1. Amyloid involvement in subcortical regions predicts cognitive decline
- Author
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Cho, Soo Hyun, Shin, Jeong-Hyeon, Jang, Hyemin, Park, Seongbeom, Kim, Hee Jin, Kim, Si Eun, Kim, Seung Joo, Kim, Yeshin, Lee, Jin San, Na, Duk L, Lockhart, Samuel N, Rabinovici, Gil D, Seong, Joon-Kyung, Seo, Sang Won, and For the Alzheimer’s Disease Neuroimaging Initiative
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Basic Behavioral and Social Science ,Behavioral and Social Science ,Clinical Trials and Supportive Activities ,Neurodegenerative ,Alzheimer's Disease ,Aging ,Brain Disorders ,Acquired Cognitive Impairment ,Dementia ,Clinical Research ,Neurosciences ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Neurological ,Aged ,Amyloid ,Brain ,Case-Control Studies ,Cognitive Dysfunction ,Female ,Fluorodeoxyglucose F18 ,Hippocampus ,Humans ,Image Processing ,Computer-Assisted ,Magnetic Resonance Imaging ,Male ,Neuroimaging ,Positron-Emission Tomography ,Prognosis ,Amyloid staging ,Amyloid PET ,Alzheimer's dementia ,Thal staging ,Alzheimer’s Disease Neuroimaging Initiative ,Alzheimer’s dementia ,Other Physical Sciences ,Nuclear Medicine & Medical Imaging ,Clinical sciences - Abstract
PurposeWe estimated whether amyloid involvement in subcortical regions may predict cognitive impairment, and established an amyloid staging scheme based on degree of subcortical amyloid involvement.MethodsData from 240 cognitively normal older individuals, 393 participants with mild cognitive impairment, and 126 participants with Alzheimer disease were acquired at Alzheimer's Disease Neuroimaging Initiative sites. To assess subcortical involvement, we analyzed amyloid deposition in amygdala, putamen, and caudate nucleus. We staged participants into a 3-stage model based on cortical and subcortical amyloid involvement: 382 with no cortical or subcortical involvement as stage 0, 165 with cortical but no subcortical involvement as stage 1, and 203 with both cortical and subcortical involvement as stage 2.ResultsAmyloid accumulation was first observed in cortical regions and spread down to the putamen, caudate nucleus, and amygdala. In longitudinal analysis, changes in MMSE, ADAS-cog 13, FDG PET SUVR, and hippocampal volumes were steepest in stage 2 followed by stage 1 then stage 0 (p value
- Published
- 2018