Search

The process of glass transition during the quenching in the domain with the cold wall has been numerically simulated. We have implemented the temperature-dependent form of the previously proposed theoretical model, which combined the heat transfer in the domain and the gauge theory of glass transition, assuming the presence of topologically stable distortions (disclinations) in the forming solid. The competition between crystallization (formation of polycrystalline structure) and the formation of the amorphous disordered phase has been shown. At the relatively slow cooling rates corresponding to the formation of the crystalline phase, we observed a columnar to equiaxed transition qualitatively similar to the observed in many metallic alloys. The moving front followed the equilibrium isotherm corresponding to the equilibrium temperature of transition in the disclinations subsystem, although front drag resulted in the effect of kinetic undercooling and the emergence of the maximum velocity of the crystallization front. High thermal conductivity values associated with the substantial heat flux lead to the bulk amorphous state. The dynamics of the coarsening of the primary amorphous structure depended on the annealing temperature.

Objective: Autologous transplantation of bone marrow/peripheral blood stem cells in patients with HIV-associated lymphopoliferative disorder is a feasible and relatively safe therapeutic option. However, at the moment there are a number of unsolved problems, including optimal risk/benefit pre-transplant conditioning, taking into account drug-drug interactions and indications for hematopoietic stem cell transplantation. Methodology: Since 2020 PBSCT has been performed in 15 patients with HIV in our center. The 12 (80%), had diagnosis of HIV-associated plasmablastic lymphoma (HIV-PBL), 3 patients (20%) were with HIV-associated Hodgkin' lymphoma (HIV-HL). All of the patients with HIV-PBL were transplanted after completion of a first-line treatment and achievement of at least a partial response. The pre-transplant conditioning was performed using BEAM-like regimens. Results: Toxicity from organs and systems did not exceed grade 2 (moderate) mainly from the gastrointestinal tract, no need antiretroviral therapy in all of the cases. Median time to neutrophil engraftment was +12 days, while to platelet engraftment was +13 days. At the time of submitting the abstract all of the transplanted patients described above except one (lethal case due to progression of concomitants hepatitis C virus (HCV) infection) are in the state of remission. Conclusion: Autologous transplantation of peripheral blood stem cells in patients with HIV is a feasible and relatively safe option with clear planning of the patient's treatment strategy from the first day of therapy and accompanying consideration of drug-drug interactions which is confirmed both by world literature and our Center's own experience.

In2O3 : Er films have been synthesized on silicon substrates by RF magnetron sputter deposition. The currents through the synthesized metal/oxide/semiconductor (MOS) structures (Si/In2O3 : Er/In-contact) have been measured for n and p type conductivity silicon substrates and described within the model of majority carrier thermoemission through the barrier, with bias voltage correction to the silicon potential drop. The electron and hole injection barriers between the silicon substrate and the film have been found to be 0.14 and 0.3 eV, respectively, by measuring the temperature dependence of the forward current at a low sub-barrier bias. The resulting low hole injection barrier is accounted for by the presence of defect state density spreading from the valence band edge into the In2O3 : Er band gap to form a hole conduction channel. The presence of defect state density in the In2O3 : Er band gap is confirmed by photoluminescence data in the respective energy range 1.55–3.0 eV. The band structure of the Si/In2O3 : Er heterojunction has been analyzed. The energy gap between the In2O3 : Er conduction band electrons and the band gap conduction channel holes has been estimated to be 1.56 eV.

Objective: to study the mechanism of action of low-mineralized sulfate-chloride-sodium mineral water on the clinical picture and motor function of the stomach in patients with epigastric pain syndrome using the regulatory peptide motilin as an example. Materials and methods: 113 people of both sexes were examined, the average age was 22.3±0.21 years. The observation group (57 people) included individuals with functional dyspepsia in the variant of epigastric pain syndrome, the comparison group included practically healthy individuals (56 people). The questionnaire method was used according to the Gastrointestinal Symptom Rating Scale questionnaire; ELISA method for determining the concentration of motilin in the blood. Mineral water in a volume of 200 ml was taken once by both groups of patients, patients with EPS additionally received a course. Results: in persons with epigastric pain syndrome, abdominal pain prevails. The course intake of mineral water provides a positive clinical trend, confirmed by a decrease in the syndromes of lesions of the upper gastrointestinal tract. A single and course intake of mineral water provides a stable increase in the level of motilin in functional dyspepsia. Conclusion: patients suffering from functional dyspepsia in the variant of epigastric pain syndrome have persistent disorders of motilin secretion compared with healthy individuals. Stimulation of the stomach on a drinking test model showed inadequacy of changes in the level of this hormone. Both a single and a course intake of low-mineralized sulfate-chloride-sodium mineral water contributes to an increase in the concentration of motilin, which should be considered as a physical adaptogenic factor leading to a stable ordering of the body’s functional relationships.

The paper presents a study of the process of nitric acid dissolution of the natural minerals chalcopyrite and bornite. The influence of various parameters, including temperature, nitric acid concentration and particle sizes, on this process was examined. Based on the data obtained, the values of apparent activation energy (57.41 and 42.98 kJ/mol for chalcopyrite and bornite, respectively), empirical orders with respect to nitric acid (1.62 and 1.57 for chalcopyrite and bornite, respectively) and with respect to particle size (–1.16 and –2.53 for chalcopyrite and bornite, respectively) were calculated using the shrinking core model. Generalized kinetic equations for the dissolution process of both minerals were derived. Based on the calculations performed, it was suggested that the dissolution processes of chalcopyrite and bornite under these conditions are limited by internal diffusion.

Let [Please download the PDF to view the mathematical expression] be a weighted sum with independent, identically distributed steps [X.sub.j,n], j < n, where [a.sub.j,n] = f(j/n) for some f [member of] [C.sup.2] [0,1]. Under Cramer's condition, we prove an integro-local limit theorem for [[Please download the PDF to view the mathematical expression] as x/n [member of] [[m.sup.-],[m.sup.+]] for some [m.sup.-], [m.sup.+] and any sequence [DELTA].sub.n] tending to zero slowly enough. This result covers the whole scope of normal, moderate, and large deviations. For the stochastic process [Y.sub.n](t) corresponding to [S.sub.0],..., [S.sub.n] we obtain a conditional functional limit theorem concerning convergence [Y.sub.n](t) to the Brownian bridge given the condition [S.sub.n] [member of] [x,x + [DELTA]n)., 1. Introduction Let [Y.sub.1,n],..., [Y.sub.n,n] be a triangular array of independent random variables with nonlattice distribution. Normal, moderate, and large deviations of [Please download the PDF to view the mathematical [...]

In the present paper, we consider the problem of probability density function estimation. Our data has multiplicative noise; therefore, we cannot use direct methods. Our method is based on estimation of coefficients of the Fourier transform for the density function., 1. Introduction In the present paper, we consider the problem of detecting impurities in liquids. During the experiment, liquid is illuminated by the laser light and impurity particles are captured [...]

The efficiency of thin film photoelectric devices can be improved by redirecting incident electromagnetic radiation along their surface layers. Redirection can be achieved using antireflection coatings made of subwavelength dielectric particle arrays. In this study, we fabricate such coatings, consisting of Ge particles on quartz glass substrates via solid-state dewetting, transforming thin Ge films into compact particles. Using optically transparent substrates, we measure reflection and transmission spectra and determine absorption spectra, showing that substrates coated with Ge particles absorb much more strongly than substrates coated with continuous Ge films. The spectra obtained using objective lenses with different aperture angles indicate that scattered radiation is predominantly directed at glancing angles to the substrate surface. The lateral propagation of scattered radiation is the result of destructive interference, which suppresses both reflected and transmitted radiation.

The article presents modern views on the problem of gastroesophageal reflux disease (GERD). Data on the prevalence and risk factors for the development of the disease are presented. Emphasis is placed on the special role of slightly acidic and slightly alkaline reflux in the pathogenesis of GERD, which, in combination with dysfunction of the lower esophageal sphincter and impaired motor-evacuation function of the stomach, are important factors, determining the the lack of effectiveness of standard antisecretory therapy. The exceptional importance of the 24-hour pH impedanceometry method is emphasized for the differential diagnosis of the non-erosive form of GERD with functional heartburn and hypersensitivity of the esophagus to reflux (the so-called hypersensitive esophagus). The data of the results of domestic and foreign studies devoted to the evaluation of the effectiveness of the use of physiotherapeutic methods and drinking balneotherapy in patients with GERD are given.

Abstract The light reflection properties of Ge disk lattices on Si substrates are studied as a function of the disk height and the gap width between disks. The interdisk spacing effect is observed even at such large gap widths as 500 nm. The gap width decrease leads to the appearance of the reflection minimum in the short wavelength region relative to one originated from the magnetic and electric dipole resonances in individual Ge disks, thereby essentially widening the antireflection properties. This minimum becomes significantly deeper at small gap widths. The observed behavior is associated with the features of the resonant fields around closely spaced disks according to numerical simulation data. The result shows the importance of using structures with geometrical parameters providing the short-wavelength minimum. This can essentially enhance their other resonant properties, which are widely used for applications, in particular, based on collective lattice resonances.

Catalytic reactions on flexible sheets generate fluid flows that transform the shape of the sheet, which in turn modifies the flow. These complex interactions make computer models vital for designing and harnessing these feedback loops to create soft active matter that autonomously performs self-sustained mechanical work.

Background. Functional diseases of the gastrointestinal tract are an actual problem of gastroenterology, since the symptoms of dyspepsia are one of the most common reasons for seeking medical help. In the occurrence and development of these disorders, chronic stress and depression can often act as a causative factor. The purpose of this study is to determine the effect of depression and stress on the functional state of the gastrointestinal tract. Materials and methods. A cross-sectional study was conducted in 48 people with and without functional dyspepsia. A comparative assessment of the level of depression and stress in the studied groups of people, the impact of the above psychological conditions on the visceral hypersensitivity of the stomach was carried out. Results. Statistically significant differences in the indicators of depression and stress in persons with functional disorders of the stomach were revealed in comparison with the group of subjects without such symptoms. Statistically significant correlations were also found between the temperature of the water used in the drinking test and such parameters as the amount of fluid drunk (r=-0.966, p

The pathology of the gastrointestinal tract occupies one of the leading places in the structure of the general morbidity of the population. Despite modern diagnostic methods, their prevalence is constantly increasing. Among the diseases of the gastroenterological profile, the most common are chronic pancreatitis, gastric ulcer and duodenal ulcer, hepatitis and cirrhosis of the liver, as well as chronic intestinal diseases. Purpose. To assess the possibilities of the GSRS questionnaire as a method for differential diagnosis of diseases of various organs of the gastrointestinal tract. Materials and methods. A study of the symptoms of 91 patients with gastrointestinal diseases was carried out using a specific GSRS questionnaire. Also, to verify the diagnoses, laboratory (complete and biochemical blood tests, complete feces and urine analyzes) and endoscopic (EGDS and video colonoscopy) research methods were carried out. Results. In the course of the study, the patients were divided into three groups according to the main diagnosis. It was noted that all groups were significantly different in terms of abdominal pain syndrome (AP) and reflux syndrome (RS), as well as the overall score of the GSRS questionnaire. Laboratory data were consistent with the clinical picture of the disease. Conclusion. Shows the importance of using the GSRS questionnaire as a method of approximate differential diagnosis of diseases of various parts of the gastrointestinal tract. The necessity of its joint use with laboratory – instrumental methods in the examination of patients is noted. Thus, an integrated approach will improve the efficiency of the quality of primary health care provided.

Relevance. The topicality of the work is determined by the wide spread of hypomagnesemia among the people, which makes it necessary to correct it. The aim of the work is to elucidate the cell-mediated response of the thymus mastocytic link to magnesium deficiency and its correction by the mechanoactivated form of magnesium orotate. Materials and Methods . Animals with drug-induced magnesium deficiency (administration of furosemide 30 mg/kg for 14 days) were administered either the initial preparation Magnerot (Magnerot, Vervag Pharma, Germany), or its mechanoactivated form. The level of magnesium in the blood was determined by test systems ARKREY (Japan). The concentration of magnesium in the thymus tissue was determined by the method of emission spectroscopy with inductively coupled (argon) plasma on an atomic emission spectrometer. Density of mastocytes and the indices of degranulation and granulolosis were calculated on paraffin sections of the thymus after coloration with toluidine blue. Results and Discussion . It was shown that furosemide administration the amount of magnesium decreased in the blood (from 1,750,08 to 0,9020,18 mmol/l, p0,05), but increased in the thymus (from 1,60,6 in the control to 3,71,2 mg/l); in the gland tissue, the number of mastocytes of morphotype A decreased and the number of mastocytes of morphotype D, after active degranulation, increased (by 7,1 times, p0,05). The type of mastocyte secretion in hypomagnesemia is represented by the merocrine variant. The administration of the initial magnesium orotate led to an increase in the concentration of magnesium in the blood to 1,150,25 mmol/l, which is 65,7% of the initial level, the amount of magnesium in the thymus remained elevated (3,41,1 mg/l), the number of actively degranulating cells (morphotype D) was increased. Mechanoactivated magnesium orotate restored the concentration of Mg2+ in the blood to 89,1% (1,560,18 mmol/l, p0,05) and decreased in the thymus (to 2,30,7 mg/l), restored the subpopulation of mastocytes saturated with heparin (type A), reduced the number of mastocytes of morphotype D. Conclusion . The mechanoactivated form of magnesium orotate has a normalizing effect on the population of thymic mastocytes, shows pronounced immunomodulatory activity, which allows us to consider it as a potential therapeutic agent for clinical testing in the complex therapy of hypomagnesemia and associated immunodeficiency.

The process of glass transition during the quenching in the domain with the cold wall has been numerically simulated. We have implemented the temperature-dependent form of the previously proposed theoretical model, which combined the heat transfer in the domain and the gauge theory of glass transition, assuming the presence of topologically stable distortions (disclinations) in the forming solid. The competition between crystallization (formation of polycrystalline structure) and the formation of the amorphous disordered phase has been shown. At the relatively slow cooling rates corresponding to the formation of the crystalline phase, we observed a columnar to equiaxed transition qualitatively similar to the observed in many metallic alloys. The moving front followed the equilibrium isotherm corresponding to the equilibrium temperature of transition in the disclinations subsystem, although front drag resulted in the effect of kinetic undercooling and the emergence of the maximum velocity of the crystallization front. High thermal conductivity values associated with the substantial heat flux lead to the bulk amorphous state. The dynamics of the coarsening of the primary amorphous structure depended on the annealing temperature. [ABSTRACT FROM AUTHOR]