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2. [14Co-dimetinur distribution in mice in relation to the stage of the development of tumor process].

Author

Ostrovskaia LA, Rykova VA, Kondarov AA, Etvesh L, Shimon-Trompler E, Sokolova IS, and Korman DB

Subjects
Administration, Oral, Animals, Antineoplastic Agents administration & dosage, Leukemia P388 pathology, Male, Methylnitrosourea administration & dosage, Methylnitrosourea pharmacokinetics, Mice, Mice, Inbred C57BL, Mice, Inbred DBA, Tissue Distribution, Antineoplastic Agents pharmacokinetics, Cobalt Isotopes, Leukemia P388 drug therapy, Leukemia, Experimental drug therapy
Abstract

Pharmacokinetics of the antitumour agent 14CO-dimetinur (100 mg/kg) after oral administration to the intact mice and those with solid leukemia P 388 is characterized by its rapid delivery to organs and tumours with the achievement of maximum radioactivity 5 hours later and the further gradually decline during 4 days. The increased accumulation of the 14CO-products in kidneys and their retarded output from the brain and lungs against a background of the relatively equal distribution of radioactivity between other tested organs have been established. The same level of carbamoylated products in large tumours (the 16th day after leukemia transplantation) as well as in small tumours (the 9th day after inoculation) is in agreement with the conservation of the initial marked inhibitory effect of the drug against advanced tumours.

Published
1990

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