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2. Übergaben auf der Intensivstation

Author

Reifarth, Eyleen, Naendrup, Jan-Hendrik, Garcia Borrega, Jorge, Altenrath, Lisa, Shimabukuro-Vornhagen, Alexander, Eichenauer, Dennis Alexander, Kochanek, Matthias, and Böll, Boris

Published
2024
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6. Veno-venous extracorporeal membrane oxygenation (vv-ECMO) for severe respiratory failure in adult cancer patients: a retrospective multicenter analysis

Author

Kochanek, Matthias, Kochanek, Jan, Böll, Boris, Eichenauer, Dennis A., Beutel, Gernot, Bracht, Hendrik, Braune, Stephan, Eisner, Florian, Friesecke, Sigrun, Günther, Ulf, Heinz, Gottfried, Hallek, Michael, Karagiannidis, Christian, Kluge, Stefan, Kogelmann, Klaus, Lebiedz, Pia, Lepper, Philipp M., Liebregts, Tobias, Lueck, Catherina, Muellenbach, Ralf M., Hansen, Matthias, Putensen, Christian, Schellongowski, Peter, Schewe, Jens-Christian, Schumann-Stoiber, Kathrin, Seiler, Frederik, Spieth, Peter, Weber-Carstens, Steffen, Brodie, Daniel, Azoulay, Elie, and Shimabukuro-Vornhagen, Alexander

Published
2022
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8. Handoffs in the intensive care unit

Author

Reifarth, Eyleen, primary, Naendrup, Jan-Hendrik, additional, Garcia Borrega, Jorge, additional, Altenrath, Lisa, additional, Shimabukuro-Vornhagen, Alexander, additional, Eichenauer, Dennis Alexander, additional, Kochanek, Matthias, additional, and Böll, Boris, additional

Published
2024
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9. Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Bazzalo, Ignacio J., Casas, Marcelo M., Nuñez, Sebastián A., Pere, Yael, Ibarrola, Carlos M., Solis Aramayo, Marco A., Cuesta, Maria C., Duarte, Andrea E., Gutierrez Fernandez, Pablo M., Iannantuono, Maria A., Miyazaki, Erica A., Silvio, Javier P., Scublinsky, Dario G., Bales, Alessandra, Catarino, Daniela, Fiss, Elie, Mohrbacher, Sara, Sato, Victor, Baylao, Antonio, Cavalcante, Adilson, Correa, Francini, de Andrade, Celso A., Furtado, Juvencio, Ribeiro Filho, Nelson, Telles, Valéria, Trevelin, Leopoldo T., Vipich, Ricardo, Boldo, Rodrigo, Borges, Paula, Lobo, Suzana, Luckemeyer, Graziela, Machado, Luana, Alves, Maysa B., Iglessias, Ana C., Lago, Marianna M., Santos, Daniel W., Chapdelaine, Hugo, Falcone, Emilia L., Jamal, Rahima, Luong, Me-Linh, Durand, Madeleine, Doucet, Stephane, Carrier, François-Martin, Coburn, Bryan A., Del Sorbo, Lorenzo, Walmsley, Sharon L., Belga, Sara, Chen, Luke Y., Mah, Allison D., Steiner, Theodore, Wright, Alissa J., Hajek, J., Adhikari, Neill, Fowler, Robert A., Daneman, Nick, Khwaja, Kosar A., Shahin, Jason, Gonzalez, Carolina, Silva, Rafael, Lindh, Marcelo, Maluenda, Gabriel, Fernandez, Patricia, Oyonarte, Maite, Lasso, Martin, Boyer, Alexandre, Bronnimann, Didier, Bui, Hoang-Nam, Cazanave, Charles, Chaussade, Helene, Desclaux, Arnaud, Ducours, Mailys, Duvignaud, Alexandre, Malvy, Denis, Martin, Lisa, Neau, Didier, Nguyen, Duc, Pistone, Thierry, Soubrane-Wirth, Gaetane, Leitao, Julie, Allavena, Clotilde, Biron, Charlotte, Bouchez, Sabelline, Gaborit, Benjamin, Gregoire, Antoine, Le Turnier, Paul, Lecompte, Anne-Sophie, Lecomte, Raphael, Lefebvre, Maeva, Raffi, Francois, Boutoille, David, Morineau, Pascale H., Guéry, Romain, Chatelus, Emmanuel, Dumoussaud, Nathalie, Felten, Renaud, Luca, Florina, Goichot, Bernard, Schneider, Francis, Taquet, Marie-Caroline, Groh, Matthieu, Roumier, Mathilde, Neuville, Mathilde, Bachelard, Antoine, Isernia, Valentina, Lescure, F-Xavier, Phung, Bao-Chau, Rachline, Anne, Sautereau, Aurelie, Vallois, Dorothee, Bleher, Yves, Boucher, Delphine, Coudon, Clémentine, Esnault, Jean, Guimard, Thomas, Leautez-Nainville, Sophie, Merrien, Dominique, Morrier, Marine, Motte-Vincent, Pauline, Gabeff, Romain, Leclerc, Hélène, Cozic, Céline, Decours, Romain, Février, Ronan, Colin, Gwenhael, Abgrall, Sophie, Vignes, Dorothee, Sterpu, Raluca, Kuellmar, Mira, Meersch-Dini, Melanie, Weiss, Raphael, Zarbock, Alexander, Antony, Christiane, Berger, Marc, Brenner, Thorsten, Taube, Christian, Herbstreit, Frank, Dolff, Sebastian, Konik, Margarethe, Schmidt, Karsten, Zettler, Markus, Witzke, Oliver, Boell, Boris, Garcia Borrega, Jorge, Koehler, Philipp, Zander, Thomas, Dusse, Fabian, Al-Sawaf, Othman, Köhler, Philipp, Eichenauer, Dennis, Kochanek, Matthias, Shimabukuro-Vornhagen, Alexander, Mellinghoff, Sibylle, Claßen, Annika, Heger, Jan-Michel, Meyer-Schwickerath, Charlotte, Liedgens, Paul, Heindel, Katrin, Belkin, Ana, Biber, Asaf, Gilboa, Mayan, Levy, Itzchak, Litachevsky, Vladislav, Rahav, Galia, Finesod Wiedner, Anat, Zilberman-Daniels, Tal, Oster, Yonatan, Strahilevitz, Jacob, Sviri, Sigal, Baldissera, Elena M., Campochiaro, Corrado, Cavalli, Giulio, Dagna, Lorenzo, De Luca, Giacomo, Della Torre, Emanuel, Tomelleri, Alessandro, Bernasconi De Luca, Davide, Capetti, Amedeo F., Coen, Massimo, Cossu, Maria V., Galli, Massimo, Giacomelli, Andrea, Gubertini, Guido A., Rusconi, Stefano, Burastero, Giulia J., Digaetano, Margherita, Guaraldi, Giovanni, Meschiari, Marianna, Mussini, Cristina, Puzzolante, Cinzia, Volpi, Sara, Aiello, Marina, Ariani, Alarico, Chetta, Alfredo A., Frizzelli, Annalisa, Ticinesi, Andrea, Tuttolomondo, Domenico, Aliberti, Stefano, Blasi, Francesco B., Di Pasquale, Marta F., Misuraca, Sofia, Pilocane, Tommaso, Simonetta, Edoardo, Aghelmo, Alessio M., Angelini, Claudio, Brunetta, Enrico, Canonica, Giorgio W., Ciccarelli, Michele, Dal Farra, Sara, De Santis, Maria, Ferri, Sebastian, Folci, Marco, Guidelli, Giacomo M., Heffler, Enrico M., Loiacono, Ferdinando, Malipiero, Giacomo, Paoletti, Giovanni, Pedale, Rosa, Puggioni, Francesca A., Racca, Francesca, Zumbo, Aurora, Satou, Morihiko, Honda, Hitoshi, Lisun, Tatyana, Protsenko, Denis, Rubtsov, Nikolay, Beloglazova, Irina, Fomina, Daria, Lysenko, Mariana, Serdotetskova, Sofia, Firstov, Vitali, Gordeev, Ivan, Kokorin, Ilia, Komissarova, Ksenia, Lapochkina, Nina, Luchinkina, Elena, Malimon, Valentin, Mamedguseyinova, Sevinch, Polubatonova, Ksenia, Suvorova, Natalia, Arribas, Jose, Borobia Perez, Alberto M., de la Calle Prieto, Fernando, Figueira, Juan Carlos, Motejano Sanchez, Rocio, Mora-Rillo, Marta, Prados Sanchez, Concepcion, Queiruga Parada, Javier, Fernandez Arnalich, Francisco, Guerro Barrientos, Maria, Bendala Estrada, Alejandro, Caballero Marcos, Aranzazu, Garcia Leoni, Maria E., García-Martínez, Rita, Collado, Ana María, Munoz Garcia, Patricia, Torres do Rego, Ana, Villalba García, María V., Burrillo, Almudena, Valerio Minero, Maricela, Gijon Vidaurreta, Paloma, Infante Herrero, Sonsoles, Velilla, Elena, Machado, Marina, Olmedo, Maria, Pinilla, Blanca, Almirante Gragera, Benito, Cañas Ruano, Maria de la Esperanza, Contreras Medina, Sofia, Cortés Herrera, Alejandro, Falcó Ferrer, Vicenç, Ferrer Roca, Ricard, Nuvials Casals, Xavier, Ribera Pascuet, Esteve, Suanzes Diez, Paula, Rebollo Castro, Pedro, Garcia Alcaide, Felipe, Soriano, Alejandro, Oliver Caldes, Aina, González Cordón, Ana, Cardozo, Celia, De la Mora Cañizo, Lorena, Pena López, Romina, Chamorro, Sandra, Crespillo-Andujar, Clara, Escudero Sanchez, Rosa, Fortún-Abete, Jesús, Monge-Maillo, Begoña, Moreno Zamora, Ana, Norman, Francesca, Sanchez Conde, Matilde, Serrano Villar, Sergio, Vizcarra, Pilar, Lescure, François-Xavier, Fowler, Robert A, Lazar, Jennifer Sloane, Shi, Genming, Wung, Peter, Patel, Naimish, and Hagino, Owen

Published
2021
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12. A diagnostic challenge—First case of chronic lymphatic leukemia‐associated necrotizing sweet syndrome.

Author

Neumann, Marie Anne‐Catherine, Nieper, Pascal, Simon, Florian, Shimabukuro‐Vornhagen, Alexander, Hallek, Michael, and Garcia Borrega, Jorge

Subjects
SWEET'S syndrome, NECROTIZING fasciitis, PYODERMA gangrenosum
Abstract

Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a rare disorder typically characterized by the clinical triad including a sudden onset of fever, painful skin lesions, and neutrophilia. The histopathological findings are a dense neutrophilic infiltrate and oedema of the dermis and epidermis without evidence of a vasculitis. Besides treatment of the underlying cause, sweet syndrome is typically treated with high‐dose corticosteroids leading to a relapse‐free response in 70% of patients. However, if left unrecognized or untreated, the condition may lead to serious complications. Here, we report on the case of a 38‐year‐old patient in whom, under the assumption of the presence of necrotizing fasciitis, exarticulation of the right arm was performed. In the absence of pathogen detection and insufficient response to anti‐infective therapies, the diagnosis of a sweet syndrome was assumed and, later, confirmed by an excellent response to high‐dose administration of systematic glucocorticoids. The case emphasizes the need to be aware of this rare syndrome, which can be easily misdiagnosed due to its close resemblance to infection and stresses the need of further research to define distinct diagnostic tools. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Airway Pressure Release Ventilation in COVID-19-Associated Acute Respiratory Distress Syndrome—A Multicenter Propensity Score–Matched Analysis.

Author

Naendrup, Jan-Hendrik, Steinke, Jonathan, Garcia Borrega, Jorge, Stoll, Sandra Emily, Michelsen, Per Ole, Assion, Yannick, Shimabukuro-Vornhagen, Alexander, Eichenauer, Dennis Alexander, Kochanek, Matthias, and Böll, Boris

Subjects
ADULT respiratory distress syndrome, COVID-19, VENTILATION, INTENSIVE care units, CRITICAL care medicine
Abstract

Background: There are limited and partially contradictory data on the effects of airway pressure release ventilation (APRV) in COVID-19-associated acute respiratory distress syndrome (CARDS). Therefore, we analyzed the clinical outcome, complications, and longitudinal course of ventilation parameters and laboratory values in patients with CARDS, who were mechanically ventilated using APRV. Methods: Respective data from 4 intensive care units (ICUs) were collected and compared to a matched cohort of patients receiving conventional low tidal volume ventilation (LTV). Propensity score matching was performed based on age, sex, blood gas analysis, and APACHE II score at admission, as well as the implementation of prone positioning. Findings: Forty patients with CARDS, who were mechanically ventilated using APRV, and 40 patients receiving LTV were matched. No significant differences were detected for tidal volumes per predicted body weight, peak pressure values, and blood gas analyses on admission, 6 h post admission as well as on day 3 and day 7. Regarding ICU survival, no significant difference was identified between APRV patients (40%) and LTV patients (42%). Median duration of mechanical ventilation and duration of ICU treatment were comparable in both groups. Similar complication rates with respect to ventilator-associated pneumonia, septic shock, thromboembolic events, barotrauma, as well as the necessity for hemodialysis were detected for both groups. Clinical characteristics that were associated with increased mortality in a Cox proportional hazards regression analysis included age (hazard ratio [HR] 1.08, 95% confidence interval [CI] 1.04-1.1; P <.001), severe acute respiratory distress syndrome (HR 2.62, 95% CI 1.02-6.7; P =.046) and the occurrence of septic shock (HR 17.18, 95% CI 2.06-143.2; P =.009), but not the ventilation mode. Interpretation: Intensive care unit survival, duration of mechanical ventilation, and ICU treatment as well as ventilation-associated complication rates were equivalent using APRV compared to conventional LTV in patients with CARDS. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Figure S2 from CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses

Author

Wennhold, Kerstin, primary, Thelen, Martin, primary, Lehmann, Jonas, primary, Schran, Simon, primary, Preugszat, Ella, primary, Garcia-Marquez, Maria, primary, Lechner, Axel, primary, Shimabukuro-Vornhagen, Alexander, primary, Ercanoglu, Meryem S., primary, Klein, Florian, primary, Thangarajah, Fabinshy, primary, Eidt, Sebastian, primary, Löser, Heike, primary, Bruns, Christiane, primary, Quaas, Alexander, primary, von Bergwelt-Baildon, Michael, primary, and Schlößer, Hans A., primary

Published
2023
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18. Table S1 from CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses

Author

Wennhold, Kerstin, primary, Thelen, Martin, primary, Lehmann, Jonas, primary, Schran, Simon, primary, Preugszat, Ella, primary, Garcia-Marquez, Maria, primary, Lechner, Axel, primary, Shimabukuro-Vornhagen, Alexander, primary, Ercanoglu, Meryem S., primary, Klein, Florian, primary, Thangarajah, Fabinshy, primary, Eidt, Sebastian, primary, Löser, Heike, primary, Bruns, Christiane, primary, Quaas, Alexander, primary, von Bergwelt-Baildon, Michael, primary, and Schlößer, Hans A., primary

Published
2023
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19. Data from CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses

Author

Wennhold, Kerstin, primary, Thelen, Martin, primary, Lehmann, Jonas, primary, Schran, Simon, primary, Preugszat, Ella, primary, Garcia-Marquez, Maria, primary, Lechner, Axel, primary, Shimabukuro-Vornhagen, Alexander, primary, Ercanoglu, Meryem S., primary, Klein, Florian, primary, Thangarajah, Fabinshy, primary, Eidt, Sebastian, primary, Löser, Heike, primary, Bruns, Christiane, primary, Quaas, Alexander, primary, von Bergwelt-Baildon, Michael, primary, and Schlößer, Hans A., primary

Published
2023
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20. Data from Using Antigen-Specific B Cells to Combine Antibody and T Cell–Based Cancer Immunotherapy

Author

Wennhold, Kerstin, primary, Thelen, Martin, primary, Schlößer, Hans Anton, primary, Haustein, Natalie, primary, Reuter, Sabrina, primary, Garcia-Marquez, Maria, primary, Lechner, Axel, primary, Kobold, Sebastian, primary, Rataj, Felicitas, primary, Utermöhlen, Olaf, primary, Chakupurakal, Geothy, primary, Theurich, Sebastian, primary, Hallek, Michael, primary, Abken, Hinrich, primary, Shimabukuro-Vornhagen, Alexander, primary, and von Bergwelt-Baildon, Michael, primary

Published
2023
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21. Supplementary Figures 1-8 from Using Antigen-Specific B Cells to Combine Antibody and T Cell–Based Cancer Immunotherapy

Author

Wennhold, Kerstin, primary, Thelen, Martin, primary, Schlößer, Hans Anton, primary, Haustein, Natalie, primary, Reuter, Sabrina, primary, Garcia-Marquez, Maria, primary, Lechner, Axel, primary, Kobold, Sebastian, primary, Rataj, Felicitas, primary, Utermöhlen, Olaf, primary, Chakupurakal, Geothy, primary, Theurich, Sebastian, primary, Hallek, Michael, primary, Abken, Hinrich, primary, Shimabukuro-Vornhagen, Alexander, primary, and von Bergwelt-Baildon, Michael, primary

Published
2023
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22. Adressen

Author

Lehmann, Clara, primary, Ruf, Bernhard R., additional, Jung, Norma, additional, Böll, Boris, additional, Boesecke, Christoph, additional, Breuninger, Marianne, additional, Cornely, Oliver A., additional, Draenert, Rika, additional, Graeff, Luisa Durán, additional, Fätkenheuer, Gerd, additional, Fischer, Julia, additional, Gielen, Jörg, additional, Gillor, Daniel, additional, Glück, Thomas, additional, Grajewski, Rafael S., additional, Gruell, Henning, additional, Hagel, Stefan, additional, Hamacher, Laura, additional, Hamprecht, Axel, additional, Hanses, Frank, additional, Hitzenbichler, Florian, additional, Huth, Alexandra, additional, Jansen, Stefanie, additional, Jazmati, Nathalie, additional, Kaasch, Achim J., additional, Kastenbauer, Ulrich, additional, Kochanek, Matthias, additional, Köhler, Carsten, additional, Köhler, Philipp, additional, Lehmann, Helmar C., additional, Lehmann, Lorenz H., additional, Lichtenstein, Thorsten, additional, Lüers, Jan-Christoffer, additional, Meller, Stephan, additional, Metzger, Wolfram, additional, Nierhoff, Dirk, additional, Otto-Lambertz, Christina, additional, Platten, Martin, additional, Reuter, Stefan, additional, Rieg, Siegbert, additional, Roehr, Philipp, additional, Rybniker, Jan, additional, Schlaak, Max, additional, Schmiedel, Stefan, additional, Schulze zur Wiesch, Julian, additional, Schwarze-Zander, Carolynne, additional, Seybold, Ulrich, additional, Shimabukuro-Vornhagen, Alexander, additional, Spinner, Christoph D., additional, Sprenger, Alina, additional, Stephan, Christoph, additional, Suárez, Isabelle, additional, Vehreschild, Jörg Janne, additional, Vehreschild, Maria, additional, Wassilew, Nasstasja, additional, Wieland, Ulrike, additional, Witzke, Oliver, additional, and Wolf, Timo, additional

Published
2018
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23. Prognostic accuracy of SOFA, qSOFA and SIRS criteria in hematological cancer patients: a retrospective multicenter study

Author

Probst, Lucie, Schalk, Enrico, Liebregts, Tobias, Zeremski, Vanja, Tzalavras, Asterios, von Bergwelt-Baildon, Michael, Hesse, Nina, Prinz, Johanna, Vehreschild, Jörg Janne, Shimabukuro-Vornhagen, Alexander, Eichenauer, Dennis A., Garcia Borrega, Jorge, Kochanek, Matthias, Böll, Boris, and for the Working Party on Intensive Care Medicine in Hematologic and Oncologic Patients (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO)

Published
2019
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25. Characteristics and outcomes of patients undergoing high-dose chemotherapy and autologous stem cell transplantation admitted to the intensive care unit: a single-center retrospective analysis

Author

Garcia Borrega, Jorge, primary, Böll, Boris, additional, Kochanek, Matthias, additional, Naendrup, Jan-Hendrik, additional, Simon, Florian, additional, Sieg, Noelle, additional, Hallek, Michael, additional, Borchmann, Peter, additional, Holtick, Udo, additional, Shimabukuro-Vornhagen, Alexander, additional, Eichenauer, Dennis A., additional, and Heger, Jan-Michel, additional

Published
2022
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27. Reactivation of EBV and CMV in Severe COVID-19—Epiphenomena or Trigger of Hyperinflammation in Need of Treatment? A Large Case Series of Critically ill Patients

Author

Eichenauer Dennis Alexander, Shimabukuro-Vornhagen Alexander, Garcia Borrega Jorge, Jan-Hendrik Naendrup, Böll Boris, and Kochanek Matthias

Subjects
Ganciclovir, Epstein-Barr Virus Infections, Herpesvirus 4, Human, medicine.medical_specialty, ARDS, Critical Illness, Congenital cytomegalovirus infection, Cytomegalovirus, Critical Care and Intensive Care Medicine, law.invention, Cohort Studies, Sepsis, law, Internal medicine, medicine, Humans, Retrospective Studies, business.industry, COVID-19, medicine.disease, Intensive care unit, Cytomegalovirus Infections, Virus Activation, Rituximab, business, Viral load, Cohort study, medicine.drug
Abstract

Background Reactivation of viruses such as Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are common in critically ill patients and have been described in patients with severe COVID-19. However, it is unclear whether these reactivations are associated with increased mortality and whether targeted treatments are beneficial. Methods In a retrospective single-center cohort study, patients with severe COVID-19 treated on our intensive care unit (ICU) were screened for EBV and CMV reactivation as detected by polymerase chain reaction. If present, patient characteristics, temporal connections to severe acute respiratory syndrome coronavirus 2 diagnosis and corticosteroid use, the use of targeted treatments as well as the course of disease and outcome were analyzed. As control group, non-COVID-19 patients with sepsis, treated within the same time period on our ICU, served as control group to compare incidences of viral reactivation. Results In 19 (16%) of 117 patients with severe COVID-19 treated on our ICU EBV reactivations were identified, comparable 18 (14%) of 126 in the non-COVID-19 control group ( P = .672). Similarly, in 11 (9%) of 117 patients CMV reactivations were identified, comparable to the 16 (13%) of 126 in the non-COVID-19 sepsis patients ( P = .296). The majority of EBV (58%) and CMV reactivations (55%) were detected in patients under systemic corticosteroid treatment. 7 (37%) of 19 patients with EBV reactivation survived the ICU stay, 2 (29%) of 7 patients with rituximab treatment and 5 (42%) of 12 patients without treatment ( P = .568). Five (50%) of 10 patients with CMV reactivation survived the ICU stay, 5 (83%) of 6 patients with ganciclovir treatment and 0 of 4 patients without treatment ( P = .048). Follow-up analysis in these patients showed that the initiation of treatment lead to decrease in viral load. Conclusion Critically ill patients with COVID-19 are at a high risk for EBV and CMV reactivations. Whether these reactivations are a cause of hyperinflammation and require targeted treatment remains uncertain. However, in patients with clinical deterioration or signs of hyperinflammation targeted treatment might be beneficial and warrants further studying.

Published
2021

29. Teamspezifische Auswirkungen der Corona-Pandemie auf Mitarbeiter:innen der Internistischen Intensivmedizin eines Krankenhauses der Maximalversorgung

Author

Wolff, Jochen, primary, Becker, Jürgen, additional, Naendrup, Jan-Hendrik, additional, Borrega, Jorge Garcia, additional, Heger, Jan-Michel, additional, Hamacher, Laura, additional, Böll, Boris, additional, Eichenauer, Dennis A., additional, Shimabukuro-Vornhagen, Alexander, additional, and Kochanek, Matthias, additional

Published
2022
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31. Cytokine release syndrome

Author

Shimabukuro-Vornhagen, Alexander, Gödel, Philipp, Subklewe, Marion, Stemmler, Hans Joachim, Schlößer, Hans Anton, Schlaak, Max, Kochanek, Matthias, Böll, Boris, and von Bergwelt-Baildon, Michael S.

Published
2018
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33. Aspergillus tracheobronchitis in COVID-19 patients with acute respiratory distress syndrome: a cohort study

Author

Koehler, Philipp, von Stillfried, Saskia, Garcia Borrega, Jorge, Fuchs, Frieder, Salmanton-García, Jon, Pult, Fabian, Böll, Boris, Eichenauer, Dennis A., Shimabukuro-Vornhagen, Alexander, Kurzai, Oliver, Boor, Peter, Kochanek, Matthias, and Cornely, Oliver A.

Abstract

The European respiratory journal 59(5), 2103142 (2022). doi:10.1183/13993003.03142-2021, Published by ERS, Lausanne

Published
2022

35. Aspergillus tracheobronchitis in COVID-19 ARDS patients – a cohort study

Author

Koehler, Philipp, primary, von Stillfried, Saskia, additional, Garcia Borrega, Jorge, additional, Fuchs, Frieder, additional, Salmanton-García, Jon, additional, Pult, Fabian, additional, Böll, Boris, additional, Eichenauer, Dennis A., additional, Shimabukuro-Vornhagen, Alexander, additional, Kurzai, Oliver, additional, Boor, Peter, additional, Kochanek, Matthias, additional, and Cornely, Oliver A., additional

Published
2022
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37. Allogeneic stem cell transplant recipients admitted to the intensive care unit during the peri-transplant period have unfavorable outcomes—results of a retrospective analysis from a German university hospital

Author

Garcia Borrega, Jorge, primary, Heger, Jan-Michel, additional, Koehler, Philipp, additional, Holtick, Udo, additional, Hallek, Michael, additional, Scheid, Christof, additional, Böll, Boris, additional, Shimabukuro-Vornhagen, Alexander, additional, Kochanek, Matthias, additional, and Eichenauer, Dennis A., additional

Published
2021
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42. OCTET-CY: a phase II study to investigate the efficacy of post-transplant cyclophosphamide as sole graft-versus-host prophylaxis after allogeneic peripheral blood stem cell transplantation

Author

Holtick, Udo, Chemnitz, Jens-Markus, Shimabukuro-Vornhagen, Alexander, Theurich, Sebastian, Chakupurakal, Geothy, Krause, Anke, Fiedler, Anne, Luznik, Leo, Hellmich, Martin, Wolf, Dominik, Hallek, Michael, von Bergwelt-Baildon, Michael, and Scheid, Christof

Published
2016
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43. Clinical Course and Outcome of Patients with SARS-CoV-2 Alpha Variant Infection Compared to Patients with SARS-CoV-2 Wild-Type Infection Admitted to the ICU

Author

Garcia Borrega, Jorge, primary, Naendrup, Jan-Hendrik, additional, Heindel, Katrin, additional, Hamacher, Laura, additional, Heger, Eva, additional, Di Cristanziano, Veronica, additional, Deppe, Antje-Christin, additional, Dusse, Fabian, additional, Wetsch, Wolfgang Alois, additional, Eichenauer, Dennis Alexander, additional, Shimabukuro-Vornhagen, Alexander, additional, Böll, Boris, additional, and Kochanek, Matthias, additional

Published
2021
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44. Update 2021: COVID-19 aus Sicht der Intensivmedizin

Author

Stecher, Stephanie-Susanne, additional, Stemmler, Hans Joachim, additional, Eichenauer, Dennis A., additional, Kochanek, Matthias, additional, Shimabukuro-Vornhagen, Alexander, additional, von Bergwelt-Baildon, Michael, additional, and Böll, Boris, additional

Published
2021
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46. Reactivation of EBV and CMV in Severe COVID-19--Epiphenomena or Trigger of Hyperinflammation in Need of Treatment? A Large Case Series of Critically ill Patients.

Author

Naendrup, Jan-Hendrik, Garcia Borrega, Jorge, Eichenauer, Dennis Alexander, Shimabukuro-Vornhagen, Alexander, Kochanek, Matthias, and Böll, Boris

Subjects
EPSTEIN-Barr virus, CYTOMEGALOVIRUSES, CORONAVIRUS diseases, INTENSIVE care units, SARS disease, CRITICALLY ill
Abstract

Background: Reactivation of viruses such as Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are common in critically ill patients and have been described in patients with severe COVID-19. However, it is unclear whether these reactivations are associated with increased mortality and whether targeted treatments are beneficial. Methods: In a retrospective single-center cohort study, patients with severe COVID-19 treated on our intensive care unit (ICU) were screened for EBV and CMV reactivation as detected by polymerase chain reaction. If present, patient characteristics, temporal connections to severe acute respiratory syndrome coronavirus 2 diagnosis and corticosteroid use, the use of targeted treatments as well as the course of disease and outcome were analyzed. As control group, non-COVID-19 patients with sepsis, treated within the same time period on our ICU, served as control group to compare incidences of viral reactivation. Results: In 19 (16%) of 117 patients with severe COVID-19 treated on our ICU EBV reactivations were identified, comparable 18 (14%) of 126 in the non-COVID-19 control group (P=.672). Similarly, in 11 (9%) of 117 patients CMV reactivations were identified, comparable to the 16 (13%) of 126 in the non-COVID-19 sepsis patients (P=.296). The majority of EBV (58%) and CMV reactivations (55%) were detected in patients under systemic corticosteroid treatment. 7 (37%) of 19 patients with EBV reactivation survived the ICU stay, 2 (29%) of 7 patients with rituximab treatment and 5 (42%) of 12 patients without treatment (P=.568). Five (50%) of 10 patients with CMV reactivation survived the ICU stay, 5 (83%) of 6 patients with ganciclovir treatment and 0 of 4 patients without treatment (P=.048). Follow-up analysis in these patients showed that the initiation of treatment lead to decrease in viral load. Conclusion: Critically ill patients with COVID-19 are at a high risk for EBV and CMV reactivations. Whether these reactivations are a cause of hyperinflammation and require targeted treatment remains uncertain. However, in patients with clinical deterioration or signs of hyperinflammation targeted treatment might be beneficial and warrants further studying. [ABSTRACT FROM AUTHOR]

Published
2022
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48. CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses

Author

Wennhold, Kerstin, primary, Thelen, Martin, additional, Lehmann, Jonas, additional, Schran, Simon, additional, Preugszat, Ella, additional, Garcia-Marquez, Maria, additional, Lechner, Axel, additional, Shimabukuro-Vornhagen, Alexander, additional, Ercanoglu, Meryem S., additional, Klein, Florian, additional, Thangarajah, Fabinshy, additional, Eidt, Sebastian, additional, Löser, Heike, additional, Bruns, Christiane, additional, Quaas, Alexander, additional, von Bergwelt-Baildon, Michael, additional, and Schlößer, Hans A., additional

Published
2021
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50. Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Lescure, François-Xavier, primary, Honda, Hitoshi, additional, Fowler, Robert A, additional, Lazar, Jennifer Sloane, additional, Shi, Genming, additional, Wung, Peter, additional, Patel, Naimish, additional, Hagino, Owen, additional, Bazzalo, Ignacio J., additional, Casas, Marcelo M., additional, Nuñez, Sebastián A., additional, Pere, Yael, additional, Ibarrola, Carlos M., additional, Solis Aramayo, Marco A., additional, Cuesta, Maria C., additional, Duarte, Andrea E., additional, Gutierrez Fernandez, Pablo M., additional, Iannantuono, Maria A., additional, Miyazaki, Erica A., additional, Silvio, Javier P., additional, Scublinsky, Dario G., additional, Bales, Alessandra, additional, Catarino, Daniela, additional, Fiss, Elie, additional, Mohrbacher, Sara, additional, Sato, Victor, additional, Baylao, Antonio, additional, Cavalcante, Adilson, additional, Correa, Francini, additional, de Andrade, Celso A., additional, Furtado, Juvencio, additional, Ribeiro Filho, Nelson, additional, Telles, Valéria, additional, Trevelin, Leopoldo T., additional, Vipich, Ricardo, additional, Boldo, Rodrigo, additional, Borges, Paula, additional, Lobo, Suzana, additional, Luckemeyer, Graziela, additional, Machado, Luana, additional, Alves, Maysa B., additional, Iglessias, Ana C., additional, Lago, Marianna M., additional, Santos, Daniel W., additional, Chapdelaine, Hugo, additional, Falcone, Emilia L., additional, Jamal, Rahima, additional, Luong, Me-Linh, additional, Durand, Madeleine, additional, Doucet, Stephane, additional, Carrier, François-Martin, additional, Coburn, Bryan A., additional, Del Sorbo, Lorenzo, additional, Walmsley, Sharon L., additional, Belga, Sara, additional, Chen, Luke Y., additional, Mah, Allison D., additional, Steiner, Theodore, additional, Wright, Alissa J., additional, Hajek, J., additional, Adhikari, Neill, additional, Fowler, Robert A., additional, Daneman, Nick, additional, Khwaja, Kosar A., additional, Shahin, Jason, additional, Gonzalez, Carolina, additional, Silva, Rafael, additional, Lindh, Marcelo, additional, Maluenda, Gabriel, additional, Fernandez, Patricia, additional, Oyonarte, Maite, additional, Lasso, Martin, additional, Boyer, Alexandre, additional, Bronnimann, Didier, additional, Bui, Hoang-Nam, additional, Cazanave, Charles, additional, Chaussade, Helene, additional, Desclaux, Arnaud, additional, Ducours, Mailys, additional, Duvignaud, Alexandre, additional, Malvy, Denis, additional, Martin, Lisa, additional, Neau, Didier, additional, Nguyen, Duc, additional, Pistone, Thierry, additional, Soubrane-Wirth, Gaetane, additional, Leitao, Julie, additional, Allavena, Clotilde, additional, Biron, Charlotte, additional, Bouchez, Sabelline, additional, Gaborit, Benjamin, additional, Gregoire, Antoine, additional, Le Turnier, Paul, additional, Lecompte, Anne-Sophie, additional, Lecomte, Raphael, additional, Lefebvre, Maeva, additional, Raffi, Francois, additional, Boutoille, David, additional, Morineau, Pascale H., additional, Guéry, Romain, additional, Chatelus, Emmanuel, additional, Dumoussaud, Nathalie, additional, Felten, Renaud, additional, Luca, Florina, additional, Goichot, Bernard, additional, Schneider, Francis, additional, Taquet, Marie-Caroline, additional, Groh, Matthieu, additional, Roumier, Mathilde, additional, Neuville, Mathilde, additional, Bachelard, Antoine, additional, Isernia, Valentina, additional, Lescure, F-Xavier, additional, Phung, Bao-Chau, additional, Rachline, Anne, additional, Sautereau, Aurelie, additional, Vallois, Dorothee, additional, Bleher, Yves, additional, Boucher, Delphine, additional, Coudon, Clémentine, additional, Esnault, Jean, additional, Guimard, Thomas, additional, Leautez-Nainville, Sophie, additional, Merrien, Dominique, additional, Morrier, Marine, additional, Motte-Vincent, Pauline, additional, Gabeff, Romain, additional, Leclerc, Hélène, additional, Cozic, Céline, additional, Decours, Romain, additional, Février, Ronan, additional, Colin, Gwenhael, additional, Abgrall, Sophie, additional, Vignes, Dorothee, additional, Sterpu, Raluca, additional, Kuellmar, Mira, additional, Meersch-Dini, Melanie, additional, Weiss, Raphael, additional, Zarbock, Alexander, additional, Antony, Christiane, additional, Berger, Marc, additional, Brenner, Thorsten, additional, Taube, Christian, additional, Herbstreit, Frank, additional, Dolff, Sebastian, additional, Konik, Margarethe, additional, Schmidt, Karsten, additional, Zettler, Markus, additional, Witzke, Oliver, additional, Boell, Boris, additional, Garcia Borrega, Jorge, additional, Koehler, Philipp, additional, Zander, Thomas, additional, Dusse, Fabian, additional, Al-Sawaf, Othman, additional, Köhler, Philipp, additional, Eichenauer, Dennis, additional, Kochanek, Matthias, additional, Shimabukuro-Vornhagen, Alexander, additional, Mellinghoff, Sibylle, additional, Claßen, Annika, additional, Heger, Jan-Michel, additional, Meyer-Schwickerath, Charlotte, additional, Liedgens, Paul, additional, Heindel, Katrin, additional, Belkin, Ana, additional, Biber, Asaf, additional, Gilboa, Mayan, additional, Levy, Itzchak, additional, Litachevsky, Vladislav, additional, Rahav, Galia, additional, Finesod Wiedner, Anat, additional, Zilberman-Daniels, Tal, additional, Oster, Yonatan, additional, Strahilevitz, Jacob, additional, Sviri, Sigal, additional, Baldissera, Elena M., additional, Campochiaro, Corrado, additional, Cavalli, Giulio, additional, Dagna, Lorenzo, additional, De Luca, Giacomo, additional, Della Torre, Emanuel, additional, Tomelleri, Alessandro, additional, Bernasconi De Luca, Davide, additional, Capetti, Amedeo F., additional, Coen, Massimo, additional, Cossu, Maria V., additional, Galli, Massimo, additional, Giacomelli, Andrea, additional, Gubertini, Guido A., additional, Rusconi, Stefano, additional, Burastero, Giulia J., additional, Digaetano, Margherita, additional, Guaraldi, Giovanni, additional, Meschiari, Marianna, additional, Mussini, Cristina, additional, Puzzolante, Cinzia, additional, Volpi, Sara, additional, Aiello, Marina, additional, Ariani, Alarico, additional, Chetta, Alfredo A., additional, Frizzelli, Annalisa, additional, Ticinesi, Andrea, additional, Tuttolomondo, Domenico, additional, Aliberti, Stefano, additional, Blasi, Francesco B., additional, Di Pasquale, Marta F., additional, Misuraca, Sofia, additional, Pilocane, Tommaso, additional, Simonetta, Edoardo, additional, Aghelmo, Alessio M., additional, Angelini, Claudio, additional, Brunetta, Enrico, additional, Canonica, Giorgio W., additional, Ciccarelli, Michele, additional, Dal Farra, Sara, additional, De Santis, Maria, additional, Ferri, Sebastian, additional, Folci, Marco, additional, Guidelli, Giacomo M., additional, Heffler, Enrico M., additional, Loiacono, Ferdinando, additional, Malipiero, Giacomo, additional, Paoletti, Giovanni, additional, Pedale, Rosa, additional, Puggioni, Francesca A., additional, Racca, Francesca, additional, Zumbo, Aurora, additional, Satou, Morihiko, additional, Lisun, Tatyana, additional, Protsenko, Denis, additional, Rubtsov, Nikolay, additional, Beloglazova, Irina, additional, Fomina, Daria, additional, Lysenko, Mariana, additional, Serdotetskova, Sofia, additional, Firstov, Vitali, additional, Gordeev, Ivan, additional, Kokorin, Ilia, additional, Komissarova, Ksenia, additional, Lapochkina, Nina, additional, Luchinkina, Elena, additional, Malimon, Valentin, additional, Mamedguseyinova, Sevinch, additional, Polubatonova, Ksenia, additional, Suvorova, Natalia, additional, Arribas, Jose, additional, Borobia Perez, Alberto M., additional, de la Calle Prieto, Fernando, additional, Figueira, Juan Carlos, additional, Motejano Sanchez, Rocio, additional, Mora-Rillo, Marta, additional, Prados Sanchez, Concepcion, additional, Queiruga Parada, Javier, additional, Fernandez Arnalich, Francisco, additional, Guerro Barrientos, Maria, additional, Bendala Estrada, Alejandro, additional, Caballero Marcos, Aranzazu, additional, Garcia Leoni, Maria E., additional, García-Martínez, Rita, additional, Collado, Ana María, additional, Munoz Garcia, Patricia, additional, Torres do Rego, Ana, additional, Villalba García, María V., additional, Burrillo, Almudena, additional, Valerio Minero, Maricela, additional, Gijon Vidaurreta, Paloma, additional, Infante Herrero, Sonsoles, additional, Velilla, Elena, additional, Machado, Marina, additional, Olmedo, Maria, additional, Pinilla, Blanca, additional, Almirante Gragera, Benito, additional, Cañas Ruano, Maria de la Esperanza, additional, Contreras Medina, Sofia, additional, Cortés Herrera, Alejandro, additional, Falcó Ferrer, Vicenç, additional, Ferrer Roca, Ricard, additional, Nuvials Casals, Xavier, additional, Ribera Pascuet, Esteve, additional, Suanzes Diez, Paula, additional, Rebollo Castro, Pedro, additional, Garcia Alcaide, Felipe, additional, Soriano, Alejandro, additional, Oliver Caldes, Aina, additional, González Cordón, Ana, additional, Cardozo, Celia, additional, De la Mora Cañizo, Lorena, additional, Pena López, Romina, additional, Chamorro, Sandra, additional, Crespillo-Andujar, Clara, additional, Escudero Sanchez, Rosa, additional, Fortún-Abete, Jesús, additional, Monge-Maillo, Begoña, additional, Moreno Zamora, Ana, additional, Norman, Francesca, additional, Sanchez Conde, Matilde, additional, Serrano Villar, Sergio, additional, and Vizcarra, Pilar, additional

Published
2021
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