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Abstract Self‐healing polyurethane diacrylate (PUDA) composites with outstanding thermal conductivity were prepared with variable boron nitride (BN) and a small number of graphene nanoplatelets (GNPs) (1 wt%). The thermal conductivity of PUDA composites containing 1 wt% GNPs and 29 wt% BN reached 1.73 W/(m·K), showing 27.2% increment compared to PUDA composites only with 30 wt% BN. BN and GNPs mutually promoted the dispersion in the PUDA matrix, and the small number of GNPs was enough to bridge the gaps between BN, so that GNPs and BN exerted a synergistic enhancement effect on the thermal conductivity of PUDA composites with a synergistic efficiency of 1.343. The PUDA composites maintained the tensile strength of 8.21 MPa with good electrical insulation (4.55 × 109 Ω cm). The high degrees of recovery of mechanical strength (>90%) and thermal conductivities (>84%) were also realised by the healing effect of the reversible DA reaction. The PUDA composites with excellent comprehensive properties show broad application potential in the thermal management of electronic devices.

Abstract The metabolomic profile of aging is complex. Here, we analyse 325 nuclear magnetic resonance (NMR) biomarkers from 250,341 UK Biobank participants, identifying 54 representative aging-related biomarkers associated with all-cause mortality. We conduct genome-wide association studies (GWAS) for these 325 biomarkers using whole-genome sequencing (WGS) data from 95,372 individuals and perform multivariable Mendelian randomization (MVMR) analyses, discovering 439 candidate “biomarker - disease” causal pairs at the nominal significance level. We develop a metabolomic aging score that outperforms other aging metrics in predicting short-term mortality risk and exhibits strong potential for discriminating aging-accelerated populations and improving disease risk prediction. A longitudinal analysis of 13,263 individuals enables us to calculate a metabolomic aging rate which provides more refined aging assessments and to identify candidate anti-aging and pro-aging NMR biomarkers. Taken together, our study has presented a comprehensive aging-related metabolomic profile and highlighted its potential for personalized aging monitoring and early disease intervention.

The Moon and Mars are adjacent to Earth and are starting stations for human exploration of the Universe. An in-depth study of the lithospheric structure of the Moon and Mars can reveal the composition and structure of their crust and mantle systems and deepen our understanding of their origins and thermal evolution histories, providing essential references for studies of Earth's origin and evolution. With the vigorous international development of deep space exploration in recent years, the accuracy and resolution of gravity field models for the Moon and Mars have increased. Significant scientific advances have been made in the studies of lunar and Martian lithospheric structures based on gravity data. This article briefly introduces exploration plans and gravity field models for the Moon and Mars and elaborates on achievements in the lithospheric structures of the Moon and Mars by applying their gravity fields. Finally, we present a summary and outlook on research into the lithospheric structures of the Moon and Mars. Methods to overcome uncertainties in gravitational fields for studying the lithospheric structures of the Moon and Mars have been proposed. We hope that this review can assist in promoting gravity exploration on the Moon and Mars and research into their lithospheric structures.

To improve the solubility and stability of lutein (LUT), this study utilized the electrostatic self-assembly method to encapsulate LUT within food-grade protein nanoparticles and composite nanoparticles derived from soybean protein isolates (SPI) and fucoidin (FUD). The impact of the SPI/FUD mass ratio on the formation of ternary composite nanoparticles, known as lutein-soybean protein isolate-fucoidin nanoparticles (LUT-SPI-FUD NPs), was examined. The preparation process underwent optimization through single-factor experiments and the Box-Behnken response surface methodology. Various characterization techniques, including ultraviolet spectroscopy, Fourier-transform infrared spectroscopy, differential scanning calorimetry and X-ray diffraction were employed to delve into the mechanisms governing the formation of these two types of nanoparticles to compare with their solubility, stability, and antioxidant properties. The results showed that LUT-SPI-FUD NPs with SPI/FUD mass ratio of 4:1 had an absolute value of zeta potential greater than 30 mV, a polydispersity index, and a smaller particle size. Under these conditions, the most favorable formulation and process parameters were as follows: A LUT/SPI mass ratio of 1:7.587, SPI mass concentration of 0.83 mg/mL, and a stirring time of 1.493 hours. Characterization analysis verified the ideal particle size and more concentrated distribution of both LUT-SPI NPs and LUT-SPI-FUD NPs, and the binding forces were the interplay of hydrogen bonds, hydrophobic interactions, and electrostatic forces. Solubility, stability, and antioxidant assessments indicated that the conversion of LUT into LUT-SPI NPs and LUT-SPI-FUD NPs substantially increased its solubility in purified water by 350.74 and 432.42 times, respectively. Moreover, both formulations very significant (P

Abstract Traumatic cervical spinal cord injury (TCSCI) often causes varying degrees of motor dysfunction, common assessed by the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI), in association with the American Spinal Injury Association (ASIA) Impairment Scale. Accurate prediction of motor function recovery is extremely important for formulating effective diagnosis, therapeutic and rehabilitation programs. The aim of this study is to investigate the validity of a novel nested ensemble algorithm that uses the very early ASIA motor score (AMS) of ISNCSCI examination to predict motor function recovery 6 months after injury in TCSCI patients. This retrospective study included complete data of 315 TCSCI patients. The dataset consisting of the first AMS at ≤ 24 h post-injury and follow-up AMS at 6 months post-injury was divided into a training set (80%) and a test set (20%). The nested ensemble algorithm was established in a two-stage manner. Support Vector Classification (SVC), Adaboost, Weak-learner and Dummy were used in the first stage, and Adaboost was selected as second-stage model. The prediction results of the first stage models were uploaded into second-stage model to obtain the final prediction results. The model performance was evaluated using precision, recall, accuracy, F1 score, and confusion matrix. The nested ensemble algorithm was applied to predict motor function recovery of TCSCI, achieving an accuracy of 80.6%, a F1 score of 80.6%, and balancing sensitivity and specificity. The confusion matrix showed few false-negative rate, which has crucial practical implications for prognostic prediction of TCSCI. This novel nested ensemble algorithm, simply based on very early AMS, provides a useful tool for predicting motor function recovery 6 months after TCSCI, which is graded in gradients that progressively improve the accuracy and reliability of the prediction, demonstrating a strong potential of ensemble learning to personalize and optimize the rehabilitation and care of TCSCI patients.

Abstract We explored physiological effects of the sodium-glucose co-transporter-2 inhibitor empagliflozin on intact experimentally hypertrophic murine hearts following transverse aortic constriction (TAC). Postoperative drug (2–6 weeks) challenge resulted in reduced late Na+ currents, and increased phosphorylated (p-)CaMK-II and Nav1.5 but not total (t)-CaMK-II, and Na+/Ca2+ exchanger expression, confirming previous cardiomyocyte-level reports. It rescued TAC-induced reductions in echocardiographic ejection fraction and fractional shortening, and diastolic anterior and posterior wall thickening. Dual voltage- and Ca2+-optical mapping of Langendorff-perfused hearts demonstrated that empagliflozin rescued TAC-induced increases in action potential durations at 80% recovery (APD80), Ca2+ transient peak signals and durations at 80% recovery (CaTD80), times to peak Ca2+ (TTP100) and Ca2+ decay constants (Decay30–90) during regular 10-Hz stimulation, and Ca2+ transient alternans with shortening cycle length. Isoproterenol shortened APD80 in sham-operated and TAC-only hearts, shortening CaTD80 and Decay30–90 but sparing TTP100 and Ca2+ transient alternans in all groups. All groups showed similar APD80, and TAC-only hearts showed greater CaTD80, heterogeneities following isoproterenol challenge. Empagliflozin abolished or reduced ventricular tachycardia and premature ventricular contractions and associated re-entrant conduction patterns, in isoproterenol-challenged TAC-operated hearts following successive burst pacing episodes. Empagliflozin thus rescues TAC-induced ventricular hypertrophy and systolic functional, Ca2+ homeostatic, and pro-arrhythmogenic changes in intact hearts.

Summary: Genomics studies have detected numerous genetic alterations in esophageal squamous cell carcinoma (ESCC). However, the functions of these mutations largely remain elusive, partially due to a lack of feasible animal models. Here, we report a convenient platform with CRISPR-Cas9-mediated introduction of genetic alterations and orthotopic transplantation to generate a series of primary ESCC models in mice. With this platform, we validate multiple frequently mutated genes, including EP300, FAT1/2/4, KMT2D, NOTCH2, and TGFBR2, as tumor-suppressor genes in ESCC. Among them, TGFBR2 loss dramatically promotes tumorigenesis and multi-organ metastasis. Paradoxically, TGFBR2 deficiency leads to Smad3 activation, and disruption of Smad3 partially restrains the progression of Tgfbr2-mutated tumors. Drug screening with tumor organoids identifies that pinaverium bromide represses Smad3 activity and restrains Tgfbr2-deficient ESCC. Our studies provide a highly efficient platform to investigate the in vivo functions of ESCC-associated mutations and develop potential treatments for this miserable malignancy.

Avian hepatitis E virus (HEV) has resulted in significant economic losses in the poultry industry. There is currently no commercial vaccination available to prevent avian HEV infection. Previously, a novel epitope (601TFPS604) was discovered in the ORF2 protein of avian HEV. In this study, peptides were synthesized and assessed for their ability to provide immunoprotecting against avian HEV infection in poultry. Twenty-five Hy-Line Variety Brown laying hens were randomly divided into five groups; groups 1 to 3 respectively immunized with RLLDRLSRTFPS, PETRRLLDRLSR (irrelevant peptide control), or truncated avian HEV ORF2 protein (aa 339–606), while group 4 (negative control) was mock-immunized with PBS and group 5 (normal control) was not immunized or challenged. After the challenge, all hens in groups 2 and 4 showed seroconversion, fecal virus shedding, viremia, alanine aminotransferase (ALT) level increasing, liver lesions and HEV antigen in the liver. There were no pathogenic effects in other groups. Collectively, all of these findings showed that hens were completely protected against avian HEV infection when they were immunized with the peptide containing TFPS of the avian HEV ORF2 protein.

Abstract Heart failure (HF) is a prevalent cardiovascular disease with significant morbidity and mortality rates worldwide. Due to the intricate structure of the heart, diverse cell types, and the complex pathogenesis of HF, further in‐depth investigation into the underlying mechanisms is required. The elucidation of the heterogeneity of cardiomyocytes and the intercellular communication network is particularly important. Traditional high‐throughput sequencing methods provide an average measure of gene expression, failing to capture the “heterogeneity” between cells and impacting the accuracy of gene function knowledge. In contrast, single‐cell sequencing techniques allow for the amplification of the entire genome or transcriptome at the individual cell level, facilitating the examination of gene structure and expression with unparalleled precision. This approach offers valuable insights into disease mechanisms, enabling the identification of changes in cellular components and gene expressions during hypertrophy associated with HF. Moreover, it reveals distinct cell populations and their unique roles in the HF microenvironment, providing a comprehensive understanding of the cellular landscape that underpins HF pathogenesis. This review focuses on the insights provided by single‐cell sequencing techniques into the mechanisms underlying HF and discusses the challenges encountered in current cardiovascular research.

Background Mental health problems in patients with chronic obstructive pulmonary disease (COPD) are common and frequently neglected. Digital psychological interventions may reduce mental health problems, but their effectiveness has not been evaluated in the Chinese COPD population. In this study, we will develop an integrated digital psychological intervention ( EmoEase ) and evaluate its effectiveness and cost-effectiveness in enhancing the mental wellbeing of patients with COPD in China. Methods This study is a multicenter, two-arm, randomized controlled trial (RCT) with a parallel-group design to enroll at least 420 patients with COPD with age over 35 years. Participants will be assigned to receive either usual care (control group) or usual care + EmoEase (intervention group). Assessments will take place at baseline (T0) and 4 weeks (T1), 8 weeks (T2), and 16 weeks (T3) after baseline, and participants will be asked to complete questionnaires and physical measurements. The primary outcome measure will assess mental wellbeing using the Warwick Edinburgh Mental Wellbeing Scale (WEMWBS). Secondary outcome measures will assess mental health, physical health, COPD symptoms, health risk behaviors, socioeconomic indicators, and healthcare utilization and expenditure. Analyses will utilize an intention-to-treat approach. Discussion This is the first RCT to examine the value of EmoEase , a novel digital psychological intervention for patients with COPD. If this intervention is effective and cost-effective, it could be rapidly scaled up to provide mental healthcare for patients with COPD in China. Trial registration ClinicalTrials.gov Identifier: NCT06026709. Date of first submission: 30 August 2023. https://clinicaltrials.gov/study/NCT06026709

Combining green warehousing with wind-solar-storage systems can enhance economic power consumption, energy saving, and emission reduction in green warehousing. To achieve efficient and stable operation of the wind-solar-storage microgrid, this paper proposes an optimal microgrid scheduling strategy based on the Improved Sparrow Algorithm (ISSA). Firstly, a comprehensive benefit model is established based on the economic and environmental benefits of microgrid daily operation. Then, an innovative improved sparrow search algorithm is proposed, which aims to improve the global search and local search capability of the microgrid scheduling problem by introducing improvements such as Logistic-Circle chaotic mapping, Bottle Sea Sheath swarm optimization algorithm, dynamic inertia weights, water wave dynamic factor, and Cauchy-Gaussian variational strategy. Finally, the microgrid optimal scheduling model is solved by the improved sparrow search algorithm and compared with other algorithms. In this paper, Matlab 2016b is used for simulation, and the simulation results show that the ISSA algorithm outperforms other algorithms in terms of solution stability and optimization search capability. Under three modes of operation, ISSA improves the microgrid operation revenue by 6.29%, 5.98%, and 6.31% at least. Therefore, the optimal scheduling scheme obtained based on ISSA improves the daily operating total revenue and the system operation stability of the microgrid.

Abstract Mixed reality navigation (MRN) technology is emerging as an increasingly significant and interesting topic in neurosurgery. MRN enables neurosurgeons to “see through” the head with an interactive, hybrid visualization environment that merges virtual- and physical-world elements. Offering immersive, intuitive, and reliable guidance for preoperative and intraoperative intervention of intracranial lesions, MRN showcases its potential as an economically efficient and user-friendly alternative to standard neuronavigation systems. However, the clinical research and development of MRN systems present challenges: recruiting a sufficient number of patients within a limited timeframe is difficult, and acquiring low-cost, commercially available, medically significant head phantoms is equally challenging. To accelerate the development of novel MRN systems and surmount these obstacles, the study presents a dataset designed for MRN system development and testing in neurosurgery. It includes CT and MRI data from 19 patients with intracranial lesions and derived 3D models of anatomical structures and validation references. The models are available in Wavefront object (OBJ) and Stereolithography (STL) formats, supporting the creation and assessment of neurosurgical MRN applications.

Abstract Background The Quick Delay Questionnaire (QDQ) is a short questionnaire designed to assess delay-related difficulties in adults. This study aimed to examine the reliability and validity of the Chinese version of the QDQ (C-QDQ) in Chinese adults, and explore the ecological characteristics of delay-related impulsivity in Chinese adults with attention-deficit/hyperactivity disorder (ADHD). Methods Data was collected from 302 adults, including ADHD (n = 209) and healthy controls (HCs) (n = 93). All participants completed the C-QDQ. The convergent validity, internal consistency, retest reliability and confirmatory factor analysis (CFA) of the C-QDQ were analyzed. The correlations between C-QDQ and two laboratory measures of delay-related difficulties and Barratt Impulsiveness Scale-11 (BIS-11), the comparison of C-QDQ scores between ADHD subgroups and HCs were also analyzed. Results The Cronbach’s α of C-QDQ was between 0.83 and 0.89. The intraclass correlation coefficient of C-QDQ was between 0.80 and 0.83. The results of CFA of C-QDQ favoured the original two-factor model (delay aversion and delay discounting). Significant positive associations were found between C-QDQ scores and BIS-11 total score and performance on the laboratory measure of delay-related difficulties. Participants with ADHD had higher C-QDQ scores than HCs, and female ADHD reported higher scores on delay discounting subscale than male. ADHD-combined type (ADHD-C) reported higher scores on delay aversion subscale than ADHD-inattention type (ADHD-I). Conclusion The C-QDQ is a valid and reliable tool to measure delay-related responses that appears to have clinical utility. It can present the delay-related impulsivity of patients with ADHD. Compared to HCs, the level of reward-delay impulsivity was higher in ADHD.

Abstract Background Liver cancer is a malignancy with high morbidity and mortality rates. Serpin family E member 2 (SERPINE2) has been reported to play a key role in the metastasis of many tumors. In this study, we aimed to investigate the potential mechanism of SERPINE2 in liver cancer metastasis. Methods The Cancer Genome Atlas database (TCGA), including DNA methylation and transcriptome sequencing data, was utilized to identify the crucial oncogene associated with DNA methylation and cancer progression in liver cancer. Data from the TCGA and RNA sequencing for 94 pairs of liver cancer tissues were used to explore the correlation between SERPINE2 expression and clinical parameters of patients. DNA methylation sequencing was used to detect the DNA methylation levels in liver cancer tissues and cells. RNA sequencing, cytokine assays, immunoprecipitation (IP) and mass spectrometry (MS) assays, protein stability assays, and ubiquitination assays were performed to explore the regulatory mechanism of SERPINE2 in liver cancer metastasis. Patient‐derived xenografts and tumor organoid models were established to determine the role of SERPINE2 in the treatment of liver cancer using sorafenib. Results Based on the public database screening, SERPINE2 was identified as a tumor promoter regulated by DNA methylation. SERPINE2 expression was significantly higher in liver cancer tissues and was associated with the dismal prognosis in patients with liver cancer. SERPINE2 promoted liver cancer metastasis by enhancing cell pseudopodia formation, cell adhesion, cancer‐associated fibroblast activation, extracellular matrix remodeling, and angiogenesis. IP/MS assays confirmed that SERPINE2 activated epidermal growth factor receptor (EGFR) and its downstream signaling pathways by interacting with EGFR. Mechanistically, SERPINE2 inhibited EGFR ubiquitination and maintained its protein stability by competing with the E3 ubiquitin ligase, c‐Cbl. Additionally, EGFR was activated in liver cancer cells after sorafenib treatment, and SERPINE2 knockdown‐induced EGFR downregulation significantly enhanced the therapeutic efficacy of sorafenib against liver cancer. Furthermore, we found that SERPINE2 knockdown also had a sensitizing effect on lenvatinib treatment. Conclusions SERPINE2 promoted liver cancer metastasis by preventing EGFR degradation via c‐Cbl‐mediated ubiquitination, suggesting that inhibition of the SERPINE2‐EGFR axis may be a potential target for liver cancer treatment.

Abstract Background At present, clinical nutritional care for patients with pancreatic cancer focuses more on the observation of the effect of enteral parenteral nutrition, and there is a lack of personalised care plans for weight-loss control. We used the Delphi method to construct a set of personalised nursing programmes to effectively control the rate of postoperative weight loss in patients with pancreatic cancer. Methods This study was a cross-sectional investigation. Through literature analysis, literature review and data review, a personalised nursing plan for the postoperative weight-loss control in patients with pancreatic cancer was preliminarily developed. From October to December 2022, the Delphi method was adopted to conduct two questionnaires for 32 experts working in fields related to pancreatic diseases in Grade-A tertiary hospitals from four different departments. After statistical processing, the personalised nursing plan was determined according to the perceived level of importance, coefficient of variation, full score rate and recognition rate of the indicators. Results The recovery rates of the two rounds of consultation were 93.75% and 100%, respectively, and the overall authority coefficient of the experts was 0.918, which represented ‘authoritative’. In terms of importance, the coefficient of variation was 0–0.137; in terms of feasibility, the coefficient of variation ranged from 0.09 to 0.194. Finally, a scheme consisting of 36 entries in 8 dimensions was built. This programme is comprehensive in content, meets the nutritional diagnosis and treatment needs of patients in the stage of postoperative rehabilitation, provides relatively comprehensive nutritional assessment and support and has a robust system and feasibility. Conclusions The individualised nursing plan for patients with pancreatic cancer with postoperative weight-loss control based on the Delphi method is highly scientific and reliable and has positive significance.

AbstractBackground: Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma.Objectives: This study was conducted to evaluate efficacy and safety of interferon (IFN) α-2a combined with phototherapy for early-stage MF.Methods: Thirteen patients with early-stage MF received subcutaneous injections of IFN α-2a at 3 million IU combined with phototherapy three times per week for 6 months. Treatment efficacy was measured by changes in body surface area (BSA) score and modified severity-weighted assessment tool (mSWAT) score at 1, 3, and 6 months after treatment. Histopathologic examinations of skin lesions were performed before and after treatment.Results: After 3 months of treatment, all 13 patients achieved a partial response, and BSA and mSWAT scores were significantly lower than those at baseline (p

AbstractPurpose: Atopic dermatitis (AD) adversely impacts quality of life (QoL). We evaluated the effect of upadacitinib, an oral selective Janus kinase inhibitor approved for moderate-to-severe AD, plus topical corticosteroids (+TCS) on patient-reported outcomes (PROs) over 52 weeks.Materials and methods: In the phase 3 AD Up study (NCT03568318), adults and adolescents with moderate-to-severe AD were randomized 1:1:1 to once-daily upadacitinib 15 mg, 30 mg, or placebo + TCS. Itch, skin pain/symptoms, sleep, QoL, daily activities, emotional state, mental health, and patient impressions of disease severity/improvement/treatment satisfaction were assessed.Results: This analysis included 901 patients. Within 1–2 weeks, PRO improvements were greater with both upadacitinib doses than with placebo (p

Presently, China is actively endorsing the pilot initiative for the remunerative use and trading of emission. By examining the operation and efficacy of emission trading in the context of water pollution control, one can contribute to the advancement and refinement of this system, thereby facilitating the attainment of regional pollution reduction, carbon reduction, and high-quality development objectives. In pursuit of this objective, we develop a theoretical framework for the local government and sewage enterprises evolutionary game of water pollution control, which includes two scenarios without considering and considering emission trading for studying the influencing factors and evolution trajectory of the game subject's. Through the stability analysis, the game interactive mechanism, the difference in evolutionary trajectory, and the response logic of the decision-making body in different situations become clearly visible. Further, the system sensitivity factors are analyzed by solving the partial derivation of the area formula of the phase diagram. And the efficacy of the sewage trading system in water pollution control in Zhejiang Province is empirically examined at the micro level by adopting the trading data of the first pilot area of sewage trading in the country and the case of pollution control in Jinhua City. The research reveals the following conclusions: Under specific circumstances, emission trading can incentivize businesses and even industries to enhance pollution control measures as a whole. The performance and degree of sensitivity factors vary across gaming systems, with public reputation evaluation and central government inspection serving as positive constraints. The initial cost of paid use of emission permits, as a fixed cost component for firms to address pollution, has no effect on the enterprises' behavioral actions to satisfy emission regulations. The findings can furnish local governments with a theoretical foundation and decision support in order to optimize regulatory strategies and enhance pollution control policies.

Abstract The Gardner region is a well‐known shield volcanic complex on the Moon. Its magma origin and formation mechanism are of significant interest but still enigmatic. To reveal the subsurface structure of this volcanic complex, we propose a new 3‐D inversion method of the gravity field based on the regularizations of the L1 norm of the model and its gradients. The model test indicates that our proposed method can recover the density structures with high resolution. Subsequently, we apply it to the Bouguer gravity data in the Gardner region. Our result shows a large, dense body with a volume of about 45 × 45 × 13 km3 centered under the topographic bulge of the Gardner Plateau. We infer that this structure is most likely dense basalts trapped at the crust‐mantle boundary as a sill and acted as the magma reservoir that has fed the volcanic complex in the Gardner area.

Objective To examine the effects of fish oil supplements on the clinical course of cardiovascular disease, from a healthy state to atrial fibrillation, major adverse cardiovascular events, and subsequently death.Design Prospective cohort study.Setting UK Biobank study, 1 January 2006 to 31 December 2010, with follow-up to 31 March 2021 (median follow-up 11.9 years).Participants 415 737 participants, aged 40-69 years, enrolled in the UK Biobank study.Main outcome measures Incident cases of atrial fibrillation, major adverse cardiovascular events, and death, identified by linkage to hospital inpatient records and death registries. Role of fish oil supplements in different progressive stages of cardiovascular diseases, from healthy status (primary stage), to atrial fibrillation (secondary stage), major adverse cardiovascular events (tertiary stage), and death (end stage).Results Among 415 737 participants free of cardiovascular diseases, 18 367 patients with incident atrial fibrillation, 22 636 with major adverse cardiovascular events, and 22 140 deaths during follow-up were identified. Regular use of fish oil supplements had different roles in the transitions from healthy status to atrial fibrillation, to major adverse cardiovascular events, and then to death. For people without cardiovascular disease, hazard ratios were 1.13 (95% confidence interval 1.10 to 1.17) for the transition from healthy status to atrial fibrillation and 1.05 (1.00 to 1.11) from healthy status to stroke. For participants with a diagnosis of a known cardiovascular disease, regular use of fish oil supplements was beneficial for transitions from atrial fibrillation to major adverse cardiovascular events (hazard ratio 0.92, 0.87 to 0.98), atrial fibrillation to myocardial infarction (0.85, 0.76 to 0.96), and heart failure to death (0.91, 0.84 to 0.99).Conclusions Regular use of fish oil supplements might be a risk factor for atrial fibrillation and stroke among the general population but could be beneficial for progression of cardiovascular disease from atrial fibrillation to major adverse cardiovascular events, and from atrial fibrillation to death. Further studies are needed to determine the precise mechanisms for the development and prognosis of cardiovascular disease events with regular use of fish oil supplements.

The present study conducted an extensive investigation into the durability of Na2SO4-activated binary slag cementitious materials for use in cemented paste backfill (CPB) under sulfate attack conditions. The primary objectives were to assess the feasibility of employing a cost-effective and environmentally friendly binder in CPB applications. Samples were subjected to exposure to Na2SO4 and MgSO4 solutions for a duration of 30 weeks, and multiple aspects including dimension stability, micro and macro mechanical strength evolution, changes in phase assemblage, microstructure following sulfate attack, and heavy metals leaching were examined. The study revealed that Na2SO4-activated binary slag (OPC-slag/S) exhibited superior resistance to sulfate attack, demonstrating enhanced dimension stability. Notably, sample OPC-slag/S displayed an increase in compressive strength, even after prolonged exposure to sulfate solutions for 30 weeks. This increase amounted to approximately 10.76% and 4.81% following exposure to Na2SO4 and MgSO4 solutions, respectively. The heightened resistance of binder OPC-slag/S to sulfate attack can be attributed to its low portlandite content and the early consumption of aluminates, primarily due to the formation of ettringite. This phenomenon effectively prevents the formation of detrimental and expansive products within the cement matrix during sulfate attack. On the other hand, CPB samples with binder OPC-slag/S showed the best performance in heavy metals immobilizaton capacity due to the high resistance to sulfate attack. In conclusion, this study underscores the potential of utilizing OPC-slag/S as a cost-effective and environmentally friendly binder for CPB applications in sulfate-rich environments.

This article presents a photovoltaic micro-grid system structure with multiport three-level converter(MP-TLC). In this structure, two AC power supplies/loads with different operating amplitudes and frequencies can be directly connected through MP-TLC without multiple power conversion units. Compared with the traditional configuration, the structure of the multi-port converter photovoltaic microgrid system operates under a multi-level voltage, which reduces the number of power conversion stages, reduces the number of power switches, and reduces the overall volume and cost of the system. In addition, a carrier-based time-sharing space vector modulation strategy is proposed to solve the problem of two output couplings of MP-TLC under SPWM modulation, so that the two output ports can work relatively independently. Compared with the traditional SVPWM modulation strategy, the carrier-based time-sharing space vector modulation strategy omits many trigonometric function calculation processes, which effectively improves the calculation speed of the algorithm. This article also presents a voltage-pumping DC-DC converter for the DC boost link in a photovoltaic micro-grid system. The converter can obtain a high voltage gain at a very low duty cycle and is suitable for a wider range of photovoltaic cell voltage input. The experimental results verify the effectiveness of the wide voltage input photovoltaic microgrid system based on MP-TLC.

For adapt to the function of distributed photovoltaic microgrid system of “self-generating and self-using, margin grid-connected”, from the perspective of cost saving and reducing converter volume, the paper proposed a distributed photovoltaic microgrid system (DTPV-MGS) based on the dual output T-type three-level converter (DT-TLC). The DT-TLC structure can output two sets of AC current with controllable frequency and amplitude. The working principle of the circuit is analyzed in this paper. The upper output of the DT-TLC can be directly connected to the AC source / load operating at different amplitudes and frequencies without additional AC/DC/AC converter units. The lower output is connected to the distribution network through the LCL filter to complete the grid connection. The grid-connected control method of the system is designed. Double-loop control method of grid-connected inverter based on voltage-vector directional control (VO-DCC) is used to control the reference signal of the grid-connected port. For the structure, a time-sharing modulation SVPWM technology is proposed to output the required three-phase AC voltage. In order to reduce the complex workload of SVPWM in the experiment process., a carrier-based pulse width modulation (CBPWM) based on SVPWM is proposed. The switch drive signal is obtained by comparing the modulation wave with the carrier wave. Finally, the feasibility of the proposed DT-TLC-DTPV-MGS, the effectiveness of the modulation method and the control method are experimentally verified.

An in-depth exploration of fractional vegetation coverage (FVC) changes and driving mechanisms in the Yangtze River Delta (YRD) is crucial for maintaining regional ecological health and achieving sustainable development. We therefore calculate FVC in the YRD from 2012 to 2021 based on MODIS NDVI data, and analyze its spatiotemporal evolution. Multiple regression residual analysis and geographic detector model were used along with various auxiliary data to further explore its driving mechanisms in a hierarchical manner. Finally, the Hurst index was used to forecast future trends in FVC. The results show that: 1) Significant changes in FVC occurred around 2016, rapidly declining at a rate of 8.9×10-3a-1 from 2012 to 2016, followed by fluctuating growth at a rate of 5.2×10-3a-1 thereafter. 2) Although the overall development of FVC in the YRD tends toward stability, the fluctuation was pronounced in the Taihu Lake Basin. Improvement areas were mainly concentrated on both sides of the Yangtze River in the central part of the YRD and in the southern mountainous region. Degraded areas were concentrated in cities north of the Huai River. 3) Dynamic changes in FVC were primarily driven by a combination of climate and human activities, whereas spatial heterogeneity was mainly driven by factors such as elevation, slope, and landform type. The improvement in the explanatory power of anthropogenic factors for spatial heterogeneity when combined with natural factors was significant.

Abstract Breast cancer metastasis and invasion are both promoted by the oncoprotein Metadherin (MTDH). However, the the role of Metadherin in breast cancer progression and its role in the immune microenvironment. Are not clear. A bioinformatic analysis was performed to demonstrate the prognostic value of Metadherin in BC. In the present study, we found that Metadherin is overexpressed in BC and is significantly correlated with individual cancer stage, age, subclasses, menopause and nodal metastasis status. Metadherin overexpression was associated with a significant decrease in OS and DSS. Cox multivariate analysis indicated that Metadherin was an independent negative prognostic indicator for OS and DSS. Moreover, Metadherin hypomethylation status was associated with poor prognosis. A negative correlation was also noted between Metadherin overexpression and the number of plasmacytoid dendritic cells, cluster of differentiation 8+ T cells, and natural killer cells. Association patterns varied with different subtypes. Various associations between Metadherin levels and immune cell surface markers were revealed. A total of 40 groups of BC and adjacent normal breast tissue samples were collected. Metadherin mRNA was detected by PCR, and its expression levels in BC tissues were significantly increased compared with those noted in normal tissues. The expression levels of Metadherin were also measured in normal and BC cell lines, respectively, and similar conclusions were obtained. The Metadherin mRNA levels were knocked down in SK-BR3 and MDA-MB-231 cell lines and the cell proliferative and migratory activities were determined using Cell Counting Kit-8 and scratch assays, respectively. The results indicated that the cell proliferative and migratory abilities were reduced following knockdown of Metadherin expression. Therefore, Metadherin may be considered as a novel prognostic biomarker in BC.

The Leaf Area Index (LAI) is a crucial structural parameter linked to the photosynthetic capacity and biomass of crops. While integrating machine learning algorithms with spectral variables has improved LAI estimation over large areas, excessive input parameters can lead to data redundancy and reduced generalizability across different crop species. To address these challenges, we propose a novel framework based on Bayesian-Optimized Random Forest Regression (Bayes-RFR) for enhanced LAI estimation. This framework employs a tree model-based feature selection method to identify critical features, reducing redundancy and improving model interpretability. A Gaussian process serves as a prior model to optimize the hyperparameters of the Random Forest Regression. The field experiments conducted over two years on maize and wheat involved collecting LAI, hyperspectral, multispectral, and RGB data. The results indicate that the tree model-based feature selection outperformed the traditional correlation analysis and Recursive Feature Elimination (RFE). The Bayes-RFR model demonstrated a superior validation accuracy compared to the standard Random Forest Regression and Pso-optimized models, with the R2 values increasing by 27% for the maize hyperspectral data, 12% for the maize multispectral data, and 47% for the wheat hyperspectral data. These findings suggest that the proposed Bayes-RFR framework significantly enhances the stability and predictive capability of LAI estimation across various crop types, offering valuable insights for precision agriculture and crop monitoring.

Classical frequency-stabilized lasers have achieved high-frequency stability and reproducibility; however, their extensive wavelength spacing limits their utility in various scenarios. This study introduces a novel frequency-stabilized laser scheme that integrates a Fabry-Perot etalon (FPE) with digital control technology and wavelength modulation techniques. The FPE, characterized by multiple transmission peaks at minimal frequency intervals, provides stable frequency references for different lasers, thereby enhancing the system’s flexibility and adaptability. An error signal is derived from the first-order differentiation of the FPE’s transmission curve. A 180° phase difference was observed in the feedback output signal when the laser’s central frequency diverged from the reference, determining that the direction of the frequency control was accordingly determined.Employing feedback control, the laser’s output frequency is stabilized at the transmission peak frequency of the FPE. Experimental results demonstrate that this stabilization scheme effectively locks the laser’s output wavelength to different transmission peak frequencies of the FPE, achieving 25 GHz wavelength spacing. The frequency stability is improved by two orders of magnitude on a second-level timescale, maintained within hundreds of kHz, equating to a frequency stability level of 10−10.

To provide a theoretical basis for the sustainable application of autumn mulching technology, we examined the effects of straw input on spring maize yield and water-use efficiency in film-mulched farmland. Based on the positioning tests of different mulching methods conducted in 2013, non-mulching (NM), spring mulching (SM), autumn mulching (AM), and autumn mulching combined with the return of straw (AMS) were selected in western Liaoning from 2018 to 2021. Spring maize yield, yield component factors, soil water content, and water-use efficiency under the four treatments were assessed. In each year, the AMS treatment significantly increased the maize yield, which was 48.22%, 9.33%, 30.66%, and 9.92%, and 11.78%, 7.71%, 12.86%, and 4.77% higher than that obtained after the SM and AM treatments, respectively. However, the harvest index was not significantly improved by AMS. AMS treatment significantly improved the precipitation utilization rate in all assessed years. Moreover, the crop water consumption was significantly increased by AMS treatment. Compared with the NM treatment, water-use efficiencies for economic and biological yield were also significantly improved. Thus, autumn mulching combined with straw-returning technology is an effective technical measure for improve spring maize yield and water-use efficiency in semi-arid areas of western Liaoning.

Abstract There is considerable interest in the potential of stereotactic body radiation therapy (SBRT) combined with systemic therapy such as tyrosine kinase inhibitors (TKIs) or immune checkpoint inhibitors (ICIs). However, its efficacy and safety remain unclear. The purpose of this study was to evaluate the efficacy and safety of conducting SBRT during ICI or TKI treatment in different disease settings for patients with metastatic renal cell carcinoma (mRCC). A total of 16 studies were ultimately included. Under the random effects model, the pooled 1‐year local control rate (1‐yr LCR) and objective response rate (ORR) were 90% (95% confidence interval [CI]: 80%–95%, I2 = 67%) and 52% (95% CI: 37%–67%, I2 = 90%), respectively. SBRT concomitant with different systemic therapy yield significant different 1‐yr LCR (p

Abstract Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa, the mechanism of its inflammatory progression has not yet been fully elucidated. PA28γ plays a significant role in a variety of immune‐related diseases. However, the exact role of PA28γ in the pathogenesis of OLP remains unclear. Here, we demonstrated that PA28γ is overexpressed in epithelial cells and inflammatory cells of OLP tissues but has no significant relationship with OLP subtypes. Functionally, keratinocytes with high PA28γ expression could induce dendritic cell (DC) maturation and promote the T‐cell differentiation into Th1 cells in response to the immune response. In addition, we found that a high level of PA28γ expression is associated with high numbers of infiltrating mature DCs and activated T‐cells in OLP tissues. Mechanistically, keratinocytes with high PA28γ expression could promote the secretion of C–C motif chemokine (CCL)5, blocking CCL5 or/and its receptor CD44 could inhibit the induction of T‐cell differentiation by keratinocytes with high PA28γ expression. In conclusion, we reveal that keratinocytes with high expression of PA28γ in OLP can induce DC maturation and promote T‐cell differentiation through the CCL5‐CD44 pathway, providing previously unidentified mechanistic insights into the mechanism of inflammatory progression in OLP.

BackgroundChronic obstructive pulmonary disease (COPD) is a prevalent condition that significantly impacts public health. Unfortunately, there are few effective treatment options available. Mendelian randomization (MR) has been utilized to repurpose existing drugs and identify new therapeutic targets. The objective of this study is to identify novel therapeutic targets for COPD.MethodsCis-expression quantitative trait loci (cis-eQTL) were extracted for 4,317 identified druggable genes from genomics and proteomics data of whole blood (eQTLGen) and lung tissue (GTEx Consortium). Genome-wide association studies (GWAS) data for doctor-diagnosed COPD, spirometry-defined COPD (Forced Expiratory Volume in one second [FEV1]/Forced Vital Capacity [FVC]

Abstract Background MicroRNA (miRNA) which can act as post-transcriptional regulators of mRNAs via base-pairing with complementary sequences within mRNAs is involved in processes of the complex interaction between immune system and tumors. In this research, we elucidated the profiles of miRNAs and target mRNAs expression and their associations with the phenotypic hallmarks of colorectal cancers (CRC) by integrating transcriptomic, immunophenotype, methylation, mutation and survival data. Results We conducted the analysis of differential miRNA/mRNA expression profile by GEO, TCGA and GTEx databases and the correlation between miRNA and targeted mRNA by miRTarBase and TarBase. Then we detected using qRT-PCR and validated the diagnostic value of miRNA-mRNA regulator pairs by the ROC, calibration curve and DCA. Phenotypic hallmarks of regulatory pairs including tumor-infiltrating lymphocytes, tumor microenvironment, tumor mutation burden, global methylation and gene mutation were also described. The expression levels of miRNAs and target mRNAs were detected in 80 paired colon tissue samples. Ultimately, we picked up two pivotal regulatory pairs (miR-139-5p/ STC1 and miR-20a-5p/ FGL2) and verified the diagnostic value of the complex model which is the combination of 4 signatures above-mentioned in 3 testing GEO datasets and an external validation cohort. Conclusions We found that 2 miRNAs by targeting 2 metastasis-related mRNAs were correlated with tumor-infiltrating macrophages, HRAS, and BRAF gene mutation status. Our results established the diagnostic model containing 2 miRNAs and their respective targeted mRNAs to distinguish CRCs and normal controls and displayed their complex roles in CRC pathogenesis especially tumor immunity.

Abstract Background Reduced supplies of oxygen and nutrients caused by vascular injury lead to difficult-to-heal pressure ulcers (PU) in clinical practice. Rapid vascular repair in the skin wound is the key to the resolution of this challenge, but clinical measures are still limited. We described the beneficial effects of extracellular vesicle-derived silk fibroin nanoparticles (NPs) loaded with milk fat globule EGF factor 8 (MFGE8) on accelerating skin blood vessel and PU healing by targeting CD13 in the vascular endothelial cells (VECs). Methods CD13, the specific targeting protein of NGR, and MFGE8, an inhibitor of ferroptosis, were detected in VECs and PU tissues. Then, NPs were synthesized via silk fibroin, and MFGE8-coated NPs (NPs@MFGE8) were assembled via loading purified protein MFGE8 produced by Chinese hamster ovary cells. Lentivirus was used to over-express MFGE8 in VECs and obtained MFGE8-engineered extracellular vesicles (EVs-MFGE8) secreted by these VECs. The inhibitory effect of EVs-MFGE8 or NPs@MFGE8 on ferroptosis was detected in vitro. The NGR peptide cross-linked with NPs@MFGE8 was assembled into NGR-NPs@MFGE8. Collagen and silk fibroin were used to synthesize the silk fibroin/collagen hydrogel. After being loaded with NGR-NPs@MFGE8, silk fibroin/collagen hydrogel sustained-release carrier was synthesized to investigate the repair effect on PU in vivo. Results MFGE8 was decreased, and CD13 was increased in PU tissues. Similar to the effect of EVs-MFGE8 on inhibiting ferroptosis, NPs@MFGE8 could inhibit the mitochondrial autophagy-induced ferroptosis of VECs. Compared with the hydrogels loaded with NPs or NPs@MFGE8, the hydrogels loaded with NGR-NPs@MFGE8 consistently released NGR-NPs@MFGE8 targeting CD13 in VECs, thereby inhibiting mitochondrial autophagy and ferroptosis caused by hypoxia and accelerating wound healing effectively in rats. Conclusions The silk fibroin/collagen hydrogel sustained-release carrier loaded with NGR-NPs@MFGE8 was of great significance to use as a wound dressing to inhibit the ferroptosis of VECs by targeting CD13 in PU tissues, preventing PU formation and promoting wound healing. Graphical Abstract

The process of rainwater infiltration into unsaturated multi-layered slopes is complex, making it extremely difficult to accurately predict slope behaviors. The hydrological mechanisms in multi-layered slopes could be significantly influenced by the varying hydraulic characteristics of different soils, thus influencing slope stability. A numerical model based on Hydrus 2D was constructed to investigate the hydrological mechanisms of multi-layered slopes under different slope inclinations and rainfall intensities. The results revealed hydraulic processes in response to rainfall in unsaturated multi-layered slopes, in which layered soils retard the advance of wetting fronts and affect seepage paths in the slope. The results also showed the characteristics of hydraulic parameters, including pore water pressure and moisture content, under different conditions, and explained the crucial factors at play in maintaining slope stability.

The sturgeon is an important commercial aquaculture species in China. The measurement of sturgeon mass plays a remarkable role in aquaculture management. Furthermore, the measurement of sturgeon mass serves as a key phenotype, offering crucial information for enhancing growth traits through genetic improvement. Until now, the measurement of sturgeon mass is usually conducted by manual sampling, which is work intensive and time consuming for farmers and invasive and stressful for the fish. Therefore, a noninvasive volume reconstruction model for estimating the mass of swimming sturgeon based on RGB-D sensor was proposed in this paper. The volume of individual sturgeon was reconstructed by integrating the thickness of the upper surface of the sturgeon, where the difference in depth between the surface and the bottom was used as the thickness measurement. To verify feasibility, three experimental groups were conducted, achieving prediction accuracies of 0.897, 0.861, and 0.883, which indicated that the method can obtain the reliable, accurate mass of the sturgeon. The strategy requires no special hardware or intensive calculation, and it provides a key to uncovering noncontact, high-throughput, and highly sensitive mass evaluation of sturgeon while holding potential for evaluating the mass of other cultured fishes.

This paper investigated the effects of steam explosion (SE) pretreatment on the structural characteristics and antioxidant activity of Hypsizygus marmoreus polysaccharides (HPS). Hypsizygus marmoreus samples were pretreated at different SE temperatures (120–200 °C) and polysaccharides were extracted using the water extraction and alcohol precipitation method. The results showed that SE pretreatment improved the extraction rate of HPS. Under the conditions of SE treatment time of 60 s and temperature of 160 °C, the extraction rate of HPS was the highest (8.78 ± 0.24%). After SE pretreatment, the structural changes of HPS tended to enhance the antioxidant activity, which showed that the content of Gal and Man in the monosaccharide composition increased and the molecular weight decreased. When testing antioxidant activity in vitro, the ability of SE-pretreated HPS to scavenge DPPH radicals, hydroxyl radicals, and superoxide anion radicals was better than that of HPS without SE pretreatment. Our findings shed light on SE pretreatment as an efficient method for extracting active polysaccharides, providing a new way to improve their extraction rate and biological activity.

Developing high‐performance anode current collectors with three‐dimensional structure and lithiophilic layers is of great importance to further advance the application of lithium metal batteries. However, relatively few research has focused on the transition of substrate and the intrinsic structure stability after electrodeposition of lithium on substrates, which leads to an incomplete understanding of the behavior of lithium deposition. Herein, a lithium metal anodes host with a highly stable and 3D structure has been effectively produced through in situ development of nanoflake arrays embedded with Co3O4 obtained from ZIF on nickel foams (Co3O4‐NF). And the actual lithium deposition sites and lithium deposition process on Co3O4‐NF are elucidated via a combination of characterization techniques and electrochemical analytical methods. Consequently, the resulting Co3O4‐NF@Li anodes could effectively inhibit lithium dendrite formation and mitigate volume expansion, demonstrating a significantly extended and consistent lifespan of 800 cycles (1600 h) at 1 mA cm−2 with low overpotential and insignificant voltage fluctuation for the process of lithium stripping and plating in symmetric cells. Herein, it is aimed to examine the transitions of metal oxides as a lithiophilic site for the lithium metal anode. It offers novel perspectives and approaches for the design of dendrite‐free lithium metal anodes.

Inflammation induced by angiotensin II (Ang II) is a key event in the progression of numerous cardiovascular diseases. Astragaloside IV (AS-IV), a glycoside extracted from Astragalus membranaceus Bunge, has been shown to inhibit Ang II–induced inflammatory responses in vivo. However, the mechanisms underlying the beneficial effects are still unclear. This study investigated whether AS-IV attenuates endothelial inflammation induced by Ang II via the activation of endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway. Human umbilical vein endothelial cells (HUVECs) were cultured in the presence of AS-IV with or without the specific inhibitor of NOS or Ca2+- and phosphatidylinositol 3-kinase (PI3K)/Akt-dependent cascade prior to Ang II exposure. Incubation of HUVECs with AS-IV enhanced NO production and eNOSser1177 phosphorylation. These responses were abrogated by the inhibition of NOS or Ca2+- and PI3K/Akt-dependent pathway. In addition, preincubation of HUVECs with AS-IV inhibited Ang II–induced cytokine and chemokine production, adhesion molecule expression, monocyte adhesion, and nuclear factor kappa B (NF-κB) activation as evidenced by the attenuation of inhibitor of kappa B alpha phosphorylation and subsequent NF-κB DNA binding. These effects of AS-IV were abolished by the suppression of NOS or Ca2+- and PI3K/Akt-dependent cascade. Our findings indicate that AS-IV attenuates inflammatory responses triggered by Ang II possibly via the activation of Ca2+/PI3K/Akt/eNOS/NO pathway in endothelial cells.

We study the gas inflows toward the Galactic Central Molecular Zone (CMZ) based on the gas morphological and kinematic features from the Milky Way Imaging Scroll Painting in the region of l = 1.°2–19.°0 and ∣ b ∣ ≲ 3.°0. We find that the near dust lane appears to extend to l ∼ 15°, in which the end of the large-scale gas structure intersects with the 3 kpc ring at a distance of ∼5 kpc. Intriguingly, many filamentary molecular clouds (MCs), together with the bow-like/ballistic-like clouds and continuous CO features with notable velocity gradient, are finely outlined along the long structure. These MCs also have relatively large velocity dispersions, indicating the shocked gas generated by local continuous accretion and thus the enhanced turbulence along the entire gas structure. We suggest that the ∼3.1–3.6 kpc-long CO structure originates from the accretion molecular gas driven by the Galactic bar. The gas near the bar end at the 3 kpc ring region becomes an important reservoir for the large-scale accreting flows inward to the CMZ through the bar channel. The inclination angle of the bar is estimated to be ϕ _bar = 23° ± 3°, while the pattern speed of the bar is Ω _bar ≲ 32.5 ± 2.5 km s ^−1 kpc ^−1 . The total mass of the whole near gas lane is about 1.3 ± 0.4 × 10 ^7 M _⊙ according to the calculated X _CO ∼ 1.0 ± 0.4 × 10 ^20 cm ^−2 (K km s ^−1 ) ^−1 from the large-scale ^12 CO and ^13 CO data and the complementary H i data. We revisit the gas inflow rate as a mean value of 1.1 ± 0.3 M _⊙ yr ^−1 , which seems to be comparable to the outflow's rate of the Galactic nuclear winds after applying the updated lower X-factor above.

Abstract Objective: To determine whether the Chinese heart-healthy diet (Sichuan cuisine version) (CHH diet-SC) was more expensive than the conventional Sichuan diet and explore the food groups and nutrients that mainly affected the cost of CHH diet-SC. Design: Cost analysis of 4-week intervention diets in the Sichuan center representing southwestern China in the CHH diet study. Setting: A multicentre, parallel-group, single-blind, randomised feeding trial evaluating the efficacy of lowering blood pressure with the cuisine-based CHH diet. Participants: Totally, fifty-three participants with hypertension aged 25–75 years in the Sichuan center were randomised into the control group (n 26) or the CHH diet-SC group (n 27). Results: The CHH diet-SC was more expensive than the control diet (¥27·87 ± 2·41 v. ¥25·18 ± 2·79 equals $3·90 ± 0·34 v. $3·52 ± 0·39, P < 0·001), and the incremental cost-effectiveness ratio for a 1-mm Hg systolic blood pressure reduction was ¥9·12 ($1·28). Intakes and the cost of seafood, dairy products, fruits, soybeans and nuts, whole grains and mixed beans were higher for the CHH diet-SC than for the control diet (P < 0·001). Intakes of vitamin B1, vitamin B6, vitamin C, Mg and phosphorus were positively correlated with the cost (P < 0·05). Conclusions: The CHH diet-SC costs more than the conventional Sichuan diet, partly due to the high cost of specific food groups. Positive correlations between the intakes of vitamin B1, vitamin B6, vitamin C, Mg, phosphorus and the dietary cost could be a direction to adjust the composition within the food groups to reduce the cost of the CHH diet-SC.

In the modern era, the escalating global prevalence of obesity has profound implications on female reproductive health. Obesity, transcending mere lifestyle choices, has evolved into a complex disorder affecting physiological and metabolic functions. Concurrently, female infertility is rising as a significant global health issue. Obesity, with its extensive systemic effects, is pinpointed as a major disruptor. The convergence of these health challenges reveals a multifaceted scenario: on one hand, obesity directly impacts female reproductive health, particularly in the context of conditions like polycystic ovary syndrome (PCOS) and menstrual disturbances; on the other, the psychosocial consequences of infertility might intensify weight-gain patterns, forming a challenging cycle. Additionally, the economic implications of treating obesity-related infertility are considerable. This review delves into the myriad ways obesity affects female reproductive health, drawing insights from epidemiological, clinical, and molecular studies. It explores the epidemiological relationship between obesity and PCOS, the influence of obesity on menstrual disturbances, and the broader impact of obesity on female infertility. Weight loss, through pharmacological interventions, surgical methods, or lifestyle adjustments, emerges as a promising strategy. Lastly, the efficacy of assisted reproductive technologies, such as IVF, is influenced by obesity, underscoring the importance of an optimal body mass index. The review also highlights the molecular and physiological mechanisms underlying the impact of obesity on female reproductive health, including the disruption of the hypothalamic-pituitary-ovary axis, altered adipokine secretion, and the role of chronic inflammation and oxidative stress.

Solid polymer electrolytes (SPE) offer an outstanding choice because of their lightweight, flexibility, and excellent thin‐film forming ability. However, the low ionic conductivity and poor lithium ion transfer number (tLi+) restrict its application in all‐solid‐state lithium batteries (ASSLBs). Herein, UIO66‐X metal‐organic frameworks with controllable Lewis basicity, acidity, or neutrality functional groups are synthesized successfully and then incorporated into the poly (ethylene oxide) (PEO) matrix to fabricate SPE. The influence of different organic ligands on the interface interaction between PEO and LiTFSI is investigated by solid‐state nuclear magnetic resonance, Fourier transform infrared spectoscopy and Raman tests, as well as density functional theory calculations. The Lewis acidity group plays a key role in enhancing the ionic conductivity and tLi+. As a result, the constructed Li–Li symmetrical cells retain stable cycling for 2300 h and the LiFePO4‐based ASSLBs deliver outstanding electrochemical properties with 147 mAh g−1 of reversible capacity after 500 cycles at 1C and 60 °C, 131 mAh g−1 after 150 cycles at 0.1C and 30 °C. The fabricated SPEs are self‐standing and flexible with good mechanical stability, demonstrating the great potential for practical application. The results can guide choosing the inorganic filler to prepare high‐performance SPE.

Abstract Additive manufacturing of co‐fired low temperature ceramics offers a unique route for the fabrication of novel 3D radiofrequency (RF) and microwave components, embedded electronics and sensors. This study demonstrates the fabrication, materials analysis, and RF characterization of a multi‐material bismuth molybdate—silver (Bi2Mo2O9—Ag) artificial dielectric fabricated by laser assisted direct ink writing. The proposed fabrication technique enables 3D printing of dissimilar materials while minimizing inter‐material diffusion through the liquid phases. The permittivity of the artificial dielectrics increased up to 99% over the investigated frequency range (8–12 GHz) compared to the fabricated pure ceramic sample.

Arrhythmia is one of the most common cardiovascular diseases. The search for new drugs to suppress various types of cardiac arrhythmias has always been the focus of attention. In the past decade, the screening of antiarrhythmic active substances from plants has received extensive attention. These natural compounds have obvious antiarrhythmic effects, and chemical modifications based on natural compounds have greatly increased their pharmacological properties. The chemical modification of botanical antiarrhythmic drugs is closely related to the development of new and promising drugs. Therefore, the structural characteristics and action targets of natural compounds with antiarrhythmic effects are reviewed in this paper, so that pharmacologists can select antiarrhythmic lead compounds from natural compounds based on the disease target - chemical structural characteristics.

Uveitis is a rare adverse event of dupilumab, that typically affects both eyes and often leads to discontinuation of therapy. In this article, we report a case of a 28-year-old female with atopic dermatitis who developed new-onset iridocyclitis, a form of uveitis, in her left eye 2 weeks after starting dupilumab treatment, which improved after reducing the dose, without discontinuing dupilumab. The patient also experienced asymptomatic hypereosinophilia, possibly related to dupilumab, which was gradually relieved without discontinuation. With the readers, we share our experience in managing uveitis and hypereosinophilia associated with dupilumab, which may be helpful in managing these conditions and avoiding discontinuation of dupilumab.

Considering the regional economic and social characteristics and high-quality development goals, this paper improves the calculation method of green efficiency of water resources and adopts the SBM-DEA model to calculate the green efficiency of water resources in 35 cities of four provinces in the Huaihe River Basin. The results show that (1) the green efficiency of water resources in the Huaihe River Basin decreased first and then increased from 2011 to 2020. (2) In terms of spatial distribution, the provincial-level divisions of green efficiency of water resources in the Huaihe River Basin from high to low are Shandong, Henan, Jiangsu, and Anhui. The elliptical area of green efficiency of water resources keeps expanding, and the efficiency value radiates outward along ‘Yangzhou–Zhengzhou’. (3) At the level of total-factor productivity decomposition, TC (technological change) has a more noticeable impact on factors than EC (efficiency change). TC scale technology changes mainly come from the improvement of MATC (magnitude technical change). (4) Industrial output value has a positive driving effect on the green efficiency of water resources. Government participation, resource endowment, and economic growth rate reflect China's current incongruity between economic development and water resources green efficiency improvement. HIGHLIGHTS The water resources footprint model and the grey water footprint model are integrated into the measurement of green efficiency of water resources.; The ‘high-quality development index’ is standardized and weighted to highlight the differences between indicators and make the efficiency calculation more objective and authentic.;