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13. Serum docosahexaenoic and eicosapentaenoic acid and risk of cognitive decline over 10 years among elderly Japanese

Author

Otsuka, R., Tange, C., Nishita, Y., Kato, Y., Imai, T., Ando, F., and Shimokata, H.

Subjects
Cognition disorders in old age -- Risk factors -- Prevention, Fish as food -- Nutritional aspects, Omega-3 fatty acids -- Physiological aspects, Food/cooking/nutrition, Health
Abstract

BACKGROUND/OBJECTIVES: To clarify the association of serum docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) levels with cognitive decline over 10 years. SUBJECTS/METHODS: This study was part of the National Institute for Longevity Sciences--Longitudinal Study of Aging, and was conducted with 232 male and 198 female Japanese community-dwelling subjects aged 60-79 years in the second wave (2000-2002). Cognitive function was assessed with the Mini-Mental State Examination (MMSE) in both the second and seventh (2010-2012) waves. Fasting venous blood samples were collected in the morning, and serum DHA and EPA levels were measured. Multiple logistic regression analysis was performed among participants with an MMSE score ≥ 24 in the second wave (n = 430) to estimate the odds ratio (OR) and 95% confidence interval (CI) for MMSE score [less than or equal to] 23 or MMSE score decline ≥ 4 10 years later. These estimates were based on baseline tertiles of serum DHA or EPA levels, and controlled for age, sex, education, MMSE score at baseline, alcohol consumption, current smoking, body mass index and disease history. RESULTS: Fifteen (3.5%) subjects whose MMSE score was [less than or equal to] 23 and 36 (8.3%) subjects whose MMSE score declined to [greater than or equal to] 4 showed cognitive decline. Multivariate-adjusted OR (95% CI) for the lowest through highest tertiles of serum DHA to MMSE score [less than or equal to] 23 or decline ≥ 4 were 1.00 (reference), 0.11 (0.02-0.58) and 0.17 (0.04-0.74), or 1.00 (reference), 0.22 (0.08-0.61) and 0.31 (0.12-0.75), respectively (P for trend = 0.01 or 0.04). Serum EPA was not associated with cognitive decline. CONCLUSIONS: The study gives some indication that a moderately high level of serum DHA might prevent cognitive decline among community-dwelling elderly Japanese individuals. European Journal of Clinical Nutrition (2014) 68, 503-509; doi:10.1038/ejcn.2013.264; published online 8 January 2014 Keywords: DHA; EPA; serum; cognition; Japanese; elderly, INTRODUCTION An estimated two million people in Japan suffer from dementia and this number will likely increase as the population ages. (1) The essential n-3 polyunsaturated fatty acids (PUFA), docosahexaenoic [...]

Published
2014
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17. Low Amino Acid Score of Breakfast is Associated with the Incidence of Cognitive Impairment in Older Japanese Adults: A Community-Based Longitudinal Study

Author

Kinoshita, K., primary, Otsuka, R., additional, Takada, M., additional, Tsukamoto-Yasui, M., additional, Nishita, Y., additional, Tange, C., additional, Tomida, M., additional, Jinzu, H., additional, Shimokata, H., additional, Kuzuya, M., additional, Imaizumi, A., additional, and Arai, H., additional

Published
2021
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42. Transforming Growth Factor-beta1 Gene Polymorphism and Bone Mineral Density

Author

Fujiko Ando, Niino N, Shimokata H, and Yoshiji Yamada

Subjects
Adult, Male, Bone mineral, medicine.medical_specialty, Polymorphism, Genetic, Genotype, business.industry, General Medicine, Middle Aged, Cohort Studies, Transforming Growth Factor beta1, Endocrinology, Bone Density, Risk Factors, Transforming Growth Factor beta, Internal medicine, medicine, Humans, Osteoporosis, Female, Gene polymorphism, business, Aged, Transforming growth factor
Published
2001

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