observe multi spectrum from earth. Passive thermal control was applied to decrease temperature rise when solar intrusion at midnight, and heat compensation was made to decrease thermal fluctuation in one orbit. Effort was focused on the scanning mechanism for its relatively strict temperature gradient requirement. In order to validate thermal control scheme, thermal balance experiment scheme was planned. Considering the complexity of solar heat flux into sunshade, solar simulator was used to precisely simulate the heat flux variation. Limited to the dimension of vacuum chamber and solar simulator lamp, only the flux into sunshade was simulated by solar simulator, and other parts was simulated by electrical heaters. The solar illuminated region was analysed in order to keep the total heat flux correct. Detailed test process was figured out to carry out two kinds of heat flux simulation. Date were acquired and compared to thermal analysis. Based on experiment condition, thermal model was constructed and modified. From analysis of all the effecting factors, it is find that thermal contact resistance between heatpipes and heat dissipating plate can largely effect the temperature of scanning mechanism. Thermal model of scanning mechanism was detailly constructed including features effecting heat flux absorption and temperature distribution. After modification, the prediction ability of thermal model was enhanced. And optimization of thermal design was made to decrease temperature level and gradient of scanning mechanism. Thermal analyse was done to estimate the optimization, and its effectiveness was validated.

The multi channel scanning imagery radiometer is one of the main payloads of a geostationary earth orbit satellite , which can observe multi spectrum from the earth. The radiometer will endure complicated heat flux environment in orbit, and effective thermal design for the instrument is required in order to ensure high quality scanning image. Based on characteristics of the heat flux in geostationary earth orbit and the unique structure of the radiometer, thermal design characteristic was analyzed, and detailed thermal control design was developed based on numerical analysis. The numerical results verified the validity of thermal control design.

To investigate the mechanism of heat transfer process in sand therapy in Uyghur medicine.A mathematical model was developed to describe the heat transfer process between human body and the sand during sand therapy. Temperature field was numerically simulated and analyzed based on this model.Temperature field in both human tissues and sand was calculated. The surface temperature of the sand and skin surface changed significantly at the beginning of the sand therapy, while sand temperature (5 cm deep) almost kept constant. The skin temperature dramatically increased at the beginning of the sand therapy and then slightly dropped. When sand was deeper than 10 cm, the thickness of sand would not influence the temperature field in human tissues during sand therapy. High initial temperature of sand might cause harmful skin burn. Threshold skin burn occurred if initial temperature of sand was higher than 64.6 degree C and if the therapy lasted more than 30 minutes.Temperature fieled in human tissues varies significantly with the initial temperature of sand, thickness of sand, and duration of therapy.