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This investigation mainly focused on the ability of polymer to release the Bisoprolol fumarate in a controlled pre determined manner. The polymers selected for the investigation include chitosan. HPMC, and sodium CMC. The polymers were selected on the basis of their property. The muco adhesive buccal patches were prepared by solvent casting method with appropriate modification. The prepared patches were subjected to physical evaluations, invitro diffusion study, and stability study. The result obtained was satisfactory with all the formulation, but, the patches prepared with 2% chitosan showed a better invitro diffusion result as it can diffuse 96% of drug within 12 hour of the therapy. The result of physical evaluation and stability study indicating that the Bisoprolol buccal patches with 2% chitosan could effectively treat the possible anginal attack and hypertension. [ABSTRACT FROM AUTHOR]