1. Availability of 0.3% ofloxacin ointment and solution in human conjunctiva and aqueous humor
- Author
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Shirley Blancaflor, Diane D.-S. Tang-Liu, Joseph Lambert, and Arlene Gwon
- Subjects
Male ,medicine.medical_specialty ,Ofloxacin ,Conjunctiva ,medicine.medical_treatment ,Biological Availability ,Cataract Extraction ,Pharmacology ,Dosage form ,Aqueous Humor ,Ointments ,Pharmacokinetics ,Anti-Infective Agents ,Ophthalmology ,medicine ,Animals ,Humans ,Pharmacology (medical) ,Antibacterial agent ,Aged ,business.industry ,Eye drop ,Cataract surgery ,eye diseases ,Bioavailability ,medicine.anatomical_structure ,Tears ,Female ,Rabbits ,Ophthalmic Solutions ,business ,medicine.drug - Abstract
Ofloxacin 0.3% ophthalmic solution or ointment was administered preoperatively to 13 patients undergoing cataract surgery. Mean drug concentrations in conjunctival biopsies were 2.62 and 6.55 micrograms/gm and in aqueous humor samples were 0.36 micrograms/mL and 0.43 micrograms/mL, for ointment and solution respectively. Mean conjunctival concentrations of ofloxacin achieved MIC90 values for 419 gram-positive and gram-negative organisms previously analyzed.
- Published
- 1995