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673 results on '"Shirakawa, Yasuhiro"'

7. Stroke volume variation and dynamic arterial elastance predict fluid responsiveness even in thoracoscopic esophagectomy: a prospective observational study

Author

Hikasa, Yukiko, Suzuki, Satoshi, Tanabe, Shunsuke, Noma, Kazuhiro, Shirakawa, Yasuhiro, Fujiwara, Toshiyoshi, and Morimatsu, Hiroshi

Subjects
Hydroxyethyl starch, Medical research, Pay-per-view television, Medicine, Experimental
Abstract

Author(s): Yukiko Hikasa [sup.1], Satoshi Suzuki [sup.2], Shunsuke Tanabe [sup.3], Kazuhiro Noma [sup.3], Yasuhiro Shirakawa [sup.4], Toshiyoshi Fujiwara [sup.3], Hiroshi Morimatsu [sup.2] Author Affiliations: (1) https://ror.org/03rm3gk43, grid.497282.2, Department of Anesthesia [...], Purpose It remains unknown whether stroke volume variation (SVV), pulse pressure variation (PPV), and dynamic arterial elastance (Ea.sub.dyn) are suitable for monitoring fluid management during thoracoscopic esophagectomy (TE) in the prone position with one-lung ventilation and artificial pneumothorax. Our study aimed to evaluate the accuracy of SVV, PVV, and Ea.sub.dyn in predicting the fluid responsiveness in these patients. Methods We recruited 24 patients who had undergone TE. Patients with a mean arterial blood pressure [less than or equal to] 65 mmHg received a 200-ml bolus of 6% hydroxyethyl starch over 10 min. Fluid responders showed the stroke volume index [greater than or equal to] 15% 5 min after the fluid bolus. Receiver operating characteristic (ROC) curves were generated and area under the ROC curve (AUROC) was calculated. Results We obtained 61 fluid bolus data points, of which 20 were responders and 41 were non-responders. The median SVV before the fluid bolus in responders was significantly higher than that in non-responders (18% [interquartile range (IQR) 13-21] vs. 12% [IQR 8-15], P = 0.001). Ea.sub.dyn was significantly lower in responders than in non-responders (0.55 [IQR 0.45-0.78] vs. 0.91 [IQR 0.67-1.00], P < 0.001). There was no difference in the PPV between the groups. The AUROC was 0.76 for SVV (95% confidence interval [CI] 0.62-0.89, P = 0.001), 0.56 for PPV (95% CI 0.41-0.71, P = 0.44), and 0.82 for Ea.sub.dyn (95% CI 0.69-0.95, P < 0.001). Conclusions SVV and Ea.sub.dyn are reliable parameters for predicting fluid responsiveness in patients undergoing TE.

Published
2023
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8. PD-L1-expressing cancer-associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome in esophageal cancer

Author

Kawasaki, Kento, Noma, Kazuhiro, Kato, Takuya, Ohara, Toshiaki, Tanabe, Shunsuke, Takeda, Yasushige, Matsumoto, Hijiri, Nishimura, Seitaro, Kunitomo, Tomoyoshi, Akai, Masaaki, Kobayashi, Teruki, Nishiwaki, Noriyuki, Kashima, Hajime, Maeda, Naoaki, Kikuchi, Satoru, Tazawa, Hiroshi, Shirakawa, Yasuhiro, and Fujiwara, Toshiyoshi

Published
2023
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11. Incidence of Metachronous Remnant Gastric Cancer after Proximal Gastrectomy with the Double-flap Technique (rD-FLAP-rGC Study): A Multicenter, Retrospective Study

Author

Ishida, Michihiro, Kuroda, Shinji, Choda, Yasuhiro, Otsuka, Shinya, Ueyama, Satoshi, Tanaka, Norimitsu, Hato, Shinji, Kimura, Toshikazu, Muraoka, Atsushi, Tanakaya, Kohji, Matsuda, Tatsuo, Takashima, Hirotoshi, Nonaka, Yasuyuki, Ishii, Hiroshi, Shirakawa, Yasuhiro, Kamikawa, Yasuaki, and Fujiwara, Toshiyoshi

Published
2023
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12. First-line nivolumab plus ipilimumab or chemotherapy versus chemotherapy alone in advanced esophageal squamous cell carcinoma: a Japanese subgroup analysis of open-label, phase 3 trial (CheckMate 648/ONO-4538-50)

Author

Kato, Ken, Doki, Yuichiro, Ogata, Takashi, Motoyama, Satoru, Kawakami, Hisato, Ueno, Masaki, Kojima, Takashi, Shirakawa, Yasuhiro, Okada, Morihito, Ishihara, Ryu, Kubota, Yutaro, Amaya-Chanaga, Carlos, Chen, Tian, Matsumura, Yasuhiro, and Kitagawa, Yuko

Published
2023
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18. Guidelines for cadaver dissection in education and research of clinical medicine (The Japan Surgical Society and The Japanese Association of Anatomists)

Author

Shichinohe, Toshiaki, Kondo, Takashi, Date, Hiroshi, Hiramatsu, Masako, Hirano, Satoshi, Ide, Chizuka, Iwanaga, Toshihiko, Izawa, Yoshimitsu, Kikuta, Akio, Kobayashi, Eiji, Matsui, Yoshiro, Nohara, Yutaka, Shibata, Takanori, Shirakawa, Yasuhiro, Suzuki, Takane, Takahashi, Haruo, Taneichi, Hiroshi, Tsurumoto, Toshiyuki, Uchiyama, Yasuo, Watanabe, Masahiko, Yaginuma, Hiroyuki, Yamaguchi, Kumiko, and Yoshida, Kazunari

Published
2022
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19. Usage of cadavers in surgical training and research in Japan over the past decade

Author

Shichinohe, Toshiaki, Date, Hiroshi, Hirano, Satoshi, Kobayashi, Eiji, Izawa, Yoshimitsu, Shirakawa, Yasuhiro, Hiramatsu, Masako, Mase, Mitsuhito, Taneichi, Hiroshi, Yaginuma, Hiroyuki, Fujimoto, Toyoshi, Tsurumoto, Toshiyuki, Watanabe, Masahiko, Kurita, Hiroshi, Hato, Naohito, Kato, Tomoyasu, Kanayama, Hiroomi, Suzuki, Takane, Yamaguchi, Kumiko, and Takeda, Yoshimasa

Published
2022
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23. ASO Visual Abstract: Incidence of Metachronous Remnant Gastric Cancer After Proximal Gastrectomy with the Double-Flap Technique (rD-FLAP-rGC Study): A Multicenter Retrospective Study

Author

Ishida, Michihiro, Kuroda, Shinji, Choda, Yasuhiro, Otsuka, Shinya, Ueyama, Satoshi, Tanaka, Norimitsu, Hato, Shinji, Kimura, Toshikazu, Muraoka, Atsushi, Tanakaya, Kohji, Matsuda, Tatsuo, Takashima, Hirotoshi, Nonaka, Yasuyuki, Ishii, Hiroshi, Shirakawa, Yasuhiro, Kamikawa, Yasuaki, and Fujiwara, Toshiyoshi

Published
2023
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26. Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in the tumor microenvironment

Author

Sato, Hiroaki, Noma, Kazuhiro, Ohara, Toshiaki, Kawasaki, Kento, Akai, Masaaki, Kobayashi, Teruki, Nishiwaki, Noriyuki, Narusaka, Toru, Komoto, Satoshi, Kashima, Hajime, Katsura, Yuki, Kato, Takuya, Kikuchi, Satoru, Tazawa, Hiroshi, Kagawa, Shunsuke, Shirakawa, Yasuhiro, Kobayashi, Hisataka, and Fujiwara, Toshiyoshi

Published
2022
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31. Association Between Change in Prognostic Nutritional Index During Neoadjuvant Therapy and Dental Occlusal Support in Patients with Esophageal Cancer Under Neoadjuvant Therapy: A Retrospective Longitudinal Pilot Study.

Author

Yamanaka-Kohno, Reiko, Shirakawa, Yasuhiro, Inoue-Minakuchi, Mami, Yokoi, Aya, Noma, Kazuhiro, Tanabe, Shunsuke, Maeda, Naoaki, Fujiwara, Toshiyoshi, Morita, Manabu, and Ekuni, Daisuke

Abstract

Background: A high prognostic nutritional index (PNI) is associated with good prognosis in patients with esophageal cancer. However, nutritional status often decreases during neoadjuvant therapy. Functional tooth units (FTUs) provide an index for the status of posterior occlusal support. We have previously reported that low PNI is related to low FTUs. Objectives: The purpose of this study was to retrospectively examine whether the status of occlusal support relates to changes in PNI during neoadjuvant therapy in patients with esophageal cancer. Methods: This study included 34 patients who underwent neoadjuvant therapy before esophagectomy (32 men, 2 women; age, 36–82 years) in 2012 at Okayama University Hospital. Patients were divided into the good occlusal support group (FTUs ≥ 11, n = 18) or poor occlusal support group (FTUs < 11, n = 16), and changes in PNI during neoadjuvant therapy were investigated. Results: PNI decreased significantly after neoadjuvant therapy, particularly in the good occlusal support group, and became more dispersed after neoadjuvant therapy. Decreases in PNI after neoadjuvant therapy showed a significant positive correlation with good occlusal support by multiple regression analysis (p = 0.03). The proportions of patients provided with nutritional intervention (p = 0.02) or early dental intervention (p = 0.04) were lower in the good occlusal support group than in the poor occlusal support group. Conclusions: Even in patients with esophageal cancer with good occlusal support experienced significant declines in PNI during neoadjuvant therapy, potentially due to delayed nutritional and dental interventions. Early multidisciplinary interventions are thus recommended for all patients, regardless of preoperative dental or nutritional status. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Intraoperative fluid therapy and postoperative complications during minimally invasive esophagectomy for esophageal cancer: a single-center retrospective study

Author

Hikasa, Yukiko, Suzuki, Satoshi, Mihara, Yuko, Tanabe, Shunsuke, Shirakawa, Yasuhiro, Fujiwara, Toshiyoshi, and Morimatsu, Hiroshi

Subjects
Comparative analysis, Arrhythmia -- Comparative analysis, Postoperative complications -- Comparative analysis, Cancer research -- Comparative analysis, Pneumonia -- Comparative analysis, Heart -- Comparative analysis, Esophageal cancer -- Comparative analysis, Oncology, Experimental -- Comparative analysis, Bacterial pneumonia -- Comparative analysis, Cancer -- Research, Surgery -- Complications
Abstract

Author(s): Yukiko Hikasa [sup.1], Satoshi Suzuki [sup.1], Yuko Mihara [sup.1], Shunsuke Tanabe [sup.2], Yasuhiro Shirakawa [sup.2], Toshiyoshi Fujiwara [sup.2], Hiroshi Morimatsu [sup.1] Author Affiliations: (1) grid.412342.2, 0000 0004 0631 9477, [...], Purpose Compared with open thoracotomy, minimally invasive esophagectomy (MIE) methods, such as transhiatal or thoracoscopic esophagectomy, likely have lower morbidity. However, the relationship between intraoperative fluid management and postoperative complications after MIE remains unclear. Thus, we investigated the association of cumulative intraoperative fluid balance and postoperative complications in patients undergoing MIE. Methods This single-center retrospective cohort study examined patients undergoing thoracoscopic esophagectomy for esophageal cancer in the prone position. Postoperative complications included pneumonia, arrhythmia, thrombotic events and acute kidney injury (AKI). We compared patients with higher and lower intraoperative fluid balance (higher and lower than the median). Multivariable logistic regression analyses were performed to estimate the odds ratio of intraoperative fluid balance status on the incidence of postoperative complications. Results In total, 135 patients were included in the study. Postoperative complications occurred in 43 (32%), including cardiac arrhythmia (n = 12, 9%), thrombosis (n = 20, 15%), pneumonia (n = 13, 10%), and AKI required hemodialysis (n = 1, 1%). Patients with a higher fluid balance had higher incidence of complications than those with a lower fluid balance (46% vs. 18%, p < 0.001). After adjusting for age, ASA-PS [greater than or equal to] III, blood loss, and the use of radical surgery, the higher intraoperative fluid balance group was significantly and independently associated with postoperative complications (adjusted OR 5.31, 95% CI 2.26-13.6, p < 0.0001). Conclusions In patients undergoing thoracoscopic esophagectomy in the prone position, a greater intraoperative positive fluid balance was independently associated with a higher incidence of complications.

Published
2020
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47. MicroRNAs associated with postoperative outcomes in patients with limited stage neuroendocrine carcinoma of the esophagus

Author

Okumura, Tomoyuki, primary, Fujii, Tsutomu, additional, Terabayashi, Kenji, additional, Kojima, Takashi, additional, Takeda, Shigeru, additional, Kashiwada, Tomomi, additional, Toriyama, Kazuhiro, additional, Hijioka, Susumu, additional, Miyazaki, Tatsuya, additional, Yamamoto, Miho, additional, Tanabe, Shunsuke, additional, Shirakawa, Yasuhiro, additional, Furukawa, Masayuki, additional, Honma, Yoshitaka, additional, Hoshino, Isamu, additional, Nabeya, Yoshihiro, additional, Yamaguchi, Hironori, additional, Uemoto, Shinji, additional, Shimada, Yutaka, additional, Matsubara, Hisahiro, additional, Ozawa, Soji, additional, Makuuchi, Hiroyasu, additional, and Imamura, Masayuki, additional

Published
2023
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48. Supplementary Figure S4: Evaluation of the treatment effects on luciferase activity in peritoneal dissemination xenografted mouse model bearing SKOV-3/Luc cells from Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer

Author

Ishida, Michihiro, primary, Kagawa, Shunsuke, primary, Shimoyama, Kyoko, primary, Takehara, Kiyoto, primary, Noma, Kazuhiro, primary, Tanabe, Shunsuke, primary, Shirakawa, Yasuhiro, primary, Tazawa, Hiroshi, primary, Kobayashi, Hisataka, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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49. Supplementary Figure S1: The sensitivity to trastuzumab in gastric cancer cell lines from Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer

Author

Ishida, Michihiro, primary, Kagawa, Shunsuke, primary, Shimoyama, Kyoko, primary, Takehara, Kiyoto, primary, Noma, Kazuhiro, primary, Tanabe, Shunsuke, primary, Shirakawa, Yasuhiro, primary, Tazawa, Hiroshi, primary, Kobayashi, Hisataka, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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50. Supplementary Figure S2: Transduction efficiency by Ad/HER2-ECD in organs and peritoneally disseminated tumor from Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer

Author

Ishida, Michihiro, primary, Kagawa, Shunsuke, primary, Shimoyama, Kyoko, primary, Takehara, Kiyoto, primary, Noma, Kazuhiro, primary, Tanabe, Shunsuke, primary, Shirakawa, Yasuhiro, primary, Tazawa, Hiroshi, primary, Kobayashi, Hisataka, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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