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296 results on '"Shimada, Yuki"'

2. Tumor-associated neutrophils upregulate Nectin2 expression, creating the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

Author

Luo, Haizhen, Ikenaga, Naoki, Nakata, Kohei, Higashijima, Nobuhiro, Zhong, Pingshan, Kubo, Akihiro, Wu, Chenyi, Tsutsumi, Chikanori, Shimada, Yuki, Hayashi, Masataka, Oyama, Koki, Date, Satomi, Abe, Toshiya, Ideno, Noboru, Iwamoto, Chika, Shindo, Koji, Ohuchida, Kenoki, Oda, Yoshinao, and Nakamura, Masafumi

Published
2024
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3. Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis

Author

Okuda, Kosaku, Nakahara, Kengo, Ito, Akihiro, Iijima, Yuta, Nomura, Ryosuke, Kumar, Ashutosh, Fujikawa, Kana, Adachi, Kazuya, Shimada, Yuki, Fujio, Satoshi, Yamamoto, Reina, Takasugi, Nobumasa, Onuma, Kunishige, Osaki, Mitsuhiko, Okada, Futoshi, Ukegawa, Taichi, Takeuchi, Yasuo, Yasui, Norihisa, Yamashita, Atsuko, Marusawa, Hiroyuki, Matsushita, Yosuke, Katagiri, Toyomasa, Shibata, Takahiro, Uchida, Koji, Niu, Sheng-Yong, Lang, Nhi B, Nakamura, Tomohiro, Zhang, Kam YJ, Lipton, Stuart A, and Uehara, Takashi

Subjects
Biological Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Genetics, Cancer, Digestive Diseases, Prevention, Aetiology, 2.1 Biological and endogenous factors, Animals, Humans, Mice, Cell Transformation, Neoplastic, DNA (Cytosine-5-)-Methyltransferase 1, DNA (Cytosine-5-)-Methyltransferases, DNA Methylation, DNA Modification Methylases, Epigenesis, Genetic
Abstract

DNA methyltransferases (DNMTs) catalyze methylation at the C5 position of cytosine with S-adenosyl-L-methionine. Methylation regulates gene expression, serving a variety of physiological and pathophysiological roles. The chemical mechanisms regulating DNMT enzymatic activity, however, are not fully elucidated. Here, we show that protein S-nitrosylation of a cysteine residue in DNMT3B attenuates DNMT3B enzymatic activity and consequent aberrant upregulation of gene expression. These genes include Cyclin D2 (Ccnd2), which is required for neoplastic cell proliferation in some tumor types. In cell-based and in vivo cancer models, only DNMT3B enzymatic activity, and not DNMT1 or DNMT3A, affects Ccnd2 expression. Using structure-based virtual screening, we discovered chemical compounds that specifically inhibit S-nitrosylation without directly affecting DNMT3B enzymatic activity. The lead compound, designated DBIC, inhibits S-nitrosylation of DNMT3B at low concentrations (IC50 ≤ 100 nM). Treatment with DBIC prevents nitric oxide (NO)-induced conversion of human colonic adenoma to adenocarcinoma in vitro. Additionally, in vivo treatment with DBIC strongly attenuates tumor development in a mouse model of carcinogenesis triggered by inflammation-induced generation of NO. Our results demonstrate that de novo DNA methylation mediated by DNMT3B is regulated by NO, and DBIC protects against tumor formation by preventing aberrant S-nitrosylation of DNMT3B.

Published
2023

7. Higher Frequency of Premature Atrial Contractions Correlates With Atrial Fibrillation Detection after Cryptogenic Stroke

Author

Shimada, Yuki, Todo, Kenichi, Doijiri, Ryosuke, Yamazaki, Hidekazu, Sonoda, Kazutaka, Koge, Junpei, Iwata, Tomonori, Ueno, Yuji, Yamagami, Hiroshi, Kimura, Naoto, Morimoto, Masafumi, Kondo, Daisuke, Koga, Masatoshi, Nagata, Eiichiro, Miyamoto, Nobukazu, Kimura, Yoko, Gon, Yasufumi, Okazaki, Shuhei, Sasaki, Tsutomu, Mochizuki, Hideki, Sugiyama, Shintaro, Ohara, Mariko, Ikegami, Takeshi, Wadayama, Tomoya, Murakami, Yasutaka, Sakurai, Rei, Moriyama, Takuya, Oi, Kiyotaka, Ikenouchi, Hajime, Yamaguchi, Eriko, Egashira, Shuhei, Takizawa, Shunya, Honma, Kazunari, Nakayama, Taira, Kadokura, Ayana, Hanano, Hideyuki, and Yamamoto, Shiro

Published
2024
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10. Transcriptome Analysis Identified SPP1+ Monocytes as a Key in Extracellular Matrix Formation in Thrombi

Author

Kitano, Takaya, primary, Sasaki, Tsutomu, additional, Matsui, Takahiro, additional, Kohara, Masaharu, additional, Ogawa, Kotaro, additional, Todo, Kenichi, additional, Nakamura, Hajime, additional, Sugiura, Yuri, additional, Shimada, Yuki, additional, Okazaki, Shuhei, additional, Iida, Junichi, additional, Shimazu, Kohki, additional, Morii, Eiichi, additional, Sakaguchi, Manabu, additional, Nishio, Masami, additional, Yokoe, Masaru, additional, Kishima, Haruhiko, additional, and Mochizuki, Hideki, additional

Published
2024
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11. Mobile Spatial Statistics Key to Enhancing Healthcare Planning in Futaba County with Complex Population Flows after the Great East Japan Earthquake

Author

Higuchi, Asaka, primary, Yoshimura, Hiroki, additional, Saito, Hiroaki, additional, Abe, Toshiki, additional, Murakami, Michio, additional, Zhao, Tianchen, additional, Amir, Isamu, additional, Ito, Naomi, additional, Yamamoto, Chika, additional, Nonaka, Saori, additional, Sawano, Toyoaki, additional, Shimada, Yuki, additional, Ozaki, Akihiko, additional, Oikawa, Tomoyoshi, additional, and Tsubokura, Masaharu, additional

Published
2024
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13. Anisotropic B-T Phase Diagram of Non-Kramers System PrRh2Zn20

Author

Yoshida, Taichi, Machida, Yo, Izawa, Koichi, Shimada, Yuki, Nagasawa, Naohiro, Onimaru, Takahiro, Takabatake, Toshiro, Gourgout, Adrien, Pourret, Alexandre, Knebel, Georg, and Brison, Jean-Pascal

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We have investigated the low temperature quadrupolar phenomena of the non-Kramers system PrRh2Zn20 under magnetic fields in the [100] and [110] directions. Our experiments reveal the B-T phase diagram of PrRh2Zn20 involving four electronic states regardless of the field direction, namely, a non-Fermi liquid (NFL) state, an antiferro-quadrupolar (AFQ) ordered state, a novel heavy-fermion (HF) state, and a field-induced singlet (FIS) state. In the wide range of the NFL state, the resistivity can be well scaled by a characteristic temperature, suggesting the realization of the quadrupole Kondo effect. The HF state exhibits a Fermi liquid behavior with a large A coefficient of the T^2 term in the resistivity, suggesting the formation of nontrivial heavy quasi-particles. The FIS state results from the considerable splitting of a non-Kramers doublet by a magnetic field. The phase diagram shows a large anisotropy with respect to the field direction. It is found that the anisotropy of the phase diagram can be explained in terms of that of the energy splitting of the non-Kramers doublet by a magnetic field. This indicates that the low temperature properties of PrRh2Zn20 are governed by the non-Kramers doublet, namely, quadrupole degrees of freedom. Since a similar phase diagram has been obtained for the related compound PrIr2Zn20, it is expected that the B-T phase diagram constructed in this work is universal throughout non-Kramers systems., Comment: to appear in Journal of the Physical Society of Japan

Published
2017
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15. Whole-body counter surveys of over 2700 babies and small children in and around Fukushima Prefecture 33 to 49 months after the Fukushima Daiichi NPP accident

Author

Hayano, Ryugo S., Tsubokura, Masaharu, Miyazaki, Makoto, Ozaki, Akihiko, Shimada, Yuki, Kambe, Toshiyuki, Nemoto, Tsuyoshi, Oikawa, Tomoyoshi, Kanazawa, Yukio, Nihei, Masahiko, Sakura, Yu, Shimmura, Hiroaki, Akiyama, Junichi, and Tokiwa, Michio

Subjects
Physics - Medical Physics
Abstract

BABYSCAN, a whole body counter (WBC) for small children was developed in 2013, and units have been installed at three hospitals in Fukushima Prefecture. Between December, 2013 and March, 2015, 2707 children between the ages of 0 and 11 have been scanned, and none had detectable levels of radioactive cesium. The minimum detectable activities (MDAs) for $^{137}$Cs were $\leq 3.5$ Bq kg$^{-1}$ for ages 0-1, decreasing to $\leq 2$ Bq kg$^{-1}$ for ages 10-11. Including the $^{134}$Cs contribution, these translate to a maximum committed effective dose of $\sim 16 \mu$Sv y$^{-1}$ even for newborn babies, and therefore the internal exposure risks can be considered negligibly small. Analysis of the questionnaire filled out by the parents of the scanned children regarding their families' food and water consumption revealed that the majority of children residing in the town of Miharu regularly consume local or home-grown rice and vegetables, while in Minamisoma, a majority avoid tap water and produce from Fukushima. The data show, however, no correlation between consumption of locally produced food and water and the children's body burdens., Comment: 8 pages, 7 figures, 1 table

Published
2015

19. A case of Adult-onset Acute Flaccid Myelitis Accompanied by Rhombencephalitis which First Presented with Prominent Psychiatric Symptoms and Dysautonomia Mimicking Anti-N-methyl-d-aspartate Receptor Encephalitis

Author

Sumikura, Hiroyuki, primary, Ito, Mai, additional, Sato, Takuma, additional, Hatayama, Naoki, additional, Fujioka, Tomohiro, additional, Nagashima, Nozomi, additional, Shimada, Yuki, additional, Fukasaka, Isao, additional, Shimizu, Mikito, additional, Higashida, Kyoko, additional, Hoshi, Taku, additional, Tanaka, Keiko, additional, and Sakaguchi, Manabu, additional

Published
2024
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20. Adjunctive brexpiprazole 1 mg and 2 mg daily for Japanese patients with major depressive disorder following inadequate response to antidepressants: a phase 2/3, randomized, double‐blind (BLESS) study

Author

Kato, Masaki, primary, Shiosakai, Masako, additional, Kuwahara, Kazuo, additional, Iba, Katsuhiro, additional, Shimada, Yuki, additional, Saito, Mizuki, additional, Isogai, Yuki, additional, Sekine, Daisuke, additional, Aoki, Kazuo, additional, Koga, Nobuyuki, additional, and Higuchi, Teruhiko, additional

Published
2023
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22. Immature stroma and high infiltration of CD15+ cells are predictive markers of poor prognosis in different subsets of patients with pancreatic cancer.

Author

Yamada, Yutaka, Yamamoto, Takeo, Tsutsumi, Chikanori, Matsumoto, Takashi, Noguchi, Shoko, Shimada, Yuki, Nakata, Kohei, Ohuchida, Kenoki, Nakamura, Masafumi, and Oda, Yoshinao

Abstract

Preoperative treatment is commonly carried out for borderline resectable pancreatic ductal adenocarcinoma (PDAC). However, the relationship between the combination of immune cells in the tumor microenvironment and their intratumoral heterogeneity along with their association with histological findings remains unclear, especially in patients receiving preoperative chemotherapy. We aimed to explore the therapeutic strategies for patients with PDAC with poor prognosis after receiving chemotherapy based on histological and immunological microenvironmental classifications. We investigated the correlation between the prognosis and histological immune microenvironmental factors of patients who initially underwent surgery (n = 100) and were receiving gemcitabine plus nab‐paclitaxel (GEM + nabPTX) as preoperative chemotherapy (n = 103). Immune profiles were generated based on immune cell infiltration into the tumor, and their correlation with patient outcomes and histological features was analyzed. Tumor‐infiltrating neutrophils (TINs) were identified as independent poor prognostic factors using multivariate analysis in both surgery‐first and preoperative chemotherapy groups. The patients were further classified into four groups based on immune cell infiltration into the tumor. Patients with high CD15 infiltration into the tumor and immature stroma at the cancer margins showed the worst prognosis in the preoperative chemotherapy group. The analysis of mRNA expression and immunohistochemical features revealed that CXCR2, the receptor for CXCL8, was correlated with disease‐free and overall survival. We inferred that patients with immature stroma at the margins and high infiltration of CD15+ neutrophils within the tumor showed the worst prognosis and they could particularly benefit from treatment with inhibitors targeting CXCR2 or CXCL8. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Adjunctive brexpiprazole 1 mg and 2 mg daily for Japanese patients with major depressive disorder following inadequate response to antidepressants: a phase 2/3, randomized, double‐blind (BLESS) study.

Author

Kato, Masaki, Shiosakai, Masako, Kuwahara, Kazuo, Iba, Katsuhiro, Shimada, Yuki, Saito, Mizuki, Isogai, Yuki, Sekine, Daisuke, Aoki, Kazuo, Koga, Nobuyuki, and Higuchi, Teruhiko

Abstract

Aims: Inadequate antidepressant response interrupts effective treatment of major depressive disorder (MDD). The BLESS study evaluates the dosage, efficacy, and safety of brexpiprazole adjunctive therapy in Japanese patients with inadequate antidepressant therapy (ADT) response. Methods: This placebo‐controlled, randomized, multicenter, parallel‐group phase 2/3 study randomized Japanese MDD patients (Hamilton Rating Scale for Depression 17‐item total score ≥ 14; historical inadequate response to 1–3 ADTs) with inadequate response to 8‐week single‐blind, prospective SSRI/SNRI treatment to 6‐week adjunctive treatment with brexpiprazole 1 mg, 2 mg, or placebo. The primary endpoint was change in Montgomery‐Åsberg Depression Rating Scale (MADRS) total score from baseline. Secondary endpoints included MADRS response, remission rate, and Clinical Global Impression‐Improvement score. Safety was comprehensively evaluated, especially regarding antipsychotic adverse events (AEs). Results: Of 1194 screened patients, 740 were randomized and 736 (1 mg, n = 248; 2 mg, n = 245; placebo, n = 243) had ≥1 baseline/post‐baseline MADRS total score. The LSM (SE) change from baseline in MADRS total score at Week 6 by MMRM analysis was −8.5 (0.47) with brexpiprazole 1 mg, −8.2 (0.47) with brexpiprazole 2 mg, and −6.7 (0.47) with placebo (placebo‐adjusted LSM difference [95% CI]: 1 mg, −1.7 [−3.0, −0.4]; P = 0.0089; 2 mg, −1.4 [−2.7, −0.1]; P = 0.0312). Secondary efficacy results supported the primary endpoint. Brexpiprazole was generally well tolerated. Conclusion: Brexpiprazole 1 mg daily was an appropriate starting dose and both 1 mg and 2 mg daily were effective and well tolerated as adjunctive therapy for Japanese MDD patients not adequately responsive to ADT. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Single-cell RNA-seq analysis identifies distinct myeloid cells in a case with encephalitis temporally associated with COVID-19 vaccination

Author

Ishikawa, Masakazu, primary, Shimada, Yuki, additional, Ozono, Tatsuhiko, additional, Matsumoto, Hisatake, additional, Ogura, Hiroshi, additional, Kihara, Keigo, additional, Mochizuki, Hideki, additional, Okuno, Tatsusada, additional, Sakakibara, Shuhei, additional, Kinoshita, Makoto, additional, and Okuzaki, Daisuke, additional

Published
2023
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32. Pyogenic Granuloma of the Jejunum: An Uncommon Cause of Obscure Gastrointestinal Bleeding

Author

Okawara, Kazuma, primary, Mizuuchi, Yusuke, additional, Shimada, Yuki, additional, Yamamoto, Takeo, additional, Sada, Masafumi, additional, Nagayoshi, Kinuko, additional, Nagai, Shuntaro, additional, Koga, Yutaka, additional, Torisu, Takehiro, additional, Nakata, Kohei, additional, Ohuchida, Kenoki, additional, Oda, Yoshinao, additional, and Nakamura, Masafumi, additional

Published
2023
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41. Biliary Microhamartoma in a Patient with Esophagogastric Junction Cancer That Resembled a Metastatic Liver Tumor and Significantly Influenced the Surgical Indication: Report of a Case

Author

Shimada, Yuki, primary, Ohuchida, Kenoki, additional, Matsumoto, Takashi, additional, Shindo, Koji, additional, Moriyama, Taiki, additional, Mizuuchi, Yusuke, additional, Nakata, Kohei, additional, Yamamoto, Takeo, additional, Hashisako, Mikiko, additional, Oda, Yoshinao, additional, and Nakamura, Masafumi, additional

Published
2022
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42. 脳梗塞を含む全身性多発血栓症を来し，SARS-CoV-2 PCR検査複数回陰性も後に抗体陽性が判明した1例

Author

Shimada, Yuki, primary, Hoshi, Taku, additional, Sumikura, Hiroyuki, additional, Higashida, Kyoko, additional, Shimizu, Mikito, additional, Fukasaka, Isao, additional, Asai, Kanako, additional, Nagashima, Nozomi, additional, Tamaki, Ryo, additional, Iida, Jyunichi, additional, Nishida, Takeshi, additional, Nakata, Syuichi, additional, Fujimi, Satoshi, additional, Ito, Hideyuki, additional, Oba, Yuichiro, additional, and Sakaguchi, Manabu, additional

Published
2022
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45. Potential association of prolonged patient interval and advanced anatomic stage in breast cancer patients in the area affected by the 2011 triple disaster in Fukushima, Japan

Author

Ozaki, Akihiko, Toyoaki, Sawano, Tsukada, Manabu, Shimada, Yuki, Kawamoto, Ayumu, Wang, Ji-Wei, Bhandari, Divya, Tsubokura, Masaharu, and Ohira, Hiromichi

Subjects
Time Factors, Incidence, Observational Study, Breast Neoplasms, Middle Aged, Disasters, help-seeking behavior, Japan, breast neoplasms, Fukushima Nuclear Accident, Humans, Female, neoplasm staging, Stress, Psychological, Research Article, Fukushima nuclear accident, Neoplasm Staging, Retrospective Studies
Abstract

For five years after the 2011 triple disaster (earthquake, tsunami, and nuclear disaster) in Japan, the proportion of patients with undiagnosed symptomatic breast cancer remained elevated in the coastal area of Fukushima. These individuals experienced a prolonged interval from first symptom recognition to initial medical consultation (hereafter referred to as the patient interval). We aimed to investigate how this prolonged patient interval affected disease staging. Using patient records, we retrospectively extracted females with newly and pathologically diagnosed breast cancer who initially presented to Minamisoma Municipal General Hospital from March 2011 to March 2016. We estimated the proportion with advanced-stage disease (III, IV) according to the patient interval duration (

Published
2021

47. Evaluation of the emergency medical system in an area following lifting of the mandatory evacuation order after the Fukushima Daiichi Nuclear Power Plant accident

Author

Yamamoto, Chika, primary, Sawano, Toyoaki, additional, Nishikawa, Yoshitaka, additional, Ozaki, Akihiko, additional, Shimada, Yuki, additional, Morita, Tomohiro, additional, Zhao, Tianchen, additional, Hasegawa, Arifumi, additional, Oikawa, Tomoyoshi, additional, and Tsubokura, Masaharu, additional

Published
2021
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50. An Older Thrombus Delays Reperfusion after Mechanical Thrombectomy for Ischemic Stroke

Author

Kitano, Takaya, additional, Hori, Yumiko, additional, Okazaki, Shuhei, additional, Shimada, Yuki, additional, Iwamoto, Takanori, additional, Kanki, Hideaki, additional, Sugiyama, Shintaro, additional, Sasaki, Tsutomu, additional, Nakamura, Hajime, additional, Oyama, Naoki, additional, Hoshi, Taku, additional, Beck, Goichi, additional, Takai, Hiroki, additional, Matsubara, Shunji, additional, Mizuno, Hiroya, additional, Nishimura, Hirotake, additional, Tamaki, Ryo, additional, Iida, Junichi, additional, Iba, Jiro, additional, Uno, Masaaki, additional, Kishima, Haruhiko, additional, Fushimi, Hiroaki, additional, Hattori, Satoshi, additional, Murayama, Shigeo, additional, Morii, Eiichi, additional, Sakaguchi, Manabu, additional, Yagita, Yoshiki, additional, Shimazu, Takeshi, additional, Mochizuki, Hideki, additional, and Todo, Kenichi, additional

Published
2021
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