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545 results on '"Shiozaki, Hitoshi"'

1. Phase II Adjuvant Cancer-specific Vaccine Therapy for Esophageal Cancer Patients Curatively Resected After Preoperative Therapy With Pathologically Positive Nodes; Possible Significance of Tumor Immune Microenvironment in its Clinical Effects

Author

Yasuda, Takushi, Nishiki, Kohei, Hiraki, Yoko, Kato, Hiroaki, Iwama, Mitsuru, Shiraishi, Osamu, Yasuda, Atsushi, Shinkai, Masayuki, Kimura, Yutaka, Sukegawa, Yasushi, Chiba, Yasutaka, Imano, Motohiro, Takeda, Kazuyoshi, Satou, Takao, Shiozaki, Hitoshi, and Nakamura, Yusuke

Published
2022
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6. Treatment of Benign Esophageal Stricture

Author

Kobayashi, Kenji, Shiozaki, Hitoshi, Inoue, Masatoshi, Tamura, Shigeyuki, Tujinaka, Toshimasa, Murata, Atsuo, Nishijima, Jun-ichi, Kadowaki, Takatoshi, Matsui, Shigeo, Kido, Yoshihiro, Mori, Takesada, Nabeya, Kin-ichi, editor, Hanaoka, Tateo, editor, and Nogami, Hiroshi, editor

Published
1993
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26. Clinical significance of immunohistochemically detected lymph node micrometastasis in patients with histologically node-negative esophageal carcinoma: a multi-institutional study

Author

Shiozaki, Hitoshi, Fujiwara, Yoshiyuki, Hirai, Toshihiro, Matsubara, Hisahiro, Mori, Masaki, Nakamura, Tsutomu, Nakanishi, Yukihiro, Natsugoe, Shoji, Noguchi, Tsuyoshi, Ozawa, Soji, Shimada, Yutaka, Udagawa, Seiji, Yamana, Hideaki, Yano, Masahiko, Yasuda, Takushi, and Yanagisawa, Akio

Published
2007
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42. Phase II Adjuvant Cancer-specific Vaccine Therapy for Esophageal Cancer Patients Curatively Resected After Preoperative Therapy With Pathologically Positive Nodes; Possible Significance of Tumor Immune Microenvironment in its Clinical Effects

Author

Yasuda, Takushi, primary, Nishiki, Kohei, additional, Hiraki, Yoko, additional, Kato, Hiroaki, additional, Iwama, Mitsuru, additional, Shiraishi, Osamu, additional, Yasuda, Atsushi, additional, Shinkai, Masayuki, additional, Kimura, Yutaka, additional, Sukegawa, Yasushi, additional, Chiba, Yasutaka, additional, Imano, Motohiro, additional, Takeda, Kazuyoshi, additional, Satou, Takao, additional, Shiozaki, Hitoshi, additional, and Nakamura, Yusuke, additional

Published
2020
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50. Gene expression of albumin and liver-specific nuclear transcription factors in liver of protein-deprived rats

Author

Ogawa, Atsuhiro, Yano, Masahiko, Tsujinaka, Toshimasa, Ebisui, Chikara, Morimoto, Takashi, Kishibuchi, Masanori, Fujita, Junya, Morita, Syunji, Shiozaki, Hitoshi, and Monden, Morito

Subjects
Gene expression -- Research, Albumin -- Genetic aspects, Genetic transcription -- Research, Rats -- Physiological aspects, Protein deficiency -- Physiological aspects, Food/cooking/nutrition
Abstract

Protein-energy malnutrition causes hypoalbuminemia. Recent work has suggested that this may be partly due to decreased transcription of the albumin gene. This study examined the role of cis-acting and transacting elements of the albumin gene during protein deprivation. Male 7-wk-old Donryu rats were fed a protein-free diet (0% casein diet) for 10 d or given restricted (pair-fed control) or free access (freely fed control) to a 25% casein diet. Serum albumin concentrations were significantly lower in the protein-deprived rats (29 [+ or -] 1 g/L) than in the pair-fed controls (42 [+ or -] 3 g/L) or the freely fed controls (45 [+ or -] 3 g/L). The albumin mRNA level was also significantly lower in livers of protein-deprived rats (36% of pair-fed control). However, gel mobility shift analysis using liver nuclear extracts did not show any significant difference between the protein-deprived rats and the pair-fed controls in the binding activity to the B and D sites of the albumin promoter. Furthermore, gel mobility shift-Western blot analysis showed no significant difference between the two groups in the protein levels of nuclear transcription factors binding to the D sites. The amounts of mRNA of hepatocyte nuclear factor-1 binding to the B site were not significantly different between these two groups. These results suggest that the proximal promoter region may not play a major role in the down-regulation of the albumin gene during protein deprivation. KEY WORDS: albumin; nuclear transcription factors; protein deprivation; rats

Published
1997

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