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Landslide term is used for all mass movements on slopes, including falling, overturns and flow debris. Using the potential landslide hazard zonation, areas with high potential of landslide hazard can be detected and so prevent the landslide occurrence with providing appropriate solutions. In this study, the landslide hazard zonation along the water transmission lines of the Shirin-dare Dam Water Supply Pipeline has been done. Studied area is located at the western part of the Northern Khorasan (Bojnord). Study procedure is included of the general geology of the studied area, recognition the most important effective parameters on the landslide phenomena (such as slope, lithology, faults and streams) and also, mapping them as a layer on the basic maps. Then, each layer was validated based on the importance of the effective factors using the maps weighting method in ArcGIS software. Finally, the studied area was zoned based on the landslide potential using the overlapping of the various layers. Final zonation map shows that the North, Northwestern and Median parts of the studied area have highest landslide potential. These areas are included of Marl and red Marl and to some extend loss deposits with slopes between 14 to more of 50 degrees. Seemingly, faults (due to low occurrence) and streams (due to drought) have lower effect on the landslide potential. However, the degree of the slope and type of lithology are the most important parameters on the landslide potential, respectively. [ABSTRACT FROM AUTHOR]

Thus far, there are only a few sports activities in which people with and without intellectual disabilities can participate together and on an equal footing. The situation is even more complicated when people who are dependent on a wheelchair want to take part. The sports project Freiwurf Hamburg aims to make team handball playable for everyone. This case study documents how this can be achieved with a modified version of the handball game for runners and wheelchair users. Qualitative and quantitative data are collected and evaluated. The results show that players tend to distinguish between the roles of runner and wheelchair user rather than between disabled and non-disabled.

Real-time connectivity and employment of sustainable materials empowers point-of-care diagnostics with the capability to send clinically relevant data to health care providers even in low-resource settings. In this study, we developed an advantageous kit for the on-site detection of carcinoembryonic antigen (CEA) in human serum. CEA sensing was performed using cellulose-based lateral flow strips, and colorimetric signals were read, processed, and measured using a smartphone-based system. The corresponding immunoreaction was reported by polydopamine-modified gold nanoparticles in order to boost the signal intensity and improve the surface blocking and signal-to-noise relationship, thereby enhancing detection sensitivity when compared with bare gold nanoparticles (up to 20-fold in terms of visual limit of detection). Such lateral flow strips showed a linear range from 0.05 to 50 ng/mL, with a visual limit of detection of 0.05 ng/mL and an assay time of 15 min. Twenty-six clinical samples were also tested using the proposed kit and compared with the gold standard of immunoassays (enzyme linked immunosorbent assay), demonstrating an excellent correlation (R = 0.99). This approach can potentially be utilized for the monitoring of cancer treatment, particularly at locations far from centralized laboratory facilities.

Antibodies (Abs) are naturally derived materials with favorable affinity, selectivity, and fast binding kinetics to the respective antigens, which enables their application as promising recognition elements in the development of various types of biosensors/bioassays, especially in rapid tests. These tests are low-cost and easy-to-use biosensing devices with broad applications including medical or veterinary diagnostics, environmental monitoring and industrial usages such as safety and quality analysis in food, providing on-site quick monitoring of various analytes, making it possible to save analysis costs and time. To reach such features, the conjugation of Abs with various nanomaterials (NMs) as tags is necessary, which range from conventional gold nanoparticles to other nanoparticles recently introduced, where magnetic, plasmonic, photoluminescent, or multi-modal properties play a critical role in the overall performance of the analytical device. In this context, to preserve the Ab affinity and provide a rapid response with long-term storage capability, the use of efficient bio-conjugation techniques is critical. Thanks to their prominent role in rapid tests, many studies have been devoted to the design and development of Abs-NMs conjugates with various chemistries including passive adsorption, covalent coupling, and affinity interactions. In this review, we present the state-of-the-art techniques allowing various Ab-NM conjugates with a special focus on the efficiency of the developed probes to be employed in in vitro rapid tests. Challenges and future perspectives on the development of Ab-conjugated nanotags in rapid diagnostic tests are highlighted along with a survey of the progress in commercially available Ab-NM conjugates.

In this work, we presented the development of cost-effective dual sensitivity enhancement in gold nanoparticle-based lateral flow test strip for detection of carcinoembryonic antigen. On the one hand, we employed protein G as a host matrix for oriented immobilization of antibodies within the nitrocellulose membrane. On the other hand, we utilized gold enhancement approach to visualize the final signals effectively. Primary examinations revealed that the smaller sized nanoparticles have greater signal enhancement compared to bigger ones. So, mono-dispersed gold nanoparticles with average diameters of 11.40 ± 1.40 nm were utilized as tags. The measurement of fluorescent intensity of FITC-tagged secondary antibody attached to the polyclonal antibody, in the presence/absence of protein G as a host matrix on microplate wells, showed the successful oriented immobilization of antibodies via the host matrix. The FESEM images confirmed the attachment and growth of nanoparticles within the porous nitrocellulose membrane, after gold enhancement. Finally, under the optimized conditions, the developed strip could quantify the standard values of target within 2-50 ng/mL range with a limit of detection of 0.35 ng/mL. This strategy enabled the reduction of antibody consumption from a conventional amount of 0.6 µg/strip down to 0.012 µg/strip. The serum samples containing carcinoembryonic antigen were also successfully analyzed by the developed strip with a visual detection limit of 10 ng/mL, which confirms favorable characteristics of the developed test strip for point-of-care applications., Competing Interests: There are no conflict of interest associated with this work.T. Mahmoudi and B. Shirdel performed the research. T. Mahmoudi and B. Baradaran designed the research study. B. Baradaran contributed essential reagents or tools. T. Mahmoudi, B. Baradaran, and B. Mansoori analyzed the data. T. Mahmoudi and B. Baradaran wrote the paper., (© 2020 The Authors. Analytical Science Advances published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)