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7 results on '"Shiomi, Yoshihiro"'

4. A Novel Peroxisome Proliferator-activated Receptor (PPAR)α Agonist and PPARγ Antagonist, Z-551, Ameliorates High-fat Diet-induced Obesity and Metabolic Disorders in Mice

Author

Shiomi, Yoshihiro, primary, Yamauchi, Toshimasa, additional, Iwabu, Masato, additional, Okada-Iwabu, Miki, additional, Nakayama, Ryo, additional, Orikawa, Yuki, additional, Yoshioka, Yoshichika, additional, Tanaka, Koichiro, additional, Ueki, Kohjiro, additional, and Kadowaki, Takashi, additional

Published
2015
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5. Acotiamide (Z-338), a Novel Gastroprokinetic Agent for the Treatment of Functional Dyspepsia, Restores Delayed Gastric Emptying Induced by Restraint Stress via the Vagal Afferent Pathway in Rats

Author

Kobayashi, Nobuyoshi, primary, Seto, Koichi, additional, Sasaki, Takahiro, additional, Katsunuma, Kokichi, additional, Orikawa, Yuki, additional, Yoshimura, Makoto, additional, Shiomi, Yoshihiro, additional, Ohira, Yuta, additional, Takei, Mineo, additional, and Tanaka, Koichiro, additional

Published
2011
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7. Z-360 Suppresses Tumor Growth in MIA PaCa-2-bearing Mice via Inhibition of Gastrin-induced Anti-Apoptotic Effects.

Author

Shiomi Y, Yoshimura M, Kuki K, Hori Y, and Tanaka T

Subjects
Animals, Cell Line, Tumor, Cell Proliferation drug effects, Deoxycytidine administration & dosage, Deoxycytidine analogs & derivatives, Endopeptidases administration & dosage, Gastrins administration & dosage, Gene Expression Regulation, Neoplastic drug effects, Humans, Inhibitor of Apoptosis Proteins biosynthesis, Mice, Myeloid Cell Leukemia Sequence 1 Protein biosynthesis, Pancreatic Neoplasms genetics, Pancreatic Neoplasms pathology, Receptor, Cholecystokinin B antagonists & inhibitors, Receptor, Cholecystokinin B biosynthesis, Survivin, X-Linked Inhibitor of Apoptosis Protein biosynthesis, Xenograft Model Antitumor Assays, Gemcitabine, Apoptosis drug effects, Benzodiazepinones administration & dosage, Pancreatic Neoplasms drug therapy, Receptor, Cholecystokinin B genetics
Abstract

Background/aim: The aim of the study was to evaluate the anti-tumor mechanism of Z-360, a gastrin/cholecystokinin-2 receptor (CCK2R) antagonist, in MIA PaCa-2 cells and in a subcutaneous xenograft mice model., Materials and Methods: The anti-tumor effects of Z-360 and/or gemcitabine were monitored using a MIA PaCa-2 xenograft model. The effect of Z-360 on apoptosis in the model was examined by TUNEL staining and real-time PCR analysis and the effect in MIA PaCa-2 cells stably expressing human CCK2R was also evaluated by caspase-3/7 activity., Results: In this xenograft model, Z-360 significantly reduced the tumor weight, increased TUNEL-positive cells and suppressed the expression of anti-apoptosis factors such as survivin, XIAP and Mcl-1, and these effects of Z-360 combined with gemcitabine were more effective. Furthermore, gastrin-17 and gastrin-34 inhibited apoptosis in vitro and Z-360 dose-dependently abrogated this effect., Conclusion: These results suggest that Z-360 exerts an anti-tumor effect through a reduction in anti-apoptosis factors by blocking CCK2R., (Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2017
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